SNDT Women’s University

(Sndt.digitaluniversity.ac)

Syllabus – Bachelors in Pharmacy

SNDT Women’s University 1, Nathibai Thackersey Road, Mumbai 400 020

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S. .D.T. WOMEN’S UNIVERSITY, MUMBAI
Shreemati Nathibai Damodar Thackersey Women’s University, founded in 1916 by Maharashi Dhondo Keshav Karave was nurtured by Sir Vithaldas Thackersey and Lady Premlila Thackersey and many other social workers who very firmly and correctly believed in women’s full participation in all spheres of life. Thus began the empowerment process in a very modest way. The University was started from a very small “Kutir” in Pune. As years passed by the reforms came and social mind set began to change. More and more parents started believing in the mission of the University and enrolled their daughters in the educational institutions. This led to expansion of the University. Today it has three campuses, one each in Churchgate (HQ), Juhu and Pune. The University is making rapid strides and with All India Jurisdiction, the number of colleges affiliating to the University is increasing at a fast pace. In the beginning the University started diploma courses but quickly initiated degree and PG courses in the faculty of arts, commerce, home-science, nursing, library science, education, computer science, PHARMACY, management studies and engineering. Befitting with the objectives of the University and due to the rapid changes taking place in society wherein more girls are opting for professional courses, the University started a full fledged degree course in Pharmacy in Juhu Campus at C.U.Shah College of Pharmacy in 1980,with the generous donation of Rs. five lacs from C.U.Shah Charitable Trust and later a further donation of Rs. eight lacs. Padmashree A. V. Mody of Unichem Laboratories also gave a donation of Rs. five lacs to the college. The University now offers the following courses in Pharmaceutical Sciences. • • • • • • • Four Year Bachelor of Pharmacy Four Semester – Master of Pharmacy (Quality Assurance) Four Semester – Master of Pharmacy (Pharmaceutics-Industrial Pharmacy) One Year P. G. Diploma in Pharmaceutical Analysis One Year P.G. Diploma in Cosmeticology One Year P.G. Diploma in Drug Information. Ph. D. in Faculty of Technology The special features of Bachelor of Pharmacy course are : Project work is carried under the guidance of teachers by each student in the 4th year and a report is presented at a seminar and copy is submitted to the college. At the end of the third year, practical training in Industry or Hospitals attached to Medical Colleges especially Pharmacology Department is imparted. Visits are arranged to pharmaceutical industries, analytical laboratories and hospitals, during which staff members accompany students. Special training in hospital pharmacy and in the newly emerging field of Clinical Pharmacy is imparted not only in theory classes but also in practicals conducted in laboratories. Analysis and Packaging of Pharmaceuticals is given more emphasis, as girls are usually preferred by Industry in these fields. For proper all round development of students, co-curricular activities are also given due importance. To suit women’s need, a complete one year theory and practical course in Cosmeticology is included. These are all devised with a focus on the aptitude, talents and job potential for
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women and emerging needs of society, by a committee of experts specially appointed by the University. The emerging subjects like Computers, Informatics and Biotechnology are also included in the course. Hostel : A limited number of seats are available in the hostel. Eligibility: Only girl students can join any of the above-mentioned courses. The eligibility for each course varies and is as per the Govt./University rules prevailing at the time. PATTERN OF EXAMINATIONS : (Subject to revision and modifications) A candidate shall be required to attend at least 75% of the number of lectures and the number of practicals separately for each subject of study in each term, only then subject to other conditions being fulfilled, a student will be eligible to appear at the University Examinations. The Principal of the College will have the discretion to condone 10% of the attendance in theory and/or practicals of any one subject or subjects if he/she is fully convinced of the student’s absence on the ground of health or reasons beyond control. There will be University examination at the end of each year. Internal Assessment : The framework of subjects for the B.Pharm. Degree states that there is internal assessment to the tune of 30% marks in each subject separately for theory & practicals. Periodic tests in theory: During each academic year there will be three unit tests for each theory subject. Marks of the best two U.T. will be sent to the University as internal assessment marks. Periodic tests in practicals: During each term there will be one unit test in Practicals. Each regular practical will be assessed by the teachers. Quiz assignments may be given and marks will be allotted. NO REPEAT UNIT TEST IN THEORY OR PRACTICALS WILL BE GIVEN. Standard of Passing : University Examination : These rules are subject to revision and modification from time to time) (i) A candidate shall obtain at least 40% marks (internal assessment and University examination combined) separately in theory and in practical of each subject for passing in the University examination. (ii) A candidate shall also obtain, at least 50% marks in the aggregate of all the prescribed subjects to pass in the University examination. (iii) Thereafter the grand total of marks at the Internal Assessment and the University examination shall be converted into a specified Grade on the basis of the following table.

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Exemption and A T K T Rules: The rules are prescribed by the University from time to time.GRADE B A A+ 0 Second First CLASS MARKS REQUIRED At least 50% but less than 60% marks At least 60% but less than 70% marks At least 70% but less than 80% marks At least 80% marks and above First class with Distinction First class Outstanding Candidate who is not able to clear all the subjects at the same attempt will be declared as passed with ‘C’ Grade. if failed subjects are cleared in subsequent examinations. Refund of fees : Tuition fees and College fees will be refunded as per the rules prescribed by the Government from time to time. 4|Page . Schedule of fees : Tuition fees will be charged as prescribed by the Government of Maharashtra and is subject to revision.

5 1. SUBJECT HRS.4 4.4 1.B.1 2.1 Mathematics & -Statistics 2 1.PHARM.PHARM.5 2.6 3.3 4../W TH PR Pharmaceutical 2 -Engineering Pharmacognosy-I 2 3 Microbiology-II Pathophysiology & Health Education Pharmaceutical Analysis-I Organic Chemistry-II Pharmaceutical Chemistry-II Pharmaceutics-II Physical Pharmacy Total Hours/Week 2 2 2 2 2 2 2 18 35 3 -3 --4 4 17 Sr.1 3.7 3.PHARM.7 2.PHARM./W TH PR 1.6 2.7 4.2 3.1 THIRD YEAR B.No SUBJECT HRS.6 4. SYLLABUS FIRST YEAR B.3 1.2 2.6 1.7 1.8 Microbiology-I Anatomy./W TH PR Pharmaceutical 2 -Jurispendence Pharmacognosy-II 2 Clinical Pharmacy & 1 Drug Interactions Pharmacology-I 2 Pharmaceutical 2 Analysis-II Dispensing & Hospital 2 Pharmacy Pharmaceutical 2 Chemistry-III Pharmaceutics-III 2 Total 15 35 3 -2 4 3 4 4 20 Sr.8 2.3 2. Sr.4 3. No 2. Physiology & Hygiene Physical Chemistry Organic Chemistry-I Pharmaceutical Chemistry-I Pharmaceutics-I 2 2 2 2 2 2 3 3 4 4 4 Total Hours/Week 15 35 20 SECOND YEAR B./W TH PR -Industrial Organisation 2 & Drug Store Management Cosmeticology 2 3 Biopharmaceutics & 1 -Pharmacokinetics Pharmacology-II 2 4 Biochemistry 2 3 Biotechnology Pharmaceutical Chemistry-IV Pharmaceutics-IV Project & Seminar Total Hours/Week 1 2 2 2 16 34 -4 4 -18 Hours/Week 5|Page .4 2.5 3. SUBJECT HRS.. No 4..2 4.PHARM. No 3.9 Sr.3 3.9 FINAL YEAR B.2 Computers 1 2 1.8 4.8 4.5 4. SUBJECT HRS.

3 I Pharmaceutical Chemistry-I Pharmaceutics-I 3 3 23 1.4 Microbiology-I Anatomy.5 1.Examination pattern FIRST YEAR B.7 1.6 3 30 30 70 70 100 100 6 6 30 30 70 70 100 100 Organic Chemistry.1 Mathematics & Statistics 1. Physiology & Hygiene Physical Chemistry 3 2 3 3 1.3 1.No SUBJECT 1. MARKS MARKS MARKS INT EXT 100 TOTAL 50 100 100 4 4 30 30 70 70 100 100 Sr.8 30 30 70 70 100 100 750 6 26 30 70 100 500 6|Page . EXAM THEORY HRS.PHARM. MARKS INT EXT 30 70 15 30 30 35 70 70 EXAM PRACTICAL TOTAL HRS.2 Computers 1.

Sr.No SUBJECT 2.5 2. MARKS MARKS INT 30 30 EXT 70 70 - 3 3 3 3 100 100 100 100 4 4 - 100 100 - 2.3 2.PHARM.Anal.9 30 30 30 70 70 70 100 100 100 850 6 6 25 30 30 70 70 100 100 450 7|Page .II Pharmaceutics-II Physical Pharmacy 3 3 3 26 2.6 3 30 30 70 70 100 100 6 - 30 - 70 - 100 - Organic Chemistry.8 2.Engg 2.3 II Pharmaceutical Chem.2 2.4 Pharmacognosy-I Microbiology-II Pathophysiology and Health Education Pharm.7 2.1 Pharm. MARKS INT EXT 30 70 30 30 30 70 70 70 TOTAL EXAM PRACTICAL TOTAL MARKS HRS.I YEAR EXAM THEORY HRS.Examination pattern SECOND B.

No SUBJECT 3. Analysis II Dispensing & Hospital Pharmacy Pharm.2 Pharmacognosy II 3. MARKS MARKS INT EXT 100 100 50 4 30 70 100 - Sr.ChemistryIII Pharmaceutics III 3 3 3 30 30 30 30 70 70 70 70 100 100 100 100 3 6 6 6 15 30 30 30 35 70 70 70 50 100 100 100 3.4 3. MARKS INT EXT 30 70 30 15 70 35 TOTAL EXAM PRACTICAL TOTAL MARKS HRS.7 Clincial Pharmacy 2 & Drug Interactions Pharmacology I 3 Pharm.1 Pharmaceutical Jurisprudence 3. EXAM THEORY HRS.8 3 23 30 70 100 750 6 6 30 30 70 70 100 550 8|Page .5 3.3 3 3 3.PHARM.6 3.Examination pattern THIRD YEAR B.

9 3 30 15 30 30 15 30 30 70 35 70 70 35 70 70 100 50 100 100 50 100 100 6 4 4 6 6 30 30 30 30 30 GRADE 70 70 70 70 70 100 100 100 100 100 Biopharmaceutics & 2 Pharmacokinetics Pharmacology-II 3 Biochemistry Biotechnology Pharmaceutical Chemistry IV Pharmaceutics-IV Project & Seminar 3 2 3 3 700 500 9|Page .2 Cosmeticology 4.3 4.Examination pattern FINAL YEAR B.No SUBJECT 4.6 4.8 4.4 4. MARKS INT EXT - Sr. MARKS INT EXT 3 30 70 100 TOTAL EXAM PRACTICAL TOTAL MARKS MARKS HRS.PHARM.1 Industrial Organisation & Drug Store Management 4.5 4. EXAM THEORY HRS.7 4.

Pharmaceutical Statistics. 4) Definite integrations. RECOMMENDED BOOKS : Latest editions of the following books. Legendre’s linear equations. Mean value theorems./Yr. Testing of hypothesis Curve fitting and Principle of least squares. Regression. 2) Random variables and distribution functions. Mathematical expectations. Equations reducible to linear equations with constant coefficients. Higher Engineering Mathematics. Joint probability distribution functions and Marginal distribution functions. 2) Higher derivatives.FIRST YEAR B. Statistics : 1) Probability.. fundamental theorems of integral calculus. Total differential: Euler’s Theorem for homogenous functions. 2) S. Leibnitz’s theorem. 3) Boltan. 1) Partial differentiation. 3) Differential equations of first order. Fundamentals of Mathematical Statistics Sultan Chand & Sons. 10 | P a g e . Marcel Dekker Publications. 3) 4) 5) 6) Discrete and continuous distributions. 2003. Linear or differential equations. 1) Grewal. Correlation. K. Gupta & V. B. C.PHARM MATHEMATICS AND STATISTICS (THEORY) Mathematics Minimum 50 Hr. Joint density function and marginal density function. 4) Pharmaceutical Statistics : Practical & Clinical applications. Kapoor. Moments and moment generating function. Quality Control. S. Khanna Publishers.

Spread sheets. DBMS.The Internet and the W eb : Internet applications. Search tools. Microwave. ASCII Codes. Computer hardware: Components. Boolean algebra. Basic anatomy of computers. Integrated packages. Satellite. Truth tables.FIRST YEAR B. Online processing. Mini. Organizational internets. 7. Online services. Project management.ces. Application Software: General Purpose applications. Computer codes and arithmetics Binary number system. Access. 11 | P a g e . Internet services Browsers. logic gates. Communications and Connectivity : Fax machines. Graphic programs. Types of modems. 8. 5. Character data representation./Yr.PHARM COMPUTERS (THEORY) Minimum 25Hr. Historical development Present and future applications of computers in everyday life and scientific research. Truth tables. 11 Multimedia and Web Authoring: Multimedia. Types of connections. loc g 6. E-mail. 9. Data transmission. Computer logic. 3. Video conferencing systems. Telephone lines. Micro. Web utilities. Fixed point and floating point numbers. E-commerce. W eb pages. Software suites. Arithmetic Logic Unit. Word processors. Input Devices. Communication channels. Control Unit. Fiber optic cable. 1. Memory devices. Boolean algebra. Coaxial cable. Time-sharing. Secondary storage devices. 4. 10. Machine language. Presentation graphics. Artificial intelligence. Mainframe. Super computers. Network architecture. W eb authoring. E-mail. Voice messaging systems. Software Components: System Software. High-level languages. Shared resources. Central Processing Unit. Network types. Intranets & extranets. User connection. Data Processing Concepts: Types of data processing. Types of Computers. Introduction to Computers 2. Modems. Output devices. Virtual reality.

/Yr. 12 | P a g e . William & Christensen Dale. Tata Mc. N..Computer application in Pharmacy by Fassett. John Shelley. Graw Hill Publishing Co.PHARM COMPUTER (PRACTICALS ) Minimum 50Hr. Subramanian. B. 1. Introduction to Computer and fundamentals of Computer Science. Practicals based on topics covered in theory including introduction to : 1) 2) 3) Microsoft Word Microsoft Excel Microsoft Powerpoint RECOMMENDED BOOKS : Latest editions of the following books. New Delhi. ‘Computers and Commonsense’. Ltd.FIRST YEAR B. Roger Hunt. 2. Prentice Hall of India Pvt.

Study of bacteria with respect to its morphology.PHARM MICROBIOLOGY-I (THEORY) Minimum 50 Hr. Growth phases and factors affecting growth of bacteria. (3) 3. Principles of microscopy. media for special purposes. 1. 9. Microbiology and its applications to pharmacy and medicine (3) 2. rickettsiae. Microbiology of air. milk and water. molds.FIRST YEAR B. Study of yeast. Maintenance and preservation of pure cultures. habits. viruses. staining of nuclear body or material. Culture media such as cultivation and storage media. cell wall staining. reproduction. With respect to their morphology. (7) 7. cell reproduction. differential media. observation of motility etc. (3) 8. flagella staining. Staining methods including (3) Gram’s staining negative staining. acid fast staining. algae./Yr. cultivation and pathogens. chalmydiae and protozoa (5) habits. selective media. 13 | P a g e . Flora of normal human body. measurement of growth (4) bacteria. nutrition. cultivation. cell characteristics. soil. 5. 10. 6. nutrition. enrichment media. (10) 4. (4) (5) characteristics.

Negative staining. 2. Crabtree. 8. Saunder’s Company. 4.PHARM MICROBIOLOGY-I (PRACTICALS) Minimum 75 Hr. 1. Good heart. Balliere publication. water. Measurement of size of microorganisms. staining of nuclear body or material. temp and pH 7. Saunder’s Company Rawlines(ed). flagella staining. ‘Bentleys text book of Pharmaceutics’. nutrient agar media slant. ‘Fundamentals of Microbiology’ 9 th ed. 3. Spore staining. 3. W. Hugo and Roussel ‘Pharmaceutical Microbiology’. RECOMMENDED BOOKS : Latest edition of the following books. stab & plates. Frobisher. Preparation & inoculation of nutrient broth medium. Pelczar. Factors affecting growth of organisms.W. 1. Counting the number of micro organisms/ml of the culture 5. Carpenter ‘Fundamentals of Microbiology. B. Motility-hanging drop preparation. Capsule staining. Determination of Thermal Death Time 6. Staining techniques : Staining of Cell wall. Study of yeast observation of motility. Tata Mc Graw Hill Publishing Co. Microbiological analysis of air. Scientific Tindall 14 | P a g e . S. Gram’s staining. 4. Reid and Chan ‘Microbiology’. Study of microscope 2.FIRST YEAR B. 5. Blackwell Publications./Yr.

FIRST YEAR B.PHARM ANATOMY PHYSIOLOGY AND HYGIENE (THEORY) Minimum 50 Hr./Yr. 1. Introduction to the human body parts as a whole and various systems. (1) 2. Cellular Physiology: Sub cellular organization, membrane transport process, genetic action and normal cell division. (2 ) 3. Basic tissue structure and function of epithelial, connective, muscular nervous and glandular tissue, tissue repair and homeostasis, nerve impulse generation and transmission. 4. Musculoskeletal system: Cartilage, skeletal system, types of bones and joints, properties of the muscle, Components and functions of the joints. 5. Digestive System : Anatomy, physiology and functions of the alimentary, (4) (4) (6)

tract, mouth, pharynx, esophagus, stomach, small and large intestine. Functions – Absorption and digestion, ingestion, propulsion, mechanical and chemical digestion, defecation. Control of digestion-intrinsic and extrinsic reflexes, Blood supply to the digestive system, Enteric nervous system of the alimentary tract, The Tongue and salivary glands, saliva and control of salivation The Teeth – tooth and gum diseases. Digestive processes in the mouth, Heartburn, The Stomach Regulation of the three phases of gastric secretion Role of gastrin, intestinal gastrin, Acetylcholine and histamine Gastric contractility and emptying The Small Intestine, Structure adapted for absorption of nutrients The Liver and Gallbladder, functions of the liver, Liver lobules and Kupffer cells, Bile components, synthesis and secretion Functions of the gallbladder and Cholecystokinin (CCK) The Pancreas, Exocrine (digestive) function, pancreatic enzymes The Large Intestine, Regions and Function, Bacterial flora. 6. Respiratory system: (4) Structure of the respiratory system, blood supply to the lungs, pulmonary ventilation, compliance and airway resistance, lung volume and capacities, exchange of 02 and C02 , control of respiration and maintenance of acid base balance. 7. Cardiovascular system: Blood; Composition and functions of blood, formation of cellular components,
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Maintenance of homeostasis, blood groups, and blood types.Heart; Structure of heart, blood supply to the heart, conduction system and pacemaker, physiology of cardiac muscle contraction, ECG, cardiac cycle and cardiac output. 8. Lymphatic system: ic Lymphatic vessels, lymph circulation, lymphatic tissues, non-specific lresistance to the disease, immunity and functions of the immune system. 9. Excretory system : Structure of kidney and urinary tract, renal physiology, mechanism of urine formation, regulation of urine output and diuresis. 10. Integument and special senses: Anatomy and physiology of the skin, epidermal derivatives, anatomy and physiology of the eye and ear, anatomy of the olfactory receptors and physiology of the olfaction. 11. Nervous system: Structure of brain and spinal cord, neurotransmitters and anatomy and physiology of the autonomic nervous system, EEG. 12. Endocrine system: Endocrine glands, mechanism of hormone action, control of hormone secretion. Hypothalamus and pituitary gland, thyroid gland, parathyroid gland, thymus gland, adrenal gland and pineal gland. 13. Reproductive system : Anatomy and physiology of the male and female reproductive system, the female reproductive cycle, pregnancy and birth control methods. 14. Fluid electrolytes, acid-base homeostasis, fluid compartments and fluid balance, electrolytes and body fluids, movements of the body fluids acidbase balance and maintenance of acid base balance. 15. Personal hygiene, outline of public health, measures for the prevention of diseases. (2) (2) (4) (5) (5) (4) (4) (2 ) vessels,

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ANATOMY PHYSIOLOGY & HYGIENE (PRACTICALS) Minimum 75 Hr./Yr.B 1. Study of Neubuer’s chamber. 2. 3. 4. 5. 6. 7. 8. 9. Determination of total WBC count Determination of total RBC count Determination of Differential WBC count Determination of platelet count Estimation of Haemoglobin Determination of bleeding time Determination of clotting time Determination of blood group

10. Determination of Erythrocytes sedimentation rate. 11. Effect of single impulse on nerve muscle stimulation 12. Effect of successive stimuli on nerve muscle stimulation 13. Effect of fatigue on gastronemius sciatic nerve muscle preparation. 14. Genesis of tetanus using the nerve muscle preparation 15. Demonstration of recording of ECG by Biopac system 16. Demonstration of recording of EEG 17. Demonstration of recording of blood pressure 18. Effect of osmotic pressure on human blood cells 19. Demonstration of recording of pulse 20. Demonstration of recording of heart sounds 21. Demonstration of recording of Airflow 22. Demonstration of recording of respiratory parameters 23. Demonstration of recording of lung capacity 24. Study of histological slides of cells and tissues 25. Effect of temperature on frog’s heart

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Mumbai. Grabowski. Practical Anatomy – Physiology and Biochemistry.W. Churchill Livingstone Publishers. 18 | P a g e . 4. Evelyn P.... Ahmedabad. 3. India. India... Textbook of Medical Physiology. U. 1.. New York. Harper Collins publisher. Bhalani Publishing House.S. and Hall J. Prakashan. Anatomy and Physiology Brothers Publications. U. B.S. Ltd. for Nurses. Published by Jaypee 5.A. India. Guyton A. Shah 6.P.A.E. Textbook of Medical Laboratory Technology..C. Godkar P. India. Bangalore. Ross and Wilson. Published by Prism books Pvt. Wilson J. S. Godkar D. Goyal P. Tortora Principles of Anatomy and Physiology. New Delhi. 2.RECOMMENDED BOOKS : Latest edition of the following books.B.S.. Anatomy and Physiology in Health and Illness.

molarity. reversible processes. liquification of gases.PHARM PHYSICAL CHEMISTRY (THEORY) Minimum 50 Hr. Principles of Physical Chemistry should be treated with reference to their applications in Pharmacy. elevation of boiling point. mole 7. heat capacity.critical solution temperature. two and three component systems. Composition and physical states of matter: (8) Intermolecular forces and their impact on the state of matter and various physical properties of matter. Distillation of binary systems.Solute solvent interactions. types of solutions. 4. isothermic and adiabetic processes. liquids in liquids and solids in liquids. and critical phenomenon. Phase rule : (9) One. Thermodynamics: (5) First law. dielectric constant. conductometric titrations and applications. 5. heat content. electron transport. (5) Faraday’s law of electrolysis. Refractive index. refractometers. solid-solid. depression of freezing point. vapour pressure. dipole moment. 6. measurement and applications. specific refractivity. molar refractivity. fraction and percentage expressions. ideal and real solutions. azeotropic mixtures. enthalpy. molality./Yr. Van Der Vaal’s equation 2. thermochemical laws. Solubility of gases in liquids. single electrode potential. steam distillation. Electro-chemistry : Properties of electrolyte solutions. pH and other factors on solubility. Optical rotation: theory. vacuum distillation. Ionic equilibrum : Theory of conductivity. 19 | P a g e . effect of co-solvency. Colligative properties : (7) The liquid state. determine of molecular weight based on colligative properties. concentration cells. fractional distillation. Expression of concentration of pharmaceutical solutions and calculations. electrolysis. work of expansion. solubility curves (10) (4) 3. osmotic pressure. Solutions : Solubility. factors affecting solubility. Aerosols. law of partitioning and its applications. Raoult’s law. solid-liquid and liquid-liquid systems. and their applications. (2) 8. 1.FIRST YEAR B.

11) 12) 13) Determination of molecular weight by Rast’s camphor method. 20 | P a g e . Study of mutual solubility of ternary systems: benzene acetone-water. Determination of specific gravity of liquid solutions. Determination of partition coefficient: . Standardization of acid/ base solutions./Yr. 10) Determination of optical rotation of an optically active substance using polarimeter. Conductometric titrations: strong acid and strong base. equipment and instruments. Strong acid and weak base. Determination of critical solution temperature of phenol-water system. 14) 15) 16) 17) 18) Determination of normality of acid solution. Potentiometer: Determination of buffer capacity of a solution of a weak acid and its salt. Toluene-acetone-water. Iodine in carbon tetrachloride water. 7) 8) 9) Determination of partition co-efficient of benzoic acid in toluene water system. Preparation of normal and molar solutions. Determination of heat of solubilization of benzoic acid in water. Determination of critical solution temperature of triethylamine-water system.PHYSICAL CHEMISTRY (PRACTICALS) Minimum 100 Hr. Determination of specific refractivity and molar refractivity using refractometer. Experiments based on topics specified in theory syllabus will include the following: 1) 2) 3) 4) 5) 6) Introduction to GLP. introduction to apparatus.

RECOMMENDED BOOKS : Latest editions of the following books. CB. 1.. B. 5. Samuel.S. 2. Subramanyam.. Waverley New Delhi. and Laddha.I. Hadkar.S.. CVS. Bahl Arun Finally’s Practical Physical Chemistry . Vasudevan.D. A. ‘Essentials of Physical Pharmacy’ Vallabh Prakashan. Glasstone.N.. Delhi. Chand and Co. McMilan. ‘Textbook of Physical Chemistry’. 3. Dombivli.. India. ‘Physical Pharmacy’. Tuli. 4. G. T.N. K. Martin. 21 | P a g e .. ‘Practical Physical Pharmacy. Yucca Publishing House. Bahl S. S.

Huckel’s rule and criteria for determining aromaticity of a compound. Concept of resonance and hyperconjugation. ix) Acid chlorides and acid anhydrides (3). 3. Aromatic amines. Sp2 and Sp hybridization. ii) Alkenes (3). (The stereochemical (3) (2) aspects of these reactions should be dealt with appropriately wherever applicable). Classification and sources of organic compounds. giving emphasis on the mechanism of the reaction: i) ii iii) iv) v) vi) Benzene and aromatic hydrocarbons Aromatic nitro compounds. Sp3. 2. (3) (2) (2) (2) (2) (2) (2) 5 The following classes of compounds should be covered in details regarding 22 | P a g e . Diazonium salts. Structure and aromatic character of benzene. vii) Aldehydes and Ketones (2). (b) (c) Physical properties and Chemical reactions. including their mechanisms. bond angles and bond energies. x) Esters (2). v) Aliphatic hydroxy compounds (3). Calculations for determining empirical and molecular formula. b) physical properties and c) chemical reactions. Aromatic halides and Aromatic hydroxy compounds. Fission of a covalent bond. xi) Aliphatic amines (4) xiii) Amides (2). Nomenclature of organic compounds based on IUPAC system (to be covered while discussing each class of compounds). viii) Carboxylic acids (5). Sigma and ∏ bonds. 1. The following classes of compounds will be discussed in details regarding their(a) General methods of preparation. 4 Aromaticity. Bond lengths./Yr. their a) general methods of preparations.PHARM ORGANIC CHEMISTRY-I (THEORY) Minimum 50 Hr. iii) Alkynes (2).FIRST YEAR B. iv) Aliphatic halogen compounds (4). i) Alkanes (3). vi) Ethers (2). Acidity and basicity. Bond polarization and inductive effects.

./Yr. International Students edition. Organic Chemistry’. Phenols: and β naphthol. oxalic acid. Ltd. Ltd. aminophenols. 23 | P a g e . Preparation of derivatives Compounds identification such as :Acids :benzoic acid. Natural compounds: hydrocarbons.. New Delhi. sulphanilic acid etc. amides. J. nitrophenols. G.S. tartaric acid. B.S. McGraw Hill. Tata McGraw Hill Publishing Co. Cram. II] Synthesis of some organic compounds involving following one-step reactions:Acetylation :acetanilide from aniline Nitration :p-nitrosalicylic acid from salicylic acid.. R. etc.FIRST YEAR B. salicylic acid. nitroacids. I] Qualitative organic tests for identification of organic compounds such as: 1) 2) 3) 4) 5) Determination of physical constants Preliminary tests Determination of elements Determination of functional groups. D. E. cresols. 2) Hendrickson J. toluidines. New Delhi. 1) Morrison. J. New Delhi – 110001. Kogakusha Ltd. 3) Eliel. carbohydrates etc. ‘Stereochemistry of carbon compounds’. L. and Hammond. etc. G. anilides. citric acid. Boyd.T.. Bromination :p-bromoacetanilide from acetanilide. nitroanilines. phthalic acid.PHARM ORGANIC CHEMISTRY – I (PRACTICALS) Minimum 100 Hr. Prentice Hall of India Pvt. Organic Chemistry. Bases: aniline. esters.. and Hammond. RECOMMENDED BOOKS : Latest edition of the following books.. D. aminoacids.

Acidity. assay and pharmaceutical use : (4) Sodium citrate. Calibration of weights. Heavy metals. 1. Impurities in pharmaceutical substances. Moisture content. (3) 8.131. Alkalinity./Yr. Monograph and its importance. Radiopharmaceuticals and their application to Pharmacy and medicine. 2. Guiacol. laxatives. Chromium-51.PHARM PHARMACEUTICAL CHEMISTRY-I (THEORY) Minimum 50 Hr. 6. (b) Local anesthetics: (2) Procaine*. Cyclopropane. Limit tests of Chlorides. Mode of action. types and (6) effects of impurities. such as : Loss on drying. Copper sulphate. 5. Henderson Hasselbalch equation. Technitium-99M.P. pka and their effect on the absorption and excretion of (2) drugs. Iodine-125. Phosphorus–32. Assay etc. Paraldehyde. Radium-226. Gold-198. A study of following compounds with respect to methods of preparation. glassware (pipettes) instruments (balance. Ethyl alcohol. (a) General anaesthetics : (3) Chloroform*. structure activity relationship and simple synthesis. Lidocaine*. Acetylcysteine. Pentylene tetrazole. Ammonium chloride. Arsenic. antidiarrhoeal agents. (f) Purgatives. Iron-59. Tests for purity. Phenyl propanolamine* (e) CNS stimulants and hallucinogens (3) Imipramine. Extractive values. Receptor site theory with simple examples. Iron. pH meter). (3) 24 | P a g e . Ash values. Ketamine HCl. 7. Silver nitrate. sources of impurities. various tests included in monographs as per (4) I. Importance of pH. Thiopental Sodium. light and heavy Kaolin. Identification tests. Sulphates. Mercury as per I. Study of the following classes of drugs with regard to their biological activity. Benzocaine* (c) Antiseptics and disinfectants (3) Hexachlorophene. Cobalt-60.P. Nikethemide.FIRST YEAR B. Lead. (2) 9. Ether*. (d) Upper respiratory tract drugs : (4) Ephedrine*. Physicochemical properties of drugs and their relation to drug action. 4. Radioisotopes (4) Iodine . Ferrous gluconate. Halothane. (2) 3.

Roche F. J. B. 6) Atherden. Burger. M. I. L. O.B.E.. John W iley and Sons. anticoagulants and plasma expanders. Chemistry’. and Wilson. T. II & III. Varghese Publishing House Mumbai-14. Textbook of Organic Pharmaceutical Chemistry. ‘Bentley and Drivers Textbook of Pharmaceutical Chemistry’..B. Block. Toronto.(g) (h) Diagnostic agents (2) Coagulants. Lippincot Company. J. (3) ( * = Synthesis of compounds) RECOMMENDED BOOKS : Latest editions of the following books. and Doerge.O. Inc. I & II... C. ‘Principles of Medicinal Chemistry’. York. 1996. H. Medicinal Chemistry.. Vol.Mumbai – 31.. Part I. W.. 1) 2) 3) 4) 5) Foye. C. K. Gisvold. Wilson. J.B.. Soine.O. Inorganic Medicinal& Pharmaceutical IndianEdition.N. Medical and 25 | P a g e . A.Varghese and Company.. Indian Pharmacopoeia.Oxford Medical Publications.

5) a) Principles. paediatric drops. size reduction. Decoctions./Yr. maceration. such as decoction. 1) History of Pharmacy a) Origin and early history of pharmacy b) c) d) Development of Profession of Pharmacy and pharmaceutical industry in India. Introduction to Formulation of Dosage forms (5) 4) Principles. Processes of extraction. elixirs.. manufacture (15) and quality control of monophasic liquid dosage forms including Waters.P. B. mixing. percolations and modifications thereof for large scale extractions. Infusions. infusion. and International Pharmacopoeia. 3) a) b) Classification and definitions of pharmaceutical products.FIRST YEAR B.P. syrups. Pharmaceutical organizations and regulatory authorities. b) (10) 26 | P a g e .S. Scope of Pharmacy practice Ethics of pharmacy to sources of pharmaceutical literature and (6) 2) Introduction publications. Extracts. processes and equipment involved in the formulation. (2) Development of I.PHARM PHARMACEUTICS – I (THEORY) Minimum 50 Hr. clarification and filtration. U.P. methods and equipments involved in the extraction of crude (12) drugs for the preparation of Tinctures. Aromatic waters.. Resins and Oleoresins. glycerites and spirits. 6) Unit operations used in making of the above formulations. Solutions (oral and topical). illustrated with suitable examples.

D (I. 7. Acetic acid 6% w/w B.P. Coal tar solution I. Paedratic Paracetamol Elixir BPC.P..F. Preparation of Syrups: Simple Syrup U. Citric Acid Syrup N.P. P.S.. Preparation of Elixirs :Compound Benzaldehyde Elixir NF... Compound thymol glycorine BPC. Ferrous Sulphate Syrup N. Artificial Syrup BPC. 3. Preparation of Dilute acids ammonia and alcohol from concentrated solutions. Starch Glycerite BPC. Glycerotannic acid IP. Ammonia Solution 4% w/w Ammonia Solution 4% w/v Alcohol 70% v/v... Peppermint Water B. Ferrous iodide solution BPC.. P Dill Water I.P. Ephedrine Sulphate syrup N. Lemon Syrup... P. Strong B P C.P. Hydrocholoric acid 10% w/w B. Concentrated Solution of Vit A. Surgical Chlorinated Soda Solution BPC... Sodium Phosphate solution N F Lugol’s solution I P 66 (5% I2 w/v). 1966). P.P. Solution of Tolu.. 6. Strong Solution of Iodine I P 66 Compound Sodium Chloride solution I P. 27 | P a g e ./Yr. Strong solution of ammonium acetate I P 66. Ferrous Iodide Syrup B.. Aluminum acetate solution. Decoctum Aloes Compositac BPC..F. Artificial Syrup E P.P. 5.. Tinctures: Infusion of Quassia Recenes I P. Vasaka Syrup I P. P.PHARMACEUTICS – I ( PRACTICALS ) Minimum 100 Hr. Piperazine citrate Elixir BPC..P. Vinegar of Squill B. Chloroform Water B.. Cinnamon Water B. Solution of Cresol with soap B P.C. Preparation of Solutions : Benzoic acid solution I. 85% w/v. Preparation of Glycerites : Glycerine of Borax I P.F... Aromatic Elixir N... Decoction. BPC.. Three Bromides Elixir NF.BPC Codeine Phosphate Syrup BPC. Alcohol 40% v/v.. 2 .P.P. P. Simple Syrup IP 66% v/v... 8. Chloral Hydrate syrup U. Quality Control tests for Purified Water. 1. and Vit.S. Magnesium Citrate Solution N F. Gripe Water. Infusion of Chirata I.F. I. 4. Preparation of Infusions. Preparation of Aromatic Waters : Camphor Water I.

Liquid Extract of Glycerrhiza I. Introduction to Pharmaceutical Dosage forms. CBS Publishers and Distributors.P. 14. 7.P. Conc. B. Pennsylvania. Allen. Bailliere Tindall. Preparation of Liquid Extracts: Liquid Extract of Vasaka I. Bael Liquid Extract I.A. Carter. H. 9. form design Churchill Living-stone. 2. London. ‘Pharmaceutical Dosage Forms and Drug Delivery Systems’.P. The science of dosage. 6.Lemon Tincture. Varghese Publishing House. Liquid Extract of Nuxvomica I. Mack Publishers.. Lachman. W averly Pvt. Pharmaceutics. H. New Delhi.. Codeine Linctus BPC 12. Extra Pharmacopoeia IP.P. RECOMMENDED BOOKS : Latest edition of the following books. Philadelphia..P.I. Jr. Osol (ed) Remington’s Pharmaceutical Sciences.. London. Liberman. 5. Compound Benzoin Tincture. All India Traveller Books seller.(ed) Cooper and Gunn’s Tutorial Pharmacy. L. 3. Ansel. C.. H. Senna Infusion BPC.A. 28 | P a g e . 8. Orange Tincture. Delhi. Popovich. S. Ansel. Ltd. 1. Industry visit Report. 10. Determination of Alcohol content 13. Aulton. Compound Cardamom Tincture BPC.. E. Lea & Febiger.C. ‘The Theory and Practice of Industrial Pharmacy’... Mumbai.. Demonstration of machines/equipment used in manufacture of above products.. USP current editions. BP.Rawlins. Bentley’s Textbook of Pharmaceutics. Liquid Extract of Ashoka I. 4. M. Delhi.E.J. Preparation of Linctus : Simple linctus BPC. Preparation of Spirits : Aromatic Spirit of Ammonia 11.

fractional distillation. Flash distillation. 1) 2) Concept of materials and energy balance (3) Flow of fluids : Types of fluids. drying curves. Pipe fittings. dryers. Size reduction : Theory of size reduction. (3) 10) Distillation : Vapour-liquid equilibrium. 13) Drying : Purpose of drying. mechanical.SECOND YEAR B. Corrosion : Types of corrosion. ENGINEERING (THEORY) Minimum 50 Hrs/Yr. glass etc. 29 | P a g e . freeze drying. (5) Copper and its alloys. flow etc. Mixers for solid-solid. moisture contents. enamel. Methods for corrosion prevention. Evaporation : Types of evaporators. (3) 8) 9) Material handling : Equipments for material handling such as belt conveyors. temperature. electrical and fire hazards. filter aids. liquid-liquid and solid-liquid and solid-liquid systems. spray drying. filter media. aluminum and its alloys. Overall heat transfer coefficient. Introduction to refrigeration. finned tube heat exchangers. plastic. 12) Extraction and leaching : Selection of solvents. Transporation of fluids. rubber. 15) (3) (3) (3) (3) Industrial plant hazards : occupational. (2) apron conveyors etc. Sublimation. 11) Crystallization : Temperature – solubility relationship crystallization from solutions and melts. Bernoulli equation. properties of fluids. PHARM PHARM. 14) Filtration : Theory of filtration. (3) 3) Heat transfer : Modes of heat transfer. various types including. Centrifugal filtration. Crystallizers. equipments for extraction. Azeotropes and their separation. Distillation under vacuum. Laminar and turbulent flow. statics. Mixing fundamentals. size reduction equipment.Filtration equipments. distillation equipment. Nickel and its alloys. Steam distillation. (1) (2) 16) Instruments for measurement of pressure. Heat (4) transfer media Shell and tube plate. Selection of mixers. (2) (4) (4) 4) 5) 6) 7) Materials of construction for pharmaceutical plants : Iron and its alloys. size reduction equipment.

New Delhi. 1. 18) Introduction to Integrated automated production lines and robotics. Varghese Publishing House. W. “Unit Processes in Pharmacy”. 3. 1998. 5. 7. RECOMMENDED BOOKS: Latest editions of the following books. 2. 4.. McGraw Hill. Libberman H.. Lachman L. Samabamurthy. David Gandertion. Delhi. Delhi. “Theory and Practice of Industrial Pharmacy”.17) Process engineering and preventive maintenance. A. New age Intermational (P) Ltd. “Chemical Engineers Handbook”.T.. Perry and Chilton. Publishers. “Pharmaceutical Engineering”. “Indroduction to Chemical Engineering”. Roussal Gackenback. (1) (1) K. Tata Mcgraw Hill. L. 30 | P a g e . 1997. 6. “Plant Engineering Handbook”. Badger. Banchero J. “Material selection for process plants”. Stainer. Macmillan Publications.

(1) Carbohydrates : Simple and polysaccharides including gums and Mucilages. ashoka bark. 11) Isothiocyanate glycosides : Mustard seeds. Cardiac glycosides : Digitalis leaves. stphanthus seeds. (3) Honey. chemistry. linseed seeds. squill bulb etc. geographical source. substitutes and adulterants.. quillaia barck. black catechu. processing & storage of crude drugs. Extractive values. sisal. gokharu fruits. TKP. quantitative microscopy including lycopodium spore method and leafconstants. export potential of medicinal plants. cascara bark. 31 | P a g e . 2) General Pharmacognosy : Classification of crude drugs – alphabetical. chemical and biological. chemical and biological. extraction. Systematic description of crude drugs. guar gum. Preliminary phytochemical screening (5) WHO guidelines for quality control of medicinal plants. active constituents. collection. ginseng. galls. chemical tests. isolation of the classes of chemical constituents mentioned in (5) to (9). cochineal etc. (5) 3) Evaluation of crude drugs : Different methods of evaluation – organolepic.SECOND YEAR B. (3) (2) 10) Cynogenetic glycosides: Almonds seeds. underlined in (5) to (18). Solanum (2) spp. Commerce in crude drugs – cultivation. (2) (2) (1) 4) 5) 7) 8) 9) Saponin glycosides : Dioscorea corns. PHARM PHARMACOGNOSY-I (THEORY) Minimum 50 Hrs/Yr 1) General Introduction : Definition. 6) Tannins : Pale catechu.. history. glycyrrhiza roots and stolons. wild cherry bark etc. morphological. cultivation. senega roots etc. taxonomical.Chemotaxonomy and chemical races. bael fruits. The systematic study of crude drugs including biological source. biogenesis. acacia. therapeutic uses etc. occurrence. Adulteration of crude drugs and its detection. carrageenan. tragacanth. rhubarb roots. Organised and unorganized drugs. aloes. commercial starches. arjuna bark. ash values. morphology histology. kinos. Nature. microscopic. frangula back. psyllium seeds. Indian tragacanth. agar. Anthraquinone glycosides : Senna leaves & pods. determination of foreign organic matter. isapghula seeds. sarsaparilla. cellulose and its derivatives. moisture content. physiochemical. development and scope of pharmacognosy. (2) myroblans (harda & beharda). alginates. collection and preparation. shatavari roots.

Visnaga fruits. (1) coconut oil. rutin etc. 17) Fixed oils. cannabis. neem oil. asafoetida. turmeric rhizomes. 13) Coumarin glycosides : Tonco beans. copaiba. cod-liver oil. vanilla pods. olive oil. bees wax. kieselghur. Kalmegh herb. balsam of Tolu. (3) benzoin. Indian podophyllum roots. picrorrhiza roots. kokum oil. talc. quassia wood. 18) Plant acids : Citrus. (2) (2) (2) 32 | P a g e . psoralea fruits etc. 14) Simple phenolic glycosides : Male fern roots. colocynth fruits. 19) Proteins : Gelatin 20) Drugs of mineral origin : Bentonite. gentian roots. cotton seed oil. myrrh. fats & waxes : Castor oil. hesperidin. Brazilian and Indian jalap roots. jalap roots. kaladana seeds. spermasceti wax etc. vidang fruits. shark liver oil. garcinia. mustard oil. chaulmoogra oil. storax. tamarind. capsicum fruits 15) Bitter glycosides : Chirata herb. galang rhizomes etc. arachis oil.12) Flavonoid glycosides : Citrus fruits. balsam of Peru. amla. chalk. (2) (3) (3) (3) 16) Resins & resin combinations : Colophony. gamboges. wool fat. wheat germ oil. sesame oil. lanolin.

Textbook of Pharmacognosy. PHARM PHARMACOGNOSY-I . 5. 5) Kokate C.. Study of detailed histology including powder characteristics of Senna. Quassia. 5th edition. Nirali Prakashan. Wright-scient chnica. E. Tyler V. Gokhale S. Gross morphological identification of drugs mentioned in theory. Practical Pharmacognosy. Ispaghula. 8. & Brain K.E. S. 1975. ash values. Shah Prakashan. Extraction of any two chemical constituents from those mentioned in the theory. B. 6) Turner T. Practical Evaluation of Phytopharmaceuticals. B. 1) Trease and Evans Pharmanosy. R. Pune.. 9th edition 1988. Morophological and chemical identification of unorganized drugs. Nirali Prakashan. Leaf constants. Pharmacognosy. E. K. fibres.R. Study of commercial starches. Part Ist & IInd Government of India Ministry of Health Family Welfare ..B.. D.. R. Wallis. 15th edition W. Lycopodium spore method 3.. extractive values. Texbook of Pharmacognosy.. Purohit A.M. Bristol. trichomes. 1998.SECOND YEAR B. 7) Khandelwal K. 6. Textbook of Pharmacognosy. 2. 4) Brady L. 4. Pune.. CBS Publishers & Distributors. K. Robbers J. T. stone cells etc. E. Souders Co.(PRACTICALS) Minimum 75 Hrs/Yr 1. Measurement of cell contents : Calcium oxalate crystals. Varghese Company.. 2) Wallis T. S. Linseed. 7th edition. 33 | P a g e ..S. RECOMMENDED BOOKS : Latest editions of the following books. P. 7. 2000. starch grains. and Quadri J. Glycerhiza. Ltd. 3) Shah C.. Cascara. 8) Ayurvedic formulary of India. 1989-90.. Ahmedabad.

Microbial limit tests (3) Pharmacopoeial standards for microbial contamination of various raw materials used in Pharmaceutical and Cosmetic industry. 5. Introduction to microbial drug resistance Aflatoxins – organisms producing them. nonthermal methods. classification. nephrotoxins 6. evaluation. factors governing their efficiency. sterility tests for typical Pharmaceutical products. their applications to Pharmaceuticals. (4) Chemical Sterilization Disinfectants Antisepetics Sanitizers Bactericides Fungicides Preservatives. membrane filters. Leishmanial parasites. inactivation. Medical Parasitology: Protozoa and infections. Treponemal parasites. Malarial Parasites. Sterilization. 4. cultural. Validation of hot air oven and autoclave. Proteus with respect to their morphological. Fungi and yeast causing skin infections. Klebshiella. Sterility tests : Methodology and interpretation. Mycobacterium. Treponema. Entamoeba histolytica. c. Pseudomonas. operation of sterilizers like autoclaves. biochemical characteristics and diseases caused by them. 2. Biological Indicators. their mode of action. PHARM PHARMACEUTICAL MICROBIOLOGY-II (THEORY) Minimum 50 Hrs/Yr 1. b.SECOND YEAR B. hot air ovens. (5) Principles. Escherchia. d. Shigella. prevention. removal of aflatoxins. 3. Immunology 34 | P a g e (2) (3) (8) . (5) Aseptic techniques and their applications Hepa filter validation. Clostridium.Medical Microbiology (10) Study of common pathogenic micro organisms like Staphylococci. Control of Microorganisms a. Physical methods of sterilization like thermal methods. Salmonella. Introduction to mycotoxins like ergot.

Preparation and standardization of vaccines. (10) 9. Hypersensitivity reactions.T cell biology B cell biology Antigen-Antibody reactions. HLA System Complement System 8. (4) 35 | P a g e . diagnostic biologicals. Microbial assays of antibiotics and vitamins Interpretation of results. sera.

5th edition 2002. 1986..K. Determination of efficiency of preservatives. Sterility test of selected sterile products. 6. on selected samples like starch. crystal violet. Microbiology. Michael J. 10. 36 | P a g e . talc. Mc Graw Hill Inc. 1. Microbial assay of antimicrobial agents like penicillin. Inc. Microbiology.K. gram negative bacteria with respect to their cultural. 7. paper disc. 8.. ditchplate method and gradient plate technique. 5. 4. 2. Prescott H. 2. Study of a gram positive. 9. Experimentation on sterilization. biochemical characteristics.P. Noel R. PHARM PHARMACEUTICAL MICROBIOLOGY-II (PRACTICALS) Minimum 75 Hrs/Yr 1.C. Determination of MIC of antimicrobial agents. gelatin.5th edition. morphological. Microbial Limit Test as per I.P.. Comparison of different antibiotics or antimicrobial agents by cup plate method. RECOMMENDED BOOKS : Latest editions of the following books. Laboratory Rules of operating some common equipments. Chan E.. Immunodiffusion in agar gel..SECOND YEAR B. Tata Mc Graw-Hill. International edition. 3.

Hematological disorders: Anemia. A general introduction of diseases and their causes Disease etiology: Genetic. hernia. 1. Its causes. hematological disorders. ii) Renal failure. acquired coagulation disorder. PHARM PATHOPHYSIOLOGY AND HEALTH EDUCATION (THEORY) Minimum 50 Hrs/Yr. peptic ulcer.SECOND YEAR B. iv) Bacterial infections. Pneumothorax disorders and acid base disorders Renal and urologic disorders: i) Acid-base disorders. Immunology: Allergic disorders. (2) (2) (3) (2) (2) (4) 6. biology of immune system. gas. Infections and parasitic diseases a) Viral b) Bacterial. and Tumor immunology 4. (3) 8. Transplantation-HLA system. Acquired. v) Obstructive uropathy vi) Urinary incontinence. gastritis. Congenital. Coronary Artery Diseases (Angina. atherosclerosis. vii) Urinary calculi and viii) Kidney transplantation Gastrointestinal disorders: Hiatus. (2) 37 | P a g e . appendicitis. peripheral vascular diseases) Pulmonary disorders: Haemoptysis. c) Caused by Spirochetes d) Rickettsia e) Chlamydia f) Systemic fungal g) Parasitic infections i) Protozoal and intestinal j) Sexually transmitted diseases 3. Leukemia and Lymphoma 5. bronchial asthma. Cell injury and origin of diseases i) Cellular deficiencies ii) Cellular intoxication a) Exogenous toxins b) Endogenous toxins 2. iii) Dialysis. Hypersensitivity reactions and their disorders. Cardiovascular disorders: i) Hypertension ii) Cardiac arrhythmias iii) Congenital. immunodeficiency diseases. heart diseases iv) Myocardial disorders v) Rheumatic heart diseases vi) Extra cardiac influence on heart. (2) 7. occupational lung diseases. such as vascular platelet. heredity. stroke. pancreatitis. Idiopathic.

ENT (disorders of ear. Personality disorders. contact lenses. rheumatic and osteoarthritis ii) lupus erythematosus: cutaneous and systemic iii) gout and v) myasthenia gravis. Endocrine glands: i) Thyroid-cretinism. neurotic illness and their types. Musculoskeletal and connective tissue disorders: i) Arthritis. 9. (4) 13. nose and throat). disorders of eye corneal ulcer. hemorrhoids. skin infections. Psychiatric disorders: Psychosomatic medicine. insomnia. hyperthyroidism ii) parathyroid. fitula and peritonitis. anal fissure. retinal detachment. hepatitis. 19. hospital facilities like ambulance services.encephalitis iii) multiple sclerosis iv) parkinsonism v) headache vi) pain vii) sleep disorders viii) mood disorders ix) anxiety disorders and x) narcolepsy 14. toxicity and obesity 11. myxoedema. First aid measures (2) (1) (2) (2) 38 | P a g e .constipation. prevention of infections b) establishment of clinics like childcare. Hepatic and biliary disorders: Jaundice. Newer procedures used in diagnosis. Health education a) Cause and mode of spread of infections. 10. 15 Management of burns (3) (2) (2) 16. blood centers etc c) environment hygiene and d) outline of public health measures for prevention of disease 20. cirrhosis and fibrosis of liver. hyper and hypo calcium metabolism iii) pancreas-diabetes mellitus. Nutritional and metabolic disorders: Vitamin deficiency. Neurologic disorders: (4) Neurological illness: i) Epilepsy and convulsive disorders ii) Meningitis and its type. and inflammation 18. schizophrenia and child psychiatry 17. glaucoma. Gynaecology and obstetrics: i) Endometriosis ii) uterine bleeding disorders and their types iii) premenstrual tension iv) dysmenorrhoea v) prenatal diagnosis and genetic counseling vi) drugs and pregnancy with relation to duration of pregnancy types of drugs and vii)amniocentesis. cataract. (2) (4) 12.

Robbin S.S. 1997. Martin J. Root R. U..RECOMMENDED BOOKS: Latest editions of the following books. Braunwald E. Pathophysiology of diseases and clinical medicine.. 3.L. Fauci A. 12th edition.An introduction.. Vishwanath R. Published by Prentice-hall International 39 | P a g e ...L. 2nd edition. Wilson.. 1992. Isselbacher K.S. Saunders Company.B.J. Petersbors R.. 1.K.. Kumar V.. India. Jack D. Basic Pathology.A.G.Harrison’s Principles of Internal medicine. William F. New York. New Delhi.. 2. J.L.. Vol I& II.D. Cotran R.S.V.. Published by Mc Graw Hill..G.. Stephen J.M. Published by W. 6th edition.

dissociation constant. precipitation from homogenous solution washing and drying the precipitate Drying and ignition of precipitate. pH calculations of weak acids and weak bases. Buffers. preparation and standardization of some redox titrants like potassium permanganate. 40 | P a g e .Theory. biological and pharmaceutical application. distribution law. Inert solute. Complexometric titrations: (6) Concept of complexation and chelation. Precipitation titrations :.SECOND YEAR B. Factors affecting the (5) precipitation. metal ion indicators. Non-aqueous titrations : Theory.Law of mass action. Theory of acid base indicators. scope and limitations. impurities in analytical precipitate conditions of precipitation. the emulsion problems in extraction. Extraction procedures : Liquid solid extraction. buffered isotonic solution. (5) (4) (4) 6. Acid base equilibria in (2) 4. 9. sodium 2. PHARM PHARMACEUTICAL ANALYSIS-I (THEORY) Minimum 50 Hrs/Yr. buffer capacity. (7) use and application of pH meter. Titration curve method. solvents and indicators used. 3. potassium dichromate. masking and demasking agents. strengths of acids and bases. factors influencing the stability of complexes. End point determination by Volhard method. (4) separation of mixtures by extractions. Buffer : concept. Neutralization curves. application. Applications.Principles of gravimetry. 6 dichlorophenol indophenol. Application of redox titration in Pharmacy. sodium thiosulfate. Hydrolysis of salts. colloidal state. Fajan method. continuous counter – current extractions. Gravimetry :. pH and hydronium ion concentration in aqueous systems. 1. (3) non-aqueous media. Applications of acid-base titration in Pharmacy. Experimental techniques of drying and ignition. iodine. liquid-liquid extraction. stability constants. formation and properties of precipitate. 7. Importance of quality control in Pharmacy (4) Acid-Base titrations:. the Craig method of multiple extraction. successive extraction. titanous chloride.Preparation and standardization of titrants like silver nitrate and ammonium thiocynate. effect of temperature. association ion pair formation. Titrants. 8. Application of precipitation titrations. titration curves. Oxidation reduction titrations :. cerric ammonium sulfate. 2. potassium bromide. pH. 5. pH scale. Application of non aqueous titration in Pharmacy. equivalent weights and standard solutions. Co-ordination number and structure of complexions. Mohrs Method. acid base equillibria.

11. measuring the relative voltage of half cells. Potentiometry: Theoretical consideration. electrode potential. 41 | P a g e .10. types of half cells. Nerst equation. calculation of standard potential. Miscellaneous methods of Analysis (3) Diazotization titration. half cells. redox titration curve. activity series standard potential. applications to Pharmacy. 12. Electroanalytical techniques :(4) The electrical cell. ion selective electrodes. indicator electrodes. relation of pH to potential. (3) measurement of potential. Kjeldhal’s nitrogen determination. sign convention. oxygen flask combustion method. the salt bridge. SHE. reference electrodes. Determination of alcohol in Liquid galenicals. Karl Fisher titration. pH measurement.

13. Beckett and J. percentage purity of ZnO oride To det. Vol I & II.1N H2SO4.H. 9. John Wiley and Sons. 4. Stenlake. RECOMMENDED BOOKS: Latest editions of the following books. A. ANALYSIS – I (PRACTICALS) Minimum 75 Hrs/Yr.. 14. acid value of castor oil. 2. 21. 17.The Athlone Press of the University of London. percentage purity of Lactic acid To determine percentage purity of sodium benzoate To determine aspirin content of given tablet To determine percentage purity of antimony potassium tartarate To determine percentage purity of CuSO4. To determine the percentage purity of Borax To det. PHARM PHARM. 16. Stephen & Brewer Solving Problems in analytical chemistry by Stephen and Brewer. Sap value of Castor oil To det iodine value of given oil To det. 10. 7. New York. 11. 20. Connors. 18. 19. 12. 2) 3) 42 | P a g e . To det. 3. To determine percentage purity of sodium nitrite To determine percentage purity of Magnesium sulphate To determine percentage purity of Aluminium sulphate To determine percentage purity of phenol To determine percentage purity of Ephedrine HCl To determine percentage purity of Sodium Chloride To determine percentage purity of Calcium Carbonate and calcium gluconate injection To determine percentage purity of Ferrous fumarate To determine content of salicylic acid in compound benzoic acid ointment. 8. 15.B. 6. Practical Pharmaceutical Chemistry. John W iley and Sons New York. 5. Standardization of 0. .SECOND YEAR B. 1) A. 1.1N NaOH using KHP To prepare and standardize 0. K. A text Book of Pharmaceutical Analysis.

Formation and use of enol ethers. electrocyclic reactions (4) including allowed and disallowed. PHARM ORGANIC CHEMISTRY II (THEORY) Minimum 50 Hrs/Yr. 6. Robinson annulation 8. four. Bamford Steven reaction 4. Mannich reaction 9. DCC oxidtion of alcohol. Carbonyl Chemistry : The following reactions will be covered along with their reaction echanisms. (2) (6) 4. W. 5. 8. Synthesis of indoles by FI synthesis. retro Micheal reaction 7. Classification of carbohydrates. 3. (Naphthalene & Anthracene). Methylene transfer reactions. Enantiomerism.IUPAC nomenclature of heterocyclic ring systems. Reverse aldol reaction 6. 1 . 13. (13) 2. Resolution of racemic mixtures. (8) 1. isoprene rule. Pericyclic reactions.K. Mono and dialkylations in 1. (5) 43 | P a g e . Synthesis and reactions of three. Skraup quinoline synthesis and Bishler-Napirialski synthesis. Darzen’s reaction 11. reduction. Molecular rearrangements of electron rich and electron deficient systems. Cis-trans relationship in a cyclic system. conformational and geometric isomerism. Synthesis and reactions of bicyclic and tricyclic fused ring systems. 3. Michael addition. 12.3 dicarbonyl compounds. enamines and enol acetates . Huang Minlong modification 2. Conformations of cyclohexane. Nomenclature of bridgehead rang systems. (3) (2) 7. D and L nomenclature of sugars. Stobbe condesation. sigmatropic rearrangements. Bayer Villeger rearrangement. five and six membered heterocycles. Classification of terpenes.SECOND YEAR B. diastereomerism. Stereochemistry of acyclic and cyclic compounds. Reduction of arylsulfonyl hydrazines/ hydrazones to alkane. 15.Use of CH 2 N 2 & Sulfurylides in the same. 10. 14. Structure and chemical reactions of glucose. Beckmann rearragement. conrotatory and disrotatory cyclisation 2+2 and 4+2 cycloaddition reactions. 5.

Graw Hill Publishing Co. Ltd. S. Organic Chemistry Vol. Tata Mc. (5) 10. M.. and Boyd R. test for identification and general methods of isolation of alkaloids. Eliel E. Prentice Hall of India Pvt.B... H.L.S. New Delhi. (2) RECOMMENDED BOOKS Latest editions of the following books. Cram D. Organic Chemistry. 110 001.. Natural amino acids and their classification. Hendrickson J..A. Mc.L. Isoelectric point. Ltd.. 2. Morrison R. Finar I. New Delhi. and Hammond G. B. Modern Synthetic Reactions. Stereochemistry of Carbon Compounds. Simple chemical reactions of amino acids. peptides and proteins.Graw – Hill..E.London. Chemical classification. I & II . J. 44 | P a g e .Benjamin. Kogakusha Ltd. Amino acids.. L.. Organic Chemistry.. International Student Edition.. 4. London. New Delhi.O. 5.9. House. W. T. determination of C-and N-terminal residue of a peptide. 1. 3. Longman Group Ltd.

mechanism of action & toxicity. amoxicillin.S – Synthesis of those drugs to be studied. Biosythesis. II (THEORY) Minimum Hrs/Yr. classification of antibiotics (12) a) ß-lactam antibiotics e. classification Acidic. according to their generation. c) Tetracycline Antibiotics : Introduction to tetracyclines. bacampicillin.. chemistry of Quinolone. other ß lactam antibiotics such as imipenam. Ist. ß-lactamase inhibitors such as clavulanic acid and sulbactam. structure activity relationship and synthesis of some compounds.] b) Aminoglycoside Antibiotics : Introduction to aminoglycosides. selectivity of action. ampicillin. CHEM. IInd IIIrd & IVth generation. classification of aminoglycosides. mechanism of action and toxicity. Trimethoprim* b) Quinolone : History. pivampicillin. 2) The following classes of drugs to be covered in details with respect to their physico chemical properties.SECOND YEAR B. and synthesis ciprofloxacin* c) Antibiotics : History. Hetacillin.membered and activity. (3) classification of sulpha drugs sulphoxazole*. basic and neutral. aztreonam.Broad spectrum penicillins such as aminopenicillin e. chemistry. classification of cephalosporins. (6) 50 1. acidic or basic f) Polypeptide Antiboitics : Introduction. sulphadiazine*. chemical classification. Target (3) site. mechanism of action. Antibacterial agents: a) Sulpha drugs :Introduction to sulpha drugs.g. chemistry. 45 | P a g e . Chemistry. chemistry and classification-12 membered. chemistry. [Note* :. d) Macrolide Antibiotics : Introduction. 1) Introduction to metabolism of drugs based on their functional groups. vancomycin. e) Lincomycin Antibiotics: Introduction and chemistry. 16.g. g) Unclassified Antibiotics : Chloramphnicol*. talampicillin. Chemistry. acid and penicillinase degradation of penicillin. pencillin and cephalosporin i) Penicillin: Detection of antibiotic producing Organisms. 14 membered. mode of action. sulphathiazol*. ii) Cephalosporins : Introduction to cephalosprins. crystal urea formation. PHARM PHARM. activity.

ethambutol. sontaquine. Tuberculin Test. Haloprogin. Antiamoebic agents : (3) Introduction and classification. O. Nifurtimox. Tetrachloroethylene. Tolnaphthale . 3. acyclovir. Methisazone. Aminoquinoline. PAS. Kanamycin. Biguanide. Bithinol. RECOMMENDED BOOKS : Latest editions of the following books. Pyrvinium palmoate. reasons for multidrug therapy. albenadazole*. Candicidin D. pyrimidine derivatives such as pyrimethamine*. Antimonial compounds such as antimony potassium tatarate. Co. 46 | P a g e Foye W. 1. 9-aminoacridine . Antimycobacterial Agents : (6) Introduction to mycobacteria. antiviral agents amantadine HCL. miconazole. Antiviral Agents : Introduction. Salicylic acid. Poly ICLC. pyrantel pamoate. Diethyl carbamazine citrate*.. and dihydroemetine. rifampin. trimethoprim. piperazine citrate*. Grisvold. Tinidazole*. B. pyrazinamide*. chloroquine. Praziquantal. Bephenium hydroxynaphthoate. suramin. Interferon inducer-poly 1:C. Antifungal agents : (5) Classification of fungal infection fatty acid. Undecylenic acid. 4-amino quinolines such as chloroquine* hydroxychloroquine. Diloxanide furoate*. Natamycin. sodium antimony dimercaptosuccinate. Wilson C. Ltd. Medicinal and Pharmaceutical Chemistry. clofazimine. hycanthone. Imidazole derivatives such as Benzimidazole. sulphone.. capreomycin. pentaquinee and isopentaquine. 5. Amidoquine. flucytosin. O. Principles of Medicinal Chemistry. propionic acid.2. Lippin Cott. ketoconazole. zidovudine. Tetramisole. Griseofulvin. Antimalarial agents : (5) Introduction. stibofen. Isoniazid*.. 3. 2. Emetine. econazole. metrifonate. phenol and its derivatives. Ethionamide*. Waverly Pvt. fluconazole*. metronidazole*. types of viral diseases. mebendazole*. . Text Book of Organic. Halofantrine. Philadelphia. I. Triacetin. dapson*. Emetine. Types of therapy. viral replication. butaconazole. life cycle of malaria parasite. Paramomycin. lucanthone. 4. Arsenical pentamidine. cycloserin. Niclosamide. Antibiotics such as streptomycin. mefloquine. pamaquine*. Anthelmintic agents : (4) Classification. Acrisorcin. Nystatin. 6. viomycin. vidarabine. Antifungal antibiotics such as Amphotericin B. Diiodohydroxyquine*. primaquine*. xytarabine. Toronto. oxamniquine. substituted imidazoles such as clotrimazole*. cinchona alkaloids. 7. Iodoxouridine. Thiabendazole*.

creams. 5. plasters. Different types of tablets including chewable. (10) 2) Dermatological preparations : Percutaneous absorption. pasters. emulsions. processes including direct compression. of controlled flocculation. buccal. Part I. PHARM PHARMACEUTICS – II (THEORY) Minimum 50 Hrs/Yr. mucilages. reconstituted suspensions and industrial processing of suspensions and emulsions. manufacture and quality control of suppositories. Formulation factors including excipients and processing. 1) Biphasic dispersed systems : (10) Suspensions. stabilization and evaluation of such systems including theories of emulsification. drug release from suppositories. New York. Different types of machines used for compression of tablets. Burger A. 3) Suppositories : (5) Rectal absorption. gels and jellies – formulation. II.4. Evaluation of drug release from dermatological preparations. processes and equipment employed in the manufacture and filling of hard gelatin capsules. and dispersible tablets. liniments. methods of preparation. effervescent. methods of preparation. different types of bases.. stabilization. & III John Wiley & Sons Inc. formulation and preparation. formulation. equipment employed in the preparation and manufacture of granules. SECOND YEAR B. magmas.. mixtures. 5) Capsules : (10) Principles. Evaluation and quality control of tablets. wet and dry granulation. manufacture and packaging of ointments. Excipients used in formulation of capsules and quality control testing. Medicinal Chemistry. mechanism. 47 | P a g e . lotions. 4) Tablets : (15) Principles. sublingual. manufacture of soft gelatin capsules. collodions and poultice.

vi) Benzyl benzoate application BPC vii) Compound calamine application BPC. II] III] IV] V] VI] VII] LINIMENTS: i) Soap liniment BPC ii) Ammoniated camphor liniment iii) Compound methyl salicylate liniment. Extra Pharmacopoeia. VIII] JELLYS : i) Ephedrine sulphate jelly ii) Sodium CMC jelly iii) Zinc gelatin 48 | P a g e . iv) Turpentine limiment BPC. PHARM PHARMACEUTICS – II (PRACTICALS) Minimum 100 Hrs/Yr. BPC. I] MIXTURES : i) Kaolin mixture BPC ii) Paediatric chalk mixture BPC iii) Paediatric Ferric ammonium citrate mixture BPC iv) Magnesium hydroxide mixture BPC v) Magnesium trisilicate mixture BPC SUSPENSIONS : i) Trisulfapyrimidine suspension USP ii) Paracetamol Oral Suspension MAGMA : i) Bentonite magma BPC GEL : i) Aluminium hydroxide gel USP.SECOND YEAR B. v) White lotion USP vi) Benzyl benzoate lotion USP vii) Oily calamine lotion BPC viii Salicylic acid and Mercuric chloride lotion. EMULSIONS: i) Conc. peppermint emulsion BPC ii) Liquid Paraffin emulsion I P iii) Vitamin A & D emulsion iv) Castor oil emulsion LOTIONS: i) Calamine Lotion BPC ii) Copper and zinc sulfate lotion BPC iii) Compound sulfur lotion BPC iv) Resorcinol and sulfur lotion Extra pharmacopoeia. v) White liniment BPC.

49 | P a g e . a) b c) d) e) Paracetamol tablets I P Paediatric aspirin tablets BPC Calcium carbonate tablets BPC Compound ferrous sulphate tablets Riboflavin tablets X] XI] XII] XIII] XIV] XV] CAPSULES : i) Demonstration of capsule filling machine.IX] OINTMENTS: i) Paraffin ointment IP ii) Simple ointment IP iii) Sulphur ointment BPC iv) Emulsifying ointment BPC v) Compound Benzoic acid ointment BPC vi) Hydrophillic ointment vii) Polyethylene glycol ointment USP viii) Nitrofurazone ointment USP ix) Non-staining Iodine ointment BPC CREAMS : i) Aqueous cream (hydrous emulsifying ointment) ii) Oily cream iii) Cetrimide Cream BPC iv) Proflavin Cream BPC PASTES: i) Titanium dioxide paste BPC ii) Mangnesium sulphate paste BPC iii) Zinc and salicylic acid paste BPC POULTICES i) Kaolin poultice BPC. TABLETS : i) Monograph of tablets ii) Preparation and evaluation of granules and / or tablets of the following. ii) Preparation of capsules of one model drug. vi) Zinc oxide suppositories. SUPPOSITORIES: i) Monograph of Suppositories ii) Polyethylene glycol suppositories USP iii) Soap glycerine Suppositories USP iv) Glycerol suppositories BP v) Compound bismuth subgallate suppositories.

Delhi (1987). 4. S. Vol. 3. USP & NF 2005. Bailliere and Tindall and ELBS. Osol.I. 50 | P a g e . 1-3. A. B. Liberman and J. J.. ‘Pharmaceutics : The science of Dosage Form Design’. and drug delivery systems’. 2nd Ed. New York.The Pharmaceutical Press London (Current editions). ‘Pharmaceutical Dosage forms : Tablets : vol.. 7.. 10. 2nd ed. ‘Cooper and Gunn’s Dispensing for Pharmaceutical Students’..Waverly Pvt. I & II.. ed. Martin et. a. Churchill Livingstone. Ltd. H. New Delhi. Marcel Dekker Inc. Lachman et. (1979). IP 1996. 8th Ed. Carter. 9.. ‘Remington’s Pharmaceutical Sciences’. New York. CBS Publishers & distributors. 6th Ed. I. Aulton. Easton. New York (1990). ‘Bentley’s Text book of Pharmaceutics’. 4th Ed. a. (1996).RECOMMENDED BOOKS : Latest editions of the following books. ‘Theory and Practice of Industrial Pharmacy’.N. Miceel E. Perisylvania.. ed. New York. ‘Modern Pharmaceutics’ 3rd Ed. Varghese Publishing House. ‘Physical Pharmacy’.A.. 1. 6. Matindale extra Pharmacopoeia 29th Ed. (1993). Marcel Dekker Inc.. ‘Introduction to Pharmaceutical Dosage Forms’.. BP 2003. (1987). Rawlin.. Banker & Rhodes. New Delhi. Ansel. 8. 5. Mach Publishing Company. Bombay. Ltd. Lachman. 2. B. L. Kanig.L. (1999). Waverly Pvt.

dilatometric analysis. wetting and spreading agents. micellization. Thermodynamics : Second and third law of thermodynamics. Chemical equilibria and kinetics : Law of mass action. Gels and syneresis. Kraft point and cloud point. bulkiness. hydrolysis. Comparison of zero. thixotropy and its measurement. entropy. distribution. Colloids: Colloidal state. flow properties and cohesiveness. characteristics of surface active agents. size distribution. statistical (7) diameters. drug absorption. Complex reactions catalysis. microscopy. measurement (8) and applications. optical. solubilizing agents. porosity. biological half life. packaging arrangements. kinetic (8) and electrical properties. Micromeritics : Particle size measurement. compaction of powders. effect (7) of temperature. particle shape. Accelerated stability testing: Introduction to kinetics of elimination. maximum net work. first and second order reactions. sensitization and protective action. preparation and stability. free (4) energy functions and applications. first and second order reactions.SECOND YEAR B. Differential Thermal Analysis (DTA). Classius-clapeyron equation. polymorphism. X-ray diffraction. melting (6) point and heat of fusion melting point and intermolecular forces. surface area and volume. antithixotropy. Rheology : Types of flow. HLB system. effect of temperature (10) and pressure on equilibrium rates. particle number. Vant Hoff equation. metabolism and 51 | P a g e . measurement of rheological characteristics. application of rheology in pharmacy. adsorption isotherms. PHARM PHYSICAL PHARMACY (THEORY) Minimum 50 Hrs/Yr. Differential Scanning Calorimetry DSC). criteria for equilibrium. Determination of order of reaction. densities of particles. detergents. order of reaction : zero. rheology of semisolids. adsorption on solid or liquid surfaces. Surfactants: Surface tension & interfacial tension: concept. bulges and spurs. sieving and sedimentation methods of particle size determination. Decomposition of medicinal agents and protection from degradation: oxidation and reduction. foaming and antifoaming agents. phase volume ratio on viscosity of dispersion. type & applications of colloids. Crystalline state : Structure of crystalline solids.

. gladiants. ‘Physical Pharmacy’. L. 9. I.g. effect of electrolyte concentration on cloud point. J. 7.SECOND YEAR B. N. 4. fine. PHARM PHYSICAL PHARMACY . Method. 10. Effect of electrolytes on stability of colloids. Order of reaction : First order. e. 8. 5. Determination of surface tension by drop number method 3. Waverley. ‘The theory and Practice of Industrial Pharmacy’. H. osol. 6. (Mack). They should include (but not restrict to) the followings: 1.(PRACTICALS) Minimum 100 Hrs/Yr. Determination of particle size by microscopy sieving. Determination of viscosity using Ostwald’s viscometer. Experiments based on the topics covered in theory. 1) Martin. Preparation and stability of colloids. Determination of cloud point. Study of sedimentation : Behaviour of suspensions. 1995. Penn. electrolytes and surfactants. L. Liberman. Mumbai. Easton. pseudofirst order and second order reactions. sedimentation.. glidant concentration. effect of different concentrations of flocculating agents. 2. Varghese Publishing House. flcoulated v/s defloculated suspensions. 1987 52 | P a g e . IVth ed. A. Angle of repose : Effect of granule size. Determination of critical HLB of emulsion by phase inversion method. 1994 2) Remington’s Pharmaceutical Sciences. 3) Lachman. and Kanig. A. B.. IInd ed.T. RECOMMENDED BOOKS: Latest editions of the following books. Determination of critical Micelle concentration [cmc] using S. ed. New Delhi..

The Pharmacy Act. manufacture. b) c) d) Prevention of Cruelty to Animals Act. Legislation to regulate the import. (5) 53 | P a g e . c) Shops Establishment Act of Maharashtra State (4) 6. Introduction to Indian Patent Regulations. b) Prevention of Food Adulteration Act 1954. PHARM PHARMACEUTICAL JURISPRUDENCE (THEORY) Minimum 50 Hrs. Code of Pharmaceutical Ethics framed by Pharmacy Council of India. 1955.THIRD YEAR B. b) Poisons Act 1919 c) Opium Act 1978. FDA.(15) 3. Legislations to control the operations relating to Dangerous Drugs./Yr 1. Drugs and Cosmetics Act. Legislations affecting pharmaceutical & food industry. Legislations to control the advertisements. a) Dangerous Drugs Act 1930. Drug Prices and Control Order 1979. excise-duty and prices of drugs. 1948 (5) 2.. W HO. WTO and FDA. Medicinal & Toilet Preparations Excise Duty Act. Introduction to various drug regulatory authorities vis. (5) 8. Miscellaneous Acts a) Consumer Protection Act. 5. ISO. 1951. (6) 4. 1950 and Rules 1945 and amendments there of. Legislation to regulate profession of Pharmacy. a) b) c) (5) The Drugs and Magic Remedies (Objectionable Advertisements) Act 1954. a) Industries (Development & Regulations) Act. (5) 7. distribution and sale of drugs. Insecticides Act. Drug Import Export Policy.

Vallabh Prakashan. “Hand book of Drug Laws”. Pune. 3) Kuchekar B. Allahabad. Pune. Allahabad. 5) 6) 7) 8) 54 | P a g e . 1989.S.RECOMMENED BOOKS : Latest editions of the following books. ‘Manual of Drugs and Pharmacy Laws in India’. Mehta. 1) Mithal B. Jain N. Beotr Law Book Co.. No. Current Government of India Publications of all Drugs Acts and Rules. & Khandatare A. Forensic Pharmacy Industrial and Labour Laws. Paramount Law Publications Year 1987.. 1989. National Book Centure. 1985. ‘A Text Book of Forensic Pharmacy (Pharmaceutical 2) Jurisprudence)’. “Laws of Drugs and Medicines”. 7 th ed. including 4) ‘Code of Pharmaceutical Ethics’. 337). Nirali Publication. University Book Agency. ‘Text Book of Forensic Pharmacy’.M.M. Bharti. New Delhi Year. Pharmacy Council of India (P. Calculta.K. B.

shankhapushpi. withania roots. (3) bromelain. garlic bulbs. anise. opium. valerian roots. acetate rayon. mace of nutmeg. ephedra stems. punarnava roots. silk. extraction. and isolation of the classes of chemical constitutents mentioned in (2) to (7). wool. saffron. cantharides (2) 5. Indian dill. mineral & synthetic origin : Cotton. cinnamon bark. vinca leaves. banafsa leaves. Some aspects of standardization of ayurvedic formulations. caraway. Drugs & dosage forms of ayurvedic medicines. stramonium herb (17) hyoscymus herb. 8. aconite roots. cultivation. The systematic study including biological source. chemistry. Applications of plant harmones. veratrum roots. coriander. orlon. pepper fruits. Detailed study of papain. pilocarpus leaves. calabar beans. European dill.of the drugs underlined in (2) to (7). peppermint oil. chemical tests. abscisic acid & (3) others. colchicum corms. polythene. gibberellines. 2. Nature. cardamom fruits. umbelliferous fruits – fennel. cumin. biognesis. tobacco leaves. 3. flax. jaborandi leaves. Enzymes: Their classification. collection and preparation. geographical source. belladonna herb. ocimum leaves. (3) hemp. jute. Plant growth regulators : Auxins. Commercial fibres of vegetable. eucalyptus leaves. substitutes and adulterants. coca leaves. therapeutic uses etc. malt extract. sassurea roots. trypsin.THIRD YEAR B. (18) cassia bark. cinchona bark. 7. Introduction to Ayurvedic Pharmacy: Brief account of basic principles of ayurveda. jatamansi roots. kurchi bark. buchu leaves. 6. clove buds. asbestos. PHARM PHARMACOGNOSY-II (THEORY) Minimum 50 Hrs/Yr. lobelia herb. nylon. 4. camphor. active constituents. mentha oil. cytokinins. pepsin. chymotrypsin & other pharmaceutically useful enzymes & their applications. regenerated fibres-rayon. Volatile oils: terpentine oil. glass wool. terylene. nux-vomica seeds. animal. rauwolfia roots. occurrence. acorus roots. ipecac roots. datura herb. 1. chenopodium oil. ergot. musk. Alkaloids: Areca nuts. histology. orange & lemon peels. (4) 55 | P a g e . mylabris. nutmeg seeds. Miscellaneous: Pyrethrum flowers. morphology.

..E. 9) Ayurvedic formulary of India. 1) Trease and Evans. 2.E. Textbook of Pharmacognosy. 3... Sounders Co. N. Vallabh Prakashan.Gokhale S. Part I & II.S. Bladt. 6) Turner T. Practical Pharmacognosy. Shah Prakashan.Y. Tokyo. Ginger. . Textbook of Pharmacognosy . Practical Evaluation of Phytopharmaceuticals Wrightscientechnica. Kurchi. 1975.S. Ltd. 7) Kokate C. Study of detailed histology including powder characteristics of Fennel.S. 5) Kokate C..R. 56 | P a g e . Study of the components of alkaloids &volatile oils by TLC.B. & Brain K. Clove. Government of India.. Cinchona. 6. Vasaka. 10) Wagner H. Varghese Company. Tyler V. 7. Pharmacognosy.. and Zganiski E. Datura. Plant Drug Analysis. D. 4) Brady L. Cardammom. K. 5. Nirali Prakashan. Rauwolfia. Pune.B. W. 3) Shah C. Identification of adulterants in powdered crude drugs by microscopy. CBS Publishers & Distributors. Berlin. Hedelberg.P. 1.A TLC Atlas translated by A. 2) Wallis T. Practicals will be based upon the theory mentioned in the syllabus. R. Identification of fibres by microchemical tests. Coriander.K.. Study of detailed histology including powder characteristics of Nux-vomica. PHARM PHARMACOGNOSY-II – (PRACTICALS) Minimum 50 Hrs/Yr. Pharmacognosy. Purohit A. Extraction of alkaloids and volatile oils.. 4. Springer Verlag. 15th edition.... Ministry of Health & Family W elfare. and Quadri J.M. Robbers J.THIRD YEAR B.S.E. Bristol. Practical Pharmacognosy. 8) Khandelwal K.M. Nirali Prakashan. Eucalyptus. Textbook of Pharmacognosy.R. Delhi. Pune.K.Scott.. B... Ahmedabad. Gross morphological identification of drugs mentioned in theory. RECOMMENDED BOOKS : Latest editions of the following books.

selection. clinical and biological. Patient drug profiles. Intravenous admixtures. preparation and administration. pharmacokinetic and pharmacodynamic interactions. Monitoring the patients in health and illness. pharmacist conducted patient interviews and presentation of medication history. (5) Drug interference with diagnostic tests. total parenteral nutrition. admixtures. Clinical pharmacy practice opportunities in hospital and community pharmacy practice. Objective and scope of clinical pharmacy. examples. 4. using clinical pharmacokinetics for dosage individualization. (3) 8. (1) (1) 9. ‘ (2) Investigational drugs and clinical research. 3. Therapeutic drug monitoring. Essential Drugs & Rational Drug use. (2) 6. alcohol. present status. 57 | P a g e . care of neonates. Adverse drug reactions. legal and ethical considerations (2) Prevention of Drug abuse and Drug Toxicity. different manifestations. (1) Role of pharmacist in patient care in hospitals from time of admission to discharge and follow up. significance of selected pathological tests. (1) Drug Information Services and Centres. (2) 5. 7. phases.THIRD YEAR B. Discharge interviews. detection and reporting. elements of drug literature utilization. pediatric. PHARM CLINICAL PHARMACY & DRUG INTERACTIONS (THEORY) Minimum 25 Hrs/Yr. mechanisms. Factors predisposing ADR’s. evaluation and communication. physical.V. abstracting services. pharmacist’s role in clinical trials. geriatric patients. 1. interactions of drugs with food. Drug Interactions. Incompatibilities in I. 10. Clinical significance and evaluation. 11. tobacco and during pregnancy. Monitoring of patients with chronic diseases. computer applications. (1) 2. statistical methods of interpretation. Patient counseling and assessment of compliance (4) Long term care facilities. 12. activities.

R. Klejiin & Jonders J. 6. W. 1972. Clinical Pharmacy & Hospital Drug Management by Chapman & Halls Publication.. ‘Hanstens’ Text book of Drug interactions. Hirschman J.F.. Webb L. (Whitney). 1982.RECOMMENED BOOKS: Latest editions of the following books.. T. 8. 4. Drug Intelligence Publications. Clinical Pharmacy Handbook..V. N. 58 | P a g e . 1. Clinical significance of DrugDrug interaction. Herfindal E. ‘Clinical Pharmacy and Therapeutics’ The Williams and Willkins Company Baltimore 1977. ‘Clinical Pharmacy’. Hamilton. P. 5. Bajaj A. and Lea Febriger. India 2003. 2. Philadelphia. Blissit C. ‘Clinical Pharmacy’ Career Publications. 5th edition Philadeiphia Lea Febiger 1985. 7. Tipnis. Lea & Febiger. (Editors) Clinical Pharmacy Practice. Kabat Hugh.. Lawson & Richards. Stanaszek W. H. Preceptives in Clinical Pharmacy Ed. Dr. 3. Elsevier / North Holland Biomedical Press New York 1977. E. L.

3. The need for Therapeutic Intervention A) Therapeutic modalities : i) Surgery. Excretion through other body fluids. iii) Genetic iv) Immunological v) Pharmacological B) Pharmacotherapy : i) Therapeutic goals. Factors affecting drug metabolism.THIRD YEAR B. Selective accumulation of drugs. Binding of drugs to plasma proteins. PHARM PHARMACOLOGY-I (THEORY) Minimum 50 Hrs. iii) rectal mucosa b) Injection (parenteral) c) d) e) f) g) B) Pulmonary Integumentary: i) Topical. ii) Radiation. biliary and pulmonary excretion of drugs. D) Excretion of drugs : a) b) Renal. Physiological barriers to drug distribution viz. blood CSF barrier. and placental barrier. C) Biotransformation of drugs : a) Pathways of drug metabolism. ii) Transdermal iii) Intraocular Other routes of administration Merits and demerits of various routes Mechanism of absorption into vascular or lymphatic system (15) Distribution : a) Factors influencing drug distribution. buccal. ii) Oral mucosa: sublingual. ii) Rational design iii) Use of drugs (3) 2./Yr 1. Descriptive Pharmacokinetics: A) Absorption/ Administration: a) Alimentary canal: i) Enteral. Pharmacodynamics: 59 | P a g e . blood brain barrier. fecal. b) c) d) e) Volume of distribution. b) c) Inhibition and induction of drug metabolism.

antiemetics. 6. Quantitative aspects of drug action. Enzyme selectivity. therapeutic efficacy and tolerance Factors modifying the effects of the drug : a) Age b) Pharmacogenetics. (4) (6) (2) 60 | P a g e . d) Drug allergy. Drugs used in Gastrointestinal system Hyperacidity and peptic ulcer. Drugs acting on Endocrine systems Hypothalamic and pituitary hormones. Pancreatic hormones Antidiabetic drugs Parathyroid hormones 8. (6) 5.a) b) c) d) Quantitative aspects of drug action and receptors. laxatives and antidiarrhoeals Drugs for inflammatory bowel diseases. and gout. Emetics. Drug response. c) Drug resistance. e) Drug tolerance 4. Autocoids : a) b) c) d) Histamine and histamine antagonist Serotonin and serotonin antagonist Kinins. Drugs used for Cough and Asthma 7. osteoarthritis. Anti-inflammatory drugs : NSAID drugs used in the treatment of musculo skeletal disorders: rheumatoid arthritis. Thyroid and antithyroid drugs Adrenocorticosteroids and adrenocortical antagonist Gonadal hormone and inhibitors. potency. and angiotensin Lipid derived autocoids: Prostaglandins. leukotrienes and platelet activating factor.

heart rate. PHARM PHARMACOLOGY-I (PRACTICALS) 1) 2) 3) 4) 5) Minimum 50 Hrs. 9) Effect of atropine on acetylcholine and potassium induced responses using perfused frog heart 10) Effect of adrenergic and cholinergic drugs on mean blood pressure./Yr Effect of Acetylcholine on frog rectus abdominus muscle preparation Dose response curve of acetylcholine using frog rectus abdominus muscle. respiratory rate of dog. Dose response curve of histamine using guinea pig ileum Effect of acetylcholine on rat intestine Competitive antagonism between acetylcholine and atropine on rat ileum 6) Competitive antagonism between histamine and diphenhydramine on guinea pig ileum 7) Effect of Phytostigmine on acetylcholine induced responses using rectus abdominus muscle of frog 8) Effect of adrenaline and acetylcholine on frog heart preparation.THIRD YEAR B. 11) Effect of myotics and mydriatics on rabbit’s eye 12) Demonstration of routes of administration 61 | P a g e .

2) Ultraviolet – Visible Spectroscopy: Beer-Lambert’s law. various regions in IR spectrum and their use for characterization of functional groups. shielding constant. refractive index detector. absorption spectroscopy. doublet and 62 | P a g e (2) (6) (5) (5) (6) (4) . absorbance etc. chemical shifts. Fuels and oxidants. sample preparation techniques. detectors-Barrier cell. instrumentation. band spectrum. structure of a molecule and fluorescence. nuclear spin and spin quantum numbers. coupling constant. Explanation of singlet. emission spectroscopy. effect of solvents and pH on max. 3) Infrared Spectroscopy: Principle. magnetic shielding. electromagnetic spectrum. Mg+1 ion and A1+2 ion. photomultiplier tube. Problems based on Beer Lambert’s law. detail explanation of transitions involved in flame spectroscopy of Na metal. transmittance. bathochromic and hypsochromic shifts. wave properties. Flipping of the nucleus. factors affecting fluorescence. relaxation processes. Mechanism of fluorescence and phosphorescence. auxochromes. filtersabsorption and interference. photocell. auxochromic effect. 6. applications.II (THEORY) Minimum 50 Hrs/Yr. E1cm1% and max. Applications of UV spectroscopy. saturation and ringing effect. Flame Photometry / Atomic Absorption Spectroscopy : Principle. flame absorption. Instrumentation with sources. 1) General Principles of Spectroscopy: Wave-particle duality. various electronic transitions. instrumentation. 5) Spectrofluorimetry : Principle. quenching of fluorescence. particulate properties. absorptivity. deviations in Beer’s law. singlet and triplet states. 4) Nuclear Magnetic Resonance (NMR) Spectroscopy : Principle. single and double beam UV spectrometers. line spectrum. meaning of various terms like absorbance. emission and fluorescence spectroscopy. radio-frequency. stretching and bending vibrations. monochromators-prisms and gratings. Applications. its derivation. PHARM PHARMACEUTICAL ANALYSIS . Fine structure of NMR spectrum-multiplicity of peaks. transmittance. definition and types of luminescence. magnetogyric constant. instrumentation and applications. Standards used in NMR spectroscopy-TMS. Resonance fluorescence and Stokes’ effect. solvents used.THIRD YEAR B. molar absorptivity. Problems based on functional group characterization and structure elucidation based on wave numbers.

dropping mercury electrode. Paper Chromatography . different types. liquid . 10. Amperometric titrationsprinciple. m/z ratio and its derivation. Mass Spectroscopy : (4) Principle.plate and rate theory. Temperature profiles.Chromatography: (10) Principle. flame absorption and flame emission profiles. Ilkovic equation (no derivation) – importance of factors in it. identification of compounds on plates from R f va lues and other methods.triplet states. Atomizers and burners. ion-exchange and gel chromatography. (5) 7. Theories of chromatography .liquid junction potential. Tyndall effect. qualitative and quantitative estimation. Polarography : Principle. electric field deflection. Applications. instrumentation. instrumentation and applications. various ways of development of a plate using mobile phase. different kinds of chromatographic techniques. internal and external standards. Optimization of column parameters column efficiency. saturated calomel electrode. explanation of origin of S-shaped C-V curve. 8. Magnetic field deflection. rearrangements and applications. Van Deemter equation (No derivation) and factors responsible for bandbroadening.Principle. TLC . flame and non-flame atomizers. instrumentation . linear elution chromatography. 63 | P a g e . Time of flight. Nephelometry and Turbidimetry : (3) Principle. HPLC -Principle. methodology and applications. partition. normalization technique. polarographic cell. fragmentations. selectivity factor & capacity factor. locating compounds using various methods. applications.Single and double focusing mass spectrometers. 9. Dubosque turbidimeter and Eeel’s nephelometer. Applications. instrumentation . Methodology and applications of adsorption.Principle. applications. Applications.

5-7 different types of formulations such as tablets. 10)Permanganate titrations: Hydrogen peroxide (solution). ascorbic acid (powder and tablets) 4) EDTA titrations : Milk of Magnesia. 7) Iodate titrations: Ascorbic acid (powder). Sodium chloride. tablets). 3) Iodi metry : Analgin (tablets). spectroscopy. Borax and Na 2 C0 3 mixture. 1) Experiments based on U. Methyl paraben. Aluminium hydroxide (gel and tablets). injections.II (PRACTICALS) Minimum 100 Hrs/Yr. Mercuric chloride. capsules. PHARM PHARM. Ferrous gluconate (injection.V. 2) Iodometric titrations : Resorcinol. boric acid mixture. 9) Cerimetry: Paracetamol (Tablets). weak iodine solution 8) Argentimetry: Thiourea. Borax and orthophosphoric acid. gels etc. suspensions. 6) Chromatography – Determination of ion-exchange capacity of resins. 64 | P a g e . Calcium gluconate (tablets/ injection).THIRD YEAR B. Calcium gluconate (injection). Isoniazid (tablets). Ammonium chloride. 5) Acid-base titrations : Milk of magnesia. ANALYSIS .

K. Part I & II . Silverstein. U. U. Practical Pharmaceutical Chemistry. Englewood. Athlone Press.A. Eds. A I. Holler. London. A.S. Vogel. and Stenlake J.A. Principles of Instrumental Analysis. Niemen. 1) 2) 3) 4) 5) 6) 65 | P a g e .. B. John R. A. Longman Group. A. H. Inc. Applications of Absorption Spectroscopy of Organic Compounds. New York. yer. Harcourt Publishers. M.. John Wiley & Sons. John Wiley & Sons. Beckett. S. Skoog. London.S.A. R.S. Qualitative Inorganic Analysis. U. U. New York. A Textbook of Pharmaceutical Analysis.. Conners. Spectrometric Identification of Organic Compounds.RECOMMENDED BOOKS : Latest editions of the following books.

(4) i) Inorganic incompatibilities including those of metals and their salts.I : Dispensing Pharmacy : 1.Intentional and unintentional. Posology : Factors affecting dosage. (4) 2. Principles of dispensing and prescription handling./Yr Part . Pills containing small doses of oxidizing substances. description. calculation of doses. saline substances and explosive mixtures. hygroscopic. Effervescent powders and granules. liquefying substances. barbiturates. throat paints and pigments. (4) 3. nasal drops. powders. Incompatibility: Definition. Pharmaceutical Arithmatic : Different systems of weights and measures. non metals. various parts of a prescription. Pastilles : Bases and Moulds. simple powders. tannins. physical or therapeutic. (2) 6. liquids. Lozenges : Base and apparatus for preparation. PHARM DISPENSING AND HOSPITAL PHARMACY (THEORY) Minimum 50 Hrs. (1) (1) 10. importance. percentage solutions. (2) 8. dispensing of mixtures. packaging of powders containing volatile. calculation of doses for renally impaired patients. allegations. disadvantages essential requirements of a good pill. proof strengths. Mixtures:Definitions.ENT Preparation :Ear drops. Tablet triturates (3) 5. classification. correction of incompatibilities. 9. quaternary ammonium compounds. various types. mouth washes. gargles. oily substances. vehicles. ii) Organic incompatibilities including acids. chemical. Preparation. acids. (2) 66 | P a g e . prescriptions. alkaloids. bulk. 7. Pills : Definition. wrapping. prescription pricing. pediatric doses. excipients and coating. vegetable extracts. extracts and water soluble drugs. tolerated and adjusted incompatibility. advantages. potent substances. alkalies. prescription refills. solids and alcohol. Compound powders.THIRD YEAR B. methods of weighing. dilution and concentration of solutions. Powders : Importance. (2) 4.

drugs. (3) 6. space and physical plant requirements in relation to the size of hospital. development and responsibility of the hospital pharmacy department. Safe use of medications in the hospital. mattresses and other surgical products. Infection control in hospitals : Nosocomial infections. Organization and administration of Hospitals. Drug distribution systems in the hospitals : Floor stock systems. tubings. Location of the Pharmacy unit in relation to other hospital departments. instruments. inpatient and outpatientdispensing and control procedures. (6) 9. controlled substances. (2) (2) 7. Central supply service department : Its location plan and activities. (1) (2) 67 | P a g e . dispensing of ancillary supplies. rubber gloves and catheters. Definition. syringes and needles. Purchase and supply : Inventory control. (2) 2. medication errors and safety practices.Part – II : Hospital Pharmacy: 1. utensils. Sterilization and quality control testing of surgical dressings. Pharmacy and Therapeutics Committee : Personnel. 10. (2) (2) 5. Hospital Formulary. (3) 3. emergency Drug Cabinet. 4. Pharmacy Procedural Manual and its preparation. policy and procedure of purchase of storage of drugs. Manufacturing in hospital pharmacy : Bulk compounding and pre-packaging. 8.

Simple mixtures Mixtures containing diffusible solids. Glycyrrhizin (viii) Pastilles : Menthol./Yr Part I : Dispensing Pharmacy : (i) Latin terms and abbreviations (ii) Different types of mixtures including the following. Bulk powders (v) Tablet triturates and displacement value calculation. tannins. (iv) Powders : Simple powders. water and containing insoluble substances.THIRD YEAR B. gums. (vi) Pills : Copper Sulphate & Phenolphthalein (vii) Lozenges : Bismuth carbonate. Effervescent mixtures Slightly soluble substances. Powders Containing Volatile. Liquefying substances. Compound powders. Vegetable extracts. alkaloids. Effervescent powders. Emulsions (iii) Emulsions containing different proportions of oil. quaternary ammonium compounds. 68 | P a g e . Ammonium Chloride (ix) Miscellaneous Preparations : Insufflations Inhalation Mouthwash Gargles (x) Incompatibilities in mixtures. Indiffusible solids Precipitate forming substances. correction thereof and mixtures containing incompatibility related to acids. Potent substances. hygroscopic substances. PHARM -DISPENSING AND HOSPITAL PHARMACY (PRACTICALS) Minimum 75 Hrs.

etc. 69 | P a g e . theatre gauze. Calculations of milliequivalent concentrations of salts and conversion into percentage concentration.Part II : Hospital Pharmacy 1) Bulk Compounding i) Sodium. Eyeswabsticks. Gamgee pads. cottonbuds. 12) 13) 14) Patient case presentation Computer applications in Hospital Pharmacy Hospital visits. iii) Absorbent cotton and gauze iv) Rubber tubings 5) Preparation of anticoagulant solution (I P) 6) Preparation of anticoagulant bulb (KEM Hospital formulary) 7) Preparation of dialysis solutions : i) Intraperitoneal Dialysis Solution (I P) ii) Haemodialysis Solution (B P) 8) Preparation of transfusion fluids and electrolyte replenisher solutions. 10) Miscellaneous preparations commonly used in Hospital Pharmacy such as i) Lubricating jelly. 2) Monographic evaluation of i) Absorbent Cotton Wool ( I P) ii) Absorbent Cotton Gauze (BP) 3) Preparation of surgical supplies like eyepads. Salicylate mixture. 4) Sterilization & sterility testing of hospital supplies like i) Surgical instruments ii) Syringes and needles. roller gauze ward gauze.KEM Hospital formulary. ii) Starch enema. iii) Neurological solution 11)Demonstration of IV admixture incompatibility in parenteral fluids like diazepam injection and Dextrose saline solution. ii) Outpatient Electrolyte Pediatric Mixture (Extra Pharmacopoeia) iii) Oral Dehydration Solution – W HO 1) Preparation and monographic evaluation of pediatric chalk mixture BPC. Eye swabs.

2. 8. 1975. N.. Aberson ‘Sterile preparations for the hospital pharmacists and procedures ‘ANN’ Arbor science publisher. Cartr. 1. India.. ‘Hospital Pharmacy’. Lea & Febiger Publications. CBS Publishers. Charles Thomas publication. 2007. H. ‘Hospital Pharmacy’.) 3. Sprowl “Prescription Pharmacy”. J. 9. ‘Husa’s Pharmaceutical Dispensing’ Ed. 70 | P a g e . Career Publications. Perkins “Principles and Methods of Sterilization in Health Sciences.RECOMMENDED BOOKS: Latest edition of the following books. J. Lippincott. 7. Nashik. M C Allwood & J. 5 th edition 1986. Hassan. Tipnis. Kenneth & Michael J. Bajaj A. Martin (Mac Publication. 4. Martin (Mac Publication) 5.Fell Blackwell “Textbook of Hospital Pharmacy” Scientific Publications Oxford London 1980. W. 12 th edition. 6. F. B. P. T .Pitman Medical. Cooper & Gunn’s ‘Dispensing for Pharmaceutical students’ Ed. 2 nd edition 1970. Remington’s Pharmaceutical Sciences-20 th edition Year 2000. J.

phensuximide. chlorthalidone. acetazolamide. Cisplatin. physico-chemical properties. tobutamide. succinimides. anti-anxiety agents. testosterone. phenobarbital. (5) 2) (7) 3) (6) 4) (3) (4) 5) 6) Thyroid and Antithyroid agents Biosynthesis of thyroid hormones. Antiallergic agents (or Antihistaminic agents) Chlorpheniramire. furosemide. progesterone. Antiepileptic agents. promethazine. pentobarbital. estrone. hydrochlorthiazide. Psychotropic drugs: Neuroleptics. haloperidol. Hypoglycemic agents : (or Antidiabetic agents) Chlorpropamide. estradiol. 1-4-benzodiazepine-4-oxides. Glyburide.THIRD YEAR B. hydantoins. (4) (2) 9) 10) Corticosteroids and anti inflammatory steroids 11) Sex steroids. Diazepam. diphenhydramine. Study of the following classes of drugs with respect to classification. trichloroethanol. gluthetimide. mepyramine. Mephenytoin. Cimetidine (6) (2) 7) 8) Diuretics : (4) Chlorthiazide. structure activity relationship and synthesis of few important drugs : 1) Sedatives and hypnotics : Amobarbital. Antiulcer agents : Ranitidine. chlorpromazine. Anticancer Agents : Carboplatin. oxazepam. Ethacrynic acid. PHARM PHARMACEUTICAL CHEMISTRY-III (THEORY) Minimum 50 hrs/Yr. Metformin HCl. 12) Oral contraceptives : DES. anabolic steroids and their antagonists. Hexestrol (4) (3) 71 | P a g e . chloral hydrate. mode of action. phenytoin.

K.O. O. 4) Medicinal Chemistry by Ashutosh Kar. John W iley & Sons. II and III . Tenth Edition.. A) Strong acid + neutral Strong base + neutral Strong acid + weak acid W eak acid + base W eak acid + neutral B) Solid + Solid Solid + Liquid Liquid + Liquid W atersoluble solids Eutectic mixtures III] Synthesis of some of the following compounds : (at least 6) i) 2-napthyl benzoate ii) Cyclohexanone from cyclohexanol iii) 1-Phenyl-2-azonaphthol iv) Methyl salicylate v) Aspirin vi) S-Methyl thiourea vii) Vitronaphthalene viii) Benzoic acid RECOMMENDED BOOKS : Latest editions of the following books..THIRD YEAR B. 1999. Toronto. Lippincot Company. W. Medicinal Chemistry Part I. B. B. PHARM PHARMACEUTICAL CHEMISTRY-III (PRACTICALS) Minimum 100 hrs/Yr. 3) Burger. C. I] Recrystallization of Organic Compounds II] Organic separation and analysis of mixtures containing two organic compounds. E. Fourth Edition. A. Inc. J. Varghese and Company. B. Principles of Medicinal Chemistry. and Doerge. 1) Foye. J. (10-12 mixture s) Some of the following combinations will be analysed. Gisvold. Mumbai-31. Textbook of Organic Medicinal and Pharmaceutical Chemistry. 2) Wilson. New York. 72 | P a g e .

Labels & Labeling. packaging and qualitycontrol. Fibrinogen. Dextran. formulation. paperboard. tablets and capsules with sugar. requirements and quality control of packaging materials used in pharmaceutical packaging including glass. sterilization processes. Albumin. Introduction to machines used in packaging. contact lens solutions. Thrombin.equipment employed and quality control. (4) Packaging of Pharmaceutical Products: Containers and Closures. plastics. aseptic processing. andling and quality control. Concentrate of factor VIII and IX Quality control of blood products and anticoagulant solutions. additives and vehicles thereof Production. Sutures and Ligatures of different types. and ancillary materials. fractionation of plasma and monographs of different plasma fractions. application. adjustment of isotonicity. formulation. Fibres and Fabrics . Preparation and Quality control testing. vehicles and additives. Large scale processing of Dextran. (16) Ophthalmic Products : Ocular absorption. (5) Surgical Dressings. paper. Product package compatibility. formulation factors. wholehuman blood. production facilities. (10) 2) 3) 4) 5) 6) 7) 73 | P a g e . collection and storage of blood. Plasma Volume Expanders. and ointments. Plasters. lotions. blister and FFS packaging. air handling systems. metals. processes and equipment involved in the coating of granules. eye drops. Aqueous film coating and quality control of coated dosage forms (5) Radiopharmaceuticals : Radioisotope Generators. environmental controls. containers and closures. 1) Parenteral Products: Product Development. film formers and enteric materials. (5) Blood Products : Historical background. PHARM PHARMACEUTICS-III (THEORY) Minimum 50 hrs/Yr. strip. (5) Coating of solid dosage forms: Principles.THIRD YEAR B.

14)Ethanolamine oleate injection 15)Trisodium edetate injection . 8) Emetine injection. 26 Coating of tablets using non-enteric polymers. 2) Filling & sealing of ampoules. PHARM PHARMACEUTICS-III (PRACTICALS) Minimum 100 hrs/Yr. 17)Thiamine injection. 24)Dissolution test for tolbutamide tablet. 20)Oily phenol injection. 3) Large Volume Parenterals 4) Sodium Chloride injection. 27) Disintegration test of enteric coated tablets. 9) Calcium gluconate injection. 18)Cortisone acetate injection. 21)Calciferol injection. A] INJECTIONS : 1) Monograph on injections. 11)Morphine Injection. Small volume parenterals 7) Adrenaline tartarate injection. 5) Dextrose injection. Oily Injections 19)Test for oily vehicles. 74 | P a g e . 10)Ascorbic acid injection. 6) Compound sodium lactate injection. B] Aseptic processing of Parenterals 16)Tetracyline injection. 22)Deoxycortisone acetate injection.THIRD YEAR B. DISSOLUTION TEST FOR TABLETS: 23)Dissolution test for ibuprofen tablet. C) FILM COATING OF TABLETS : 25)Coating of tablets using enteric polymers. 12)Digoxin injection 13)Riboflavine injection.

I. Test on plastic container I. 1) 2) 3) 4) 5) 6) 7) 8) 9) E) 10) 11) 12) 13) F) 75 | P a g e . Hypromellose eye drops. Eye Ointment Atropine Sulphate eye ointment Tetracycline eye ointment Mercuric oxide eye ointment Sulphacetamide eye ointment Eye Lotion Zinc sulphate eye lotion Sodium Chloride eye lotion. Contact Lens Solution Wetting solution for hard contact lens Soaking and cleansing solution for hard contact lens Cushioning solution for soft contact lens TESTING OF PACKAGING MATERIALS Test for hydrolytic Resistance of Glass I. Test on paper. I. STERILITY TESTING OF INJECTABLE AND OPHTHALMIC PREPARATIONS. Zinc sulphate & adrenaline eye drops. Hydrocortisone acetate and Neomycin sulphate ophthalmic suspension.P. Phenylephrine eye drops.P. Ophthalmic Suspensions 38) 39) 40) Dexamethasone ophthalmic suspension Tetracycline ophthalmic suspension.P. paper board and demonstration of packaging machines. Pilocarpine hydrocloride eye drops. Rubber closure for container for Injectiable preparation. Atropine sulphate eye drops. 28) 29) 30) 31) 32) 33) 34) 35) 36) 37) Chloramphenicol eye drops. Physostigmine eye drops. Prednisolone eye drops. Homatropine eye drops.P. Sulphacetamide eye drops.D) OPTHALMIC PREPARATIONS : Eye drops.

Churchill Livingstone. L. Cater. 1 st Edition. M. Lachman.Aulton. Mumbai. Bentley’s Textbook of Pharmaceutics. K. Rawlins. 6. 2000 British Pharmaceutical Codex.A. 4. S. E. New York.A.E. 76 | P a g e . L. 3. 10. J.Lieberman. Vol. Delhi. 5. British Pharmacopoeia. ‘Cooper and Gunn’s Dispensing for Pharmaceutical students’.Liberman. 1973.E. Remington’s Pharmaceutical Sciences. 1988. H. 1. 7. H. Varghese Publishinng House.J. Delhi. Marcel Dekker Inc. London. Pennsylvania. Osmol Mack Publishers. Indian Pharmacopoeia. ‘Pharmaceutical Dosage Parenteral Medications’. All India Traveller Book Seller. 2002 United States Pharmacopoeia. 9. 1996. 1.CBS Publishers and Distributors.Kanig. 8. Lachman. ‘Pharmaceutics – The Science of Dosage form design’. Avis. ‘The Theory and Practice of Industrial Pharmacy’.RECOMMENDED BOOKS: Latest editions of the following books. Forms– 2.

purchasing and inventory controls. by exception. development council (Drug and Pharmaceuticals) Progress in the manufacturing of bulk drugs and formulations.. (5) (b) Managerial planning – long term and short term plans. its role in national economy and national health. Competitive practices in pharmaceutical industry : product differentiation. Organization of distribution and marketing : The pharmaceutical market. Introduction to forms of business organization: (3) Introduction to the concepts of management. small scale sector. policies. influence. (c) Management by objectives. limitations. . (2) 5. Industrial Administration: Principles of Industrial Management in relation to the Pharmaceutical Industry. market research. 3. Structure of the industry : organized sector. price competition. production planning and development and materials management. 1. (2) 8. Indian pharmaceutical industry : Pharmaceutical industry in India. INDUSTRIAL ORGANISATION. A. planning product differentiation. through quality control.. Marketing communication : a) Media for communication : advertising and sales promotion methods. function of management. product classification. non-price competition-through research and development. 2. Marketing organization : the manufacturer to wholesaler to retailer. market analysis. 4. market behaviour.FINAL YEAR B. (2) 7. factory (6) building layout etc. by results. Production management : goals and organization. plant location. operating problems. (d) Decision making process (e) Management control systems. DRUG STORE MANAGEMENT AND INDUSTRIAL PSYCHOLOGY (THEORY) Minimum 50 Hrs/Yr. modifications of existing products (3) 6. patents and trade marks. (a) Managerial work. public sector.PHARM. The pharmaceutical product : market considerations in product development. b) Pharmaceutical detailing a) (2) b) c) 77 | P a g e 9.

‘Drug Stores Management’. cash book. J. 8. Koontz and O’Donnell. Olsen. Ltd. sales and its record. New Delhi.A. (J. Different types and forms of drug-store. books of accounts. losses and insurance including fire. U. . sales promotion and advertisement. Nolen and Maynard. suitable pricing.. profit and loss account. Fisher and Cox . ‘Marketing Drug Products’. Purchasing of an existing store. 12. ‘Treatise on Commercial Pharmacy’.S. New Delhi. ‘Effective Management’. (9) 11. Burley. 2. Lassers J. Drug Store Management : a) b) c) d) e) f) Factors influencing the starting and running of a drug store. W. K.S. Ltd. journal and ledger. ‘Drug Store Operating Costs and Profits’. drug-store employees and their treatment. ‘Principles of Management’ by International Student edition of McGraw Hill. ‘How to run a small business’ Prerau.Y.Publishing Co. 78 | P a g e . B. Store building and its construction. Mc Graw Publishing Co. ‘ Practice of Management’ Allied Publishers. 6. Location. 3.. O’ Connor . Internal planning and layout. C. thefts etc. Graw Hill. Accounting and Correspondence : Elementary knowledge of different kind of accounts. credit and cash sales. McGaw Hill 5. RECOMMENDED BOOKS : Latest editions of the following books. Policies in a drug store : (6) Purchase and its record. Tata M. N. principles of costing and estimating elements of double entry.. balance sheet. Reddin. B. ratio and their (10) application.A. 4.. Peter Drucker. U. furniture and fixtures. (Rutgersuni Press). 1. Lippincott) 7.d) Export and import of drugs and pharmaceuticals..

(4) 6) Perfumes in cosmetics : Synthetic. antidandruff preparations. role of hormones and vitamins in skin nutrition. (3) iii) Face powders and makeup : Face powders. hair setting lotions. rouges and eye make up.natural and artificial perfumes. classification of perfumes. (5) ix) Bath preparations : Foam baths. 2) Basic knowledge of skin. manufacturing and equipment used for following types of cosmetic preparations. Liquid make up. hair tonics. cleansing creams. all purpose and emollient creams. their applications. cold. vanishing. make. hair straightners. pigments and inorganic colours. types of perfumes. hand creams. permanent waving. nail creams. performance and evaluation of cosmetic materials. 4) Preservation. compact powder. viii) Body cosmetics : Antiperspirants and deodorants.PHARM COSMETICOLOGY (THEORY) Minimum 50 Hrs/Yr. powder. vi) Dental Products : Dentifrices and mouth washes. i) Skin creams and lotions. 5) Cosmetic colours : natural and synthetic colours including plant and animal origin colours. foundation creams. cake make up. (5) (3) (2) (1) vii) Astringents and skin tonics. nail bleach. conditioners. (2) 79 | P a g e . photosensitisaion. skin lighteners and bleaches. bath salts. bath oil and after bath products. classification of skin creams. (2) (2) (1) (4) 7) Formulation. nail whites. (5) iv) Coloured make up : Lipsticks. hair bleaches. beauty masks. 1) Introduction to cosmetics. stick make up and liquids. (1) 3) Dermatitis and allergy. hair colouring dyes. protective and barrier creams (3) ii) Hair preparations : Shampoos. manufacturing and blending of perfumes. sun screen. primary irritants. allergy and antihistaminics in cosmetics. lakes. origin and development of cosmetic science.up cream.FINAL YEAR B. suntan and antiburn preparations. v) Manicure preparations : Cuticle remover. nail lacquer and enamel remover.

(1) xi) 80 | P a g e . oils. dry shaving preparations and after shave preparations. Baby cosmetics : Baby powders. shampoos and soaps.x) Shaving preparations : Shaving creams lather and brushless. lotions. aerosol (5) shaving foams.

iv) After shave cream. iii) Compact powder iv) Liquid make up. vi) Sunscreen lotion. iv) Brilliantine VI) Shaving Preparations: i) Lather shaving cream. ii) Cream Shampoo iii) Gel Shampoo. vii) Eye shadow stick. v) After shave powder VII) Coloured make-up : i) Lipstick ii) Lipsalve iv) Wax based rouge. iii) Baby powder Hair Prgarations: i) Liquid Shampoo. ix) Liquid Eye liner VIII) Manicure Preparations: i) Nail Lacquer ii) Nail Enamel remover IX) Dental Product : i) Mouth Wash. vi) Cake make up. iii) Pressed Rouge v) Cake Mascara. v) Stick make up. Body Cosmetics: i) Hand & body lotion. v) All purpose cream vi) Foundation cream. ii) Dusting powder. iv) Corn callus preparation v) Foot cream. ii) Brushless shaving cream iii) After shave lotion. V) ii) Baby Cream. vi) Cream Mascara viii) Cream eye shadow. Face powders and make–up: i) Face powder.FINAL YEAR B. vii) Face mask. X) ii) Tooth paste Astringent and skin tonics : i) Astringent stick ii) Astringent cream iii) Skin toner Miscellaneous : Insect Repellant Cream X) 81 | P a g e .PHARM COSMETICOLOGY – (PRACTICALS) Minimum 100 Hrs/Yr. iii) Cleansing cream iv) Emollient cream. viii) All purpose mask. Preparation of following types of cosmetic preparations based on the theory I) Creams : i) Cold Cream ii) Vanishing Ceam. II) III) IV) Baby Cosmetics : i) Baby lotion. ii) Hand protective cream iii) Peeling lotion.

‘Perfumes.G. manufacturing and Quality Control:’ Vandana Publications.J. P.S. Delhi. Reprint-1985. United Book and Periodicals. 6) Pouchers. R. Bombay. Ninth edition.. Universal Publishing Corporation. III) Krieger Publishing Company. First Edition-1951. P. second Edition.Ltd. Bombay. cosmetics and soaps’. 4) E. I & II. India. Thomson. 3) Sharma. UK. ‘Cosmetics Fragrances and Flavours. Eight edition. Second Edition.. and Sagarin Edward. 1974. Chapman & Hall London. 2) Balsam M. 2002. ‘Modern Cosmetics’. 5) Louis Appell. 82 | P a g e . Reprint edition-1992.1994.’ Micelle press-England. Longman Singapore Publishers Pvt. Malabar. Wilkinson. ‘Cosmetics Science and Technology’ (Vol. Revised edition – 1994. ‘Harry Cosmeticology’. Singapore. Florida. London.More.B.Recommended Books : Latest editions of the following books. ‘Cosmetics-Formulation. 1) J.

drug-protein binding in blood and tissue. 1995. non-linear metabolism. Drug dosing regimens : Individualization and optimization in some disease states. route of administration.Year 1987. Introduction to Biopharmaceutics and Pharmacokinetics. Gibaldi M. Drug metabolism. drug absorption. concept of compartmental models. creatinine clearance. Perrier D. ‘Pharmacokinetics. 1. ‘clinical pharmacokinetics’. Swarbrick. 2 nd ed. Wellig P. volume of distribution. disposition of metabolites. physico-chemical considerations. Delhi. Drug elimination. New York. distribution. renal excretion. RECOMMENDED BOOKS : Latest editions of the following books. Newyork. (8) Determination of various pharmacokinetic parameters of drug after intravenous bolus and infusion and after single dose oral administration. role of dosage form. ‘Clinical Pharmacokinetics’. Tse F. applications.. intravascular and extravascular routes. 9. calculation of absorption rate constant and elimination rate constants and other parameters using residual method and Wagner Nelson method. Ltd. concepts. methods and limitations of such studies.. 1995. in-vivo-in-vitro correlations. 2 nd ed. absolute and comparative bioavailability. Marcel Dekker Inc. bioequivalence of pharmaceutical formulations. gastrointestinal absorption. (6) 4. (2) 7. 83 | P a g e 3.S. Marcel Dekker Inc. .. 1. rate Processes. basic definitions. Waverly Pvt. extraction ratio. (2) 6.. N. Pharmacokinetic considerations of drug concentrations in plasma. Bioavailability studies.FINAL YEAR B. Regulatory Industrial Academic Perspectives’. (2) 2. hepatic clearance.. one compartment model.L. Rowland M. biological considerations. Monitoring drug concentrations in Urine. (3) (1) (1) 8. (6) 3. 5.PHARM BIOPHARMACEUTICS & PHARMACECOKINETICS (THEORY) Minimum 25 Hrs/Yr. Lea and Febiger B. first pass effect.G. 4.I. Factors affecting drug absorption. Drug Dispostion. Tozer T. 2. ‘Pharmacokinetics’. renal clearance.

Philadelphia. ‘Textbook of Biopharmaceutics and Pharmacokinetics’... ed. Vallabh Prakashan. 2001. 7. & Jaiswal Sunil. ‘Biopharmaceutics & Pharmacokinetics’. Lea & Febiger. Career publications. Nashik.. 84 | P a g e .5.1995. Bajaj A. P. Brahmankar D. Tipnis H. Swarbrick. 6. N. James. 1 st edition .. ‘Current concepts in the Pharmaceutical Sciences: Biopharmaceutics’. M.

FINAL YEAR B.PHARM PHARMACOLOGY-II (THEORY) Minimum 50 Hrs/Yr. 1. Drugs used in cardiovascular disorders: Antihypertensive agents Vasodilators Treatment of angina pectoris, Cardiac glycosides and drugs used in congestive heart failure, Agents used in cardiac arrhythmias. Drugs used in blood disorders: Agents used to treat anemias, Drugs affecting coagulation, bleeding and clotting time Drugs used in hyperlipidemia and plasma expanders. 2. Chemotherapy: Principles of chemotherapy, Antibacterials penicillins, cephalosporins, chloramphenicol, tetracyclines, macrolides, clindamycin, aminoglycosides, polymyxins, vancomycin, sulfonamides, trimethoprim, Antifungals, Antivirals, Antimycobacterial drugs, Anthelmintic drugs Antiprotozoal agents Pharmacotherapy of septic shock Pharmacotherapy of sexually transmitted diseases Pharmacotherapy of urinary tract infections Pharmacotherapy of HIV Drugs for cancer chemotherapy (antineoplastic agents) 3. Drugs for Immunomodulation and gene therapy 4. Toxicology Introduction to toxicology General measures taken in the treatment of poisoning Specific antidotal treatment of poisoning produced by: a) Metals like Pb, As and Fe b) Opioids c) Solanaceous drugs d) Barbiturates and e) Salicylates
85 | P a g e

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(10)

(5)

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5. Drugs acting on the Central Nervous system: General anesthetics and local anesthetics Sedatives hypnotics and anxiolytics Drugs used in psychiatric disorders CNS stimulants Antiepileptics Skeletal muscle relaxants Opioid analgesics and antagonist Antipyretics Drugs used for Parkinsonism and other neuro degenerative disorders Drugs for cognitive dysfunction.

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FINAL YEAR B.PHARM PHARMACOLOGY-II-(PRACTICALS) Minimum 100 Hrs/Yr. 1. 2. 3. 4. 5. 6. 7. 8. 9. Effect of drugs on isolated frog’s heart. Bioassay of histamine using guinea pig ileum by interpolation method Bioassay of histamine using guinea pig ileum by bracketing method Four point bioassay of acetylcholine on rectus abdominus muscle of frog Bioassay of the antagonist d- tubocurarine using frog’s rectus muscle preparation. Effect of Phenobarbitone on righting reflex of mice Effect of diazepam on muscle relaxant of mice on rota rod apparatus Determination of analgesic response of pentazocine Determination of analgesic response of aspirin

10. Determination of anticonvulsant activity of phenobarbitone 11. Determination of anticonvulsant activity of diazepam 12. Determination of anticonvulsant activity of phenytoin 13. Effect of diazepam on locomotor activity 14. Effect of barbiturates on sleeping time in mice. 15. Chlorpromazine induced catatonia in rats. 16. Effect of calcium and potassium ions on furog heart 17. Effect of Propranolol on calcium and adrenaline induced responses using perfused frog heart 18. Effect of digitalis on failing heart 19. Identification of test substances with the help of suitable blockers using perfused frog Heart 20. Tutorials in Pharmacology

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. Prakashan. Ltd. 9th edition. Satoskar R. 18th edition. K. Published by Churchill Livingstone Pvt. New York. 1999.S. Determination of passive avoidance by using cook’s Pole climbing Apparatus. ‘Pharmacology and Pharmacotherapeutics’. International edition. 2003. Kulkarni S. 4th edition. 10th edition. Determination of explanatory behavior by using Hole board apparatus in rats.S. Mumbai. 2nd edition.50% of the Practicals will be computer-simulated experiments. 1999. Wilson and Gisvold’s Textbook of ‘Organic. Ainapure S. India. 1998. 1999. 22. ‘Practicals in Pharmacology’. published by B. Sheth S.S. Published by Mc GrawHill. Determination of contancity activity of diazepam by using elevated plus more in mice. Goodman and Gilman. ‘The Pharmacological basis of therapeutics’... ‘Essentials of Medical Pharmacology’. Published by Popular Prakashan..D. U. RECOMMENDED BOOKS : Latest editions of the following books : 1 2 3 4 Tripathi K.Shah Prakashan. 3 5 6 7 88 | P a g e . 1999. Philadelphia. 20. New Delhi.D.S. Published by Jaypee brothers.. India. Ahmedabad.New Delhi. Bhand arkar S. 2000. 21. India. India. ‘Textbook of Pharmacology’.. K.New Delhi. Medicinal and Pharmacological chemistry’.A.. 2nd edition.D. India. Published by Vallabh rd edition. Published by Lippincott-Raven publishers. Goyal R.. ‘Handbook of Experimental Pharmacology’.

5. sequence determination methods. creatine. Ketone bodies. estrogens and testosterone. Biosynthesis of cholesterol. (7) Vitamins : classifications of Vitamins. cytochromes. quaternary structure. gluconeogenesis. 7. 89 | P a g e . structure-primary secondary tertiary. daily requirements.FINAL YEAR B.(6) Nucleic acids: Purine & pyrimidine bases. Enzyme inhibition and kinetics. glycogenolysis. conenzymes.Menten equation and its transformations : double reciprocal plot. biochemical role. deficiency symptoms of vitamins and other growth factors. r-RNA [as carriers of genetic information] functions and structure of RNAS. Replication of DNA. Diseases associated with protein metabolism. 9. Applications of biochemical principles to Pharmacy Ultrastructure of a cell. (6) Biological oxidations : electron transport chain. Functions of cellular constituents. sources. bile acids. digestion. 4. nucleosides (12) and their biosynthesis. absorption Amino acids. DNA-W aston and Crick model. RNA-m-RNA. Carbohydrates-Types digestion and absorption of carbohydrates with examples Anaerobic and aerobic glycolysis with energy transactions. (2) 2. 8. (6) Proteins-Types. Hereditory diseases.PHARM BIOCHEMISTRY (THEORY) Minimum 50 Hrs/Yr. (2) 3. 1. adrenocorticoids Progesterone. t-RNA. Enzyme kinetics Michaelis. β-oxidation of fatty acids. Hexose monophosphate shut and energetics. B from. metabolism and absorption of proteins. 6. (3) Enzymes : classification of enzymes. Transcription and Protein synthesis. (6) Lipids : Types. formation of urea. factors affecting enzyme action. Its significance. oxidative phosphorylation. Diseases associated with carbohydrate metabolism.type. nucleotides. urea cycle. Diseases associated with lipid metabolism. DNA as the Carrier of genetic information. glycogenesis. digestion and absorption of lipids.

3. Wilstaters method for estimation of Glucose III. Biochemistry by Conn & Stump. Lane Eynon’s method for estimation of Glucose II. RECOMMENDED BOOKS : 1. plant extracts etc. and Cox M. 90 | P a g e . Textbook of Biochemistry by Praful Godkar. Harper H. Quantitative estimation of Vitamin C by dye method and KIO 3 method.L. 1993. Qualitative Analysis of Carbohydrates Qualitative Analysis of Proteins Qualitative Analysis of Amino acids Quantitative Analysis of Carbohydrates I. Harper’s Review of Biochemistry.. 5.L. CBS Publishers and Distributors... Estimation of Casein. Estimation of Vitamin C in fruit juices.FINAL YEAR B. A Textbook of Practical Biochemistry by Plummer. Quantitative estimation of ß-amylase Effect of pH. Los Altos Large Medical Publication. Nelson D. 1981. Delhi. 4.M. temperature. 2. ions on enzyme activity. Benedicts method for estimation of Glucose IV.A. Selvinoffs method for estimation of Sugars Quantitative analysis of Proteins-Biuret Method.PHARM BIOCHEMISTRY (PRACTICALS) Minimum 75 Hrs/Yr. 2 nd edition. Principles of Biochemistry by Lehninger A.

Basic PCR & its modifications. cell-lines and cloning. principles and methods. Tissue Cultures: Animal cell & tissue culture. advantages and disadvantages. Organ cultures. and somatic hybridisation.PHARM BIOTECHNOLOGY (THEORY) Minimum 25 Hrs/Yr. DNA polymorphism. SSRs. DNA finger printing. 1. Totipotency. Gene synthesis machines and human gene therapy. & genetic engineering. isolation of mutants. Introduction to Clinical Genetics. cloning of cell lines. b) Transgenic animals. somaclonal variation. Brain. callus and suspension cultures. artificial chromosomes. milestones. mutagenes. Recombinant DNA Technique. Microbial Genetics : Gene transformation. laboratory technique. Organogenesis. kidney. role of mutation in strain improvement. Yeast artificial chromosomes. application of PCR in biotechnology. Bacterial mutation and mutagenesis. sequencing and synthesis of genes. Somatic cell fusion. VNTRs. - - - 91 | P a g e . Disaggregation of tissue and primary culture. Large Scale Cell cultures in Biotechnology. induced mutations. 3. lungs. Plant Tissue Cultures: (8) Development of plant tissue cultures. Recombinant DNA and gene cloning. Yeasts and other eucaryotes. RAPDs. somatic embryo genesis. (1) 2. Protoplast fusion. tissue engineering. germyplasm storage including cryopreservation. Cloning in bacteria virus. biological significance of mutation. Isolation. cultured cells and evolution of cell lines. molecular probes and gene libraries. Development of Biotechnology. Polymerase Chain Reactions (PCR) and gene amplification. primary culture. Tissue and Organ culture. Inheritance Pattern in man Mandelian Inheritance Dominant Recessive Lethal Sex linked Sex influenced multifactoral and mitochondrial inheritance Genetic diseases of heart. transduction. gene tagging. cloning and expression vectors. chimaeric DNA. plasmids and their biological significance.FINAL YEAR B. types of mutation. conjugation. Sex Organs. whole embryo culture. A brief account of genetic phenomenon in eucaryotics.

A. New Delhi.. Vit.enzymes (amylases.. vinegar.. Ignocimuthu. 3 rd ed. ‘A Textbook on Biotechnology’. Gupta P. S. Dr. butanol). ‘Elements of Biotechnology’. A detailed account of industrial fermentation processes of alcoholic beverages. S. Fermentation and bioprocess monitoring. BARC. Meerut. and Roberts L. 1998. Rastogi Publications.W. Affiliated East-W est Press Private Ltd. (8) RECOMMENDED BOOKS : Latest editions of the following books.D..S.H.. streptomycin. Casida D. tetracycline). Rw Fr. Keshav Trehan. 1995. Tissue.J.R. Rw Fr. Dodds J.. and Organ Culture’. Industrial Microbiology.. 2 nd ed. Ed. l-glutamate).S. 1995. Biotechnology. (Penicillin. ‘Biotechnological Applications of Plant Cell & Tissue Cultures: Problems and Prospects’. 1980. S. lipases. antibiotics. Chhadda M. 92 | P a g e . amino acids (l-lysine. ‘Applied Plant Biotechnology’. New Delhi. Microbial bioconversions (industrial hydroxylation.. Narosa Publishing House. Vitamins ( Vit. Single Cell Proteins. and fermentation processes. & Heble M. 1996. gluconic acid).J. Kumar S. ‘Applied and Fundamental Aspects of Plant cell. Basic Biotechnology. Tata Mc Graw-Hill Publishing Company Ltd. Cambridge University Press. Dr. hydrogenation of steroids). 1) 2) 3) 4) 5) 6) 7) 8) 9) 10) Remington’s Pharmaceutical Sciences. New Delhi.J. Tata McGraw-Hill Publishing Company Ltd. ‘Experiments in Plant Tissue Culture’. Reinert J and Bajaj YPS.5) Fermentation Technology : (7) Types of Fermentation. lactic acid. solvents (acetone.Ignacimuthu. Martin. 1990. 1998. proteases). Mack Publications. organic acids (citric acid. Vit B 12 ). role of genesis in fermentation..B 2 . New Age International (P) Ltd.K..

IUPAC nomenclature of drugs and their therapeutic uses. Isoetharine. adrenergic receptors alpha and beta.PHARM PHARMACEUTICAL CHEMISTRY-IV (THEORY) Minimum 50 Hrs/Yr. Hydroxyamphetamine. Physostigmine. 1) (3) Adrenergic Agents Adrenergic Neurotransmitters – their structures and physicochemical properties. Tolazoline.FINAL YEAR B. Bethanchol*. Pilocarpine. Ephedrine*. Phenoxybenzamine*. A study of the following topics with regard to the physico-chemical properties. Metoprolol*. Dopamine*. 3) Cholinergic Agents (3) (2) Cholinergic Neurotransmitters. Metaproterenol*. Dobutamine. Beta Blockers : Propranolol*. Norepinephrine*Isoproterenol*. Mephentermine*. 2) Adrenergic Blocking Agents Classification of Adrenergic Blocking Agents Neuronal Blocking Agents Bretylium tosylate and guanethidine sulphate Alpha Blockers : Ergot alkaloids-Ergonovine. Phentolamine*. Ambenonium chloride. Neostigmine*. Acetylcholine*. muscarinic and nicotinic. Prazosin*. Practolol*. Parathion. Carbachol*. Isoxsuprine. synthesis of a few important drug molecules marked*. Isoflurophate. Terbutaline*. Methacholine*. Epinephrine*. ergotamine & Methysergide.Naphazoline* and Tetrahydrazoline. Imidazoline Derivatives . Directly acting cholinergic agonists and reversible and irreversible cholinesterase inhibitors. Alpha and Beta agonists : Phenylephrine. Labetalol. Timolol. 93 | P a g e . mode of action of drug molecules. Nylidrin. Cholinergic agonists and their classification. Malathion. directly and indirectly acting sympathomimetics and agents with a mixed mechanism of action. Pyridostigmine. Nadolol. structure activity relationships (SAR). Salbutamol*.

Ethaverine and Doxycycline. (iv) Benzomorphans –Pentazocine. Aminoalcohols – Biperiden. Procyclidine Aminoumides – Isoproamide Miscellaneous – Diphemanil. Scopolamine. Meperidine*. Mecamylamine* Neuromuscular Blocking Agents : Classification. Methadone*. (4) Methantheline* 5) Narcotic Analgesics Morphine and its therapeutic applications Synthetic Analgesics: (5) A) Peripheral Modifications – Codeine. Prodilidine. Papaverine alkaloids – Paraverine. Isomethadone*. cyclorphan. Anilerdine* Propionoxy and phenyl derivatives of meperidine. their alkylated analogs.4) Cholinergic Blocking Agents Parasympathetic Postganglionic Blockers : General structure. butorphanol. Amino alcohol ethers – Benztropine*. Ganglionic Blocking Agents : Depolarizing and non-depolarizing Trimetharphan. Proheptazine. Clidinium bromide. Hydrocodone. Curare and Curare alkaloids. Tubocurarine. Thebaine. Hyoscyamine. LAAM. Heroin. Oxycodone. Ketobemidone*. Ethopropazine*. Hydromorphone. Fentanyl*. Ethoheptazine*. Dextromethorphan. Cyclazocine 94 | P a g e . Dionin. and Orphenadrine*. Aminoalcohols-Cyclopentolate*. and Apomorphine B) Skeletal Modifications : (i) Meperidine Analogs-SAR. Solanaceous alkaloids-Atropine. Levorphanol. chemical classification. Gallamine. (ii) Methadone Analogs-SAR. Piperidolate. (iii) Morphinan Analogs – N-methylmorphinan. Decamethonium. Oxymorphone. Propoxyphen*.

Aminopyrine. Diclofenac. ß – Blockers – Phentolamine*. Drugs acting on smooth muscles-Hydrallazine. Oxyphenbutazone* Drugs used in the Treatment of Neuromuscular Disorders A. Nicardipine. Norapomorphine. inhibitors. Acebutol. ß – hydroxylase inhibitor – Fusaric acid. Minoxidil. Phenacetin*. Fenoprofen. Naloxone. Ganglionic blockers – Hexamethonium and Trimethorphan Guanethidine. Naproxen*. Drugs acting centrally : Clonidine. Drugs acting on post ganglionic nerve endings- 95 | P a g e . Decarboxylase (3) Ibuprofen*. Enalapril. Levallorphan. Phenylbutazone*. Apomorphine. Ketorolac. MAO Inhibitors – selegiline. Methyldopa. Aspirin*. Benazepril. Non-steroidal Antiinflammatory Agents (4) Chemical classification. Other Dopaminergic agents – Amantadine. Mephenesin. Nimodipine*. Drugs used in parkinson’s disease : Anticholinergics. salicylic acid and its derivatives. (4) Dopamine. viii) Antianginal agents – Organic nitrates. salols. beta blockers. Ketoprofen. Acetaminophen. Propranolol*. Diazoxide. 6. i) ii) iii) iv) v) vi) vii) Reserpine. Carbidopa. Methocarbamol. Bromocriptine. Prazosin. 7) Antihypertensives and Antianginal agents All the classes of antihypertensive drugs. Muscle Relaxants – Antodyne.Narcotic Anatagonists – Nalorphine. Ca-channel Blockers – Nifedipine*. Phenoxybenzamine*. Levodopa. Rampiril. Indomethacin*. Fasinopril. Lisinopril. calcium channel blockers. Antipyrine*. Mefenamic* acid* and Meclofenamate. Chlorphensin. Bretyllium. Atenolol. Piroxicam*. Amlodipine . Metoprolol*. ACE Inhibitors – Captopril. Flurbiprofen. antiplatelet drugs and cytoprotectives. Dopamine*. B.

PHARM 96 | P a g e . molar refractivity. chirality pool. Ribivirin. and libraries. need of chiral compounds. enantiospecificity. 10) (1) Introduction to QSAR (5) Need of QSAR. Acyclovir. methodology advantages and disadvantages or limitations of Hansch Analysis. distomers. partition coefficient. Rm. enantioselectivity. simple and valence molecular connectivity to indicate electronic effects. role of cycloxygenases in prostaglandin synthesis. B and C viruses Interferon alfa. use of octanol in determination of partition coefficient. Entecavir. Lamivudine. Hepatitis : Hepatitis A. Eutomers. databases. lipophilic effects and steric effects. prochiral moiety. Es. Rofecoxib. asymmetric synthesis. Indroduction. classification and therapeutics. isomeric ballast. Etodolac. kinetic resolution. Meloxicam their advantages over nonselective cyclooxygenase inhibitors. Introduction to asymmetric synthesis (4) Chirality. enantiomers.9) Nomenclature. Emtrucutabine. diastereoselectivity. Combinatorial Chemistry – basics. eudismic ratio. synthesis of prostaglandins. clevudine. Celecoxib. Chemical shifts. Nimesulide*. diastereomers. nonselective inhibitors of cyclooxygenases (commonly used NSAIDS) Selective inhibitors of cox-2. and physic chemical parameters such as pKa. Use of substituent constants such as. Cox 2 inhibitors – Eicosanoids. (4) (4) 11) 12) 13) 14) (4) FINAL YEAR B. uses of prostaglandins. Nabumetone.

6 – Tribromoaniline to 1. 4. Diazotisation & Deamination . 5-tribromobenzene Riemer – Tiemann Reaction. Aniline to 2. Betanaphthol benzoate from benzoic acid. Orthophenylenediamine to benzimidazole Orthophenylene diamine to 2.) Fridel-Crafts alkylation and acylation Preparation of an alkylating agent.2. Benzene to acetophenone / benzophenone / triphenylmethane Hoffmann bromamide reaction Phthalimide to anthranilic acid.nitroaniline Resorcinol to 2-nitroresorcinol Grignard reaction Preparation of grignard reagent and sysnthesis of secondary alcohols using corresponding alkyl halide Perkin condensation Cinnamic acid from benzaldehyde and acetic anhydride. 3-diphenylquinoxaline 1) 2) 3) 4) 5) 6) 7) 8) 9) 10) 11) 12) 13) 14) II 1) 2) 3) 4) 5) 6) 97 | P a g e . I : Long Experiments: Synthesis of drugs and drug intermediates using following reactions. Sandmeyer Reaction (2 expts) Anthranilic acid to o-cholorbenzoic acid and Anthranilic acid to o-iodobenzoic acid.) Benzilic acid : rearrangement : Benzil to Benzilic acid Pinacol-Pinacolone Rearrangement : Benzil to 5.) : p-Nitrotoluene to p-nitrobenzoic acid (sodium dichromate) Reduction : p-Nitrobenzoic acid to PABA (1 Expt) Esterification : PABA to benzocaine (1 Expt.3. Claisen condensation Benzaldehyde to ethylcinnamate. Phenol to Salicylaldehyde Small Experiments: Benzamide to Benzoic acid Cyclohexanone to1.Aniline to tribromobenzene. t-butyl chloride and conversion of benzene to t-butylbenzene. At least fifteen experiments from following different classes) Oxidation : Benzoin to benzil (HNO3) (2 Expts.4 tetrahydrocarbazole Oxime of benzaldehyde.5-diphenylhydantoin (1 Expt. 3.PHARMACEUTICAL CHEMISTRY (PRACTICALS) Minimum 100 Hrs/Yr. Nitration (2 Expts) Acetanilide to p .

Robert F. John Wiley & Sons Inc. Doerge. New Delhi.Foye .O. Williams.L.I. Abraham. Lemke and D.S. Ltd. ed. J.S. Waverly Pvt. T. U. 98 | P a g e . ‘Principles of Medicinal chemistry’. New York. ed. U. A..A. 1) Wilson and Gisvold’s ‘Textbook of Organic Medicinal and Pharmaceutical Chemistry’. Lippincott Company... D. B.. 2) W.RECOMMENDED BOOKS : Latest editions of the following books.A. 3) Burger’s ‘Medicinal Chemistry and Drug Discovery’.

MDIS. Introduction to novel drug delivery systems and Drug carrier systems like liposomes. (5) 4. equipment. core material. statistical quality control. Microencapsulation : Concept. release rate and dose considerations. 99 | P a g e . components. 6. (5) 2) Controlled release drug delivery systems. stability testing. Diffusion and dissolution based systems. Aerosols. processing and equipment for microencapsulation. physico chemical properties of drugs affecting formulation : particle size. Bulk characterization.FINAL YEAR B. ICH guidelines. pulmonary. raw materials. in-process controls.. sampling method and sampling plans. process optimization. evaluation of formula. formulations. Quality control charts. shelf life determination. propellants and loading methods. nasal. Nebulizers. manufacturing documents. 3. Quality audits and documentation. mechanisms of drug release. solubility analysis etc. Criterion for selection of drugs for controlled release. polymorphism. personnel requirements. building design and plant layout. physical form. Total Quality Management. 1) Preformulation studies : Stages of product development. nanoparticles for ocular. Dry powder inhalers. Controls on (15) personnel. applications. Drug excipient interactions. Oral and parenteral controlled release drug delivery systems. transdermal. (5) 5. (15) Types of controlled release dosage forms. quality control.PHARM PHARMACEUTICS – IV (THEORY) Minimum 50 Hrs/Yr. polymers used. coating materials. Good Manufacturing Practices. nasal sprays. intra uterine routes of administration. Pilot Plant Scale up techniques : (5) Manufacture of pharmaceuticals. microspheres. factorial designs. storage and distribution of products. general facilities. environmental controls and other controls during manufacture. Quality Assurance and quality control department.

Evaluation of controlled release granules by dissolution studies using rate test apparatus I.P. Calcium carbonate pellets with Microcrystalline cellulose. Dissolution rate studies on sustained release granules using pH change method (i e) variable buffers using USP dissolution test apparatus. Study of diffusion rate from Transdermal films using diffusion cells. 1. 10. 9. Microencapulation of drugs using phase separation coacervation technique (eg) Liquid paraffin with gelatin. Filling of Hard gelatin capsules using Hand operated capsule filling machine and dissolution validation of the processes. eg. 13. 4. Preparation of sustained release granules by embedding in hydrophilic matrix eg. 2. Preparation & Evaluation of controlled release dosage forms. Preparation and evaluation of transdermal films eg Ibuprofen TDS. 5. Chloroquine granules coated with Ethyl cellulose. Ibuprofen in Guar gum matrix. Preparation and evaluation of controlled release pellets using Extruder pelletizer. phase separation induced by salt addition.FINAL YEAR B. Monographic Evaluation of Inhalation Aerosols (eg) Salbutamol metered dose Inhalation aerosol. 6. 8. Preparation of sustained release granules using hydrophobic matrix (eg) salicylic acid in stearic acid by fusion method. 7. 100 | P a g e . 3. Preparation and evaluation of Ibuprofen gel prepared using carbopol. Prepare of asprin granules by roll compaction & direct compression to tablets. 11.PHARM PHARMACEUTICS – IV (PRACTICALS) Minimum 100 Hrs/Yr. 12. 14. Preparation of sustained release granules with polymer coating eg.

Lieberman & J. Controlled drug delivery fundamentals and applications. Mack publishing company.W. Kanig Lea. K ed. A. Mumbai-1987. H. 3 rd edition. Verghese Publishing house. 5.L. 2. Marcel Dekker Publication. Microencapulation of drug using orifice method.. I & II. ‘Novel drug delivery systems’.. Ka. Pennsylvania. Pharmacokinetic studies after oral administration of a sulpha drug using rabbit as a model. 3.A.Gennard. 1999. ‘Advances in controlled and Novel drug delivery’. Marcel Dekker Inc. 4. Vol.V.. 1. and 22. Chien Y. 3 rd ed. 17. Preparation of quality control charts and validation and documentation of liquidfilling operation. Lee V.A. 1987. eg. 1996.T.U.H. 101 | P a g e .. RECOMMENDED BOOKS : Latest editions of the following books. Banker G S. CBS publisher. Robinson. Microencapulation of drugs by phase separation coacervation induced by complexation (eg) Activated charcoal by gelatin and gum Acacia. Lachman. Determination of pharmacokinetic parameteres like t max . ‘Theory and Practice of Industrial Pharmacy’. 19 th edition. L.. ‘Modern Pharmaceutics’.S. 7. Rhoder C.H.. c max . AUC after oral or Intra venous administration.R. Ansel HC. Calcium carbonate by Polyvinyl alcohol and non solvent Acetone. Demonstration of machines available for pilot plant studies. ‘Pharmaceutical Dosage forms and Drug Delivery Systems’. Ke.. 21. Willig S. Publication. Effect of accelerated humidity conditions on Aspirin tablets. 16. – ‘Good Manufacturing Practices for Pharmaceuticals’ Marcel Dekker Inc. Publication. 6. Microencapulation of drugs by inducing phase separation coaceration using non solvent (eg) ferrous fumarate by Polyvinyl alcohol and Acetone. 1995. 20. Ltd. popwich NG. Allen L. 23. Marcel Dekker Publication.15. New Delhi. Accelerated stability studies on Aspirin solution. B I W averby Pvt. 18. 8. Remington: ‘The science and Practice of Pharmacy’. 1992. 19. Jain N.