Summary of Peer Reviewed Clinical Studies on Protandim Complete studies available at Pubmed.

gov – search “Protandim”
1. “The Induction of Human Superoxide Dismutase and Catalase in Vivo: A fundamentally New Approach to

Antioxidant Therapy, Free Radical Biology and Medicine (2006) University of Colorado ● Protandim completely eliminates the age-related increase in cell aging factors, oxidative stress. ● Reduces oxidative stress by a minimum of 40 percent - to the progressive aging rate of a 20 year old. ● Significantly increases activity of SOD and CAT antioxidant enzymes by 54 percent - substantially increasing the body’s antioxidant defenses.
2. “Synergistic Induction of Heme Oxygenase-1 by the Components of an Antioxidant Supplement Protandim”, Free

Radical Biology and Medicine (2008) University of Colorado ● Protandim produces a 300 percent increase in glutathione, a key antioxidant and anti-aging factor. ● Protandim’s synergistic formulation provides more antioxidant power than any food or supplement.
3. “Protandim, a Fundamentally New Antioxidant Approach in Chemoprevention Using Mouse Two-Stage Skin

Carcinogenesis as a Model”, PLoS ONE Journal (2009) Louisiana State University ● Reduced tumor incidence by 33% and tumor multiplicity by 57%. ● Increased expression of antioxidant and anti-inflammatory enzymes. ● Overall, induction of antioxidant enzymes by Protandim may serve as a practical and potent approach for cancer prevention.
4. “Chronic Pulmonary Artery Pressure Elevation is Insufficient to Explain Right Heart Failure”, American Heart

Association, Circulation 2009 Virginia Commonwealth University ● Protandim prevented the formation of scar tissue in the heart ● Prevented capillary loss in the heart muscle; prevented death of heart cells. ● Osteopontin levels reduced by more than 50%. ● Heart output was preserved and cardiac fibrosis prevented.
5. “The Chemopreventive Effects of Protandim: Modulation of p53 Mitochondrial Translocation and Apoptosis

during Skin Carcinogenesis”, PLoS ONE Journal (2010) Louisiana State University ● Protandim's ability to modulate relationship between superoxide dismutase and tumor suppressor p53 believed responsible for reduction of skin cancers. ● Protandim's ability to increase production of the body's Nrf2-regulated protective genes, sometimes referred to as "survival genes".
6. “The Dietary Supplement Protandim Decreases Plasma Osteopontin and Improves Markers of Oxidative Stress

in Muscular Dystrophy Mdx Mice”, Journal of Dietary Supplements (2010) Harvard Medical School, Mass General Hospital ● 48% decrease in plasma TBARS, a marker of lipid peroxidation and oxidative stress. ● 57% decrease in plasma Osteopontin, a fibrosis-promoting factor linked to heart failure, ● 35% increase in beneficial, protective plasma PON1 activity, an enzyme that protects against atherosclerosis by
Contact: Jason & Brooke Northrup 415-223-3965

preventing the oxidation of low-density lipoprotein (LDL) cholesterol.
7. “Protandim Attenuates Intimal Hyperplasia in Human Saphenous Veins Cultured ex vivo via a Catalase-Dependent

Pathway." Free Radical Biology and Medicine (2010) AHA, NIH, Ohio State University ● Protandim’s prevents the proliferation of cells that can cause re-blockage of vessels following coronary artery bypass surgery, stenting, and carotid enarterectomy. ● Treatment with Protandim, reduced intimal proliferation to the level seen in a normal healthy saphenous vein.

PROTANDIM A Promise of Protection
Developed after forty years of research, Protandim is a true scientific breakthrough in age-related diseases. Protandim is a one-a-day, all natural supplement that activates our body’s internal defenses to sustain itself, protecting our cells from damage and disease. Protandim is a Nrf2 activator in the nutrigenomics arena. Nutrigenomics is the science of how dietary components interact with the genome, or DNA, to regulate gene expression. Nutrigenomics studies how the things we eat affect our genes. Nrf2 is a key protein in the body and regulates approximately 500 of the 25,000 genes in the body. Think of every gene as having a “dimmer switch”. Nrf2 is the protein that can reach the dimmer switch. Protandim helps your body balance and regulate its 25,000 genes by “turning some up” or “turning some down”. In fact, the 500 genes Protandim regulates are termed by scientists as “survival genes”. There are three categories of survival genes: antioxidant enzymes (like SOD, catalase and glutathione), anti-inflammatory genes (that fight the process of inflammation in the body) and anti-fibrotic genes (that fight the process of scar tissue formation in the body; although scar tissue formation is helpful when you have a cut, scar tissue formation can be fatal if it occurs in the heart and lungs.) Independent research by Harvard, VCU, LSU and OSU, have validated this ability and measured Protandim’s impact in tuning over 500 survival genes and what that means for our health and our battle against age-related diseases, including cancer and heart disease. Additional studies are being conducted on osteoarthritis, diabetes, HIV/AIDS, periodontal disease, asthma, reduced injury recovery rates, neurodegenerative diseases like Parkinson’s and Alzheimer’s and many others. Below are some of the genes tuned by Protandim, as demonstrated by seven published, peer-reviewed clinical studies: ● Antioxidant enzymes increased over 40% - reducing oxidative stress and cellular aging ● Glutathione increased by 300% - antioxidant, blood booster, cell detoxifier ● Anti-inflammatory genes increased ● Anti-fibrotic genes increased – reducing scarring of the heart and lungs
Contact: Jason & Brooke Northrup 415-223-3965

PON1 activity increased – protects against arteriosclerosis and oxidized LDL cholesterol P-53increased - a tumor suppressor gene Osteopontin reduced by 57%. – directly linked to a wide variety of cancers, autoimmune diseases, and osteoporosis ● FABP-4 reduced by 85% - associated with multiple pro-inflammatory responses ● FABP -5 reduced by 66% - lowers likelihood of calcified arteries ● Akr1B10 increased - promotes cell survival
● ● ●

Protandim provides a remarkable promise of protection from all kinds of age-related diseases, unleashing the power within our own bodies, which is the most powerful and safest first line of defense.
*Protandim is not intended to diagnose, treat, cure or prevent any disease.


Jason & Brooke Northrup 415-223-3965

Sign up to vote on this title
UsefulNot useful

Master Your Semester with Scribd & The New York Times

Special offer for students: Only $4.99/month.

Master Your Semester with a Special Offer from Scribd & The New York Times

Cancel anytime.