SNDT Women’s University

(Sndt.digitaluniversity.ac)

Syllabus – Bachelors in Pharmacy

SNDT Women’s University 1, Nathibai Thackersey Road, Mumbai 400 020

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S. .D.T. WOMEN’S UNIVERSITY, MUMBAI
Shreemati Nathibai Damodar Thackersey Women’s University, founded in 1916 by Maharashi Dhondo Keshav Karave was nurtured by Sir Vithaldas Thackersey and Lady Premlila Thackersey and many other social workers who very firmly and correctly believed in women’s full participation in all spheres of life. Thus began the empowerment process in a very modest way. The University was started from a very small “Kutir” in Pune. As years passed by the reforms came and social mind set began to change. More and more parents started believing in the mission of the University and enrolled their daughters in the educational institutions. This led to expansion of the University. Today it has three campuses, one each in Churchgate (HQ), Juhu and Pune. The University is making rapid strides and with All India Jurisdiction, the number of colleges affiliating to the University is increasing at a fast pace. In the beginning the University started diploma courses but quickly initiated degree and PG courses in the faculty of arts, commerce, home-science, nursing, library science, education, computer science, PHARMACY, management studies and engineering. Befitting with the objectives of the University and due to the rapid changes taking place in society wherein more girls are opting for professional courses, the University started a full fledged degree course in Pharmacy in Juhu Campus at C.U.Shah College of Pharmacy in 1980,with the generous donation of Rs. five lacs from C.U.Shah Charitable Trust and later a further donation of Rs. eight lacs. Padmashree A. V. Mody of Unichem Laboratories also gave a donation of Rs. five lacs to the college. The University now offers the following courses in Pharmaceutical Sciences. • • • • • • • Four Year Bachelor of Pharmacy Four Semester – Master of Pharmacy (Quality Assurance) Four Semester – Master of Pharmacy (Pharmaceutics-Industrial Pharmacy) One Year P. G. Diploma in Pharmaceutical Analysis One Year P.G. Diploma in Cosmeticology One Year P.G. Diploma in Drug Information. Ph. D. in Faculty of Technology The special features of Bachelor of Pharmacy course are : Project work is carried under the guidance of teachers by each student in the 4th year and a report is presented at a seminar and copy is submitted to the college. At the end of the third year, practical training in Industry or Hospitals attached to Medical Colleges especially Pharmacology Department is imparted. Visits are arranged to pharmaceutical industries, analytical laboratories and hospitals, during which staff members accompany students. Special training in hospital pharmacy and in the newly emerging field of Clinical Pharmacy is imparted not only in theory classes but also in practicals conducted in laboratories. Analysis and Packaging of Pharmaceuticals is given more emphasis, as girls are usually preferred by Industry in these fields. For proper all round development of students, co-curricular activities are also given due importance. To suit women’s need, a complete one year theory and practical course in Cosmeticology is included. These are all devised with a focus on the aptitude, talents and job potential for
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women and emerging needs of society, by a committee of experts specially appointed by the University. The emerging subjects like Computers, Informatics and Biotechnology are also included in the course. Hostel : A limited number of seats are available in the hostel. Eligibility: Only girl students can join any of the above-mentioned courses. The eligibility for each course varies and is as per the Govt./University rules prevailing at the time. PATTERN OF EXAMINATIONS : (Subject to revision and modifications) A candidate shall be required to attend at least 75% of the number of lectures and the number of practicals separately for each subject of study in each term, only then subject to other conditions being fulfilled, a student will be eligible to appear at the University Examinations. The Principal of the College will have the discretion to condone 10% of the attendance in theory and/or practicals of any one subject or subjects if he/she is fully convinced of the student’s absence on the ground of health or reasons beyond control. There will be University examination at the end of each year. Internal Assessment : The framework of subjects for the B.Pharm. Degree states that there is internal assessment to the tune of 30% marks in each subject separately for theory & practicals. Periodic tests in theory: During each academic year there will be three unit tests for each theory subject. Marks of the best two U.T. will be sent to the University as internal assessment marks. Periodic tests in practicals: During each term there will be one unit test in Practicals. Each regular practical will be assessed by the teachers. Quiz assignments may be given and marks will be allotted. NO REPEAT UNIT TEST IN THEORY OR PRACTICALS WILL BE GIVEN. Standard of Passing : University Examination : These rules are subject to revision and modification from time to time) (i) A candidate shall obtain at least 40% marks (internal assessment and University examination combined) separately in theory and in practical of each subject for passing in the University examination. (ii) A candidate shall also obtain, at least 50% marks in the aggregate of all the prescribed subjects to pass in the University examination. (iii) Thereafter the grand total of marks at the Internal Assessment and the University examination shall be converted into a specified Grade on the basis of the following table.

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GRADE B A A+ 0 Second First CLASS MARKS REQUIRED At least 50% but less than 60% marks At least 60% but less than 70% marks At least 70% but less than 80% marks At least 80% marks and above First class with Distinction First class Outstanding Candidate who is not able to clear all the subjects at the same attempt will be declared as passed with ‘C’ Grade. 4|Page . if failed subjects are cleared in subsequent examinations. Schedule of fees : Tuition fees will be charged as prescribed by the Government of Maharashtra and is subject to revision. Exemption and A T K T Rules: The rules are prescribed by the University from time to time. Refund of fees : Tuition fees and College fees will be refunded as per the rules prescribed by the Government from time to time.

4 4.PHARM.. Sr.7 2.8 4. Physiology & Hygiene Physical Chemistry Organic Chemistry-I Pharmaceutical Chemistry-I Pharmaceutics-I 2 2 2 2 2 2 3 3 4 4 4 Total Hours/Week 15 35 20 SECOND YEAR B. SUBJECT HRS.5 4.1 3.PHARM.1 THIRD YEAR B./W TH PR Pharmaceutical 2 -Engineering Pharmacognosy-I 2 3 Microbiology-II Pathophysiology & Health Education Pharmaceutical Analysis-I Organic Chemistry-II Pharmaceutical Chemistry-II Pharmaceutics-II Physical Pharmacy Total Hours/Week 2 2 2 2 2 2 2 18 35 3 -3 --4 4 17 Sr.PHARM.2 3. SUBJECT HRS.5 2.6 3./W TH PR 1.2 2.5 3.3 3. SUBJECT HRS./W TH PR -Industrial Organisation 2 & Drug Store Management Cosmeticology 2 3 Biopharmaceutics & 1 -Pharmacokinetics Pharmacology-II 2 4 Biochemistry 2 3 Biotechnology Pharmaceutical Chemistry-IV Pharmaceutics-IV Project & Seminar Total Hours/Week 1 2 2 2 16 34 -4 4 -18 Hours/Week 5|Page .2 4. SYLLABUS FIRST YEAR B.8 4.1 2.4 2.7 3.9 FINAL YEAR B.9 Sr.3 2.8 Microbiology-I Anatomy.5 1. No 4.7 1.No SUBJECT HRS.3 1.6 1.B.6 4.3 4.4 3. No 3.6 2.7 4.PHARM./W TH PR Pharmaceutical 2 -Jurispendence Pharmacognosy-II 2 Clinical Pharmacy & 1 Drug Interactions Pharmacology-I 2 Pharmaceutical 2 Analysis-II Dispensing & Hospital 2 Pharmacy Pharmaceutical 2 Chemistry-III Pharmaceutics-III 2 Total 15 35 3 -2 4 3 4 4 20 Sr.4 1.1 Mathematics & -Statistics 2 1..8 2. No 2.PHARM.2 Computers 1 2 1..

PHARM.5 1. EXAM THEORY HRS.2 Computers 1. MARKS INT EXT 30 70 15 30 30 35 70 70 EXAM PRACTICAL TOTAL HRS.Examination pattern FIRST YEAR B.No SUBJECT 1.4 Microbiology-I Anatomy.6 3 30 30 70 70 100 100 6 6 30 30 70 70 100 100 Organic Chemistry.3 1. MARKS MARKS MARKS INT EXT 100 TOTAL 50 100 100 4 4 30 30 70 70 100 100 Sr.7 1. Physiology & Hygiene Physical Chemistry 3 2 3 3 1.8 30 30 70 70 100 100 750 6 26 30 70 100 500 6|Page .1 Mathematics & Statistics 1.3 I Pharmaceutical Chemistry-I Pharmaceutics-I 3 3 23 1.

II Pharmaceutics-II Physical Pharmacy 3 3 3 26 2.9 30 30 30 70 70 70 100 100 100 850 6 6 25 30 30 70 70 100 100 450 7|Page .3 II Pharmaceutical Chem.Examination pattern SECOND B.3 2.8 2.I YEAR EXAM THEORY HRS. MARKS MARKS INT 30 30 EXT 70 70 - 3 3 3 3 100 100 100 100 4 4 - 100 100 - 2.5 2.6 3 30 30 70 70 100 100 6 - 30 - 70 - 100 - Organic Chemistry. Sr.4 Pharmacognosy-I Microbiology-II Pathophysiology and Health Education Pharm.Engg 2.No SUBJECT 2.Anal.PHARM.1 Pharm.7 2.2 2. MARKS INT EXT 30 70 30 30 30 70 70 70 TOTAL EXAM PRACTICAL TOTAL MARKS HRS.

8 3 23 30 70 100 750 6 6 30 30 70 70 100 550 8|Page .3 3 3 3.ChemistryIII Pharmaceutics III 3 3 3 30 30 30 30 70 70 70 70 100 100 100 100 3 6 6 6 15 30 30 30 35 70 70 70 50 100 100 100 3. MARKS MARKS INT EXT 100 100 50 4 30 70 100 - Sr.2 Pharmacognosy II 3.4 3. EXAM THEORY HRS.1 Pharmaceutical Jurisprudence 3.Examination pattern THIRD YEAR B. Analysis II Dispensing & Hospital Pharmacy Pharm.7 Clincial Pharmacy 2 & Drug Interactions Pharmacology I 3 Pharm.6 3. MARKS INT EXT 30 70 30 15 70 35 TOTAL EXAM PRACTICAL TOTAL MARKS HRS.5 3.No SUBJECT 3.PHARM.

PHARM.6 4. MARKS INT EXT - Sr. EXAM THEORY HRS.1 Industrial Organisation & Drug Store Management 4.5 4.No SUBJECT 4.7 4.9 3 30 15 30 30 15 30 30 70 35 70 70 35 70 70 100 50 100 100 50 100 100 6 4 4 6 6 30 30 30 30 30 GRADE 70 70 70 70 70 100 100 100 100 100 Biopharmaceutics & 2 Pharmacokinetics Pharmacology-II 3 Biochemistry Biotechnology Pharmaceutical Chemistry IV Pharmaceutics-IV Project & Seminar 3 2 3 3 700 500 9|Page .4 4.8 4.3 4.2 Cosmeticology 4.Examination pattern FINAL YEAR B. MARKS INT EXT 3 30 70 100 TOTAL EXAM PRACTICAL TOTAL MARKS MARKS HRS.

FIRST YEAR B. Mathematical expectations. Correlation. S. Kapoor. Fundamentals of Mathematical Statistics Sultan Chand & Sons. 3) 4) 5) 6) Discrete and continuous distributions. Mean value theorems. 2) S. 1) Grewal. Pharmaceutical Statistics. B. 3) Boltan. 10 | P a g e . 3) Differential equations of first order. Leibnitz’s theorem. Khanna Publishers. Joint density function and marginal density function. Equations reducible to linear equations with constant coefficients. Linear or differential equations. K. Testing of hypothesis Curve fitting and Principle of least squares. RECOMMENDED BOOKS : Latest editions of the following books. Higher Engineering Mathematics. C. Quality Control. 4) Pharmaceutical Statistics : Practical & Clinical applications. 1) Partial differentiation. Legendre’s linear equations. 2) Random variables and distribution functions. fundamental theorems of integral calculus. 4) Definite integrations. Joint probability distribution functions and Marginal distribution functions./Yr.. Marcel Dekker Publications. Moments and moment generating function. 2) Higher derivatives. Gupta & V. Statistics : 1) Probability. Total differential: Euler’s Theorem for homogenous functions. 2003. Regression.PHARM MATHEMATICS AND STATISTICS (THEORY) Mathematics Minimum 50 Hr.

Arithmetic Logic Unit. High-level languages. Intranets & extranets. Data Processing Concepts: Types of data processing. Basic anatomy of computers. Mainframe. Input Devices. Graphic programs. 4. Mini. 7. Network architecture. Organizational internets. Software suites. Application Software: General Purpose applications. Voice messaging systems. E-mail. Integrated packages. Character data representation. Presentation graphics. Super computers. Memory devices. Communication channels. Boolean algebra. Satellite. Historical development Present and future applications of computers in everyday life and scientific research. Word processors.ces. 10. DBMS.PHARM COMPUTERS (THEORY) Minimum 25Hr. Types of modems. Software Components: System Software. Output devices. Central Processing Unit. Internet services Browsers. Introduction to Computers 2. 11 | P a g e .FIRST YEAR B. Time-sharing. Network types. E-mail. Types of connections. Web utilities. 11 Multimedia and Web Authoring: Multimedia. 5./Yr. 3. E-commerce. loc g 6. Truth tables. User connection. Microwave. ASCII Codes. Modems. Machine language. Online processing. Search tools. Shared resources. Coaxial cable. Spread sheets. Video conferencing systems. Project management. Communications and Connectivity : Fax machines. Online services. Telephone lines. Fiber optic cable.The Internet and the W eb : Internet applications. Micro. Access. 9. W eb pages. Truth tables. 8. 1. Computer logic. Virtual reality. Secondary storage devices. Boolean algebra. Artificial intelligence. logic gates. Control Unit. Data transmission. Types of Computers. Computer codes and arithmetics Binary number system. W eb authoring. Computer hardware: Components. Fixed point and floating point numbers.

Tata Mc. Subramanian. Prentice Hall of India Pvt. 12 | P a g e .PHARM COMPUTER (PRACTICALS ) Minimum 50Hr. 2. Introduction to Computer and fundamentals of Computer Science. William & Christensen Dale. New Delhi. ‘Computers and Commonsense’. 1. N. Practicals based on topics covered in theory including introduction to : 1) 2) 3) Microsoft Word Microsoft Excel Microsoft Powerpoint RECOMMENDED BOOKS : Latest editions of the following books.Computer application in Pharmacy by Fassett. Ltd. B.FIRST YEAR B. Roger Hunt. John Shelley../Yr. Graw Hill Publishing Co.

cell reproduction. milk and water. algae./Yr. Staining methods including (3) Gram’s staining negative staining. viruses. measurement of growth (4) bacteria. flagella staining. staining of nuclear body or material. reproduction. (4) (5) characteristics. rickettsiae. 13 | P a g e . 9. cell characteristics. 6. Principles of microscopy. 5. (7) 7. Study of bacteria with respect to its morphology. Microbiology of air. selective media. differential media.FIRST YEAR B. acid fast staining. Microbiology and its applications to pharmacy and medicine (3) 2. 10. nutrition.PHARM MICROBIOLOGY-I (THEORY) Minimum 50 Hr. (10) 4. cell wall staining. (3) 8. observation of motility etc. soil. habits. Study of yeast. media for special purposes. Flora of normal human body. Culture media such as cultivation and storage media. cultivation. Maintenance and preservation of pure cultures. nutrition. chalmydiae and protozoa (5) habits. Growth phases and factors affecting growth of bacteria. molds. With respect to their morphology. cultivation and pathogens. (3) 3. 1. enrichment media.

Blackwell Publications. temp and pH 7. ‘Bentleys text book of Pharmaceutics’. ‘Fundamentals of Microbiology’ 9 th ed. Hugo and Roussel ‘Pharmaceutical Microbiology’.W. Study of yeast observation of motility. Pelczar. staining of nuclear body or material. stab & plates. Carpenter ‘Fundamentals of Microbiology. Staining techniques : Staining of Cell wall. Preparation & inoculation of nutrient broth medium. 1. 3. water. nutrient agar media slant. Microbiological analysis of air. 5. 4./Yr. 3. Study of microscope 2. RECOMMENDED BOOKS : Latest edition of the following books. 1.PHARM MICROBIOLOGY-I (PRACTICALS) Minimum 75 Hr. Motility-hanging drop preparation. flagella staining. Measurement of size of microorganisms. Counting the number of micro organisms/ml of the culture 5. 8. Reid and Chan ‘Microbiology’. Spore staining. Frobisher. B. Capsule staining. Good heart. Factors affecting growth of organisms. Balliere publication. W. Negative staining. 4. Determination of Thermal Death Time 6. 2. Gram’s staining.FIRST YEAR B. Crabtree. Saunder’s Company Rawlines(ed). S. Saunder’s Company. Scientific Tindall 14 | P a g e . Tata Mc Graw Hill Publishing Co.

FIRST YEAR B.PHARM ANATOMY PHYSIOLOGY AND HYGIENE (THEORY) Minimum 50 Hr./Yr. 1. Introduction to the human body parts as a whole and various systems. (1) 2. Cellular Physiology: Sub cellular organization, membrane transport process, genetic action and normal cell division. (2 ) 3. Basic tissue structure and function of epithelial, connective, muscular nervous and glandular tissue, tissue repair and homeostasis, nerve impulse generation and transmission. 4. Musculoskeletal system: Cartilage, skeletal system, types of bones and joints, properties of the muscle, Components and functions of the joints. 5. Digestive System : Anatomy, physiology and functions of the alimentary, (4) (4) (6)

tract, mouth, pharynx, esophagus, stomach, small and large intestine. Functions – Absorption and digestion, ingestion, propulsion, mechanical and chemical digestion, defecation. Control of digestion-intrinsic and extrinsic reflexes, Blood supply to the digestive system, Enteric nervous system of the alimentary tract, The Tongue and salivary glands, saliva and control of salivation The Teeth – tooth and gum diseases. Digestive processes in the mouth, Heartburn, The Stomach Regulation of the three phases of gastric secretion Role of gastrin, intestinal gastrin, Acetylcholine and histamine Gastric contractility and emptying The Small Intestine, Structure adapted for absorption of nutrients The Liver and Gallbladder, functions of the liver, Liver lobules and Kupffer cells, Bile components, synthesis and secretion Functions of the gallbladder and Cholecystokinin (CCK) The Pancreas, Exocrine (digestive) function, pancreatic enzymes The Large Intestine, Regions and Function, Bacterial flora. 6. Respiratory system: (4) Structure of the respiratory system, blood supply to the lungs, pulmonary ventilation, compliance and airway resistance, lung volume and capacities, exchange of 02 and C02 , control of respiration and maintenance of acid base balance. 7. Cardiovascular system: Blood; Composition and functions of blood, formation of cellular components,
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(4)

Maintenance of homeostasis, blood groups, and blood types.Heart; Structure of heart, blood supply to the heart, conduction system and pacemaker, physiology of cardiac muscle contraction, ECG, cardiac cycle and cardiac output. 8. Lymphatic system: ic Lymphatic vessels, lymph circulation, lymphatic tissues, non-specific lresistance to the disease, immunity and functions of the immune system. 9. Excretory system : Structure of kidney and urinary tract, renal physiology, mechanism of urine formation, regulation of urine output and diuresis. 10. Integument and special senses: Anatomy and physiology of the skin, epidermal derivatives, anatomy and physiology of the eye and ear, anatomy of the olfactory receptors and physiology of the olfaction. 11. Nervous system: Structure of brain and spinal cord, neurotransmitters and anatomy and physiology of the autonomic nervous system, EEG. 12. Endocrine system: Endocrine glands, mechanism of hormone action, control of hormone secretion. Hypothalamus and pituitary gland, thyroid gland, parathyroid gland, thymus gland, adrenal gland and pineal gland. 13. Reproductive system : Anatomy and physiology of the male and female reproductive system, the female reproductive cycle, pregnancy and birth control methods. 14. Fluid electrolytes, acid-base homeostasis, fluid compartments and fluid balance, electrolytes and body fluids, movements of the body fluids acidbase balance and maintenance of acid base balance. 15. Personal hygiene, outline of public health, measures for the prevention of diseases. (2) (2) (4) (5) (5) (4) (4) (2 ) vessels,

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ANATOMY PHYSIOLOGY & HYGIENE (PRACTICALS) Minimum 75 Hr./Yr.B 1. Study of Neubuer’s chamber. 2. 3. 4. 5. 6. 7. 8. 9. Determination of total WBC count Determination of total RBC count Determination of Differential WBC count Determination of platelet count Estimation of Haemoglobin Determination of bleeding time Determination of clotting time Determination of blood group

10. Determination of Erythrocytes sedimentation rate. 11. Effect of single impulse on nerve muscle stimulation 12. Effect of successive stimuli on nerve muscle stimulation 13. Effect of fatigue on gastronemius sciatic nerve muscle preparation. 14. Genesis of tetanus using the nerve muscle preparation 15. Demonstration of recording of ECG by Biopac system 16. Demonstration of recording of EEG 17. Demonstration of recording of blood pressure 18. Effect of osmotic pressure on human blood cells 19. Demonstration of recording of pulse 20. Demonstration of recording of heart sounds 21. Demonstration of recording of Airflow 22. Demonstration of recording of respiratory parameters 23. Demonstration of recording of lung capacity 24. Study of histological slides of cells and tissues 25. Effect of temperature on frog’s heart

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for Nurses. Churchill Livingstone Publishers.. Ross and Wilson. B. Textbook of Medical Laboratory Technology. Anatomy and Physiology in Health and Illness. U.. Ahmedabad. Grabowski. Evelyn P.A.. Bhalani Publishing House. 4.. and Hall J.E. Textbook of Medical Physiology. U. S. 18 | P a g e . New Delhi. Prakashan..B. Guyton A. Harper Collins publisher. Wilson J.S. Published by Prism books Pvt.W. Practical Anatomy – Physiology and Biochemistry. 1. Tortora Principles of Anatomy and Physiology. Goyal P. Ltd. Godkar D. 3. Shah 6. India.A.C..S.P.. Mumbai. India. India. Anatomy and Physiology Brothers Publications. 2. Bangalore. New York.S.. Godkar P. India.RECOMMENDED BOOKS : Latest edition of the following books. Published by Jaypee 5.

solid-liquid and liquid-liquid systems. vapour pressure. Solutions : Solubility. conductometric titrations and applications.critical solution temperature. electron transport. Composition and physical states of matter: (8) Intermolecular forces and their impact on the state of matter and various physical properties of matter. Aerosols. Distillation of binary systems. Ionic equilibrum : Theory of conductivity. and their applications. steam distillation.PHARM PHYSICAL CHEMISTRY (THEORY) Minimum 50 Hr. Refractive index. Solubility of gases in liquids. vacuum distillation. 19 | P a g e . determine of molecular weight based on colligative properties. Principles of Physical Chemistry should be treated with reference to their applications in Pharmacy. molar refractivity. isothermic and adiabetic processes.FIRST YEAR B. Optical rotation: theory. elevation of boiling point. Expression of concentration of pharmaceutical solutions and calculations. molarity. azeotropic mixtures. dielectric constant. Phase rule : (9) One. liquids in liquids and solids in liquids. specific refractivity. dipole moment. fraction and percentage expressions. Electro-chemistry : Properties of electrolyte solutions. 5. 1. liquification of gases. work of expansion. and critical phenomenon. (5) Faraday’s law of electrolysis. (2) 8. pH and other factors on solubility./Yr. depression of freezing point. law of partitioning and its applications. heat capacity. 4. osmotic pressure. thermochemical laws. Thermodynamics: (5) First law. single electrode potential. mole 7. effect of co-solvency. concentration cells. two and three component systems. solubility curves (10) (4) 3. ideal and real solutions. factors affecting solubility. enthalpy. Colligative properties : (7) The liquid state.Solute solvent interactions. 6. heat content. refractometers. electrolysis. Van Der Vaal’s equation 2. measurement and applications. reversible processes. Raoult’s law. molality. fractional distillation. types of solutions. solid-solid.

7) 8) 9) Determination of partition co-efficient of benzoic acid in toluene water system. 10) Determination of optical rotation of an optically active substance using polarimeter. Preparation of normal and molar solutions. 14) 15) 16) 17) 18) Determination of normality of acid solution. Potentiometer: Determination of buffer capacity of a solution of a weak acid and its salt. Toluene-acetone-water. Determination of heat of solubilization of benzoic acid in water. introduction to apparatus. Determination of specific gravity of liquid solutions. equipment and instruments. Standardization of acid/ base solutions.PHYSICAL CHEMISTRY (PRACTICALS) Minimum 100 Hr. Conductometric titrations: strong acid and strong base. Strong acid and weak base. 20 | P a g e ./Yr. Determination of specific refractivity and molar refractivity using refractometer. 11) 12) 13) Determination of molecular weight by Rast’s camphor method. Experiments based on topics specified in theory syllabus will include the following: 1) 2) 3) 4) 5) 6) Introduction to GLP. Determination of critical solution temperature of phenol-water system. Determination of partition coefficient: . Study of mutual solubility of ternary systems: benzene acetone-water. Determination of critical solution temperature of triethylamine-water system. Iodine in carbon tetrachloride water.

2.I. Glasstone. Bahl Arun Finally’s Practical Physical Chemistry . Delhi. Tuli. India. Hadkar. Yucca Publishing House. Samuel. ‘Textbook of Physical Chemistry’.S. B... ‘Physical Pharmacy’. 4.. Waverley New Delhi. CVS.N. ‘Essentials of Physical Pharmacy’ Vallabh Prakashan.. Vasudevan. Dombivli. 1. 5..RECOMMENDED BOOKS : Latest editions of the following books. T. and Laddha. CB. A. Subramanyam.N.S. Bahl S.D. G. S. Chand and Co.. McMilan. Martin. K. 21 | P a g e . ‘Practical Physical Pharmacy. 3.

PHARM ORGANIC CHEMISTRY-I (THEORY) Minimum 50 Hr. giving emphasis on the mechanism of the reaction: i) ii iii) iv) v) vi) Benzene and aromatic hydrocarbons Aromatic nitro compounds. ix) Acid chlorides and acid anhydrides (3). 3. Sigma and ∏ bonds. Sp3. iii) Alkynes (2). Structure and aromatic character of benzene. v) Aliphatic hydroxy compounds (3). Fission of a covalent bond.FIRST YEAR B. bond angles and bond energies. (The stereochemical (3) (2) aspects of these reactions should be dealt with appropriately wherever applicable). 1. (3) (2) (2) (2) (2) (2) (2) 5 The following classes of compounds should be covered in details regarding 22 | P a g e . i) Alkanes (3). Concept of resonance and hyperconjugation. iv) Aliphatic halogen compounds (4). x) Esters (2). The following classes of compounds will be discussed in details regarding their(a) General methods of preparation. Aromatic halides and Aromatic hydroxy compounds. Diazonium salts. Nomenclature of organic compounds based on IUPAC system (to be covered while discussing each class of compounds). ii) Alkenes (3). Calculations for determining empirical and molecular formula. Aromatic amines./Yr. Acidity and basicity. Bond lengths. viii) Carboxylic acids (5). 4 Aromaticity. b) physical properties and c) chemical reactions. Classification and sources of organic compounds. Sp2 and Sp hybridization. their a) general methods of preparations. vii) Aldehydes and Ketones (2). Huckel’s rule and criteria for determining aromaticity of a compound. xi) Aliphatic amines (4) xiii) Amides (2). vi) Ethers (2). 2. (b) (c) Physical properties and Chemical reactions. Bond polarization and inductive effects. including their mechanisms.

New Delhi. G. II] Synthesis of some organic compounds involving following one-step reactions:Acetylation :acetanilide from aniline Nitration :p-nitrosalicylic acid from salicylic acid. J. citric acid. amides. D. I] Qualitative organic tests for identification of organic compounds such as: 1) 2) 3) 4) 5) Determination of physical constants Preliminary tests Determination of elements Determination of functional groups. and Hammond. tartaric acid. cresols. 1) Morrison. Organic Chemistry’. Bases: aniline. 23 | P a g e . L. ‘Stereochemistry of carbon compounds’. International Students edition. aminophenols..T. 2) Hendrickson J. RECOMMENDED BOOKS : Latest edition of the following books./Yr. New Delhi – 110001. etc. J. D. sulphanilic acid etc. E. salicylic acid. B..S. Phenols: and β naphthol. aminoacids. nitrophenols.PHARM ORGANIC CHEMISTRY – I (PRACTICALS) Minimum 100 Hr. Bromination :p-bromoacetanilide from acetanilide. Ltd. Prentice Hall of India Pvt. Organic Chemistry. nitroacids. carbohydrates etc. Preparation of derivatives Compounds identification such as :Acids :benzoic acid. Natural compounds: hydrocarbons. McGraw Hill. R.FIRST YEAR B. Cram. Ltd. Boyd.S. Kogakusha Ltd.... phthalic acid. etc. and Hammond. 3) Eliel. New Delhi. oxalic acid. Tata McGraw Hill Publishing Co. G.. toluidines. anilides. esters. nitroanilines.

Monograph and its importance. pka and their effect on the absorption and excretion of (2) drugs. Tests for purity. Alkalinity./Yr. various tests included in monographs as per (4) I. Thiopental Sodium. types and (6) effects of impurities. Benzocaine* (c) Antiseptics and disinfectants (3) Hexachlorophene. such as : Loss on drying. (2) 3. Heavy metals.131. Mercury as per I. Ash values. Study of the following classes of drugs with regard to their biological activity. Ketamine HCl. (3) 8. Assay etc. Phenyl propanolamine* (e) CNS stimulants and hallucinogens (3) Imipramine. Halothane.P. Impurities in pharmaceutical substances. Silver nitrate. Phosphorus–32. (a) General anaesthetics : (3) Chloroform*. A study of following compounds with respect to methods of preparation. 5. Radioisotopes (4) Iodine . Ammonium chloride. Extractive values. (d) Upper respiratory tract drugs : (4) Ephedrine*. laxatives. (3) 24 | P a g e .P. Ether*. Ethyl alcohol. Calibration of weights. Moisture content. Gold-198. (f) Purgatives. light and heavy Kaolin. Lidocaine*. 7. Henderson Hasselbalch equation. Iron-59. Receptor site theory with simple examples. Limit tests of Chlorides. Acidity. Cobalt-60. Iodine-125. structure activity relationship and simple synthesis. (b) Local anesthetics: (2) Procaine*. antidiarrhoeal agents. Technitium-99M. Arsenic. Lead. Paraldehyde. Ferrous gluconate.FIRST YEAR B. Copper sulphate. 6. Cyclopropane. assay and pharmaceutical use : (4) Sodium citrate. 1. sources of impurities. Iron. (2) 9. Physicochemical properties of drugs and their relation to drug action. 2. pH meter). Radiopharmaceuticals and their application to Pharmacy and medicine. Nikethemide. 4.PHARM PHARMACEUTICAL CHEMISTRY-I (THEORY) Minimum 50 Hr. Importance of pH. Mode of action. Acetylcysteine. Radium-226. Guiacol. Chromium-51. glassware (pipettes) instruments (balance. Pentylene tetrazole. Sulphates. Identification tests.

Roche F.Varghese and Company. W. I & II. Medicinal Chemistry.B. C. Medical and 25 | P a g e .E. C. and Doerge. 1996. A.Oxford Medical Publications... ‘Principles of Medicinal Chemistry’. Textbook of Organic Pharmaceutical Chemistry. L. Wilson... J.O. anticoagulants and plasma expanders.. Inc. (3) ( * = Synthesis of compounds) RECOMMENDED BOOKS : Latest editions of the following books. Inorganic Medicinal& Pharmaceutical IndianEdition. John W iley and Sons.Mumbai – 31.B.(g) (h) Diagnostic agents (2) Coagulants. Block... Indian Pharmacopoeia. Part I. J. Gisvold. O. I. Burger. H. M. Varghese Publishing House Mumbai-14.O. K. II & III.B. ‘Bentley and Drivers Textbook of Pharmaceutical Chemistry’. T. Vol. J. Toronto. B.N.. and Wilson. 6) Atherden.. Soine. Chemistry’. 1) 2) 3) 4) 5) Foye. Lippincot Company. York.

Resins and Oleoresins. such as decoction.PHARM PHARMACEUTICS – I (THEORY) Minimum 50 Hr. Processes of extraction.P. mixing. (2) Development of I. B. processes and equipment involved in the formulation. infusion.S. Infusions. Extracts.P. glycerites and spirits. elixirs... syrups. b) (10) 26 | P a g e . 5) a) Principles. clarification and filtration. paediatric drops. manufacture (15) and quality control of monophasic liquid dosage forms including Waters. 6) Unit operations used in making of the above formulations./Yr. maceration. Scope of Pharmacy practice Ethics of pharmacy to sources of pharmaceutical literature and (6) 2) Introduction publications. size reduction.P. methods and equipments involved in the extraction of crude (12) drugs for the preparation of Tinctures. Solutions (oral and topical). and International Pharmacopoeia. percolations and modifications thereof for large scale extractions. Pharmaceutical organizations and regulatory authorities. 1) History of Pharmacy a) Origin and early history of pharmacy b) c) d) Development of Profession of Pharmacy and pharmaceutical industry in India. illustrated with suitable examples. 3) a) b) Classification and definitions of pharmaceutical products. Aromatic waters. Decoctions. Introduction to Formulation of Dosage forms (5) 4) Principles.FIRST YEAR B. U.

Lemon Syrup. Aluminum acetate solution. Starch Glycerite BPC. Strong solution of ammonium acetate I P 66. Infusion of Chirata I..P.. Acetic acid 6% w/w B. I.P.P... Preparation of Glycerites : Glycerine of Borax I P.F. Ammonia Solution 4% w/w Ammonia Solution 4% w/v Alcohol 70% v/v. Strong Solution of Iodine I P 66 Compound Sodium Chloride solution I P.P..P.. Hydrocholoric acid 10% w/w B. Piperazine citrate Elixir BPC.. Quality Control tests for Purified Water.P.S. P. Strong B P C. Magnesium Citrate Solution N F. Chloroform Water B. Paedratic Paracetamol Elixir BPC.... 7. Decoction. Preparation of Solutions : Benzoic acid solution I. Ephedrine Sulphate syrup N. Peppermint Water B.P.S.. Preparation of Infusions. Solution of Tolu. Glycerotannic acid IP. P. P. Coal tar solution I.PHARMACEUTICS – I ( PRACTICALS ) Minimum 100 Hr.. 6. Ferrous Iodide Syrup B. Decoctum Aloes Compositac BPC. Tinctures: Infusion of Quassia Recenes I P.. 4. Vinegar of Squill B.. Sodium Phosphate solution N F Lugol’s solution I P 66 (5% I2 w/v). P.. Chloral Hydrate syrup U. 8..P.. Citric Acid Syrup N.. Cinnamon Water B.. Alcohol 40% v/v. Simple Syrup IP 66% v/v. 27 | P a g e .P. Gripe Water.. P.. Surgical Chlorinated Soda Solution BPC. BPC. Ferrous iodide solution BPC. Preparation of Aromatic Waters : Camphor Water I.C.. Ferrous Sulphate Syrup N. Artificial Syrup BPC.BPC Codeine Phosphate Syrup BPC. 5. 85% w/v. Vasaka Syrup I P. Aromatic Elixir N. 1966). Three Bromides Elixir NF./Yr. Concentrated Solution of Vit A.P.D (I.. and Vit.F. 2 . Preparation of Dilute acids ammonia and alcohol from concentrated solutions. Preparation of Syrups: Simple Syrup U. Solution of Cresol with soap B P. Artificial Syrup E P.F. Preparation of Elixirs :Compound Benzaldehyde Elixir NF..F. P Dill Water I. Compound thymol glycorine BPC. 1. 3..

Preparation of Spirits : Aromatic Spirit of Ammonia 11. 10. London. Mumbai. 14. ‘The Theory and Practice of Industrial Pharmacy’. Delhi. Orange Tincture.P. Compound Cardamom Tincture BPC. W averly Pvt.P. Liquid Extract of Nuxvomica I. B. Bentley’s Textbook of Pharmaceutics.C.P. ‘Pharmaceutical Dosage Forms and Drug Delivery Systems’. Jr.A. Compound Benzoin Tincture. The science of dosage.Lemon Tincture. H. Carter. All India Traveller Books seller. Senna Infusion BPC. Ansel.P. Bael Liquid Extract I. Bailliere Tindall. H. 6... 28 | P a g e . Ansel.(ed) Cooper and Gunn’s Tutorial Pharmacy.. E.. 1... form design Churchill Living-stone.P. Mack Publishers. Determination of Alcohol content 13. 7. Preparation of Linctus : Simple linctus BPC. L. Liquid Extract of Glycerrhiza I. 3. RECOMMENDED BOOKS : Latest edition of the following books. S. USP current editions. Conc. 5. 8. London. Allen. 2. H.J. Aulton.. 9. Pennsylvania. CBS Publishers and Distributors.A.I. Delhi. Extra Pharmacopoeia IP. Demonstration of machines/equipment used in manufacture of above products. 4. New Delhi.. Industry visit Report.Rawlins.. Ltd. Liberman. Varghese Publishing House.E. Preparation of Liquid Extracts: Liquid Extract of Vasaka I. Pharmaceutics. Lachman. Codeine Linctus BPC 12. Popovich. Lea & Febiger. C. Osol (ed) Remington’s Pharmaceutical Sciences. Introduction to Pharmaceutical Dosage forms.. Philadelphia. M. Liquid Extract of Ashoka I. BP.

Centrifugal filtration. distillation equipment. 12) Extraction and leaching : Selection of solvents. mechanical. electrical and fire hazards. Selection of mixers. Nickel and its alloys. Evaporation : Types of evaporators. liquid-liquid and solid-liquid and solid-liquid systems. 29 | P a g e . equipments for extraction. rubber. Azeotropes and their separation. Pipe fittings. Heat (4) transfer media Shell and tube plate. (3) 10) Distillation : Vapour-liquid equilibrium. properties of fluids. (2) apron conveyors etc. Transporation of fluids. glass etc. aluminum and its alloys. Overall heat transfer coefficient. dryers. 13) Drying : Purpose of drying. various types including. filter aids. ENGINEERING (THEORY) Minimum 50 Hrs/Yr. drying curves. 11) Crystallization : Temperature – solubility relationship crystallization from solutions and melts. Laminar and turbulent flow.SECOND YEAR B. Mixing fundamentals. 1) 2) Concept of materials and energy balance (3) Flow of fluids : Types of fluids. Crystallizers. plastic. Mixers for solid-solid. temperature. Corrosion : Types of corrosion. size reduction equipment. Distillation under vacuum. filter media. Steam distillation. size reduction equipment. moisture contents. 14) Filtration : Theory of filtration. Flash distillation. (2) (4) (4) 4) 5) 6) 7) Materials of construction for pharmaceutical plants : Iron and its alloys. Introduction to refrigeration. enamel. (1) (2) 16) Instruments for measurement of pressure. Bernoulli equation. (3) 8) 9) Material handling : Equipments for material handling such as belt conveyors. statics. fractional distillation. flow etc.Filtration equipments. freeze drying. 15) (3) (3) (3) (3) Industrial plant hazards : occupational. Size reduction : Theory of size reduction. PHARM PHARM. (5) Copper and its alloys. finned tube heat exchangers. spray drying. (3) 3) Heat transfer : Modes of heat transfer. Methods for corrosion prevention. Sublimation.

1. Tata Mcgraw Hill. Macmillan Publications. 4. RECOMMENDED BOOKS: Latest editions of the following books. L. Publishers. (1) (1) K. 18) Introduction to Integrated automated production lines and robotics. 2. “Material selection for process plants”. David Gandertion. Badger.T. Perry and Chilton. “Theory and Practice of Industrial Pharmacy”. 5. McGraw Hill. Delhi.. 6. 3. W. Stainer. New Delhi.17) Process engineering and preventive maintenance. 1997. Libberman H.. 1998. Roussal Gackenback. Banchero J. 30 | P a g e . Delhi. 7. Samabamurthy.. New age Intermational (P) Ltd. “Plant Engineering Handbook”. “Unit Processes in Pharmacy”. A. “Pharmaceutical Engineering”. Varghese Publishing House. Lachman L. “Chemical Engineers Handbook”. “Indroduction to Chemical Engineering”.

active constituents. microscopic. guar gum. cochineal etc. sisal. biogenesis. quantitative microscopy including lycopodium spore method and leafconstants. 31 | P a g e . history. ginseng. physiochemical. quillaia barck. underlined in (5) to (18). export potential of medicinal plants. cultivation. wild cherry bark etc. (3) Honey. collection and preparation. agar. Solanum (2) spp. kinos. development and scope of pharmacognosy.. The systematic study of crude drugs including biological source. (5) 3) Evaluation of crude drugs : Different methods of evaluation – organolepic. 6) Tannins : Pale catechu. 2) General Pharmacognosy : Classification of crude drugs – alphabetical. acacia. geographical source. aloes. (2) (2) (1) 4) 5) 7) 8) 9) Saponin glycosides : Dioscorea corns. (2) myroblans (harda & beharda). gokharu fruits. (1) Carbohydrates : Simple and polysaccharides including gums and Mucilages. (3) (2) 10) Cynogenetic glycosides: Almonds seeds. Preliminary phytochemical screening (5) WHO guidelines for quality control of medicinal plants. rhubarb roots. extraction. Anthraquinone glycosides : Senna leaves & pods. ashoka bark. PHARM PHARMACOGNOSY-I (THEORY) Minimum 50 Hrs/Yr 1) General Introduction : Definition. Extractive values. linseed seeds. therapeutic uses etc. TKP.Chemotaxonomy and chemical races. bael fruits. occurrence. ash values. Systematic description of crude drugs. taxonomical. shatavari roots. galls. substitutes and adulterants. collection. Cardiac glycosides : Digitalis leaves. carrageenan. chemistry. moisture content. commercial starches.. Commerce in crude drugs – cultivation. cellulose and its derivatives. isapghula seeds. Adulteration of crude drugs and its detection. morphological. determination of foreign organic matter. frangula back. alginates. chemical and biological. glycyrrhiza roots and stolons. cascara bark. Indian tragacanth. morphology histology. squill bulb etc. Organised and unorganized drugs. chemical tests. processing & storage of crude drugs. senega roots etc. arjuna bark. sarsaparilla. tragacanth. psyllium seeds.SECOND YEAR B. 11) Isothiocyanate glycosides : Mustard seeds. black catechu. isolation of the classes of chemical constituents mentioned in (5) to (9). stphanthus seeds. chemical and biological. Nature.

olive oil. Kalmegh herb. arachis oil. asafoetida. mustard oil. capsicum fruits 15) Bitter glycosides : Chirata herb. quassia wood. hesperidin. copaiba. lanolin. neem oil. galang rhizomes etc. cotton seed oil. picrorrhiza roots. turmeric rhizomes. colocynth fruits. fats & waxes : Castor oil. cod-liver oil. (2) (3) (3) (3) 16) Resins & resin combinations : Colophony. (3) benzoin. cannabis. wool fat. vidang fruits. storax. shark liver oil. tamarind. garcinia. rutin etc. 19) Proteins : Gelatin 20) Drugs of mineral origin : Bentonite. vanilla pods. bees wax. spermasceti wax etc. gentian roots. myrrh. (2) (2) (2) 32 | P a g e . jalap roots. talc. 17) Fixed oils. 14) Simple phenolic glycosides : Male fern roots. wheat germ oil. balsam of Tolu.12) Flavonoid glycosides : Citrus fruits. balsam of Peru. kokum oil. Indian podophyllum roots. 13) Coumarin glycosides : Tonco beans. amla. gamboges. kaladana seeds. Visnaga fruits. 18) Plant acids : Citrus. chaulmoogra oil. chalk. (1) coconut oil. sesame oil. psoralea fruits etc. kieselghur. Brazilian and Indian jalap roots.

Linseed. 33 | P a g e . D. B.E. 1998.S. Texbook of Pharmacognosy. Pune. Leaf constants. Wallis.M. 2000. Ahmedabad. Gross morphological identification of drugs mentioned in theory. Purohit A. 3) Shah C. Shah Prakashan. Glycerhiza. Lycopodium spore method 3. 8. Quassia. 2. CBS Publishers & Distributors. 7th edition... 8) Ayurvedic formulary of India. 7) Khandelwal K. Nirali Prakashan..SECOND YEAR B... & Brain K. Ispaghula. Varghese Company. 4) Brady L. R. Part Ist & IInd Government of India Ministry of Health Family Welfare . 5. Study of commercial starches. R. 6. and Quadri J. Nirali Prakashan. stone cells etc.B. Bristol. Gokhale S. Measurement of cell contents : Calcium oxalate crystals. Tyler V.(PRACTICALS) Minimum 75 Hrs/Yr 1. trichomes. RECOMMENDED BOOKS : Latest editions of the following books.. Practical Evaluation of Phytopharmaceuticals. 7. T. 1) Trease and Evans Pharmanosy. Cascara. extractive values. E.. Pharmacognosy. E.. P.. 2) Wallis T. 15th edition W. 1989-90. Textbook of Pharmacognosy.. S. ash values.. 5) Kokate C. 5th edition. 6) Turner T. Morophological and chemical identification of unorganized drugs. 4. B. 9th edition 1988.. S. PHARM PHARMACOGNOSY-I . starch grains. K. Practical Pharmacognosy. Robbers J. Wright-scient chnica. Ltd. 1975. E.R. Extraction of any two chemical constituents from those mentioned in the theory. Pune. fibres. K. Textbook of Pharmacognosy. Study of detailed histology including powder characteristics of Senna. Souders Co.

SECOND YEAR B. (5) Principles. their mode of action. PHARM PHARMACEUTICAL MICROBIOLOGY-II (THEORY) Minimum 50 Hrs/Yr 1. Entamoeba histolytica. nonthermal methods. prevention. Control of Microorganisms a. (4) Chemical Sterilization Disinfectants Antisepetics Sanitizers Bactericides Fungicides Preservatives. biochemical characteristics and diseases caused by them. 5. Sterilization. removal of aflatoxins. b. Malarial Parasites. Treponemal parasites. sterility tests for typical Pharmaceutical products. evaluation. factors governing their efficiency. Shigella. Validation of hot air oven and autoclave. Physical methods of sterilization like thermal methods. Microbial limit tests (3) Pharmacopoeial standards for microbial contamination of various raw materials used in Pharmaceutical and Cosmetic industry. d. Clostridium. cultural. Introduction to microbial drug resistance Aflatoxins – organisms producing them. classification. c. inactivation. Mycobacterium. nephrotoxins 6. Salmonella. Proteus with respect to their morphological. Leishmanial parasites. hot air ovens. their applications to Pharmaceuticals. Medical Parasitology: Protozoa and infections. membrane filters. 4. Introduction to mycotoxins like ergot. Biological Indicators. Immunology 34 | P a g e (2) (3) (8) .Medical Microbiology (10) Study of common pathogenic micro organisms like Staphylococci. Treponema. Escherchia. 3. Fungi and yeast causing skin infections. Pseudomonas. 2. Klebshiella. (5) Aseptic techniques and their applications Hepa filter validation. operation of sterilizers like autoclaves. Sterility tests : Methodology and interpretation.

(10) 9. Microbial assays of antibiotics and vitamins Interpretation of results. sera. Preparation and standardization of vaccines.T cell biology B cell biology Antigen-Antibody reactions. HLA System Complement System 8. Hypersensitivity reactions. (4) 35 | P a g e . diagnostic biologicals.

Tata Mc Graw-Hill. Microbiology. talc. International edition. PHARM PHARMACEUTICAL MICROBIOLOGY-II (PRACTICALS) Minimum 75 Hrs/Yr 1.. Mc Graw Hill Inc. Michael J. Noel R.. Chan E. biochemical characteristics. Microbiology.. 7. gram negative bacteria with respect to their cultural. Comparison of different antibiotics or antimicrobial agents by cup plate method.5th edition. 5. Determination of MIC of antimicrobial agents.P. 9. morphological. 1. on selected samples like starch.. 2. Immunodiffusion in agar gel. Microbial Limit Test as per I. 1986. RECOMMENDED BOOKS : Latest editions of the following books. 6. Inc. 10. Laboratory Rules of operating some common equipments. 36 | P a g e . gelatin. 8. 2.K. Prescott H. paper disc. Study of a gram positive.C.SECOND YEAR B. 4. ditchplate method and gradient plate technique..K. Sterility test of selected sterile products. Microbial assay of antimicrobial agents like penicillin.P. 5th edition 2002. Experimentation on sterilization. Determination of efficiency of preservatives. crystal violet. 3.

peripheral vascular diseases) Pulmonary disorders: Haemoptysis. (2) (2) (3) (2) (2) (4) 6. Congenital. iii) Dialysis. peptic ulcer. biology of immune system. Coronary Artery Diseases (Angina. appendicitis. Cell injury and origin of diseases i) Cellular deficiencies ii) Cellular intoxication a) Exogenous toxins b) Endogenous toxins 2. ii) Renal failure. A general introduction of diseases and their causes Disease etiology: Genetic. v) Obstructive uropathy vi) Urinary incontinence. PHARM PATHOPHYSIOLOGY AND HEALTH EDUCATION (THEORY) Minimum 50 Hrs/Yr. occupational lung diseases. immunodeficiency diseases. Transplantation-HLA system. and Tumor immunology 4. acquired coagulation disorder. gastritis. hernia. heart diseases iv) Myocardial disorders v) Rheumatic heart diseases vi) Extra cardiac influence on heart. vii) Urinary calculi and viii) Kidney transplantation Gastrointestinal disorders: Hiatus. heredity. Leukemia and Lymphoma 5. Immunology: Allergic disorders.SECOND YEAR B. c) Caused by Spirochetes d) Rickettsia e) Chlamydia f) Systemic fungal g) Parasitic infections i) Protozoal and intestinal j) Sexually transmitted diseases 3. Pneumothorax disorders and acid base disorders Renal and urologic disorders: i) Acid-base disorders. Infections and parasitic diseases a) Viral b) Bacterial. (2) 7. gas. iv) Bacterial infections. Hematological disorders: Anemia. Idiopathic. Hypersensitivity reactions and their disorders. bronchial asthma. Cardiovascular disorders: i) Hypertension ii) Cardiac arrhythmias iii) Congenital. Its causes. (2) 37 | P a g e . such as vascular platelet. 1. atherosclerosis. pancreatitis. (3) 8. hematological disorders. Acquired. stroke.

Health education a) Cause and mode of spread of infections. Psychiatric disorders: Psychosomatic medicine. rheumatic and osteoarthritis ii) lupus erythematosus: cutaneous and systemic iii) gout and v) myasthenia gravis. Personality disorders. glaucoma. prevention of infections b) establishment of clinics like childcare. cataract. hyperthyroidism ii) parathyroid. 15 Management of burns (3) (2) (2) 16. toxicity and obesity 11. neurotic illness and their types. 19. 9. Endocrine glands: i) Thyroid-cretinism. hemorrhoids. insomnia. contact lenses. cirrhosis and fibrosis of liver. hospital facilities like ambulance services. schizophrenia and child psychiatry 17. Neurologic disorders: (4) Neurological illness: i) Epilepsy and convulsive disorders ii) Meningitis and its type. First aid measures (2) (1) (2) (2) 38 | P a g e . anal fissure.encephalitis iii) multiple sclerosis iv) parkinsonism v) headache vi) pain vii) sleep disorders viii) mood disorders ix) anxiety disorders and x) narcolepsy 14. ENT (disorders of ear. Nutritional and metabolic disorders: Vitamin deficiency. 10. and inflammation 18. retinal detachment. disorders of eye corneal ulcer. Gynaecology and obstetrics: i) Endometriosis ii) uterine bleeding disorders and their types iii) premenstrual tension iv) dysmenorrhoea v) prenatal diagnosis and genetic counseling vi) drugs and pregnancy with relation to duration of pregnancy types of drugs and vii)amniocentesis.constipation. blood centers etc c) environment hygiene and d) outline of public health measures for prevention of disease 20. hepatitis. (4) 13. myxoedema. (2) (4) 12. Musculoskeletal and connective tissue disorders: i) Arthritis. nose and throat). hyper and hypo calcium metabolism iii) pancreas-diabetes mellitus. Hepatic and biliary disorders: Jaundice. Newer procedures used in diagnosis. skin infections. fitula and peritonitis.

India. Kumar V.L. Vol I& II.. William F..L.A..B. 2.. Vishwanath R. 2nd edition.M. Basic Pathology.. Published by W. Fauci A. Saunders Company. 1. Jack D.. Petersbors R..S.S.Harrison’s Principles of Internal medicine. Robbin S. Wilson.... Published by Prentice-hall International 39 | P a g e .RECOMMENDED BOOKS: Latest editions of the following books. 6th edition.S.K. Root R. Martin J.G..G. 1997.V. U.. 3.L. New Delhi.D. 1992. Pathophysiology of diseases and clinical medicine.. Stephen J. Cotran R. Isselbacher K. Published by Mc Graw Hill. J.J. Braunwald E..An introduction. 12th edition. New York.

Neutralization curves. pH and hydronium ion concentration in aqueous systems. Buffers. Application of precipitation titrations. scope and limitations. Theory of acid base indicators. metal ion indicators.Law of mass action. Mohrs Method. potassium bromide. 7. Titrants. Applications. liquid-liquid extraction. Precipitation titrations :. 40 | P a g e . stability constants. 8. (7) use and application of pH meter. Factors affecting the (5) precipitation. 9. biological and pharmaceutical application.Theory. impurities in analytical precipitate conditions of precipitation. successive extraction. End point determination by Volhard method. continuous counter – current extractions. Oxidation reduction titrations :. Hydrolysis of salts.Principles of gravimetry. (5) (4) (4) 6. solvents and indicators used. Importance of quality control in Pharmacy (4) Acid-Base titrations:. Co-ordination number and structure of complexions. (3) non-aqueous media. Applications of acid-base titration in Pharmacy. association ion pair formation. 2. Titration curve method. effect of temperature. dissociation constant. equivalent weights and standard solutions. potassium dichromate. buffer capacity. Application of redox titration in Pharmacy. sodium thiosulfate. Complexometric titrations: (6) Concept of complexation and chelation. pH scale. iodine. the Craig method of multiple extraction. pH. 1. the emulsion problems in extraction. masking and demasking agents. Inert solute. titration curves.Preparation and standardization of titrants like silver nitrate and ammonium thiocynate. Gravimetry :.SECOND YEAR B. preparation and standardization of some redox titrants like potassium permanganate. precipitation from homogenous solution washing and drying the precipitate Drying and ignition of precipitate. colloidal state. (4) separation of mixtures by extractions. 3. factors influencing the stability of complexes. Fajan method. application. acid base equillibria. 6 dichlorophenol indophenol. buffered isotonic solution. cerric ammonium sulfate. formation and properties of precipitate. Experimental techniques of drying and ignition. Acid base equilibria in (2) 4. strengths of acids and bases. 5. distribution law. Buffer : concept. Extraction procedures : Liquid solid extraction. titanous chloride. Non-aqueous titrations : Theory. PHARM PHARMACEUTICAL ANALYSIS-I (THEORY) Minimum 50 Hrs/Yr. Application of non aqueous titration in Pharmacy. sodium 2. pH calculations of weak acids and weak bases.

pH measurement. redox titration curve. 41 | P a g e . Electroanalytical techniques :(4) The electrical cell. oxygen flask combustion method. Nerst equation. reference electrodes. SHE. activity series standard potential. 12. Karl Fisher titration. (3) measurement of potential. types of half cells. 11. Miscellaneous methods of Analysis (3) Diazotization titration. electrode potential. half cells. sign convention.10. Potentiometry: Theoretical consideration. applications to Pharmacy. ion selective electrodes. indicator electrodes. Determination of alcohol in Liquid galenicals. measuring the relative voltage of half cells. relation of pH to potential. Kjeldhal’s nitrogen determination. the salt bridge. calculation of standard potential.

10. 6. To determine the percentage purity of Borax To det. 20. 16. A. 13. 14. ANALYSIS – I (PRACTICALS) Minimum 75 Hrs/Yr. . 18. 4. 17. Beckett and J. John Wiley and Sons. acid value of castor oil. Practical Pharmaceutical Chemistry. Vol I & II.The Athlone Press of the University of London.1N H2SO4. 3. 9.H. RECOMMENDED BOOKS: Latest editions of the following books.SECOND YEAR B.B. 21. 5. 1) A. John W iley and Sons New York. K. 19. 11. Connors. percentage purity of ZnO oride To det. To determine percentage purity of sodium nitrite To determine percentage purity of Magnesium sulphate To determine percentage purity of Aluminium sulphate To determine percentage purity of phenol To determine percentage purity of Ephedrine HCl To determine percentage purity of Sodium Chloride To determine percentage purity of Calcium Carbonate and calcium gluconate injection To determine percentage purity of Ferrous fumarate To determine content of salicylic acid in compound benzoic acid ointment.. 1. Stephen & Brewer Solving Problems in analytical chemistry by Stephen and Brewer. A text Book of Pharmaceutical Analysis. 8. 2. Stenlake. Sap value of Castor oil To det iodine value of given oil To det. To det. 2) 3) 42 | P a g e . percentage purity of Lactic acid To determine percentage purity of sodium benzoate To determine aspirin content of given tablet To determine percentage purity of antimony potassium tartarate To determine percentage purity of CuSO4.1N NaOH using KHP To prepare and standardize 0. 12. PHARM PHARM. New York. Standardization of 0. 15. 7.

Robinson annulation 8. 5. Bayer Villeger rearrangement. 14.K. (13) 2. Darzen’s reaction 11. DCC oxidtion of alcohol. Stobbe condesation. Classification of terpenes. 5. 6. Stereochemistry of acyclic and cyclic compounds. 15.3 dicarbonyl compounds. Carbonyl Chemistry : The following reactions will be covered along with their reaction echanisms. 3. Mono and dialkylations in 1. Mannich reaction 9. retro Micheal reaction 7. Conformations of cyclohexane. Nomenclature of bridgehead rang systems. Skraup quinoline synthesis and Bishler-Napirialski synthesis. Synthesis and reactions of three. Methylene transfer reactions. PHARM ORGANIC CHEMISTRY II (THEORY) Minimum 50 Hrs/Yr. Enantiomerism. conrotatory and disrotatory cyclisation 2+2 and 4+2 cycloaddition reactions. 13. Synthesis and reactions of bicyclic and tricyclic fused ring systems. Bamford Steven reaction 4. Formation and use of enol ethers. 3. Molecular rearrangements of electron rich and electron deficient systems. enamines and enol acetates .IUPAC nomenclature of heterocyclic ring systems. Pericyclic reactions. five and six membered heterocycles. Beckmann rearragement. 1 . Classification of carbohydrates. Resolution of racemic mixtures. sigmatropic rearrangements. (2) (6) 4.Use of CH 2 N 2 & Sulfurylides in the same. Michael addition. four. reduction. D and L nomenclature of sugars. (3) (2) 7.SECOND YEAR B. W. Huang Minlong modification 2. isoprene rule. 12. (5) 43 | P a g e . 10. conformational and geometric isomerism. Structure and chemical reactions of glucose. 8. Synthesis of indoles by FI synthesis. (8) 1. diastereomerism. electrocyclic reactions (4) including allowed and disallowed. Cis-trans relationship in a cyclic system. Reverse aldol reaction 6. Reduction of arylsulfonyl hydrazines/ hydrazones to alkane. (Naphthalene & Anthracene).

W. Organic Chemistry. (2) RECOMMENDED BOOKS Latest editions of the following books. New Delhi. Kogakusha Ltd. S... New Delhi. Morrison R..Benjamin. peptides and proteins.B.E. 4. and Hammond G. J. 5. 1.. Tata Mc. Isoelectric point. Hendrickson J. Finar I. House..A. Organic Chemistry Vol. H. Organic Chemistry. Longman Group Ltd. Mc. Stereochemistry of Carbon Compounds. determination of C-and N-terminal residue of a peptide. L. 3. M. Amino acids.S. Simple chemical reactions of amino acids.. Prentice Hall of India Pvt.. Eliel E. Natural amino acids and their classification. I & II . Modern Synthetic Reactions.. (5) 10. T. 44 | P a g e . B.L. 2. International Student Edition. Ltd..London..L. Cram D. test for identification and general methods of isolation of alkaloids. Ltd.. New Delhi. Chemical classification. and Boyd R. Graw Hill Publishing Co.O. London.9.Graw – Hill. 110 001.

chemistry. (3) classification of sulpha drugs sulphoxazole*. vancomycin.g. bacampicillin. other ß lactam antibiotics such as imipenam.. (6) 50 1. aztreonam. sulphathiazol*. mechanism of action.membered and activity. mechanism of action & toxicity. chemistry of Quinolone. chemistry. basic and neutral. g) Unclassified Antibiotics : Chloramphnicol*. pivampicillin. Trimethoprim* b) Quinolone : History. ß-lactamase inhibitors such as clavulanic acid and sulbactam. according to their generation. structure activity relationship and synthesis of some compounds. mechanism of action and toxicity.SECOND YEAR B.] b) Aminoglycoside Antibiotics : Introduction to aminoglycosides. pencillin and cephalosporin i) Penicillin: Detection of antibiotic producing Organisms. 16. Ist. chemical classification. classification Acidic. Antibacterial agents: a) Sulpha drugs :Introduction to sulpha drugs. crystal urea formation. [Note* :. classification of cephalosporins. acid and penicillinase degradation of penicillin. Biosythesis. amoxicillin. talampicillin. chemistry. ampicillin. ii) Cephalosporins : Introduction to cephalosprins. PHARM PHARM. sulphadiazine*. d) Macrolide Antibiotics : Introduction. 2) The following classes of drugs to be covered in details with respect to their physico chemical properties. IInd IIIrd & IVth generation. Chemistry. chemistry and classification-12 membered. classification of antibiotics (12) a) ß-lactam antibiotics e. Target (3) site. 45 | P a g e . Hetacillin. activity. e) Lincomycin Antibiotics: Introduction and chemistry. II (THEORY) Minimum Hrs/Yr. mode of action.g. and synthesis ciprofloxacin* c) Antibiotics : History. Chemistry. CHEM. classification of aminoglycosides. acidic or basic f) Polypeptide Antiboitics : Introduction.S – Synthesis of those drugs to be studied.Broad spectrum penicillins such as aminopenicillin e. c) Tetracycline Antibiotics : Introduction to tetracyclines. 14 membered. 1) Introduction to metabolism of drugs based on their functional groups. selectivity of action.

reasons for multidrug therapy. dapson*. Medicinal and Pharmaceutical Chemistry. Waverly Pvt. and dihydroemetine. Tolnaphthale . Candicidin D. Diloxanide furoate*.2. primaquine*. econazole. Griseofulvin. Arsenical pentamidine. fluconazole*. butaconazole. Antibiotics such as streptomycin. Acrisorcin. Niclosamide. Natamycin. piperazine citrate*. Antiamoebic agents : (3) Introduction and classification. Poly ICLC. Ethionamide*.. sontaquine. Co. Ltd. pentaquinee and isopentaquine. Kanamycin. Biguanide. clofazimine. hycanthone. Tetrachloroethylene. Halofantrine. pyrazinamide*. ketoconazole. propionic acid. stibofen. suramin. Emetine. albenadazole*. Antifungal agents : (5) Classification of fungal infection fatty acid.. life cycle of malaria parasite. sulphone. Paramomycin. pyrantel pamoate. antiviral agents amantadine HCL. Antifungal antibiotics such as Amphotericin B. Praziquantal. Philadelphia. vidarabine. PAS. 4. Lippin Cott. Tinidazole*. Triacetin. trimethoprim. flucytosin. Diiodohydroxyquine*. pyrimidine derivatives such as pyrimethamine*. lucanthone. B. Antimonial compounds such as antimony potassium tatarate. Imidazole derivatives such as Benzimidazole. Nystatin. cinchona alkaloids. Nifurtimox. 2. metrifonate. Wilson C. 4-amino quinolines such as chloroquine* hydroxychloroquine. Isoniazid*. Tuberculin Test. types of viral diseases. Salicylic acid. substituted imidazoles such as clotrimazole*. Undecylenic acid. pamaquine*. Bephenium hydroxynaphthoate. RECOMMENDED BOOKS : Latest editions of the following books. metronidazole*. Iodoxouridine. acyclovir. Toronto. capreomycin. . Thiabendazole*. Tetramisole. 3. Aminoquinoline. phenol and its derivatives. sodium antimony dimercaptosuccinate. Emetine. Types of therapy. Principles of Medicinal Chemistry. Bithinol. Antiviral Agents : Introduction. Interferon inducer-poly 1:C. Grisvold. viomycin. 1. viral replication. 3. Antimalarial agents : (5) Introduction. 9-aminoacridine . I. xytarabine. Amidoquine. cycloserin. mefloquine. Pyrvinium palmoate. 5. Anthelmintic agents : (4) Classification. mebendazole*. 46 | P a g e Foye W. rifampin. O. Text Book of Organic. Diethyl carbamazine citrate*. miconazole.. chloroquine. Methisazone. oxamniquine. 6. ethambutol. Haloprogin. zidovudine. O. Antimycobacterial Agents : (6) Introduction to mycobacteria. 7.

collodions and poultice. creams. Formulation factors including excipients and processing. 3) Suppositories : (5) Rectal absorption. Different types of tablets including chewable. lotions. sublingual. stabilization and evaluation of such systems including theories of emulsification. mixtures. reconstituted suspensions and industrial processing of suspensions and emulsions. SECOND YEAR B. Different types of machines used for compression of tablets. drug release from suppositories. buccal. wet and dry granulation. manufacture of soft gelatin capsules. effervescent. 5) Capsules : (10) Principles. pasters.. New York. emulsions.. Excipients used in formulation of capsules and quality control testing. methods of preparation. Evaluation and quality control of tablets. 1) Biphasic dispersed systems : (10) Suspensions. stabilization. 4) Tablets : (15) Principles. manufacture and quality control of suppositories. mucilages. processes including direct compression. and dispersible tablets. methods of preparation. II. magmas. mechanism. gels and jellies – formulation. manufacture and packaging of ointments. 5. 47 | P a g e . & III John Wiley & Sons Inc. Part I. Medicinal Chemistry. liniments. processes and equipment employed in the manufacture and filling of hard gelatin capsules. equipment employed in the preparation and manufacture of granules. Burger A. formulation.4. (10) 2) Dermatological preparations : Percutaneous absorption. plasters. PHARM PHARMACEUTICS – II (THEORY) Minimum 50 Hrs/Yr. different types of bases. of controlled flocculation. Evaluation of drug release from dermatological preparations. formulation and preparation.

v) White lotion USP vi) Benzyl benzoate lotion USP vii) Oily calamine lotion BPC viii Salicylic acid and Mercuric chloride lotion. Extra Pharmacopoeia. PHARM PHARMACEUTICS – II (PRACTICALS) Minimum 100 Hrs/Yr. II] III] IV] V] VI] VII] LINIMENTS: i) Soap liniment BPC ii) Ammoniated camphor liniment iii) Compound methyl salicylate liniment. iv) Turpentine limiment BPC. vi) Benzyl benzoate application BPC vii) Compound calamine application BPC. VIII] JELLYS : i) Ephedrine sulphate jelly ii) Sodium CMC jelly iii) Zinc gelatin 48 | P a g e . v) White liniment BPC. peppermint emulsion BPC ii) Liquid Paraffin emulsion I P iii) Vitamin A & D emulsion iv) Castor oil emulsion LOTIONS: i) Calamine Lotion BPC ii) Copper and zinc sulfate lotion BPC iii) Compound sulfur lotion BPC iv) Resorcinol and sulfur lotion Extra pharmacopoeia.SECOND YEAR B. I] MIXTURES : i) Kaolin mixture BPC ii) Paediatric chalk mixture BPC iii) Paediatric Ferric ammonium citrate mixture BPC iv) Magnesium hydroxide mixture BPC v) Magnesium trisilicate mixture BPC SUSPENSIONS : i) Trisulfapyrimidine suspension USP ii) Paracetamol Oral Suspension MAGMA : i) Bentonite magma BPC GEL : i) Aluminium hydroxide gel USP. BPC. EMULSIONS: i) Conc.

vi) Zinc oxide suppositories. 49 | P a g e .IX] OINTMENTS: i) Paraffin ointment IP ii) Simple ointment IP iii) Sulphur ointment BPC iv) Emulsifying ointment BPC v) Compound Benzoic acid ointment BPC vi) Hydrophillic ointment vii) Polyethylene glycol ointment USP viii) Nitrofurazone ointment USP ix) Non-staining Iodine ointment BPC CREAMS : i) Aqueous cream (hydrous emulsifying ointment) ii) Oily cream iii) Cetrimide Cream BPC iv) Proflavin Cream BPC PASTES: i) Titanium dioxide paste BPC ii) Mangnesium sulphate paste BPC iii) Zinc and salicylic acid paste BPC POULTICES i) Kaolin poultice BPC. ii) Preparation of capsules of one model drug. a) b c) d) e) Paracetamol tablets I P Paediatric aspirin tablets BPC Calcium carbonate tablets BPC Compound ferrous sulphate tablets Riboflavin tablets X] XI] XII] XIII] XIV] XV] CAPSULES : i) Demonstration of capsule filling machine. TABLETS : i) Monograph of tablets ii) Preparation and evaluation of granules and / or tablets of the following. SUPPOSITORIES: i) Monograph of Suppositories ii) Polyethylene glycol suppositories USP iii) Soap glycerine Suppositories USP iv) Glycerol suppositories BP v) Compound bismuth subgallate suppositories.

‘Physical Pharmacy’. S. 2nd Ed. a. Perisylvania. Waverly Pvt. ‘Introduction to Pharmaceutical Dosage Forms’. Rawlin. Matindale extra Pharmacopoeia 29th Ed. ‘Pharmaceutics : The science of Dosage Form Design’. (1999).. 5. 1-3.A. Delhi (1987). I. Osol. ‘Bentley’s Text book of Pharmaceutics’. 1. New York.. New York (1990).I. Bombay. ed. Churchill Livingstone.. and drug delivery systems’. 4th Ed. Carter. Bailliere and Tindall and ELBS.. Banker & Rhodes. Lachman et. Lachman. Mach Publishing Company. H. ‘Remington’s Pharmaceutical Sciences’. New Delhi. 8th Ed. New York. Easton. 6th Ed.. 9. 6. (1993). (1979).RECOMMENDED BOOKS : Latest editions of the following books.... I & II.. B.. (1987). Kanig. 50 | P a g e . ‘Modern Pharmaceutics’ 3rd Ed.The Pharmaceutical Press London (Current editions). Varghese Publishing House. 7. 3. Ansel. J. New Delhi. New York. 4.N. 8..L. BP 2003. Marcel Dekker Inc. B. Ltd. ‘Cooper and Gunn’s Dispensing for Pharmaceutical Students’. CBS Publishers & distributors. 2nd ed. A. ‘Theory and Practice of Industrial Pharmacy’. 2. ‘Pharmaceutical Dosage forms : Tablets : vol. Martin et. ed. Miceel E. USP & NF 2005.Waverly Pvt. (1996). 10. Vol. IP 1996. Aulton. a. L. Marcel Dekker Inc. Liberman and J. Ltd.

microscopy. kinetic (8) and electrical properties. type & applications of colloids. adsorption on solid or liquid surfaces. rheology of semisolids. melting (6) point and heat of fusion melting point and intermolecular forces. bulkiness.SECOND YEAR B. Comparison of zero. phase volume ratio on viscosity of dispersion. detergents. Micromeritics : Particle size measurement. packaging arrangements. effect (7) of temperature. wetting and spreading agents. biological half life. characteristics of surface active agents. polymorphism. sensitization and protective action. drug absorption. X-ray diffraction. antithixotropy. thixotropy and its measurement. statistical (7) diameters. measurement (8) and applications. Accelerated stability testing: Introduction to kinetics of elimination. distribution. Kraft point and cloud point. preparation and stability. Thermodynamics : Second and third law of thermodynamics. bulges and spurs. Decomposition of medicinal agents and protection from degradation: oxidation and reduction. criteria for equilibrium. Determination of order of reaction. Classius-clapeyron equation. size distribution. entropy. solubilizing agents. densities of particles. hydrolysis. porosity. adsorption isotherms. Crystalline state : Structure of crystalline solids. Colloids: Colloidal state. PHARM PHYSICAL PHARMACY (THEORY) Minimum 50 Hrs/Yr. dilatometric analysis. first and second order reactions. Surfactants: Surface tension & interfacial tension: concept. Rheology : Types of flow. particle number. sieving and sedimentation methods of particle size determination. metabolism and 51 | P a g e . flow properties and cohesiveness. compaction of powders. order of reaction : zero. Vant Hoff equation. effect of temperature (10) and pressure on equilibrium rates. Differential Thermal Analysis (DTA). free (4) energy functions and applications. measurement of rheological characteristics. Chemical equilibria and kinetics : Law of mass action. micellization. application of rheology in pharmacy. optical. first and second order reactions. maximum net work. surface area and volume. Gels and syneresis. HLB system. foaming and antifoaming agents. particle shape. Complex reactions catalysis. Differential Scanning Calorimetry DSC).

Easton. Determination of viscosity using Ostwald’s viscometer. sedimentation. Varghese Publishing House. J. IInd ed. Angle of repose : Effect of granule size. New Delhi. pseudofirst order and second order reactions. Liberman. ed. Determination of surface tension by drop number method 3. H. electrolytes and surfactants. 9. 1) Martin.(PRACTICALS) Minimum 100 Hrs/Yr. They should include (but not restrict to) the followings: 1. and Kanig. 10. B. 1995. osol. 6. Effect of electrolytes on stability of colloids. Study of sedimentation : Behaviour of suspensions. ‘The theory and Practice of Industrial Pharmacy’. 5. 2. RECOMMENDED BOOKS: Latest editions of the following books. 7. 1987 52 | P a g e . gladiants.T. Penn. effect of different concentrations of flocculating agents. Experiments based on the topics covered in theory. L. Determination of particle size by microscopy sieving. Determination of cloud point... N. I. fine. 3) Lachman. Mumbai. Determination of critical Micelle concentration [cmc] using S. e. flcoulated v/s defloculated suspensions. Order of reaction : First order. IVth ed.. ‘Physical Pharmacy’. 1994 2) Remington’s Pharmaceutical Sciences. L.g. glidant concentration. 4. PHARM PHYSICAL PHARMACY . A. 8. (Mack).. Determination of critical HLB of emulsion by phase inversion method.SECOND YEAR B. Waverley. Preparation and stability of colloids. effect of electrolyte concentration on cloud point. Method. A.

b) Prevention of Food Adulteration Act 1954. WTO and FDA. (5) 7. Introduction to various drug regulatory authorities vis. 1955.(15) 3. Drug Import Export Policy. distribution and sale of drugs. Legislation to regulate the import. manufacture. a) Industries (Development & Regulations) Act. W HO.. Legislations affecting pharmaceutical & food industry. Legislation to regulate profession of Pharmacy. a) Dangerous Drugs Act 1930. 1950 and Rules 1945 and amendments there of. (5) 53 | P a g e . (5) 8. 1948 (5) 2. a) b) c) (5) The Drugs and Magic Remedies (Objectionable Advertisements) Act 1954. Code of Pharmaceutical Ethics framed by Pharmacy Council of India. PHARM PHARMACEUTICAL JURISPRUDENCE (THEORY) Minimum 50 Hrs. Insecticides Act. FDA. Legislations to control the operations relating to Dangerous Drugs./Yr 1. Drugs and Cosmetics Act. The Pharmacy Act. Miscellaneous Acts a) Consumer Protection Act. excise-duty and prices of drugs.THIRD YEAR B. b) Poisons Act 1919 c) Opium Act 1978. (6) 4. Medicinal & Toilet Preparations Excise Duty Act. c) Shops Establishment Act of Maharashtra State (4) 6. ISO. Introduction to Indian Patent Regulations. 5. Drug Prices and Control Order 1979. 1951. Legislations to control the advertisements. b) c) d) Prevention of Cruelty to Animals Act.

. “Laws of Drugs and Medicines”. Pune.K. 1985. University Book Agency. National Book Centure. B. Pharmacy Council of India (P. ‘Text Book of Forensic Pharmacy’.RECOMMENED BOOKS : Latest editions of the following books. Calculta. 5) 6) 7) 8) 54 | P a g e . Beotr Law Book Co. No. ‘Manual of Drugs and Pharmacy Laws in India’. Pune. Vallabh Prakashan. “Hand book of Drug Laws”. New Delhi Year. 1989. Allahabad. Allahabad. Bharti. including 4) ‘Code of Pharmaceutical Ethics’. & Khandatare A. 1989. Mehta. 1) Mithal B.M. Forensic Pharmacy Industrial and Labour Laws. 7 th ed. 337). Current Government of India Publications of all Drugs Acts and Rules. Paramount Law Publications Year 1987.M. Jain N. 3) Kuchekar B. ‘A Text Book of Forensic Pharmacy (Pharmaceutical 2) Jurisprudence)’.. Nirali Publication.S.

Indian dill. orlon. histology. Volatile oils: terpentine oil. punarnava roots. animal. vinca leaves. Drugs & dosage forms of ayurvedic medicines. withania roots. 4. coriander. calabar beans. cinchona bark. acetate rayon. terylene. polythene. anise. cytokinins. substitutes and adulterants. opium. malt extract. 3. datura herb. chemistry. nutmeg seeds. ipecac roots. pilocarpus leaves. cantharides (2) 5. garlic bulbs. jute. kurchi bark. buchu leaves. collection and preparation. pepsin. banafsa leaves. Commercial fibres of vegetable. (4) 55 | P a g e . ergot. nylon. Introduction to Ayurvedic Pharmacy: Brief account of basic principles of ayurveda. 8. 1. shankhapushpi. ephedra stems. Applications of plant harmones. musk. coca leaves. belladonna herb. orange & lemon peels. nux-vomica seeds. valerian roots. Enzymes: Their classification. cumin. PHARM PHARMACOGNOSY-II (THEORY) Minimum 50 Hrs/Yr. and isolation of the classes of chemical constitutents mentioned in (2) to (7). morphology. cultivation. eucalyptus leaves. stramonium herb (17) hyoscymus herb. sassurea roots. mylabris.of the drugs underlined in (2) to (7). chymotrypsin & other pharmaceutically useful enzymes & their applications. mentha oil. European dill. chenopodium oil. jaborandi leaves. therapeutic uses etc. 7. pepper fruits. The systematic study including biological source. lobelia herb. acorus roots. chemical tests.THIRD YEAR B. regenerated fibres-rayon. caraway. (18) cassia bark. occurrence. extraction. Alkaloids: Areca nuts. (3) hemp. Nature. mace of nutmeg. wool. ocimum leaves. clove buds. asbestos. biognesis. geographical source. active constituents. aconite roots. 6. abscisic acid & (3) others. mineral & synthetic origin : Cotton. Miscellaneous: Pyrethrum flowers. veratrum roots. tobacco leaves. glass wool. 2. colchicum corms. cardamom fruits. (3) bromelain. trypsin. silk. Some aspects of standardization of ayurvedic formulations. Detailed study of papain. jatamansi roots. umbelliferous fruits – fennel. camphor. cinnamon bark. rauwolfia roots. peppermint oil. Plant growth regulators : Auxins. saffron. flax. gibberellines.

Study of detailed histology including powder characteristics of Nux-vomica. Springer Verlag. Vallabh Prakashan. Ltd.S.. 4) Brady L. 7.S. .. Cardammom. 1) Trease and Evans. & Brain K. CBS Publishers & Distributors.P. PHARM PHARMACOGNOSY-II – (PRACTICALS) Minimum 50 Hrs/Yr. 5) Kokate C. and Quadri J. W. Tokyo. Textbook of Pharmacognosy.. 9) Ayurvedic formulary of India.Gokhale S. Datura. 3. 15th edition. D. Ahmedabad.Y. 10) Wagner H. Identification of fibres by microchemical tests. Practical Pharmacognosy. Sounders Co. Pharmacognosy. Textbook of Pharmacognosy. Hedelberg.E. 5.B. Extraction of alkaloids and volatile oils. 4..K. 3) Shah C.THIRD YEAR B. 2. 8) Khandelwal K.A TLC Atlas translated by A.. Tyler V. Shah Prakashan. Purohit A. Plant Drug Analysis. Varghese Company. Cinchona. Kurchi. 6. Practicals will be based upon the theory mentioned in the syllabus.... 56 | P a g e . Ginger. Berlin.R. 1975.M. Pune. 2) Wallis T. Nirali Prakashan. Vasaka.. 7) Kokate C.K.E. B.S. and Zganiski E. Identification of adulterants in powdered crude drugs by microscopy..S. Practical Evaluation of Phytopharmaceuticals Wrightscientechnica. Coriander. Pune.. Robbers J.. Bristol.E. RECOMMENDED BOOKS : Latest editions of the following books. R. 6) Turner T. Practical Pharmacognosy.M.R.Scott.B. 1.. Eucalyptus. Study of detailed histology including powder characteristics of Fennel. Clove. Part I & II. Nirali Prakashan. Government of India. Study of the components of alkaloids &volatile oils by TLC. Bladt. Pharmacognosy. Textbook of Pharmacognosy . Gross morphological identification of drugs mentioned in theory. Rauwolfia.. K.. Delhi. N. Ministry of Health & Family W elfare.

(1) (1) 9. Clinical pharmacy practice opportunities in hospital and community pharmacy practice. Monitoring of patients with chronic diseases. Patient counseling and assessment of compliance (4) Long term care facilities. pharmacist conducted patient interviews and presentation of medication history. evaluation and communication. 12. elements of drug literature utilization. ‘ (2) Investigational drugs and clinical research. Therapeutic drug monitoring. abstracting services. using clinical pharmacokinetics for dosage individualization. admixtures. detection and reporting. present status. examples. different manifestations. Adverse drug reactions. 3. Objective and scope of clinical pharmacy. (2) 5. tobacco and during pregnancy. preparation and administration. Monitoring the patients in health and illness. 57 | P a g e . legal and ethical considerations (2) Prevention of Drug abuse and Drug Toxicity. interactions of drugs with food. Patient drug profiles. activities.THIRD YEAR B. care of neonates. phases. PHARM CLINICAL PHARMACY & DRUG INTERACTIONS (THEORY) Minimum 25 Hrs/Yr. Incompatibilities in I. clinical and biological. Intravenous admixtures. statistical methods of interpretation. 7. Drug Interactions. Clinical significance and evaluation. significance of selected pathological tests.V. pediatric. pharmacist’s role in clinical trials. Discharge interviews. pharmacokinetic and pharmacodynamic interactions. (2) 6. 10. (1) Drug Information Services and Centres. Factors predisposing ADR’s. geriatric patients. (1) Role of pharmacist in patient care in hospitals from time of admission to discharge and follow up. mechanisms. selection. physical. (5) Drug interference with diagnostic tests. Essential Drugs & Rational Drug use. 4. alcohol. total parenteral nutrition. 11. (3) 8. (1) 2. computer applications. 1.

Bajaj A. 5th edition Philadeiphia Lea Febiger 1985. Klejiin & Jonders J. Clinical significance of DrugDrug interaction. N. Clinical Pharmacy Handbook.. P. Tipnis. 1972. ‘Clinical Pharmacy and Therapeutics’ The Williams and Willkins Company Baltimore 1977. India 2003. 5. Kabat Hugh. 2. Drug Intelligence Publications. Hamilton. (Whitney).. Herfindal E. Hirschman J. Lea & Febiger. W. 8. Webb L. 58 | P a g e . Elsevier / North Holland Biomedical Press New York 1977. ‘Clinical Pharmacy’ Career Publications.F.RECOMMENED BOOKS: Latest editions of the following books. Philadelphia. ‘Hanstens’ Text book of Drug interactions. (Editors) Clinical Pharmacy Practice. Lawson & Richards. L. 6. Preceptives in Clinical Pharmacy Ed. T. Clinical Pharmacy & Hospital Drug Management by Chapman & Halls Publication.. and Lea Febriger. Dr. Stanaszek W. H. ‘Clinical Pharmacy’. 1982. Blissit C...V. R. 4. 7. E. 3. 1.

ii) Rational design iii) Use of drugs (3) 2./Yr 1. Factors affecting drug metabolism. iii) rectal mucosa b) Injection (parenteral) c) d) e) f) g) B) Pulmonary Integumentary: i) Topical. The need for Therapeutic Intervention A) Therapeutic modalities : i) Surgery. D) Excretion of drugs : a) b) Renal. b) c) d) e) Volume of distribution. iii) Genetic iv) Immunological v) Pharmacological B) Pharmacotherapy : i) Therapeutic goals. Excretion through other body fluids. blood brain barrier. biliary and pulmonary excretion of drugs. ii) Radiation. C) Biotransformation of drugs : a) Pathways of drug metabolism. b) c) Inhibition and induction of drug metabolism. fecal.THIRD YEAR B. Pharmacodynamics: 59 | P a g e . Selective accumulation of drugs. Physiological barriers to drug distribution viz. 3. blood CSF barrier. Descriptive Pharmacokinetics: A) Absorption/ Administration: a) Alimentary canal: i) Enteral. ii) Transdermal iii) Intraocular Other routes of administration Merits and demerits of various routes Mechanism of absorption into vascular or lymphatic system (15) Distribution : a) Factors influencing drug distribution. buccal. PHARM PHARMACOLOGY-I (THEORY) Minimum 50 Hrs. Binding of drugs to plasma proteins. ii) Oral mucosa: sublingual. and placental barrier.

laxatives and antidiarrhoeals Drugs for inflammatory bowel diseases. (4) (6) (2) 60 | P a g e . d) Drug allergy. 6. Emetics. osteoarthritis. Drug response. antiemetics. c) Drug resistance. therapeutic efficacy and tolerance Factors modifying the effects of the drug : a) Age b) Pharmacogenetics. e) Drug tolerance 4. potency. Anti-inflammatory drugs : NSAID drugs used in the treatment of musculo skeletal disorders: rheumatoid arthritis. Quantitative aspects of drug action. Drugs used for Cough and Asthma 7. and gout. Drugs used in Gastrointestinal system Hyperacidity and peptic ulcer. Autocoids : a) b) c) d) Histamine and histamine antagonist Serotonin and serotonin antagonist Kinins. and angiotensin Lipid derived autocoids: Prostaglandins. leukotrienes and platelet activating factor. (6) 5.a) b) c) d) Quantitative aspects of drug action and receptors. Drugs acting on Endocrine systems Hypothalamic and pituitary hormones. Thyroid and antithyroid drugs Adrenocorticosteroids and adrenocortical antagonist Gonadal hormone and inhibitors. Enzyme selectivity. Pancreatic hormones Antidiabetic drugs Parathyroid hormones 8.

THIRD YEAR B. 11) Effect of myotics and mydriatics on rabbit’s eye 12) Demonstration of routes of administration 61 | P a g e . heart rate. 9) Effect of atropine on acetylcholine and potassium induced responses using perfused frog heart 10) Effect of adrenergic and cholinergic drugs on mean blood pressure. PHARM PHARMACOLOGY-I (PRACTICALS) 1) 2) 3) 4) 5) Minimum 50 Hrs./Yr Effect of Acetylcholine on frog rectus abdominus muscle preparation Dose response curve of acetylcholine using frog rectus abdominus muscle. Dose response curve of histamine using guinea pig ileum Effect of acetylcholine on rat intestine Competitive antagonism between acetylcholine and atropine on rat ileum 6) Competitive antagonism between histamine and diphenhydramine on guinea pig ileum 7) Effect of Phytostigmine on acetylcholine induced responses using rectus abdominus muscle of frog 8) Effect of adrenaline and acetylcholine on frog heart preparation. respiratory rate of dog.

Standards used in NMR spectroscopy-TMS. Fine structure of NMR spectrum-multiplicity of peaks. absorptivity. shielding constant. quenching of fluorescence. chemical shifts. magnetic shielding. radio-frequency. band spectrum. Fuels and oxidants. instrumentation and applications. deviations in Beer’s law. magnetogyric constant.THIRD YEAR B. transmittance. Explanation of singlet. structure of a molecule and fluorescence. line spectrum. Flipping of the nucleus. emission spectroscopy. various electronic transitions. relaxation processes. refractive index detector. 6. 5) Spectrofluorimetry : Principle. Applications. auxochromic effect. transmittance. sample preparation techniques. 4) Nuclear Magnetic Resonance (NMR) Spectroscopy : Principle. Mg+1 ion and A1+2 ion. photomultiplier tube. E1cm1% and max. PHARM PHARMACEUTICAL ANALYSIS . absorbance etc. Applications of UV spectroscopy. 1) General Principles of Spectroscopy: Wave-particle duality. instrumentation.II (THEORY) Minimum 50 Hrs/Yr. its derivation. auxochromes. definition and types of luminescence. wave properties. doublet and 62 | P a g e (2) (6) (5) (5) (6) (4) . instrumentation. 3) Infrared Spectroscopy: Principle. detectors-Barrier cell. Resonance fluorescence and Stokes’ effect. bathochromic and hypsochromic shifts. various regions in IR spectrum and their use for characterization of functional groups. effect of solvents and pH on max. Instrumentation with sources. monochromators-prisms and gratings. Problems based on functional group characterization and structure elucidation based on wave numbers. meaning of various terms like absorbance. Flame Photometry / Atomic Absorption Spectroscopy : Principle. Mechanism of fluorescence and phosphorescence. singlet and triplet states. Problems based on Beer Lambert’s law. electromagnetic spectrum. emission and fluorescence spectroscopy. flame absorption. photocell. stretching and bending vibrations. factors affecting fluorescence. filtersabsorption and interference. detail explanation of transitions involved in flame spectroscopy of Na metal. saturation and ringing effect. coupling constant. single and double beam UV spectrometers. absorption spectroscopy. applications. solvents used. nuclear spin and spin quantum numbers. particulate properties. molar absorptivity. 2) Ultraviolet – Visible Spectroscopy: Beer-Lambert’s law.

liquid junction potential. selectivity factor & capacity factor. Applications. Optimization of column parameters column efficiency. TLC . m/z ratio and its derivation.dropping mercury electrode. identification of compounds on plates from R f va lues and other methods. Tyndall effect. instrumentation . applications. Polarography : Principle. (5) 7. Time of flight. polarographic cell. Methodology and applications of adsorption. Magnetic field deflection. linear elution chromatography. flame and non-flame atomizers. liquid . Mass Spectroscopy : (4) Principle. applications. internal and external standards. locating compounds using various methods. electric field deflection. ion-exchange and gel chromatography. 9. HPLC -Principle.Principle. Amperometric titrationsprinciple. Applications. 10. instrumentation and applications. Atomizers and burners.triplet states. Temperature profiles. Theories of chromatography . explanation of origin of S-shaped C-V curve. fragmentations. methodology and applications.Principle. different kinds of chromatographic techniques. rearrangements and applications. 8. Applications. Nephelometry and Turbidimetry : (3) Principle. different types. instrumentation . instrumentation. Van Deemter equation (No derivation) and factors responsible for bandbroadening.Chromatography: (10) Principle.plate and rate theory. saturated calomel electrode. normalization technique. flame absorption and flame emission profiles. various ways of development of a plate using mobile phase. 63 | P a g e . partition. qualitative and quantitative estimation. Paper Chromatography . Ilkovic equation (no derivation) – importance of factors in it. Dubosque turbidimeter and Eeel’s nephelometer.Single and double focusing mass spectrometers.

1) Experiments based on U. ANALYSIS . 7) Iodate titrations: Ascorbic acid (powder). Aluminium hydroxide (gel and tablets). 10)Permanganate titrations: Hydrogen peroxide (solution). Isoniazid (tablets).II (PRACTICALS) Minimum 100 Hrs/Yr. gels etc. Borax and Na 2 C0 3 mixture. Sodium chloride. 5) Acid-base titrations : Milk of magnesia. tablets). 2) Iodometric titrations : Resorcinol. 64 | P a g e .THIRD YEAR B. weak iodine solution 8) Argentimetry: Thiourea.V. Ammonium chloride. boric acid mixture. 3) Iodi metry : Analgin (tablets). injections. suspensions. 9) Cerimetry: Paracetamol (Tablets). Calcium gluconate (injection). Mercuric chloride. Calcium gluconate (tablets/ injection). 6) Chromatography – Determination of ion-exchange capacity of resins. Methyl paraben. ascorbic acid (powder and tablets) 4) EDTA titrations : Milk of Magnesia. capsules. Borax and orthophosphoric acid. Ferrous gluconate (injection. spectroscopy. PHARM PHARM. 5-7 different types of formulations such as tablets.

U. Principles of Instrumental Analysis.. R. 1) 2) 3) 4) 5) 6) 65 | P a g e . Englewood. John Wiley & Sons.RECOMMENDED BOOKS : Latest editions of the following books. Qualitative Inorganic Analysis.S. Harcourt Publishers.A. John Wiley & Sons. K. New York. Applications of Absorption Spectroscopy of Organic Compounds. A I. A. London. Inc.S. New York. London. John R.A. Athlone Press. H. U. Vogel. Part I & II . A. B. Holler.A. A. Eds. U. Beckett. Skoog. Conners. A Textbook of Pharmaceutical Analysis. Longman Group. S..S.. yer. Spectrometric Identification of Organic Compounds. M. Silverstein. Niemen. U. Practical Pharmaceutical Chemistry. and Stenlake J.

disadvantages essential requirements of a good pill. dispensing of mixtures. acids. nasal drops. extracts and water soluble drugs. excipients and coating. solids and alcohol.I : Dispensing Pharmacy : 1. prescription refills. Principles of dispensing and prescription handling.THIRD YEAR B. tannins. oily substances.ENT Preparation :Ear drops. packaging of powders containing volatile. percentage solutions. Tablet triturates (3) 5. calculation of doses for renally impaired patients. Preparation. tolerated and adjusted incompatibility. Compound powders. quaternary ammonium compounds. methods of weighing. ii) Organic incompatibilities including acids. vegetable extracts. Posology : Factors affecting dosage. Pills : Definition. alkalies. importance. Powders : Importance. throat paints and pigments. Mixtures:Definitions. (4) i) Inorganic incompatibilities including those of metals and their salts. (2) 6. saline substances and explosive mixtures. Pastilles : Bases and Moulds. powders. various parts of a prescription. physical or therapeutic. gargles. potent substances. alkaloids. hygroscopic. Lozenges : Base and apparatus for preparation. chemical. simple powders. classification. wrapping. description. dilution and concentration of solutions. non metals. liquids. prescription pricing. proof strengths./Yr Part . mouth washes. Pills containing small doses of oxidizing substances. bulk. (2) 4. Pharmaceutical Arithmatic : Different systems of weights and measures. various types. (4) 2. 7. (1) (1) 10. (2) 66 | P a g e . vehicles. advantages. allegations. prescriptions. Incompatibility: Definition. liquefying substances. Effervescent powders and granules. (4) 3. correction of incompatibilities. (2) 8. calculation of doses. pediatric doses. PHARM DISPENSING AND HOSPITAL PHARMACY (THEORY) Minimum 50 Hrs. 9.Intentional and unintentional. barbiturates.

Drug distribution systems in the hospitals : Floor stock systems. Pharmacy Procedural Manual and its preparation. Definition. tubings. controlled substances. Central supply service department : Its location plan and activities. development and responsibility of the hospital pharmacy department. Organization and administration of Hospitals. Sterilization and quality control testing of surgical dressings. emergency Drug Cabinet. medication errors and safety practices. (6) 9. utensils. (3) 3.Part – II : Hospital Pharmacy: 1. dispensing of ancillary supplies. 8. Manufacturing in hospital pharmacy : Bulk compounding and pre-packaging. Infection control in hospitals : Nosocomial infections. drugs. (2) (2) 5. (1) (2) 67 | P a g e . (3) 6. rubber gloves and catheters. (2) 2. instruments. inpatient and outpatientdispensing and control procedures. Location of the Pharmacy unit in relation to other hospital departments. mattresses and other surgical products. syringes and needles. Purchase and supply : Inventory control. 10. (2) (2) 7. space and physical plant requirements in relation to the size of hospital. Safe use of medications in the hospital. Hospital Formulary. policy and procedure of purchase of storage of drugs. 4. Pharmacy and Therapeutics Committee : Personnel.

Bulk powders (v) Tablet triturates and displacement value calculation. correction thereof and mixtures containing incompatibility related to acids./Yr Part I : Dispensing Pharmacy : (i) Latin terms and abbreviations (ii) Different types of mixtures including the following.THIRD YEAR B. Compound powders. quaternary ammonium compounds. Glycyrrhizin (viii) Pastilles : Menthol. water and containing insoluble substances. Effervescent powders. (vi) Pills : Copper Sulphate & Phenolphthalein (vii) Lozenges : Bismuth carbonate. Vegetable extracts. gums. tannins. Ammonium Chloride (ix) Miscellaneous Preparations : Insufflations Inhalation Mouthwash Gargles (x) Incompatibilities in mixtures. Indiffusible solids Precipitate forming substances. Potent substances. Liquefying substances. PHARM -DISPENSING AND HOSPITAL PHARMACY (PRACTICALS) Minimum 75 Hrs. Powders Containing Volatile. Effervescent mixtures Slightly soluble substances. hygroscopic substances. Simple mixtures Mixtures containing diffusible solids. alkaloids. Emulsions (iii) Emulsions containing different proportions of oil. (iv) Powders : Simple powders. 68 | P a g e .

iii) Absorbent cotton and gauze iv) Rubber tubings 5) Preparation of anticoagulant solution (I P) 6) Preparation of anticoagulant bulb (KEM Hospital formulary) 7) Preparation of dialysis solutions : i) Intraperitoneal Dialysis Solution (I P) ii) Haemodialysis Solution (B P) 8) Preparation of transfusion fluids and electrolyte replenisher solutions. cottonbuds. Eyeswabsticks. theatre gauze. 2) Monographic evaluation of i) Absorbent Cotton Wool ( I P) ii) Absorbent Cotton Gauze (BP) 3) Preparation of surgical supplies like eyepads. ii) Outpatient Electrolyte Pediatric Mixture (Extra Pharmacopoeia) iii) Oral Dehydration Solution – W HO 1) Preparation and monographic evaluation of pediatric chalk mixture BPC. 10) Miscellaneous preparations commonly used in Hospital Pharmacy such as i) Lubricating jelly.Part II : Hospital Pharmacy 1) Bulk Compounding i) Sodium. roller gauze ward gauze. ii) Starch enema. iii) Neurological solution 11)Demonstration of IV admixture incompatibility in parenteral fluids like diazepam injection and Dextrose saline solution. Gamgee pads. 12) 13) 14) Patient case presentation Computer applications in Hospital Pharmacy Hospital visits. 4) Sterilization & sterility testing of hospital supplies like i) Surgical instruments ii) Syringes and needles.KEM Hospital formulary. etc. Salicylate mixture. Calculations of milliequivalent concentrations of salts and conversion into percentage concentration. 69 | P a g e . Eye swabs.

F. Martin (Mac Publication) 5. J. Kenneth & Michael J. J. Perkins “Principles and Methods of Sterilization in Health Sciences. M C Allwood & J. 8. Charles Thomas publication. Remington’s Pharmaceutical Sciences-20 th edition Year 2000. Tipnis.) 3. Cooper & Gunn’s ‘Dispensing for Pharmaceutical students’ Ed. Hassan. 5 th edition 1986. J. 1975. Sprowl “Prescription Pharmacy”. Career Publications.. Bajaj A. 2. H. 12 th edition. W. N. 2007. 6. Lea & Febiger Publications. Nashik. ‘Husa’s Pharmaceutical Dispensing’ Ed. B. 1. India. 7. Martin (Mac Publication. 9. T .Pitman Medical. 2 nd edition 1970. ‘Hospital Pharmacy’. CBS Publishers. Cartr. 70 | P a g e ..Fell Blackwell “Textbook of Hospital Pharmacy” Scientific Publications Oxford London 1980. Aberson ‘Sterile preparations for the hospital pharmacists and procedures ‘ANN’ Arbor science publisher. ‘Hospital Pharmacy’. Lippincott. P.RECOMMENDED BOOKS: Latest edition of the following books. 4.

Study of the following classes of drugs with respect to classification. Diazepam. Ethacrynic acid. Mephenytoin. 12) Oral contraceptives : DES. anti-anxiety agents. hydrochlorthiazide. haloperidol. phenobarbital. Glyburide. testosterone. Antiulcer agents : Ranitidine. Metformin HCl. progesterone. estradiol. mode of action. (5) 2) (7) 3) (6) 4) (3) (4) 5) 6) Thyroid and Antithyroid agents Biosynthesis of thyroid hormones.THIRD YEAR B. gluthetimide. phenytoin. Cimetidine (6) (2) 7) 8) Diuretics : (4) Chlorthiazide. furosemide. Antiepileptic agents. Hypoglycemic agents : (or Antidiabetic agents) Chlorpropamide. pentobarbital. mepyramine. diphenhydramine. phensuximide. chlorpromazine. succinimides. Antiallergic agents (or Antihistaminic agents) Chlorpheniramire. physico-chemical properties. (4) (2) 9) 10) Corticosteroids and anti inflammatory steroids 11) Sex steroids. hydantoins. PHARM PHARMACEUTICAL CHEMISTRY-III (THEORY) Minimum 50 hrs/Yr. promethazine. Anticancer Agents : Carboplatin. 1-4-benzodiazepine-4-oxides. chlorthalidone. Psychotropic drugs: Neuroleptics. estrone. chloral hydrate. acetazolamide. oxazepam. tobutamide. anabolic steroids and their antagonists. Hexestrol (4) (3) 71 | P a g e . Cisplatin. structure activity relationship and synthesis of few important drugs : 1) Sedatives and hypnotics : Amobarbital. trichloroethanol.

J. 72 | P a g e . Inc.. O. 1999. A) Strong acid + neutral Strong base + neutral Strong acid + weak acid W eak acid + base W eak acid + neutral B) Solid + Solid Solid + Liquid Liquid + Liquid W atersoluble solids Eutectic mixtures III] Synthesis of some of the following compounds : (at least 6) i) 2-napthyl benzoate ii) Cyclohexanone from cyclohexanol iii) 1-Phenyl-2-azonaphthol iv) Methyl salicylate v) Aspirin vi) S-Methyl thiourea vii) Vitronaphthalene viii) Benzoic acid RECOMMENDED BOOKS : Latest editions of the following books. B.O. Gisvold. A. E. Medicinal Chemistry Part I..THIRD YEAR B. Toronto. W. Mumbai-31. Textbook of Organic Medicinal and Pharmaceutical Chemistry. and Doerge. PHARM PHARMACEUTICAL CHEMISTRY-III (PRACTICALS) Minimum 100 hrs/Yr. J. (10-12 mixture s) Some of the following combinations will be analysed. B. Principles of Medicinal Chemistry. 3) Burger. II and III . B. Tenth Edition. C. New York. K. Lippincot Company. Varghese and Company. 4) Medicinal Chemistry by Ashutosh Kar. 2) Wilson. 1) Foye. Fourth Edition. John W iley & Sons. I] Recrystallization of Organic Compounds II] Organic separation and analysis of mixtures containing two organic compounds.

aseptic processing. lotions. blister and FFS packaging.equipment employed and quality control. strip. (16) Ophthalmic Products : Ocular absorption. application. vehicles and additives. film formers and enteric materials. Albumin. andling and quality control. (5) Blood Products : Historical background. tablets and capsules with sugar. Thrombin. formulation. fractionation of plasma and monographs of different plasma fractions. collection and storage of blood. and ointments. production facilities. (10) 2) 3) 4) 5) 6) 7) 73 | P a g e . contact lens solutions. Product package compatibility. plastics. Fibrinogen. PHARM PHARMACEUTICS-III (THEORY) Minimum 50 hrs/Yr. Aqueous film coating and quality control of coated dosage forms (5) Radiopharmaceuticals : Radioisotope Generators. wholehuman blood. formulation factors. and ancillary materials. paperboard. packaging and qualitycontrol.THIRD YEAR B. eye drops. 1) Parenteral Products: Product Development. (5) Coating of solid dosage forms: Principles. Introduction to machines used in packaging. environmental controls. paper. (5) Surgical Dressings. Dextran. sterilization processes. requirements and quality control of packaging materials used in pharmaceutical packaging including glass. Large scale processing of Dextran. metals. containers and closures. Fibres and Fabrics . Concentrate of factor VIII and IX Quality control of blood products and anticoagulant solutions. air handling systems. additives and vehicles thereof Production. processes and equipment involved in the coating of granules. Labels & Labeling. Sutures and Ligatures of different types. formulation. (4) Packaging of Pharmaceutical Products: Containers and Closures. adjustment of isotonicity. Plasma Volume Expanders. Preparation and Quality control testing. Plasters.

9) Calcium gluconate injection. C) FILM COATING OF TABLETS : 25)Coating of tablets using enteric polymers. Oily Injections 19)Test for oily vehicles. DISSOLUTION TEST FOR TABLETS: 23)Dissolution test for ibuprofen tablet. B] Aseptic processing of Parenterals 16)Tetracyline injection. 17)Thiamine injection. 12)Digoxin injection 13)Riboflavine injection. 22)Deoxycortisone acetate injection. 27) Disintegration test of enteric coated tablets. Small volume parenterals 7) Adrenaline tartarate injection. PHARM PHARMACEUTICS-III (PRACTICALS) Minimum 100 hrs/Yr. 74 | P a g e . 24)Dissolution test for tolbutamide tablet. 14)Ethanolamine oleate injection 15)Trisodium edetate injection . 5) Dextrose injection. 26 Coating of tablets using non-enteric polymers. 18)Cortisone acetate injection. 2) Filling & sealing of ampoules. 8) Emetine injection. 10)Ascorbic acid injection. 21)Calciferol injection. 3) Large Volume Parenterals 4) Sodium Chloride injection.THIRD YEAR B. 6) Compound sodium lactate injection. 11)Morphine Injection. 20)Oily phenol injection. A] INJECTIONS : 1) Monograph on injections.

P. STERILITY TESTING OF INJECTABLE AND OPHTHALMIC PREPARATIONS. Rubber closure for container for Injectiable preparation. I.P. 28) 29) 30) 31) 32) 33) 34) 35) 36) 37) Chloramphenicol eye drops. Phenylephrine eye drops. Hypromellose eye drops. I. Sulphacetamide eye drops. Hydrocortisone acetate and Neomycin sulphate ophthalmic suspension.D) OPTHALMIC PREPARATIONS : Eye drops. Ophthalmic Suspensions 38) 39) 40) Dexamethasone ophthalmic suspension Tetracycline ophthalmic suspension. Contact Lens Solution Wetting solution for hard contact lens Soaking and cleansing solution for hard contact lens Cushioning solution for soft contact lens TESTING OF PACKAGING MATERIALS Test for hydrolytic Resistance of Glass I. 1) 2) 3) 4) 5) 6) 7) 8) 9) E) 10) 11) 12) 13) F) 75 | P a g e . Test on plastic container I. Test on paper. paper board and demonstration of packaging machines. Prednisolone eye drops. Pilocarpine hydrocloride eye drops. Physostigmine eye drops. Eye Ointment Atropine Sulphate eye ointment Tetracycline eye ointment Mercuric oxide eye ointment Sulphacetamide eye ointment Eye Lotion Zinc sulphate eye lotion Sodium Chloride eye lotion. Zinc sulphate & adrenaline eye drops.P. Atropine sulphate eye drops. Homatropine eye drops.P.

1. Bentley’s Textbook of Pharmaceutics. 1988. Varghese Publishinng House.J. 9.CBS Publishers and Distributors. Lachman. Mumbai. Rawlins. 2002 United States Pharmacopoeia. 4. All India Traveller Book Seller. 1 st Edition. S. Indian Pharmacopoeia. Delhi. Osmol Mack Publishers. 7. Lachman. ‘Pharmaceutical Dosage Parenteral Medications’. H. 1996. Churchill Livingstone. K.A. 2000 British Pharmaceutical Codex. M. 8. Marcel Dekker Inc. Pennsylvania. 76 | P a g e . L.RECOMMENDED BOOKS: Latest editions of the following books.Lieberman. ‘The Theory and Practice of Industrial Pharmacy’. ‘Cooper and Gunn’s Dispensing for Pharmaceutical students’. Avis.A. New York. British Pharmacopoeia. H. Cater. Remington’s Pharmaceutical Sciences.E. 3. 10. 5. E. L.Aulton. 1. Forms– 2.E.Liberman.Kanig. Delhi. J. ‘Pharmaceutics – The Science of Dosage form design’. London. Vol. 6. 1973.

PHARM. small scale sector. market research.FINAL YEAR B. 1. non-price competition-through research and development. market analysis. price competition. 3. modifications of existing products (3) 6. (c) Management by objectives. Structure of the industry : organized sector. factory (6) building layout etc. Industrial Administration: Principles of Industrial Management in relation to the Pharmaceutical Industry. influence. DRUG STORE MANAGEMENT AND INDUSTRIAL PSYCHOLOGY (THEORY) Minimum 50 Hrs/Yr. Introduction to forms of business organization: (3) Introduction to the concepts of management. Production management : goals and organization. production planning and development and materials management. product classification. public sector. Indian pharmaceutical industry : Pharmaceutical industry in India. INDUSTRIAL ORGANISATION. 2. (5) (b) Managerial planning – long term and short term plans. through quality control. A.. function of management. market behaviour. (a) Managerial work. operating problems. Marketing communication : a) Media for communication : advertising and sales promotion methods. 4. patents and trade marks. Marketing organization : the manufacturer to wholesaler to retailer. policies. b) Pharmaceutical detailing a) (2) b) c) 77 | P a g e 9. . development council (Drug and Pharmaceuticals) Progress in the manufacturing of bulk drugs and formulations. purchasing and inventory controls. Competitive practices in pharmaceutical industry : product differentiation. Organization of distribution and marketing : The pharmaceutical market. (d) Decision making process (e) Management control systems. (2) 5. its role in national economy and national health. (2) 7. planning product differentiation. plant location. The pharmaceutical product : market considerations in product development. by exception.. limitations. by results. (2) 8.

cash book.A.Y. profit and loss account. (9) 11. N. (Rutgersuni Press). Mc Graw Publishing Co. Purchasing of an existing store. 8. Fisher and Cox . U. principles of costing and estimating elements of double entry. ‘Drug Stores Management’. ‘ Practice of Management’ Allied Publishers. suitable pricing. Burley. New Delhi. K. Internal planning and layout. ‘Principles of Management’ by International Student edition of McGraw Hill. ‘How to run a small business’ Prerau. O’ Connor . Lassers J. sales promotion and advertisement. Olsen. books of accounts.. Reddin. losses and insurance including fire. ‘Marketing Drug Products’. J. Lippincott) 7.S. Ltd. 12. credit and cash sales. 1. Policies in a drug store : (6) Purchase and its record. Drug Store Management : a) b) c) d) e) f) Factors influencing the starting and running of a drug store. Store building and its construction. Ltd. Accounting and Correspondence : Elementary knowledge of different kind of accounts. Graw Hill. B. Peter Drucker. thefts etc. ‘Drug Store Operating Costs and Profits’.d) Export and import of drugs and pharmaceuticals. 4. balance sheet. . journal and ledger. drug-store employees and their treatment. New Delhi. B.. Tata M.. C.. W. ratio and their (10) application. RECOMMENDED BOOKS : Latest editions of the following books. Koontz and O’Donnell. Different types and forms of drug-store. 2.. U. (J.A. 3.Publishing Co. Location. sales and its record.S. 6. ‘Treatise on Commercial Pharmacy’. McGaw Hill 5. Nolen and Maynard. furniture and fixtures. 78 | P a g e . ‘Effective Management’.

1) Introduction to cosmetics. classification of perfumes. nail creams. their applications. permanent waving. vanishing. compact powder. (3) iii) Face powders and makeup : Face powders. (1) 3) Dermatitis and allergy. (4) 6) Perfumes in cosmetics : Synthetic. nail lacquer and enamel remover. cold. make.PHARM COSMETICOLOGY (THEORY) Minimum 50 Hrs/Yr. classification of skin creams. (5) ix) Bath preparations : Foam baths. hair setting lotions. hand creams. skin lighteners and bleaches. hair straightners. primary irritants. (5) (3) (2) (1) vii) Astringents and skin tonics. rouges and eye make up. vi) Dental Products : Dentifrices and mouth washes. sun screen. role of hormones and vitamins in skin nutrition. types of perfumes. allergy and antihistaminics in cosmetics. nail whites. protective and barrier creams (3) ii) Hair preparations : Shampoos. Liquid make up. origin and development of cosmetic science. bath salts. v) Manicure preparations : Cuticle remover. lakes. all purpose and emollient creams. antidandruff preparations. photosensitisaion. cleansing creams. pigments and inorganic colours. conditioners. 4) Preservation. i) Skin creams and lotions. 2) Basic knowledge of skin. nail bleach. 5) Cosmetic colours : natural and synthetic colours including plant and animal origin colours. stick make up and liquids. powder. (2) 79 | P a g e . hair tonics. manufacturing and blending of perfumes. viii) Body cosmetics : Antiperspirants and deodorants. manufacturing and equipment used for following types of cosmetic preparations. performance and evaluation of cosmetic materials. hair colouring dyes. (5) iv) Coloured make up : Lipsticks. cake make up. hair bleaches. (2) (2) (1) (4) 7) Formulation. foundation creams.up cream. suntan and antiburn preparations. bath oil and after bath products.FINAL YEAR B. beauty masks.natural and artificial perfumes.

dry shaving preparations and after shave preparations. aerosol (5) shaving foams. Baby cosmetics : Baby powders.x) Shaving preparations : Shaving creams lather and brushless. lotions. oils. shampoos and soaps. (1) xi) 80 | P a g e .

viii) All purpose mask. iv) Brilliantine VI) Shaving Preparations: i) Lather shaving cream.FINAL YEAR B. ii) Hand protective cream iii) Peeling lotion. iv) Corn callus preparation v) Foot cream. II) III) IV) Baby Cosmetics : i) Baby lotion. vi) Sunscreen lotion. v) Stick make up. ii) Cream Shampoo iii) Gel Shampoo. iii) Pressed Rouge v) Cake Mascara. vii) Eye shadow stick.PHARM COSMETICOLOGY – (PRACTICALS) Minimum 100 Hrs/Yr. ii) Brushless shaving cream iii) After shave lotion. iii) Compact powder iv) Liquid make up. Preparation of following types of cosmetic preparations based on the theory I) Creams : i) Cold Cream ii) Vanishing Ceam. ix) Liquid Eye liner VIII) Manicure Preparations: i) Nail Lacquer ii) Nail Enamel remover IX) Dental Product : i) Mouth Wash. iii) Baby powder Hair Prgarations: i) Liquid Shampoo. V) ii) Baby Cream. v) After shave powder VII) Coloured make-up : i) Lipstick ii) Lipsalve iv) Wax based rouge. vii) Face mask. ii) Dusting powder. iv) After shave cream. Face powders and make–up: i) Face powder. Body Cosmetics: i) Hand & body lotion. v) All purpose cream vi) Foundation cream. vi) Cake make up. X) ii) Tooth paste Astringent and skin tonics : i) Astringent stick ii) Astringent cream iii) Skin toner Miscellaneous : Insect Repellant Cream X) 81 | P a g e . vi) Cream Mascara viii) Cream eye shadow. iii) Cleansing cream iv) Emollient cream.

Wilkinson.J. P.1994. ‘Cosmetics Fragrances and Flavours. ‘Harry Cosmeticology’. Second Edition. Reprint edition-1992. 4) E. 5) Louis Appell. III) Krieger Publishing Company. second Edition. P. Chapman & Hall London. Delhi. 1974. London. Bombay. 3) Sharma. ‘Cosmetics-Formulation..Ltd.Recommended Books : Latest editions of the following books. ‘Cosmetics Science and Technology’ (Vol. 6) Pouchers. Eight edition. cosmetics and soaps’. Thomson. Revised edition – 1994. United Book and Periodicals. Ninth edition..G. manufacturing and Quality Control:’ Vandana Publications.More. 2002. Malabar. Reprint-1985.B. R. 2) Balsam M. 1) J.S. I & II. Florida. 82 | P a g e . Bombay. ‘Modern Cosmetics’. UK. Universal Publishing Corporation. Singapore.’ Micelle press-England. and Sagarin Edward. Longman Singapore Publishers Pvt. India. ‘Perfumes. First Edition-1951.

distribution. Factors affecting drug absorption.Year 1987. 2 nd ed. ‘Clinical Pharmacokinetics’. route of administration. concept of compartmental models. Waverly Pvt.. in-vivo-in-vitro correlations. methods and limitations of such studies. intravascular and extravascular routes. biological considerations. applications. 2 nd ed. 1. Tse F. Drug elimination. Introduction to Biopharmaceutics and Pharmacokinetics. ‘Pharmacokinetics’. first pass effect. volume of distribution. Ltd. 2. (2) 7. Wellig P. (8) Determination of various pharmacokinetic parameters of drug after intravenous bolus and infusion and after single dose oral administration. bioequivalence of pharmaceutical formulations. 1995. Marcel Dekker Inc. renal clearance. (6) 3. hepatic clearance. Pharmacokinetic considerations of drug concentrations in plasma. concepts. role of dosage form. Newyork. 1995..PHARM BIOPHARMACEUTICS & PHARMACECOKINETICS (THEORY) Minimum 25 Hrs/Yr. Monitoring drug concentrations in Urine. Bioavailability studies. gastrointestinal absorption. N. . Perrier D. calculation of absorption rate constant and elimination rate constants and other parameters using residual method and Wagner Nelson method. 1. drug-protein binding in blood and tissue. renal excretion. one compartment model. 5. Drug dosing regimens : Individualization and optimization in some disease states.FINAL YEAR B. ‘Pharmacokinetics. Rowland M. creatinine clearance. 9. disposition of metabolites. (2) 6.. (3) (1) (1) 8. Gibaldi M. New York.S. (6) 4.. extraction ratio. Delhi.G.. Drug metabolism. RECOMMENDED BOOKS : Latest editions of the following books. ‘clinical pharmacokinetics’.I. drug absorption. 4. Lea and Febiger B. 83 | P a g e 3. Marcel Dekker Inc.L. Tozer T. Swarbrick. Regulatory Industrial Academic Perspectives’. non-linear metabolism. physico-chemical considerations. absolute and comparative bioavailability. basic definitions. (2) 2. rate Processes. Drug Dispostion.

1 st edition . 84 | P a g e . Nashik. Brahmankar D.. ‘Current concepts in the Pharmaceutical Sciences: Biopharmaceutics’.. Bajaj A. 7. Tipnis H. Lea & Febiger.1995.. ed..5. Vallabh Prakashan. Career publications. ‘Textbook of Biopharmaceutics and Pharmacokinetics’. & Jaiswal Sunil. N. 2001. Swarbrick. Philadelphia. P. James. ‘Biopharmaceutics & Pharmacokinetics’. 6. M.

FINAL YEAR B.PHARM PHARMACOLOGY-II (THEORY) Minimum 50 Hrs/Yr. 1. Drugs used in cardiovascular disorders: Antihypertensive agents Vasodilators Treatment of angina pectoris, Cardiac glycosides and drugs used in congestive heart failure, Agents used in cardiac arrhythmias. Drugs used in blood disorders: Agents used to treat anemias, Drugs affecting coagulation, bleeding and clotting time Drugs used in hyperlipidemia and plasma expanders. 2. Chemotherapy: Principles of chemotherapy, Antibacterials penicillins, cephalosporins, chloramphenicol, tetracyclines, macrolides, clindamycin, aminoglycosides, polymyxins, vancomycin, sulfonamides, trimethoprim, Antifungals, Antivirals, Antimycobacterial drugs, Anthelmintic drugs Antiprotozoal agents Pharmacotherapy of septic shock Pharmacotherapy of sexually transmitted diseases Pharmacotherapy of urinary tract infections Pharmacotherapy of HIV Drugs for cancer chemotherapy (antineoplastic agents) 3. Drugs for Immunomodulation and gene therapy 4. Toxicology Introduction to toxicology General measures taken in the treatment of poisoning Specific antidotal treatment of poisoning produced by: a) Metals like Pb, As and Fe b) Opioids c) Solanaceous drugs d) Barbiturates and e) Salicylates
85 | P a g e

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5. Drugs acting on the Central Nervous system: General anesthetics and local anesthetics Sedatives hypnotics and anxiolytics Drugs used in psychiatric disorders CNS stimulants Antiepileptics Skeletal muscle relaxants Opioid analgesics and antagonist Antipyretics Drugs used for Parkinsonism and other neuro degenerative disorders Drugs for cognitive dysfunction.

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FINAL YEAR B.PHARM PHARMACOLOGY-II-(PRACTICALS) Minimum 100 Hrs/Yr. 1. 2. 3. 4. 5. 6. 7. 8. 9. Effect of drugs on isolated frog’s heart. Bioassay of histamine using guinea pig ileum by interpolation method Bioassay of histamine using guinea pig ileum by bracketing method Four point bioassay of acetylcholine on rectus abdominus muscle of frog Bioassay of the antagonist d- tubocurarine using frog’s rectus muscle preparation. Effect of Phenobarbitone on righting reflex of mice Effect of diazepam on muscle relaxant of mice on rota rod apparatus Determination of analgesic response of pentazocine Determination of analgesic response of aspirin

10. Determination of anticonvulsant activity of phenobarbitone 11. Determination of anticonvulsant activity of diazepam 12. Determination of anticonvulsant activity of phenytoin 13. Effect of diazepam on locomotor activity 14. Effect of barbiturates on sleeping time in mice. 15. Chlorpromazine induced catatonia in rats. 16. Effect of calcium and potassium ions on furog heart 17. Effect of Propranolol on calcium and adrenaline induced responses using perfused frog heart 18. Effect of digitalis on failing heart 19. Identification of test substances with the help of suitable blockers using perfused frog Heart 20. Tutorials in Pharmacology

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India. Wilson and Gisvold’s Textbook of ‘Organic.. Published by Mc GrawHill. ‘Essentials of Medical Pharmacology’. 21. ‘Handbook of Experimental Pharmacology’. 1999. ‘Practicals in Pharmacology’.A. 22. Goyal R. Medicinal and Pharmacological chemistry’. Philadelphia.S.. U. RECOMMENDED BOOKS : Latest editions of the following books : 1 2 3 4 Tripathi K. ‘Pharmacology and Pharmacotherapeutics’. Published by Popular Prakashan. India. New Delhi. 3 5 6 7 88 | P a g e . 1998. 9th edition. 1999. 2000. Published by Lippincott-Raven publishers. Mumbai. K. 1999.. 10th edition..S.Shah Prakashan. Ainapure S. New York. ‘The Pharmacological basis of therapeutics’.S. Sheth S. 20. Ltd.50% of the Practicals will be computer-simulated experiments. 18th edition. International edition.D. India. Kulkarni S... Determination of contancity activity of diazepam by using elevated plus more in mice. Determination of passive avoidance by using cook’s Pole climbing Apparatus. 2nd edition.New Delhi.New Delhi. Determination of explanatory behavior by using Hole board apparatus in rats. ‘Textbook of Pharmacology’. Ahmedabad.D. Goodman and Gilman. Bhand arkar S. Prakashan. India. Satoskar R. 1999. 2003. 2nd edition. published by B. Published by Vallabh rd edition. K..D..S. Published by Jaypee brothers. Published by Churchill Livingstone Pvt. 4th edition. India.

deficiency symptoms of vitamins and other growth factors. factors affecting enzyme action. metabolism and absorption of proteins. (2) 3. Ketone bodies. Biosynthesis of cholesterol. formation of urea. glycogenolysis. Enzyme kinetics Michaelis. biochemical role. digestion. Diseases associated with carbohydrate metabolism. 1. creatine. Diseases associated with protein metabolism. 89 | P a g e . daily requirements. conenzymes. (3) Enzymes : classification of enzymes. 9. adrenocorticoids Progesterone. Hereditory diseases. RNA-m-RNA. Applications of biochemical principles to Pharmacy Ultrastructure of a cell. absorption Amino acids. Carbohydrates-Types digestion and absorption of carbohydrates with examples Anaerobic and aerobic glycolysis with energy transactions.FINAL YEAR B. digestion and absorption of lipids. B from. 8. oxidative phosphorylation. (7) Vitamins : classifications of Vitamins. Diseases associated with lipid metabolism. cytochromes. sequence determination methods.PHARM BIOCHEMISTRY (THEORY) Minimum 50 Hrs/Yr. (2) 2. bile acids. 7. (6) Proteins-Types. 6. Enzyme inhibition and kinetics. Functions of cellular constituents. urea cycle. DNA-W aston and Crick model. estrogens and testosterone. nucleotides. glycogenesis. Transcription and Protein synthesis. Its significance. 4.Menten equation and its transformations : double reciprocal plot. r-RNA [as carriers of genetic information] functions and structure of RNAS. (6) Biological oxidations : electron transport chain. structure-primary secondary tertiary. 5. β-oxidation of fatty acids. gluconeogenesis. (6) Lipids : Types.(6) Nucleic acids: Purine & pyrimidine bases. nucleosides (12) and their biosynthesis. Replication of DNA. quaternary structure. DNA as the Carrier of genetic information. Hexose monophosphate shut and energetics. t-RNA.type. sources.

Estimation of Vitamin C in fruit juices. Nelson D. 2. Wilstaters method for estimation of Glucose III. Los Altos Large Medical Publication..A. Biochemistry by Conn & Stump. Qualitative Analysis of Carbohydrates Qualitative Analysis of Proteins Qualitative Analysis of Amino acids Quantitative Analysis of Carbohydrates I. Selvinoffs method for estimation of Sugars Quantitative analysis of Proteins-Biuret Method. Lane Eynon’s method for estimation of Glucose II. 5..M. Textbook of Biochemistry by Praful Godkar. Quantitative estimation of Vitamin C by dye method and KIO 3 method.L. Quantitative estimation of ß-amylase Effect of pH. temperature. 90 | P a g e . Principles of Biochemistry by Lehninger A. 1981. Benedicts method for estimation of Glucose IV. Harper’s Review of Biochemistry.FINAL YEAR B.. 3. CBS Publishers and Distributors. plant extracts etc. 2 nd edition. Estimation of Casein. RECOMMENDED BOOKS : 1. and Cox M. Delhi. 4.PHARM BIOCHEMISTRY (PRACTICALS) Minimum 75 Hrs/Yr. Harper H. 1993.L. ions on enzyme activity. A Textbook of Practical Biochemistry by Plummer.

artificial chromosomes. Bacterial mutation and mutagenesis. germyplasm storage including cryopreservation. Disaggregation of tissue and primary culture. DNA finger printing. transduction.FINAL YEAR B. Introduction to Clinical Genetics. Plant Tissue Cultures: (8) Development of plant tissue cultures.PHARM BIOTECHNOLOGY (THEORY) Minimum 25 Hrs/Yr. (1) 2. role of mutation in strain improvement. Inheritance Pattern in man Mandelian Inheritance Dominant Recessive Lethal Sex linked Sex influenced multifactoral and mitochondrial inheritance Genetic diseases of heart. b) Transgenic animals. Isolation. plasmids and their biological significance. milestones. Tissue and Organ culture. laboratory technique. Brain. sequencing and synthesis of genes. callus and suspension cultures. Protoplast fusion. Yeasts and other eucaryotes. Cloning in bacteria virus. conjugation. Recombinant DNA Technique. cell-lines and cloning. & genetic engineering. DNA polymorphism. SSRs. A brief account of genetic phenomenon in eucaryotics. Yeast artificial chromosomes. induced mutations. kidney.Basic PCR & its modifications. molecular probes and gene libraries. Somatic cell fusion. Polymerase Chain Reactions (PCR) and gene amplification. gene tagging. Organogenesis. application of PCR in biotechnology. primary culture. Totipotency. tissue engineering. somatic embryo genesis. whole embryo culture. 3. Recombinant DNA and gene cloning. somaclonal variation. Development of Biotechnology. principles and methods. isolation of mutants. Large Scale Cell cultures in Biotechnology. Tissue Cultures: Animal cell & tissue culture. and somatic hybridisation. Microbial Genetics : Gene transformation. cloning and expression vectors. biological significance of mutation. chimaeric DNA. lungs. - - - 91 | P a g e . cloning of cell lines. Gene synthesis machines and human gene therapy. Organ cultures. 1. advantages and disadvantages. RAPDs. Sex Organs. mutagenes. cultured cells and evolution of cell lines. VNTRs. types of mutation.

‘Elements of Biotechnology’.Ignacimuthu. Affiliated East-W est Press Private Ltd. Martin. Dr.. Basic Biotechnology.B 2 . and Organ Culture’. S. Rw Fr.. Fermentation and bioprocess monitoring. Rastogi Publications. Tissue. New Delhi.. Vitamins ( Vit. organic acids (citric acid. 3 rd ed. 1998. (Penicillin. 1996..S. gluconic acid)... S. Single Cell Proteins. 2 nd ed.. Reinert J and Bajaj YPS. Vit B 12 ). proteases). vinegar. New Age International (P) Ltd.W.K. ‘Biotechnological Applications of Plant Cell & Tissue Cultures: Problems and Prospects’. Cambridge University Press. ‘Applied and Fundamental Aspects of Plant cell. Rw Fr. New Delhi. Meerut. and fermentation processes. streptomycin. Dodds J. 1) 2) 3) 4) 5) 6) 7) 8) 9) 10) Remington’s Pharmaceutical Sciences. hydrogenation of steroids). 1990. 92 | P a g e . lactic acid. Tata McGraw-Hill Publishing Company Ltd. Chhadda M.. Keshav Trehan. l-glutamate). amino acids (l-lysine. & Heble M. Kumar S. ‘Experiments in Plant Tissue Culture’.J. Tata Mc Graw-Hill Publishing Company Ltd. Narosa Publishing House. 1995. 1980. role of genesis in fermentation. Industrial Microbiology. tetracycline).J. ‘A Textbook on Biotechnology’. and Roberts L. A.. Ignocimuthu. BARC. lipases. New Delhi. Casida D. Mack Publications. Microbial bioconversions (industrial hydroxylation.. Gupta P.enzymes (amylases.J.5) Fermentation Technology : (7) Types of Fermentation. Dr. antibiotics.H. Biotechnology.D.R. ‘Applied Plant Biotechnology’. 1998. A detailed account of industrial fermentation processes of alcoholic beverages. 1995. Vit. butanol).S. Ed. (8) RECOMMENDED BOOKS : Latest editions of the following books. solvents (acetone. S.

Epinephrine*. Imidazoline Derivatives . Parathion. muscarinic and nicotinic. directly and indirectly acting sympathomimetics and agents with a mixed mechanism of action. mode of action of drug molecules. Bethanchol*. Tolazoline. 2) Adrenergic Blocking Agents Classification of Adrenergic Blocking Agents Neuronal Blocking Agents Bretylium tosylate and guanethidine sulphate Alpha Blockers : Ergot alkaloids-Ergonovine.Naphazoline* and Tetrahydrazoline. Phentolamine*. Salbutamol*. Pilocarpine. Carbachol*. 3) Cholinergic Agents (3) (2) Cholinergic Neurotransmitters. adrenergic receptors alpha and beta. Ephedrine*. Pyridostigmine. Isoflurophate. Acetylcholine*. Methacholine*. Norepinephrine*Isoproterenol*. Terbutaline*. Alpha and Beta agonists : Phenylephrine. Nadolol. Nylidrin. Practolol*. synthesis of a few important drug molecules marked*. Malathion. Physostigmine. Ambenonium chloride. Metoprolol*. Phenoxybenzamine*. 1) (3) Adrenergic Agents Adrenergic Neurotransmitters – their structures and physicochemical properties. Dopamine*. Hydroxyamphetamine. Metaproterenol*. IUPAC nomenclature of drugs and their therapeutic uses. Prazosin*. Labetalol. Isoetharine. A study of the following topics with regard to the physico-chemical properties. Timolol.PHARM PHARMACEUTICAL CHEMISTRY-IV (THEORY) Minimum 50 Hrs/Yr. Directly acting cholinergic agonists and reversible and irreversible cholinesterase inhibitors. structure activity relationships (SAR). Mephentermine*.FINAL YEAR B. Cholinergic agonists and their classification. 93 | P a g e . ergotamine & Methysergide. Dobutamine. Beta Blockers : Propranolol*. Isoxsuprine. Neostigmine*.

4) Cholinergic Blocking Agents Parasympathetic Postganglionic Blockers : General structure. their alkylated analogs. chemical classification. Scopolamine. Gallamine. Anilerdine* Propionoxy and phenyl derivatives of meperidine. Ethaverine and Doxycycline. Isomethadone*. Procyclidine Aminoumides – Isoproamide Miscellaneous – Diphemanil. Mecamylamine* Neuromuscular Blocking Agents : Classification. Ethoheptazine*. Curare and Curare alkaloids. Oxymorphone. butorphanol. LAAM. Prodilidine. Hydrocodone. Amino alcohol ethers – Benztropine*. Dextromethorphan. Propoxyphen*. (iv) Benzomorphans –Pentazocine. cyclorphan. Dionin. Meperidine*. Tubocurarine. Solanaceous alkaloids-Atropine. Levorphanol. Decamethonium. Aminoalcohols – Biperiden. and Orphenadrine*. Hydromorphone. Methadone*. Thebaine. Proheptazine. Clidinium bromide. Ketobemidone*. Aminoalcohols-Cyclopentolate*. Cyclazocine 94 | P a g e . Ethopropazine*. (iii) Morphinan Analogs – N-methylmorphinan. (ii) Methadone Analogs-SAR. Fentanyl*. (4) Methantheline* 5) Narcotic Analgesics Morphine and its therapeutic applications Synthetic Analgesics: (5) A) Peripheral Modifications – Codeine. Ganglionic Blocking Agents : Depolarizing and non-depolarizing Trimetharphan. Oxycodone. Hyoscyamine. and Apomorphine B) Skeletal Modifications : (i) Meperidine Analogs-SAR. Piperidolate. Papaverine alkaloids – Paraverine. Heroin.

Levallorphan. MAO Inhibitors – selegiline. calcium channel blockers. i) ii) iii) iv) v) vi) vii) Reserpine. Ketorolac. inhibitors. Nicardipine. Mephenesin. Carbidopa. Amlodipine . Nimodipine*. salols. Phenacetin*. Flurbiprofen. ACE Inhibitors – Captopril. Fasinopril. B. salicylic acid and its derivatives. Non-steroidal Antiinflammatory Agents (4) Chemical classification. Levodopa.Narcotic Anatagonists – Nalorphine. Benazepril. Phenylbutazone*. ß – Blockers – Phentolamine*. antiplatelet drugs and cytoprotectives. Decarboxylase (3) Ibuprofen*. Methyldopa. Bromocriptine. Bretyllium. Drugs used in parkinson’s disease : Anticholinergics. Minoxidil. Diazoxide. Rampiril. 6. Oxyphenbutazone* Drugs used in the Treatment of Neuromuscular Disorders A. Prazosin. Chlorphensin. Metoprolol*. Indomethacin*. Phenoxybenzamine*. Ca-channel Blockers – Nifedipine*. (4) Dopamine. Antipyrine*. Drugs acting on smooth muscles-Hydrallazine. Piroxicam*. Methocarbamol. Naproxen*. Propranolol*. Diclofenac. Dopamine*. Aminopyrine. ß – hydroxylase inhibitor – Fusaric acid. Ketoprofen. Ganglionic blockers – Hexamethonium and Trimethorphan Guanethidine. Apomorphine. Other Dopaminergic agents – Amantadine. Aspirin*. Fenoprofen. Drugs acting centrally : Clonidine. Enalapril. beta blockers. viii) Antianginal agents – Organic nitrates. Muscle Relaxants – Antodyne. Lisinopril. Drugs acting on post ganglionic nerve endings- 95 | P a g e . Naloxone. Acebutol. 7) Antihypertensives and Antianginal agents All the classes of antihypertensive drugs. Atenolol. Mefenamic* acid* and Meclofenamate. Acetaminophen. Norapomorphine.

Entecavir. need of chiral compounds. isomeric ballast. eudismic ratio.9) Nomenclature. Rm. classification and therapeutics. Meloxicam their advantages over nonselective cyclooxygenase inhibitors. methodology advantages and disadvantages or limitations of Hansch Analysis. Es. Etodolac. diastereoselectivity. use of octanol in determination of partition coefficient. clevudine. Emtrucutabine. Eutomers. kinetic resolution. Nabumetone. enantioselectivity. B and C viruses Interferon alfa. Celecoxib. nonselective inhibitors of cyclooxygenases (commonly used NSAIDS) Selective inhibitors of cox-2. synthesis of prostaglandins. Chemical shifts. (4) (4) 11) 12) 13) 14) (4) FINAL YEAR B. role of cycloxygenases in prostaglandin synthesis. simple and valence molecular connectivity to indicate electronic effects. Rofecoxib. Nimesulide*. and physic chemical parameters such as pKa. lipophilic effects and steric effects.PHARM 96 | P a g e . 10) (1) Introduction to QSAR (5) Need of QSAR. Combinatorial Chemistry – basics. Hepatitis : Hepatitis A. databases. Cox 2 inhibitors – Eicosanoids. distomers. diastereomers. asymmetric synthesis. Ribivirin. prochiral moiety. Lamivudine. Introduction to asymmetric synthesis (4) Chirality. Indroduction. chirality pool. partition coefficient. molar refractivity. Use of substituent constants such as. Acyclovir. uses of prostaglandins. enantiomers. and libraries. enantiospecificity.

Phenol to Salicylaldehyde Small Experiments: Benzamide to Benzoic acid Cyclohexanone to1.nitroaniline Resorcinol to 2-nitroresorcinol Grignard reaction Preparation of grignard reagent and sysnthesis of secondary alcohols using corresponding alkyl halide Perkin condensation Cinnamic acid from benzaldehyde and acetic anhydride. Diazotisation & Deamination .5-diphenylhydantoin (1 Expt. Aniline to 2. I : Long Experiments: Synthesis of drugs and drug intermediates using following reactions.) Fridel-Crafts alkylation and acylation Preparation of an alkylating agent. Sandmeyer Reaction (2 expts) Anthranilic acid to o-cholorbenzoic acid and Anthranilic acid to o-iodobenzoic acid. 4.Aniline to tribromobenzene.PHARMACEUTICAL CHEMISTRY (PRACTICALS) Minimum 100 Hrs/Yr. At least fifteen experiments from following different classes) Oxidation : Benzoin to benzil (HNO3) (2 Expts. Claisen condensation Benzaldehyde to ethylcinnamate. Betanaphthol benzoate from benzoic acid. 6 – Tribromoaniline to 1. 5-tribromobenzene Riemer – Tiemann Reaction.3.) : p-Nitrotoluene to p-nitrobenzoic acid (sodium dichromate) Reduction : p-Nitrobenzoic acid to PABA (1 Expt) Esterification : PABA to benzocaine (1 Expt. 3. 3-diphenylquinoxaline 1) 2) 3) 4) 5) 6) 7) 8) 9) 10) 11) 12) 13) 14) II 1) 2) 3) 4) 5) 6) 97 | P a g e . Orthophenylenediamine to benzimidazole Orthophenylene diamine to 2.2.) Benzilic acid : rearrangement : Benzil to Benzilic acid Pinacol-Pinacolone Rearrangement : Benzil to 5.4 tetrahydrocarbazole Oxime of benzaldehyde. Nitration (2 Expts) Acetanilide to p . Benzene to acetophenone / benzophenone / triphenylmethane Hoffmann bromamide reaction Phthalimide to anthranilic acid. t-butyl chloride and conversion of benzene to t-butylbenzene.

A. J. T. John Wiley & Sons Inc. U. 3) Burger’s ‘Medicinal Chemistry and Drug Discovery’. 98 | P a g e .A. Robert F. Lemke and D.RECOMMENDED BOOKS : Latest editions of the following books.O. New York. ‘Principles of Medicinal chemistry’. Waverly Pvt. Lippincott Company.L... Ltd. Doerge.. 1) Wilson and Gisvold’s ‘Textbook of Organic Medicinal and Pharmaceutical Chemistry’. B. Abraham. ed.I. 2) W.Foye . New Delhi. A.. U. ed. D.S.S. Williams.

stability testing. nanoparticles for ocular. (5) 5. nasal. polymorphism. release rate and dose considerations. in-process controls. (5) 2) Controlled release drug delivery systems. microspheres. raw materials. solubility analysis etc. equipment. Diffusion and dissolution based systems. MDIS. Total Quality Management. 3. Quality control charts. Quality Assurance and quality control department. (15) Types of controlled release dosage forms. processing and equipment for microencapsulation. factorial designs. sampling method and sampling plans. building design and plant layout. physico chemical properties of drugs affecting formulation : particle size. polymers used. process optimization. Oral and parenteral controlled release drug delivery systems. quality control. coating materials. Good Manufacturing Practices. manufacturing documents. components. Controls on (15) personnel. propellants and loading methods. physical form. nasal sprays. general facilities. 6. applications. personnel requirements. Dry powder inhalers. (5) 4. Quality audits and documentation. core material. Introduction to novel drug delivery systems and Drug carrier systems like liposomes. 1) Preformulation studies : Stages of product development. formulations.PHARM PHARMACEUTICS – IV (THEORY) Minimum 50 Hrs/Yr. storage and distribution of products. shelf life determination. Pilot Plant Scale up techniques : (5) Manufacture of pharmaceuticals. 99 | P a g e .FINAL YEAR B.. pulmonary. ICH guidelines. statistical quality control. intra uterine routes of administration. Bulk characterization. transdermal. Microencapsulation : Concept. Aerosols. evaluation of formula. Nebulizers. environmental controls and other controls during manufacture. Criterion for selection of drugs for controlled release. Drug excipient interactions. mechanisms of drug release.

Monographic Evaluation of Inhalation Aerosols (eg) Salbutamol metered dose Inhalation aerosol. 10. 7. Microencapulation of drugs using phase separation coacervation technique (eg) Liquid paraffin with gelatin. 11. Chloroquine granules coated with Ethyl cellulose. Prepare of asprin granules by roll compaction & direct compression to tablets. 13. 12. 8.P. 100 | P a g e . 2. 14. 1. 9. Preparation of sustained release granules by embedding in hydrophilic matrix eg. 5. Preparation and evaluation of transdermal films eg Ibuprofen TDS. Preparation & Evaluation of controlled release dosage forms. 4. 6. Filling of Hard gelatin capsules using Hand operated capsule filling machine and dissolution validation of the processes.PHARM PHARMACEUTICS – IV (PRACTICALS) Minimum 100 Hrs/Yr. Study of diffusion rate from Transdermal films using diffusion cells. Preparation of sustained release granules using hydrophobic matrix (eg) salicylic acid in stearic acid by fusion method. Preparation and evaluation of Ibuprofen gel prepared using carbopol. Calcium carbonate pellets with Microcrystalline cellulose. phase separation induced by salt addition. eg.FINAL YEAR B. Preparation of sustained release granules with polymer coating eg. Dissolution rate studies on sustained release granules using pH change method (i e) variable buffers using USP dissolution test apparatus. 3. Preparation and evaluation of controlled release pellets using Extruder pelletizer. Evaluation of controlled release granules by dissolution studies using rate test apparatus I. Ibuprofen in Guar gum matrix.

A. Lachman. B I W averby Pvt. Marcel Dekker Inc. Publication. Ltd. 1999. A. 3 rd ed. Marcel Dekker Publication. Microencapulation of drugs by phase separation coacervation induced by complexation (eg) Activated charcoal by gelatin and gum Acacia. Lee V. Lieberman & J. Calcium carbonate by Polyvinyl alcohol and non solvent Acetone. Microencapulation of drug using orifice method. 3 rd edition. Ka. ‘Modern Pharmaceutics’.15. I & II. CBS publisher. Demonstration of machines available for pilot plant studies. 1996. 101 | P a g e .. AUC after oral or Intra venous administration. Verghese Publishing house.T. Kanig Lea. Mack publishing company.. Remington: ‘The science and Practice of Pharmacy’. 1987. Mumbai-1987. 1995. 1992. Effect of accelerated humidity conditions on Aspirin tablets.V. ‘Advances in controlled and Novel drug delivery’. 7.W. Marcel Dekker Publication.. 23. 5. 17. popwich NG. Publication. L. Chien Y. H. 4. 3. Rhoder C. 1. Jain N. – ‘Good Manufacturing Practices for Pharmaceuticals’ Marcel Dekker Inc. ‘Theory and Practice of Industrial Pharmacy’. Ke.L.. 19. Pharmacokinetic studies after oral administration of a sulpha drug using rabbit as a model. 19 th edition.Gennard.H. 18. Willig S. 2.A. RECOMMENDED BOOKS : Latest editions of the following books.. c max . Vol. Preparation of quality control charts and validation and documentation of liquidfilling operation. Banker G S. 21. Robinson. K ed. Microencapulation of drugs by inducing phase separation coaceration using non solvent (eg) ferrous fumarate by Polyvinyl alcohol and Acetone. Ansel HC. Controlled drug delivery fundamentals and applications. ‘Pharmaceutical Dosage forms and Drug Delivery Systems’. Determination of pharmacokinetic parameteres like t max . 6. 8. 16.. Allen L. eg. Pennsylvania. Accelerated stability studies on Aspirin solution.H. New Delhi..S.R.U. ‘Novel drug delivery systems’. and 22. 20.

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