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RHUMA-CURE

Composition
Each tablet contains:
Rofecoxib 12.5 or 25 mg

Properties and Mode of Action


RHUMA-CURE is a NSAID which inhibits prostaglandin synthesis by COX-2 inhibition.So, it has analegesic and
anti-inflmmatory actions with low incidence of gastrointestinal side effects.

Indications
Relief of signs and symptoms of osteoarthritis.
Relief of acute pain.
Treatment of Primary Dysmenorrhoea.

Dosage and Administration


Osteoarthritis:
12.5 - 25 mg Once Daily.
Acute Pain and Primary Dysmenorrhoea:
50 mg Once Daily ( for not more than 5 days).

Precautions
Caution should be used in patients with advanced renal dysfunction, moderate to severe hepatic dysfunction, patients with
hypertension, heart failure and pre-existing asthma or prior history of peptic ulcer or GI bleeding. Used in pregnancy and
lactation only if the potential benefit justifies the potential risk. RHUMA-CURE use during the third trimester of pregnancy
should be avoided.

Drug Interactions
RHUMA-CURE can be used with low-dose aspirin and other anti-inflammatory drugs; however, care should be taken
when combining RHUMA-CURE with those drugs, because gastric irritation may result.
NSAIDs may diminish the antihypertensive effect of ACE inhibitors and reduce the natriuretic effect of furosemide and
thiazides . This interaction should be given consideration in patients taking RHUMA-CURE concomitantly with ACE
inhibitors and diuretics.
NSAIDs can elevate plasma Lithium levels and reduce its renal clearance; patients taking RHUMA-CURE and lithium
concurrently should be observed for signs of lithium toxicity.
Rifampin 600 mg daily produced a 50% decrease in rofecoxib plasma concentration. A starting daily dose of 25 mg
RHUMA-CURE should be considered for osteoarthritis treatment when co-administrated with rifampin.
RHUMA-CURE effects of recommended doses for osteoarthritis (12.5 and 25 mg) on plasma Methotrexate levels are
unknown. Standard monitoring of Methotrexate toxicity should be observed when RHUMA-CURE and methotrexate are
administered concomitantly.
Prothrombin time increased in healthy individuals receiving RHUMA-CURE and warfarin but this is unlikely to be clinically
important in most patients.
Standard monitoring of PT values should be conducted when RHUMA-CURE is initiated or changed, particularly in the first
few days, in patients receiving warfarin or similar agents.

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Contra_indications
Hypersensitivity to Rofecoxib. Patients who have experienced asthma, urticaria, or allergic-type reactions after taking
aspirin or other NSAIDS.

Side effects
RHUMA-CURE is generally well-tolerated. Indigestion, heartburn, nausea, diarrhoea, hypertension and lower extremity
oedema, dizziness, sinusitis, urinary tract infection, asthenia and fatigue may occur.

Presentation
RHUMA-CURE 12.5 mg Tablets : Box of 1 blister of 10 tablets.
RHUMA-CURE 25 mg Tablets : Box of 1 blister of 10 tablets.

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