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RHUMA-CURE
Composition
Each tablet contains:
Rofecoxib 12.5 or 25 mg
Indications
Relief of signs and symptoms of osteoarthritis.
Relief of acute pain.
Treatment of Primary Dysmenorrhoea.
Precautions
Caution should be used in patients with advanced renal dysfunction, moderate to severe hepatic dysfunction, patients with
hypertension, heart failure and pre-existing asthma or prior history of peptic ulcer or GI bleeding. Used in pregnancy and
lactation only if the potential benefit justifies the potential risk. RHUMA-CURE use during the third trimester of pregnancy
should be avoided.
Drug Interactions
RHUMA-CURE can be used with low-dose aspirin and other anti-inflammatory drugs; however, care should be taken
when combining RHUMA-CURE with those drugs, because gastric irritation may result.
NSAIDs may diminish the antihypertensive effect of ACE inhibitors and reduce the natriuretic effect of furosemide and
thiazides . This interaction should be given consideration in patients taking RHUMA-CURE concomitantly with ACE
inhibitors and diuretics.
NSAIDs can elevate plasma Lithium levels and reduce its renal clearance; patients taking RHUMA-CURE and lithium
concurrently should be observed for signs of lithium toxicity.
Rifampin 600 mg daily produced a 50% decrease in rofecoxib plasma concentration. A starting daily dose of 25 mg
RHUMA-CURE should be considered for osteoarthritis treatment when co-administrated with rifampin.
RHUMA-CURE effects of recommended doses for osteoarthritis (12.5 and 25 mg) on plasma Methotrexate levels are
unknown. Standard monitoring of Methotrexate toxicity should be observed when RHUMA-CURE and methotrexate are
administered concomitantly.
Prothrombin time increased in healthy individuals receiving RHUMA-CURE and warfarin but this is unlikely to be clinically
important in most patients.
Standard monitoring of PT values should be conducted when RHUMA-CURE is initiated or changed, particularly in the first
few days, in patients receiving warfarin or similar agents.
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Contra_indications
Hypersensitivity to Rofecoxib. Patients who have experienced asthma, urticaria, or allergic-type reactions after taking
aspirin or other NSAIDS.
Side effects
RHUMA-CURE is generally well-tolerated. Indigestion, heartburn, nausea, diarrhoea, hypertension and lower extremity
oedema, dizziness, sinusitis, urinary tract infection, asthenia and fatigue may occur.
Presentation
RHUMA-CURE 12.5 mg Tablets : Box of 1 blister of 10 tablets.
RHUMA-CURE 25 mg Tablets : Box of 1 blister of 10 tablets.
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