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DEPARTMENT OF CHEMISTRY NORTH-EASTERN HILL UNIVERSITY SHILLONG – 793022

M. Sc. CHEMISTRY SYLLABUS CHOICE-BASED CREDIT SYSTEM
(APPROVED SYLLABUS: JUNE 2008)

First Semester

Che C 101
INORGANIC CHEMISTRY - I

Credits: 4

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Unit 1 Symmetry and Structure Symmetry elements and operations; equivalent symmetry elements and equivalent atoms; symmetry point groups with examples from inorganic compounds; groups of very high symmetry; molecular dissymmetry and optical activity; systematic procedure for symmetry classification of molecules and illustrative examples; molecular symmetry for compounds having co-ordination numbers 2 to 9. Unit 2 (a) Stereochemistry and Bonding: LCAO-MO theory for homonuclear and heteronuclear diatomic molecules; orbital symmetry and overlap; Walsh diagrams; electronegativity (Pauling, Mulliken and Allred-Rochow methods); group electronegativity and polarity of bonds; review of VSEPR model and the use of outer d-orbitals (b) Metal-Ligand Equillibria in Solution: Stepwise and overall formation constants; trends in stepwise formation constants; determination of binary formation constant by spectrophotometry; factors affecting stability of metal complexes and chelate effect. Unit 3 Magnetic Properties & Electronic Structure of Transition Metal Complexes Brief review of different types of magnetic behaviour, spin-orbit coupling, quenching of orbital angular momenta, temperature-independent paramagnetism, measurement of magnetic susceptibility using Gouy and Faraday methods, Term symbols for metal ions; Crystal field theory and its application to explain magnetic properties of coordination compounds, spin crossover; Structural effects: ionic radii and Jahn-Teller effect; octahedral vs. tetrahedral coordination, magnetic properties of Lanthanides and Actinides and splitting of f-orbitals in octahedral field. Unit 4 Electronic Structure of Transition Metal Complexes Electronic absorption spectra of octahedral and tetrahedral complexes, Orgel diagrams, TanabeSugano diagrams, calculation of Dq, B and ß values, selection rules, band intensities and band widths, spectra of high-spin octahedral and tetrahedral complexes of d1 to d9 systems, Spectrochemical series; Adjusted crystal field theory, Nephelauxetic series, molecular orbital theory of complexes (qualitative principles involved in complexes with and without πbonding), MO diagrams for octahedral and tetrahedral complexes and charge-transfer spectra, optical properties of Lanthanides and Actinides. Unit 5 Organometallic Chemistry Synthesis, structure, bonding and reactivity of transition metal complexes with olefins, cyclopentadienyl, cyclopentadienide, benzenoid, π-allyl and enyl systems; Transition metal-carbon σ-bond: metal-alkyls, metal-carbenes, metal-carbynes. Text Books 1. J. E. Huheey, E. A. Keiter, R. L. Keiter & O. K. Medhi. Principles of Structure and Reactivity (1st impression), Pearson Education (2006). 2. F. A. Cotton. Chemical Applications of Group Theory, (3rd edn.), John Wiley & Sons (1999).

Reference Books 1. P. Atkins, T. Overton, J. Rourke, M. Weller & F. Armstrong, Inorganic Chemistry, Oxford University Press (2006).

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Shriver and Atkins

2. N. N. Greenwood & A. Earnshaw. Chemistry of the Elements, Pergamon Press (1984). 3. F. Basolo & R. G. Pearson, Mechanism of Inorganic Reactions, Wiley Eastern (1967). 4. F. A. Cotton, G. Wilkinson, C. A. Murillo & M. Bochmann. Advanced Inorganic Chemistry (6th edition), John Wiley (1999). 5 S. F. A. Kettle, Physical Inorganic Chemistry, Spectrum (1996). 6. B. Douglas, D. McDaniel and J. Alexander. Concepts and Models of Inorganic Chemistry (3rd edn.), John Wiley & Sons (1994).

alkylation. fullerenes. amines and hydrides. Aromatic nucleophilic substitutions. (b) Structure and Reactivity: Linear free energy relationships. Acylation of carbonyl carbon. Mechanism and orientation in pyrolytic elimination. Conjugate addition reactions.and chemoselectivity. Ring expansions. Unit 2 (a) Nucleophilic Substitution Reactions: Nucleophilic substitution at saturated carbon – SN1.3-dithiane reactivity. Unit 3 (a) Elimination Reactions: Mechanism and stereochemistry of different types of elimination reactions. Barton reaction. Asymmetric synthesis (including enzymatic and catalytic nexus). Parameters influencing reaction rates. Effects of substrate structure. Regio. Photo-Fries rearrangement of ethers and anilides. Hydroboration. stereospecificity and stereoselectivity. Synthetic applications of nucleophilic substitution involving alcohols. .S). epoxidation and hydroxylation. HSAB theory. Umpolung effect. Formation of other double bonds (C=N. Aromaticity in benzenoid and non-benzenoid compounds.O. Carboxylic acids and derivatives.and diastereoselective synthesis. cryptates. Addition of halogen polar reagents to alkenes. Orientation and reactivity. thiols. Effects of conformation on reactivity.4 First Semester Che C 102 ORGANIC CHEMISTRY – I Credits: 4 Unit 1 Stereochemistry Configuration nomenclature. Photochemistry of aromatic compounds. Topicity and prostereoisomerism. Carbonyl cyclizations and cleavages. Conformational analysis of acyclic. Neighboring group participation by π and σ bonds. (cont’d…. Racemic modification and optical purity. 1. Applications of acid-base concept. C=O) and triple bonds by elimination reactions. cyclic. decarboxylation reactions. heteroannulenes. Enantio. Hoffmann-Loefller-Freytag reaction. antiaromaticity and homoaromaticity. n-annulenes. σ and ρ parameters. Homologation and dehomologation of carbonyl compounds. attacking base. Nucleophilic addition of hetero-atoms (N. (b) Addition to Carbon-Carbon Multiple Bonds: Mechanistic and stereochemical aspects of addition reactions involving electrophiles. nucleophiles and free radicals. Huckel rule. leaving group and medium. Addition to cyclopropane and carbon-heteroatom multiple bonds. SN2 and related mechanisms. heterocyclic and steroidal systems. Singlet molecular oxygen reactions. Regioselectivity. addition and substitution. (b) Photochemistry: Photochemistry of alkenes and carbonyl compounds. Photooxygenation. Photochemical isomerisation. Anchimeric assistance. Hammett and Taft equations. Axial and planar chirality and helicity. Photo-cleavages. Unit 4 (a) Carbonyl and Related Groups: Reactivity of carbonyl group. di-π-methane rearrangement.

2. Carey & R.Unit 5 Pericyclic Reactions Main features of pericyclic reactions. Conservation of Orbital Symmetry. J. S. Hoffman. Wamser & Harris. [2+2] and [4+2] reactions (hν and ∆). 5 Reference Books 1. Academic Press (1977). (2005). Sommelet-Hauser. 3. Stereochemistry. H. Conformation and Mechanism (3rd edn.). March. Advanced Organic Chemistry... 4. Advanced Organic Chemistry: Reactions. John Wiley & Sons (1976). E. Verlag-Chemie/ Academic Press (1970). J. Ltd. 3rd edn. B Woodward & R. thio-Claisen. John Wiley (1995). 3. Mechanisms and Structure (4th edn.). S.3-dipolar cycloadditions and chelotropic reactions. Organic Chemistry (5th edn. Fleming. 2. L. Cycloadditions – antarafacial and suprafacial additions. I. Depuy & O. R. Pine. F. Claisen. Fundamentals of Organic Reaction Mechanisms. Pericyclic Reactions. Frontier Orbital Theory and Organic Reactions. . A. Electrocyclic reactions – conrotatory and disrotatory motions for 4n and 4n+2 systems. Prentice-Hall of India (1975). 4. Part A and B. Sigmatropic [i. Woodward-Hoffman rules. Marchand & R. Text Books 1. Chapman. Kalsi. John Wiley (1990). correlation diagram and FMO approaches. Molecular Reactions and Photochemistry. A. Lehr. P. Sanburg.). 1. McGraw-Hill Bool (1987).j] shifts of C-H and C-C bonds. (1990). P. Wiley Student Edition. Cope and aza-Cope rearrangements. 5. C. John Wiley & Sons Asia Pte.

properties of wave functions. Solid State Chemistry and its Applications. Jander’s rate equation. P. D. 3. Viva Books Pvt Ltd (2003) A. Atkins. N. 1. valence bond (VB) and molecular orbital (MO) theory for diatomic molecules – hydrogen molecule ion. postulates. Wetting: Young-Dupre equation. Precursors to solid state reactions. Unit 5 Solid State Chemistry-I Solid State Reactions: Types. hydrophobic interaction. antisymmetry principle and many-electron wave finctions. Wagner’s diffusion theory of reaction. aggregation/micellization of surfactants. step potential and tunneling. thermodynamics of micellization: phase separation and mass action models. Chakraborty. Quantum Chemistry. excited states of H2 – singlet and triplet. Coulson’s Valence. 4. Levine. thermodynamics of Schottky and Frenkel defect formation. Tata McGraw Hill (1994). Hellmann-Feynmann theorem. John Wiley (1998). Chandra. Kinetic model: Reaction in powder compact. . B. Linear and non-linear variations method. N. Micelles: Theoretical and Applied Aspects. Solid State Chemistry. Factors influencing the reactivity of solids. Kirkendall effect. hydrogen molecule. D. Crystal Defects: Types of defects. nucleation. Huttig’s mechanism. Surfactants. hydrogen atom. uncertainty principle. New Deldi (1996). Huckel MO treatment for simple and conjugated polyenes. Adsorption on solids: Langmuir isotherm. Hannay. factors affecting the cmc. Unit 3 Chemical Binding Born-Oppenheimer approximation. classification of surfactants. Pressure across an interface: Laplace equation. A. parabolic rate law. critical micelle concentration (cmc). Material transport in solid state reaction—counter diffusion. Kelvin equation. energy eigenvalue equation. McQuarrie. applications (He atom and other simple systems). Introductory Quantum Chemistry. Y. Oxford University Press (1986) 2. 4. Text Books I. BET isotherm. equation of motion and constant of motion. A. Molecular Quantum Mechanics.First Semester Che C 103 PHYSICAL CHEMISTRY – I Credits: 4 6 Unit 1 General Principles of Quantum Mechanics Introduction. Reference Books 1. Tammann and Hedvall mechanism. Unit 2 Application to Simple Systems and Approximation Methods Exactly solvable problems: Particle in a box. West. 5. R. 3. McWeeny. K. R. operators and related theorems. New Age International. Adsorption in liquid systems: Gibbs adsorption isotherm. hybridization. Plenum (1992). Quantum Chemistry. Prentice Hall India (2001). Schrodinger equation. 2. Kroger-Vink notation for crystal defects Atomic theory of diffusion—self diffusion mechanism. rigid rotator. Solid State. Unit 4 Adsorption and Aggregation Surface tension and surface free energy. K. Moroi. Prentice-Hall (1979). ELBS (1979). non-crossing rule and correlation diagram. harmonic oscillator. W. sintering.

). Preparation of dyes i. R. piperine. Condensation reaction h.E. Wiley-Eastern (1994). Fitton & R. carotenoids. G. Systematic Identification of Organic Compounds (5th edn. Practical Heterocyclic Chemistry 2. b) Purification of tertiary mixtures of amino acids by Paper Chromatography. Shriner & R.L. 2. 3. chromic acid. 3. Organic Preparations: At least eight preparations (involving two or more than two steps) involving the following representative reactionsa. caffeine. rosine. Fuson. Practical Organic Chemistry (3rd edn. nicotine. Heterocyclic synthesis 4. Longman Group Ltd. a) Purification of binary mixtures by Thin Layer Chromatography (TLC) and Column chromatography (CC). Extraction of Natural Products: Any one of the following – solasodine. Nucleophilic substitution e. Laboratory Manual of Organic Chemistry (3rd edn. Purification Techniques of organic compounds and their spectroscopic identifications. R. East-West Press (1977). Qualitative Analysis of Binary Mixtures (only two) Text Books 1. . I. R. A. Smallery. Mn(Vll) c. Cycloaddition reaction f. K. Reference Books 1. Vogel. Grignard reaction g. O. John Wiley & Sons (1964).). Hydride reduction or hydrogenation d. Bansal.7 First Semester Che C 104 LABORATORY COURSE – I (ORGANIC CHEMISTRY) Credits: 6 1. (1973). A. Brewster & W. Mcwedn.). Esterification and saponification b. Aromatic electrophilic substitution j. K. C. 2. Oxidation (peracid. Unitized Experimental Organic Chemistry (4th edn.).

Wilkinson. Murillo & M. Inorganic Chemistry: A Modern Approach. J. A. supramolecular host-guest compounds. Bochmann. hydroformylation. Steed & J. Medhi. John Wiley (1999). O2. Shriver and Atkins Inorganic Chemistry.II Credits: 2 Unit 1 Homogeneous Catalysis Coordinative unsaturation. N2 and tertiary phosphine and arsine ligands. metal carbonyl hydrides and metal carbonyl clusters: LNCC and HNCC. Supramolecular chemistry: Definition. Supramolecular Chemistry. Structure and Reactivity (1st impression). nature of suparmolecular interactions. Unit 3 Kinetics and Mechanism of Inorganic Reactions Labile and inert complexes. E. Reference Books 1. insertion reactions. ligand displacement reactions in square planar and octahedral complexes. L. isomerisation and racemisation of tris-chelate complexes. hydrosilylation and polymerization. Moeller. John Wiley (1982). Cotton.). T. oxidative addition reactions. F. synthesis and reactivity of transition metal complexes with CO. 3. J. macrocyclic effect. electron transfer reactions. Catalytic reactions of alkenes: isomerization. Overton. Armstrong. J. A. Wade’s rule and the capping rule. W. stereochemical nonrigidity and fluxional molecules. E. hydrogenation. M. mechanisms of ligand-replacement reactions. NO. T. Principles. C. P. K. 2. Pearson Education (2006). John Wiley (2002). Atkins. Keiter. Reactions of coordinated ligand and activation of small molecules by complexation.A. Oxford University Press (2006). Keiter & O. 2. G. Huheey. Weller & F. Unit 2 Transition Metal π-acid Complexes and Supramolecular Chemistry Bonding. L.8 Second Semester Che C 201 INORGANIC CHEMISTRY . the trans effect. Rourke. . Advanced Inorganic Chemistry (6th edn. Text Books 1. R. Atwood.

Aggarwal. Carbenoids.9 Second Semester Che C 202 ORGANIC CHEMISTRY – II Credits: 2 Unit 1 Reductive Reactions (a) Catalytic hydrogenation: Scope and mechanisms for heterogeneous catalytic hydrogenation of alkenes and other functional groups. (2005). Reduction selectivity. (c) Metal hydride reductions: Scope. Cyclopropanation – spin dependence and stereochemistry. L. Acyloin condensation and related reactions. Advanced Organic Chemistry: Reactions. Catalyst poisoning and desulphurization. Rees. Nelson. oxidation of organic substrates with mercuric acetate and SeO2. March. Carbene insertion to C-H bonds. Metal-induced radical reactions. MPV reduction. K. 2. Aromatic substitution by radicals. Narosa Publishing House. Unit 2 Oxidation Reactions (a) Cr and Mn Oxidations: Oxidation of alcohols & aldehydes with Cr(VI) & Mn(VII) oxidants. Homogeneous catalytic hydrogenation with Wilkinson catalyst. J. 3. Modern Synthetic Reactions. Ahluwalia & R. structure and spin states of nitrenes. Benjamin (1972). (c) Free Radicals: Stability and fate of organic free radicals. (b) Dissolving metal reductions: Scope and basic mechanisms. Unit 3 Reactive Intermediates (a) Carbenes: Stability. House. W. H. Uses of PCC. A. stereo-selectivity and synthetic utility of alkyl boranes. Alkene double bond isomerisation. Rearrangement of acylnitrenes (Hoffmann. Wiley Student Edition. structure and spin states of carbenes. Allylic bromination by NBS and decarboxylative bromination. regioselectivity. stereochemistry and mechanism of metal hydride reductions of carbonyl compounds. Oppenauer oxidation. Mechanism of wellknown radical reactions. Curtius and Schmidt reactions with applications in organic synthesis). C-H bond insertions and aziridine formation. Mechanisms and Structure (4th edn. Wolff rearrangement of acylcarbenes and its synthetic applications. Prevost and Woodward hydroxylation of alkenes. John Wiley & Sons Asia Pte. Rearrangement to alkenes. T. Organic Synthesis: Special Techniques. Use of hydroboration in reduction. Nitrenoids. azo and oxime groups. Nitrenes and Arynes. LTA. Ltd. ptosylhydrazine. periodates. Reduction of other functional groups like nitro. Use of hydrazine with other reducing agents on conjugated systems. (c) Other methods of oxidation: DMSO and Swern oxidations. diimide and semicarbazide. 4. V. Radical cyclisation and coupling reactions. Addition to multiple bonds. O. Carbenes. Liquid ammonia reduction with alkali metals. New Delhi (2001). nitroso. oxidation and carbonylation. Gilchrist & C. Birch reduction of arenes.). London (1969). W. Oxidative cleavage of C-C single and double bonds. . (b) Nitrenes: Stability. Oxidation of C=C and C-H bonds. Textbooks 1. (b) Peroxy Oxidations: Alkene epoxidation by peracids and metal/alkyl hydroperoxides. (d) Reduction with hydrazine & derivatives: Reduction of carbonyl group with hydrazine. PDC and Collin’s reagent.

resonance phenomenon. spin densities and McConnell relationship. D. AB and AX cases). spin-spin interactions. hyperfine coupling. Photoelectron Spectroscopy: Basic principles. Franck-Condon principle. X-ray photoelectron spectroscopy (ESCA).R branches. NMR line shapes and saturation. photoelectron spectra of simple molecules. n→π* transition. Spectra of organic compounds. 19F. 1994. Simon –Physical Chemistry. VIVA Students Ed. Electron Spin Resonance: Basic principles. effect of anharmonicity.10 Second Semester Che C 203 PHYSICAL CHEMISTRY – II Credits: 2 Unit 1 Microwave. spectra of a two-spin system ( A2. examples of simple laser systems. Zero field splitting. Infrared and Raman Spectroscopy Introduction: Interaction of light with matter. rotational spectra of diatomics and polyatomics. Banwell and E. mechanism of absorption & emission of radiation. Microwave spectroscopy: Classification of molecules. Lasers: Laser action. Unit 2 Electronic Spectroscopy Electronic spectroscopy: Electronic spectra of diatomic molecules. 13C. π→π*. P. shielding and de-shielding of magnetic nuclei. and 31P NMR spectroscopy. Unit 3 Magnetic Resonance Spectroscopy Nuclear Magnetic Resonance: Nuclear spin and nuclear spin states in magnetic field. Graybeat.Q. overtones. hot bands. Raman spectroscopy: Origin. rotational and vibrational Raman spectra of diatomics. McGraw-Hill International Edition (1988). normal modes of vibration. Auger electron spectroscopy. .D. properties of laser radiation. Fundamentals of Molecular Spectroscopy. McQuarrie and J. 2. McCash.. J. Vibronic transitions. C. chemical shift. population inversion. Tata McGraw-Hill. New Delhi. (2003) Reference Books 1. M. effect of isotopic substitution and nonrigidity. A. Text Books 1. N. Vibration-rotational spectra of diatomics. rigid rotor model. relaxation processes. Vibrational spectroscopy: Vibrational spectra of diatomics. 4th edn. selection rules and intensity distribution. D. Morse potential. factors affecting g values. Molecular Spectroscopy.

L. Quantitative estimation involving volumetric (redox and complexometry). D. Practical Inorganic Chemistry (2nd edn. Chapman & Hill (1974) Reference Books 1. East-West Press (1974). 3. 5. 2. 3. Rockett. G. 11. J. H. Denney. 15. Parshall (Ed.11 Second Semester Che C 204 LABORATORY COURSE – II (INORGANIC CHEMISTRY) Credits: 6 1.). Merrit & J. English Language Book Society (1978). . Inorganic Synthesis. J. 7. 2. Vol. Basset.H. Characterization includes microanalysis. McGraw Hill. C. 6. 2. Instrumental Methods of Analysis (4th edn. 9. J. Pass & H. 4. G. magnetic susceptibility and conductance measurements and infrared. gravimetric and spectrophotometiric methods of constituents in three component mixtures and alloys 2. R. Reinecke salt Tris(oxalate) manganese(III) Tetrapyridinesilver(II)peroxidisulphate Tris(acetylacetonato) iron(III) Bis(N. Peterson Education (2000). Preparation and Characterization of the following compounds (at least 8 preparations are to be completed by turn): 1. Dean. Barnes & M. Van Nostrand (1972). Willard.2’-bipyridine)ruthenium(II) perchlorate [(p-(cymene)RuCl2]2 Tri(acetylacetonato)manganese(III) 3.N-diethyldithiocarbamato)nitrosyliron(I) Optical isomers of tris(ethylenediamine)cobalt(III)chloride Linkage isomers of nitro and nitritopentamminecobalt(III) chloride Ferrocene or dibenzene chromium Hydridochlorocarbonyl tris(triphenylphosphine)ruthenium(II) Tris(2. Practical Inorganic Chemistry. Danney. in Chief). Vogel’s Textbook of Quantitative Chemical Analysis. A. UV-Visible. G. 3.).). Mendham. W. Marr & B. 48 (1974). L. Mendham. p. C. 10. H. Sutcliffe. Thomas. G. 8. W. Jeffery & J. NMR spectroscopy and cyclic voltammetry studies Text Books 1. Vogel’s Text Book of Quantitative Analysis (4th edn. 12. R.

NMR. NO. EPR and Mossbauer Spectroscopy in Inorganic Chemistry. . McCash. New York (1990). K. O2.). OH−. isomer shift. John Wiley (1997). data reduction. Tata McGrawHill. C. CN−. planes and indices. Drago. Physical Methods in Chemistry. SO42−. M. Saunders College Publishers (1977). V. point groups. Fundamentals of Molecular Spectroscopy. Crystal growing. R. (5th edn. NQR. X-ray diffraction and Bragg’s law. 2 R. Symmetry elements: isogonal symmetry groups and reciprocal lattice. SCN−. Nakamoto. Infrared and Raman Spectra of Inorganic and Coordination Compounds. stereographic projection of 32 point groups and space groups. Nuclear magnetic resonance spectroscopy: Applications of 31P. Unit 2 (a) X-ray Crystallography: Lattices. New Delhi (2006). Banwell & E. Reference Books 1. evaluation of g values and metal hyperfine coupling constants. 2. applications to iron and tin compounds. refinement and structure solution of some compounds (b)Mossbauer Spectroscopy: Principles. 19F. 119Sn and 195Pt NMR spectroscopy in the structural assessment of inorganic compounds. N. Data collection. Ellis Horwood.NH3. Crystal systems and symmetry. S. Parish. (b) Magnetic Resonance Spectroscopy Electron spin resonance spectroscopy: ESR of d1 and d9 transition metal ions in cubic and tetragonal ligand fields. quadrupole effect of magnetic field. Text Books 1. PR3 and halides.12 Third Semester Che C 301 INORGANIC CHEMISTRY–III Credits: 2 Unit 1 (a) Infrared and Raman Spectroscopy: Structural studies (involving IR and Raman spectroscopy) of coordination compounds containing the following molecules/ions and ligands . H2O.

D Williams & I. alcohols. alkynes. New Delhi (2006). alkynes. Fleming. N. NMR and Mass spectroscopy for structure elucidation of organic compounds. Textbooks 1. Fourier transform technique and nuclear Overhauser effect (NOE). M. SH). (b) C-13 NMR Spectroscopy: Chemical shift (aliphatic. enols. nuclear magnetic double resonance. McGraw Hill (1989). two-dimensional NMR spectroscopy. G. carboxylic acids. extension to various organic molecules for structural assignment. McMillan Press Ltd. aldehydic and aromatic). (b) Mass Spectroscopy: Mass spectral fragmentation of organic compounds. lactams. NOESY. . carbonyl carbon). Karplus curve. (1991). Tata McGrawHill. Spectroscopic Identification of Organic Compounds. John Wiley (1981). aromatic compounds.). olefinic. conjugated carbonyl compounds). amides. phenols. alkenes. Banwell & E. Silverstein. aldehydes. Organic Spectroscopy (3rd edn. effect of deuteration. Protons bonded to other nuclei (alcohols. amines. Effects of H-bonding and solvent effect on vibrational frequency. esters. complex spin-spin interaction between two.13 Third Semester Che C 302 ORGANIC CHEMISTRY – III Credits: 2 Unit 1 (a) Infrared Spectroscopy: Characteristic vibrational frequencies of alkanes. acid anydrides. simplification of complex spectra using shift reagents. 2. Fundamentals of Molecular Spectroscopy. four and interacting nuclei (first order spectra). molecular peak. ethers. aromatic. amines. variation of coupling constant with dihedral angle. Basseler & T. Chemical exchange. DEPT and INEPT terminologies. C. hetero-aromatic. Detailed study of vibrational frequencies of carbonyl compounds (ketones. virtual coupling. common functional groups. R. Coupling constants. C. stereochemically hindered rotation. Unit 2 (a) Nuclear Magnetic Resonance Spectroscopy: Approximate chemical shift values of various chemically non-equivalent protons and correlation to protons bonded to carbon (aliphatic. olefinic. McLafferty rearrangements. Morill. three. Complex interaction. Spectroscopic Methods in Organic Chemistry. phenols. References 1. lactones. McCash. 3. W. amides. M. (c) Applications of IR. Kemp. C. examples of mass spectral fragmentation of organic compounds with respect to their structure determination.

Onsager reciprocity relation. Entropy production in open systems. the relation between fugacity and pressure. 2. Kalidas and M. W. Unit 2 Statistical Thermodynamics Different types of ensembles. Introduction to Thermodynamics of Irreversible Processes. Stationary non-equilibrium states states of minimum entropy production. Text Books 1. Physical Chemistry (8th edn. Prigogine. vibrational partition function. partial molar volume and its determination. Thermodynamics of open systems. Sanganarayana. A. Interscience (1960). thermodynamics of mixing. Phenomenological equations. Application of statistical thermodynamics: equipartition theorem.).. Atkins & J. chemical reactions. Rate of entropy production – generalized forces and fluxes. reference state of zero energy for evaluating partition function. New Delhi (2003) 3. OUP (2006). electronic partition function. rotational partition function for linear and non-linear molecules. Activity and activity coefficients. partition function and thermodynamic parameters. Definition of fugacity. Statistical Mechanics. electrochemical reactions) and entropy flow. Introduction to quantum statistics: Distribution law for fermions (Fermi-Dirac statistics) and for bosons (Bose-Einstein statistics). Viva Books Pvt. distribution law (Boltzmann statistics). de Paula. V. equilibrium constant in terms of partition function. Chemical potential.14 Third Semester Che C 303 PHYSICAL CHEMISTRY – III Credits: 2 Unit 1 Chemical Thermodynamics Introduction. McQuarrie. Macmillan India (2002). standard state of real gases. entropy production (heat flow. C. I. Partial molar quantities. Non-Equilibrium Thermodynamics – Principles and Applications. P. . Reference Books 1. relation between molecular and molar partition functions. translational partition function. Unit 3 Non-Equilibrium Thermodynamics Entropy of irreversible processes – Clausius inequality. Electrokinetic phenomena. Ltd. D. ensemble averaging. heat capacity behaviour of crystals.

conductometrically. D. Determination of strength of strong and weak acids in a mixture. 4. Garland & J. rate constant and energy of activation for saponification of an ester by NaOH. 12. potentiometrically. Determination of partial molar volume of a solute in solution. Nibler. McGraw Hill (1989) 2. 14. To study the kinetics of iodination of acetone. Mathur. . Determination of pH of buffer solutions and hence to calculate the E0 of quinhydrone electrode. Determination of specific rotation of sucrose and rate constant of its hydrolysis using a polarimeter. 7. conductometrically.15 Third Semester Che C 304 LABORATORY COURSE – III (PHYSICAL CHEMISTRY) Credits: 6 Students are to perform twelve experiments from the following list: 1. 13. Experiments in Physical Chemistry (5th edn. Determination of stoichiometry and formation constant of silver-ammonia complex. Textbooks 1. Athawala & P. Determination of critical micellar concentration (CMC) of sodium lauryl sulphate from the measurement of conductivities at different concentrations.10–Phenanthroline. P. Spectrophotometric determination of pKa of an indicator in micellar and microemulsion media. To study the complex formation between Ni Ions and 1. Publishers (2001). 16. V. 6. Determination of strengths of halides in a mixture. Determination of order of reaction. C. 9. W. Determination of the stability constant of the complex formed between Cu(II) ions and 5sulphosalicylic acid between pH 3-5 by colorimetric method and hence to calculate the free energy of formation of the complex. Application of particle in a box model 10. 3. W. 17. Absorption spectra of conjugated dyes. 2.) conductometrically and verification of Debye-Huckel theory. Determination of solubility product of a sparingly soluble salt (PbSO4. New Age International. 5. potentiometrically. Shoemaker. To study the kinetics of a second order reaction (saponification of ethyl acetate). 15. Determination of coordination number of Cu2+ in copper-ammonia complex by partition method. Determination of the acidic and basic dissociation constants of an amino acid and hence its isoelectric point. 18. Experimental Physical Chemistry. spectrophotometrically. D.). 8. 11. Verification of Beer-Lambert’s law and determination of pKa of an indicator. BaSO4 etc.

H. Plenum Press (1990). G. Photochemical reactions: substitution and redox reactions of Cr(III). 4. Thin films: Chemical vapor deposition and Atomic layer deposition techniques. Photochemistry and Photophysics of Metal Complexes. New Age International (2000). non-stoichiometric oxides: zeolites and clay. Applications of nanoparticles. Mehrotra & A.IV Credits: 4 Unit 1 Bioinorganic Chemistry of Alkali and Alkaline Earth Metals Essential and trace elements in biological systems. Singh. ATP and ADP. Unit 4 Nanomaterials General introduction to nanomaterials and emergence of nanotechnology. John Wiley (1988) 3. polymorphism of carbon.). mechanism of ion transport across membranes. quadrupole bonds and onedimensional solids. 2 F. Macmillan (1968). Stout & L. C. M. A.Zhong Cao. rhodium. major structural types. DTA and DSC). Fensen. isopolyacids and hetero-polyacids. Metal-metal multiple bonds. Heme proteins: hemoglobin. silicones. phosphorus and sulphur. Synthesis of nanoparticle semiconductors. Roundhill. X-ray Structure Determination: A Practical Guide. blood clotting mechanism and biological calcification.). carboranes. Unit 5 Selected Topics Synthesis. phosphazenes and S. properties and structures of boranes. structure and functions of biological membranes. Carbon fullerenes and nanotubes. and silver. Advanced Inorganic Chemistry (5th edn. nanowires and nanorods. sodium pump. Cotton & G. Wilkinson. Techniques of synthesis: electroplating and electrophoretic deposition. chemical actinometry and photochromism. role of calcium in muscle contraction. ligand field states. Imperial College Press (2004). Nitrogen fixation and nitrogenases Unit 3 Photochemistry of Metal Complexes and Metal–Metal Multiple Bonds Excited states. . Unit 2 Bioinorganic Chemistrry of Iron and Copper Iron-sulphur proteins: rubredoxin and ferredoxins. G. Nanostructures and Nanomaterials: Synthesis. ionophores: valinomycin and crown ether complexes of Na+ and K+. photosynthesis: chlorophyll a. charge-transfer states and Thexi states. H.N compounds. Ru(II) and Ru(III) complexes. Organometallic Chemistry: A Unified Approach (2nd edn. synthesis of nanoparticles of gold. D. Moore’s law. PS I and PS II. 5. thermal methods of analysis (TGA. Text Books 1.16 Fourth Semester Che C 401 INORGANIC CHEMISTRY . Metalloporphyrins. platinum. palladium. Non-heme proteins: hemerythrin and hemocyanin. myoglobin and cytochrome c. Phosphoresence and fluorescence. conversion through chemical reactions and lithography. Applications: synthesis and catalysis. Properties and Applications. R.

. 3. P. Adamgon. Ratner & D. M. . W. 4. 1. Concepts of Inorganic Photochemistry. John Wiley & Sons (1975). Adamson & P. D. C. W. J. Editor-in-Chief G. Oxford University Press (2006). Vol. Weller & F. Pearson Education (2003). Wilkinson (1985). Nanotechnology: A Gentle Introduction to the Next Big Idea. Atkins. Armstrong. Shriver and Atkins Inorganic Chemistry. A. 2. Overton. T. Ratner.. Rourke.17 Reference Books 1. Fleischauer. M. Cutal & A.Comprehensive Coordination Chemistry.

Textbooks 1. Nucleophilic and electrophilic substitutions. W. II. 4. isothiazole and isoxazole. (b) Bicyclic Heterocycles: Synthesis of quinolines. L. Modern Heterocyclic Chemistry. reserpine. Benjamin (1968). Nucleophilic. Organic Chemistry. Pergamon Press (1984). (b) Biological Heterocycles: Chemical and biological properties and total synthesis of thiamine. thiazoles & oxazoles. phenothiazines. Benzofused analogues. Vols. Kalyani Publishers (1983). Addition reactions. Indole rings in biology. W. (b) Small Ring Heterocycles: Syntheses of aziranes. Merrifield peptide synthesis.Fourth Semester Che C 402 ORGANIC CHEMISTRY – IV Credits: 4 18 Unit 1 (a) Introduction: Hantzsch-Widman nomenclature for monocyclic. fused and bridged heterocycles. 3. Synthesis of pyridazines. A. polypeptides. acridines. ELBS (1986). General approaches to heterocyclic synthesis. Vol. Unit 3 (a) Diazines: Structural & chemical properties. secondary. Gilchrist. primary. Basicity and aromaticity of heterocycles. 2. Paquette. Structure and function of mRNA. phenanthrene alkaloids. R. Natural and synthetic metalloporphyrins. electrophilic and radical substitutions. classification of proteins on basis of structure and biological function. Synthesis & reactions of azetidines. oxepines. Ring cleavages. (c)Seven-membered Rings: Synthesis & reactions of azepines. Heterocyclic Chemistry. L. L. tRNA and rRNA. DNA replication and heredity. Substitution reactions. Comprehensive Heterocyclic Chemistry. pyrimidines. (b) Proteins: Acid-base properties of amino acids. lysergic acid. . tertiary and quaternary protein structures. Lehninger. L. Aliphatic and aromatic heterocycles. pyrazines. nicotine. Unit 5 (a)Nucleic Acids: Primary. Finar. A. thiepines & diazepines Unit 4 (a)Porphyrins: Classification and synthesis of porphin rings. Unit 2 (a) Azoles: Structural and chemical properties. Katritzky & C. isoquinolines. A. oxiranes & thiiranes. 1-7. (b) Condensed Five-membered Rings (1 Heteroatom): Synthesis of indole. I. T. A. Synthesis of pyrazole. oxetanes & thietanes. Ring openings and heteroatom extrusion. benzofuran and benzo-thiophene. secondary and tertiary structure of DNA. papaverine. nucleic acids bases. Rees. benzofused diazines. Nucleophilic and electrophilic substitutions. Longman (1989). Strain. carbazoles and pteridines. importance in biology. Synthesis of imidazoles. Reference Book 1. Biochemistry.

intrinsic and extrinsic semiconductors. R. Helmholtz-Perrin model. Solid State Chemistry and its Applications. J. kinetics of surface catalyzed unimolecular & bimolecular reactions. isolation. activity coefficients and mean ionic activity coefficients. Electronic structure of solids—band theory. Reference Book 1. . Metals. Thermodynamic formulation of rate constant: effect of pressure & ionic strength. half-life and differential methods. parallel. Applications in ammonia synthesis and oxidation of carbon-monoxide. organic metals Textbooks 1. polarizable and nonpolarizable interfaces. Experimental verification: Flow.). Seakins. Electrodics: The basic electrodic equation: Butler–Volmer equation. interstitial and subtractional solid solutions & distortions. Linearized Poisson–Boltzmann equation. overpotential. expression of mean ionic activity coefficients in terms of ionic strength. M. Modern Electrochemistry. Reaction Kinetics. Unit 2 Reaction Kinetics-II Theory of reaction rates. stopped–flow. Collision theory. Reddy. electrical double layer. Born model. Temperature effect on reaction rates. Plenum. New York (1970). Activated complex theory. O’M Bockris and A. Reactions in solutions: Diffusion controlled & activation controlled reactions.Fourth Semester Che C 403 PHYSICAL CHEMISTRY – IV Credits: 4 19 Unit 1 Reaction Kinetics-I Determination of rate laws: Integral. Chemical Kinetics (4th Edn. Superconductors—Meissner effect. K. Relaxation and NMR techniques. Kinetic equations for complex reactions: Chain. K. West. Unit 4 Electrochemistry-II Ion–ion Interaction: Debye-Huckel theory of ion-ion interaction. ion–cloud and chemical potential change. BCS theory. W. Unit 3 Electrochemistry-I Ion-solvent interaction: free energy change due to ion-solvent interactions. A. NP (1995). 2. Rate constant for simple bimolecular reactions. opposing and consecutive reactions. N. Gouy-Chapman diffuse charge model and Stern model. J. Reaction in surfaces: Langmuir adsorption isotherm. Pilling and P. Laidler. Pearson Eductions (2007). insulators and semiconductors. J. Unit 5 Solid State Chemistry-II Solid Solutions: Substitutional. 3. comparison of different techniques. Electrically conducting organic solids: Organic charge-transfer complexes. p-n junction. Enzyme catalysis. John Wiley (1990).

4. S. isosterism. metabolism and elimination. 5. SAR and mode of action of penicillins. John Wiley (1998). bio-isosterism. Introduction to Medicinal Chemistry (3rd edn. Synthesis of penicillin G. Significance of drug meta-bolism in medicinal chemistry. Dimmock. D. steric. Burger. Lednicer. quantitative structure-activity relationship (QSAR). Graham & Patrick. partition coefficient. Vol-1. M. Pharmacological Basis of Therapeutics. S. 3. synthesis.20 Second Semester Che O 201 MEDICINAL CHEMISTRY-I Credits: 2 Unit 1 Introduction Concept of drug. Shelton and surface activity parameters and redox potentials. McGraw-HilI (2005). Factors affecting modes of drug administration. antibiotics inhibiting protein synthesis. electronic ionization constants. SAR and mode of action of following antibiotics: streptomycin. Wolff. R. ampicillin. structure elucidation. Unit 2 Antibiotics Cell wall biosynthesis. absorption. spatial considerations. John Wiley (1994). Goodman & Gilman. induced fit theory Concept of drug receptors – elementary treatment of drug-receptor interactions. OUP (2005). inhibitors of β-lactam rings. Physicochemical parameters – lipophilicity. Structureactivity relationship (SAR). Isolation.Introduction to Drug Design. inductive effect. Medicinal Chemistry and Drug Discovery. Pandeya & J. prodrugs and soft drugs.). structure elucidation. synthesis. Factors affecting bioactivity – resonance. Text Books 1. amoxicillin and cephalosporin.(2000). Isolation. E. Theories of drug activity – occupancy theory. penicillin V. rate theory. Strategies for Organic Drug Synthesis and Design. 2. New Age International. Ed. . tetracyclines and chloroamphanicol. lead compound and lead modification.

Ugi reaction. aldol condensation (Zimmerman and Evans models). Direction of aryne bond formation and of nucleophilic addition. Tebbe reagent. Passerini reaction. sodium cyanoborohydride. Pergamon (1991). (d) Arynes: Generation. lithium disopropylamide. Fetizon reagent. Stille coupling. manganese dioxide.Z geometry of enolates. structure and stability of arynes. Chemistry of enolates – E. trimethysilyl iodide. Mitsonobu reaction. alkylation. super hydrides. W. Mosher’s reagent. Prins reaction. 3. Reference Books 1. .21 Second Semester Che O 202 TOPICS IN ORGANIC SYNTHESIS Credits: 2 Unit 1 Reaction.). Nef reaction. Benzyne mechanism for aromatic nucleophilic substitution. Mechanism and Applications (a) Nucleophilic C-C bond formation: Henry reaction. Plenum Press (2007). Some Modern Methods of Organic Synthesis (4th edn. (2001). Mukaiyama reaction. dioxiranes. Advanced Organic Chemistry: Reactions. 2. Carruthers. Carey & R. Cambridge University Press (2004). March. baker’s yeast. Trapping of arynes. Hantzsch reaction. ceric ammonium nitrate. M. Advanced Organic Chemistry Part B. use of Os. Suzuki coupling. Sharpless asymmetric epoxidation and asymmetric dihydroxylation. McGraw-Hill. IBX. B Smith. A. Vilsmeier-Hack reaction. (c) Miscellaneous reactions: Biginelli reaction. Gilman’s reagent. stereoselective enolate reactions. Noyori reaction. 9-BBN. Ring closing metathesis (RCM) . Mechanism and Structure (4th edn. B. Pictet-Sprengler reaction. and Tl reagents and DDQ. (b) Electrophilic C-C bond formation: Nazarov cyclization. Heck reaction. trin-butyltin hydride.Grubb’s reaction. Organic Synthesis (2nd end. J. J. Vols 1-9. Peterson’s synthesis. lipase. dicyclohexylcarbodimide. reactions of allylsilane. kinetic vs thermodynamic control of enolates. Wittig reaction and Horner-WordwothEmmons reaction and their selectivities. Inc.). Sundberg. M Trost & I Fleming. Unit 2 Reagents in Organic Synthesis Use of following reagents/reactions in organic synthesis and functional group transformations: K-selecteride and L-selecteride. Text Books 1. 2. John Wiley & Sons (2005). DessMartin periodinane. reactions of π-allyl palladium complexes. F. McMurry olefination. Comprehensive Organic Synthesis.). Corey-Nicolaou reagent. Rearrangement and cyclo-addition reactions of arynes. Ru.

Numerical integration – interpolation. Computer Oriented Statistical and Numerical Methods. Advanced Engineering Mathematics (5th edn. Asian Books (1998). format specifications. Schaum’s Outline Series. Text Books 1.). 2. E.Cramer’s rule. Balagurusamy. Wiley Eastern Ltd. Programming in Fortran 77 and Numerical Methods. Unit 2 Numerical Analysis Data fitting by least square. Macmillan India Ltd. Mayo & M.22 Second Semester Che O 203 COMPUTER PROGRAMMING IN CHEMISTRY Credits: 2 Unit 1 Introduction to FORTRAN Language and Programming Constants. variables and expressions. A. arrays and subscripted variables. Gauss’s quadrature formula. Norris. E. . 2. C. C. control statements. Simpson’s 1/3 rule. (1988). Programming with FORTRAN 77. E. Reference Books 1. functions and subroutines. (1985). 3. Xavier. Newton–Raphson and iterative methods for solving non-linear equations. New York (1981). Linear simultaneous equations . John Wiley. W. Unit 3 Practicals On-hand practical training with computers on selected chemical problems based on the numerical techniques of Unit 3. nesting of loops. Chiakala. Kreyszig. New Delhi (1995). Computational Chemistry: An Introduction to Numerical Methods. trapezoidal method. input and output statements. Gauss elimination method and GaussSeidel method.

Ph) Unit 3 Syntheses of Cyclopentadienyl and Arene Metal Analogues Synthesis and reactions of cyclopentadienyl metal carbonyls. 5. Text Books 1. Bochmann. synthesis of NaCp. 2. Bochmann. M. η4-diene iron-tricarbonyls in organic synthesis (b) In Catalysis: Asymmetric hydrogenation.). Mehrotra & A. cyclopentadienyl metal halides.23 Second Semester Che O 204 ORGANOMETALLIC CHEMISTRY Credits: 4 Unit 1 Main Group Organometallics Synthesis and reactions of organolithium compounds. John Wiley (2005). Reference Books 1.). Pearson. John Wiley (1996). . 3. Wilkinson. Arylation/vinylation of olefins (Heck reaction). A. Cotton & G. Salzer. F. R. John Wiley (1988). The Organometallic Chemistry of the Transition Metals (4th edn. Me. Organometallics – A Concise Introduction (2nd edn. M. Carbonylation of Colman’s reagent. New Age International (2000). Oxford Chemistry Primers (1994). arene metal carbonyls. 2. cyclopentadienyl metal hydrides. Crabtree. Wacker process (olefin oxidation). Organo Transition Metal Chemistry. Unit 2 Transition Metal–Carbon Bond (a) Transition Metal–Carbon σ-Bond: Brief review of metal alkyl compounds. John Wiley & Sons (1985).). Mathey & A. Organometallic Chemistry: A Unified Approach (2nd edn.). 4. Oxford Chemistry Primers (1994). A. Wiley (1986). η6-arene-chromium tricarbonyl in organic synthesis. synthesis of acetic acid and glycol (Monsanto acetic acid process). Thallium(I) organyls (synthesis of TlCp). Asymmetric epoxidation. C. C. Synthesis and reactions of organomagnesium compounds. F. Organyls of sodium. 4. Organometallics-2 Complexes with Transition Metal–Carbon π-bonds. transition metalcarbene and transition metal-carbyne compounds. H. R. Elschenbroich & A.). Organometallics-I Complexes with Transition Metal-Carbon σ-Bonds. 5. J. (b) Transition Metal-Carbon π-Bond: Cyclopropenyl cation (C3R3+) as a ligand. Organometallics of zinc and mercury: preparation. 3. C.VCH Publication (1992). Elschenbroich. bonding and reactions of aluminum organyls. transition metal vinylidene and transition metal allenylidene compounds. Sevin. Singh. Silicon and tin organyls of coordination number 4. C4R4 as a ligand (R = H. Advanced Inorganic Chemistry (5th edn. Molecular Chemistry of the Transition Elements. Unit 4 Applications to Organic Synthesis and Homogeneous Catalysis (a) In Organic Synthesis: Hydrozirconation of alkenes and alkynes. Metallo-Organic Chemistry. Organometallics (3rd edn. Yamamoto. structure. Wiley-VCH Publication (2006).

Biochemistry (4th edn. saturated and unsaturated fats. Introduction to Medicinal Chemistry: How Drugs Act and Why? John Wiley & Sons (1997). chiral recognition and catalysis. Structure and function of mRNA. dextran. Springer-Verlag (1984). Protein-related transformations: Amino acid degradation (C3. pyridoxal phosphate. Unit 2 Metabolic Reactions Fatty acid metabolism: Biological importance of fatty acids and lipids. Bioorganic Chemistry: A Chemical Approach to Enzyme Action. NADP+. amino. amino acid metabolism (biosynthesis and degradation). Saenger. Gene expression – transcription and translation. apoenzymes. Gene mutation and carcinogenesis Unit 4 Enzymes and Co-Enzymes (a) Co-enzyme chemistry: Cofactors derived from vitamins. Gringauz. . P. C. Cyclodextrins. Sindell. rRNA. Zubay. Textbooks 1. tRNA. Principles of Nucleic Acid Structure. C5 family). salient features. even chain and odd chain fatty acids. FAD. calixarenes. Stryer. Reference Books 1. Polysaccharides of biological importance. diometric chemistry. Addison-Wesley (1983). Intracellular organelles and their functions.and Z-DNA. R.). Comparison of plant and animal cells. Mechanisms of reactions catalyzed by above co-factors. L. micelles. FMN. B. cryptates. Genetic code – origin. uric acid and ammonia formation. synthetic enzymes. Biochemistry. calorific value of foods. H. DNA sequence determination by chemical and enzymatic methods. thiamine pyrophosphate. ketone bodies. (b) Enzyme models: Host-guest chemistry. Cell-cell recognition and blood group substances. DNA Structure and Function. C4. Unit 3 Nucleic Acids Chemical and enzymatic hydrolysis of nucleic acids. crown ether. prosthetic groups.24 Second Semester Che O 205 BIOORGANIC CHEMISTRY Credits: 4 Unit l Cell structure and metabolism: Prokaryotic and eukaryotic cells. Amino acid sequencing. lipoic acid and vitamin B12. (1995). H. Springer Verlag (1998). W.. Carbohydrates: Structure and function of sugar derivatives (deoxy. 4. 2. molecular recognition. ATP – currency of biological energy. Dugas. sialic acid. wobble hypothesis. Enzymatic hydrolysis of proteins to peptides. 2. & Penny. properties and function of lipid bilayers and liposomes. W. Metabolic processes – catabolism and anabolism. branched chain sugars). Structure & biological function of coenzyme A. fatty acid metabolism. multi-stranded DNA. ionophores. A. 3. cyclodextrin-based enzyme models. coenzymes. Polymorphic nature of DNA. Freeman & Co. Energy-rich and energy-poor phosphates. bological membranes. NAD+. urea cycle. Academic Press (1994). S.

Fundamentals of Enzymology. Understanding Enzymes. Academic Press (2001) 25 . Page and A. & Freeman. 3. & Stevens. 7. Freeman. 5.). Oxford University Press (1989) 6 Trevan. Palmer.Continued …. N. A. Fersht. Biochemistry: The Chemical Reactions of Living Cells. Enzyme Mechanisms. C. Prentice Hall (1995). Williams (eds. Immobilized Enzymes: An Introduction and Applications Biotechnology. H. W. W. Enzyme Structure and Mechanism. (1987). D. 4.. M. Royal Society of Chemistry. M. New York (1985). Price. John Wiley (1980).H. 8 Metzler. E. D. L. T.1.

Surfactants. thermodynamics of micellization. K. Rubingh’s treatment. conductance behaviour of ionic micellar solution.). Gibbs adsorption equation. Lange. Plenum (1992). temperature dependence of cmc. M. Unit 2 Micelles Micelle formation by surfactants: Critical micelle concentration. John Wiley (2004). formation of emulsions. Unit 4 Solubilisation and Emulsification Solubilization and Emulsification by Surfactants: Factors determining extent of solubilization. factors affecting cmc. cmc of mixed micelle. Moroi. adsorption isotherms. (b) Adsorption of Surfactants: Adsorption at solid/liquid. 2. microemulsions. Kraft point. factors determining emulsion stability. conductance behaviour of microemulsions. Scamehorn. J. Y. CRC Press (2005). reactions in micellar and microemulsion media. cmc meaurement.). counterion binding constant. M. conterion binding in mixed surfactants. Zana (ed. . effect of added electrolyte on the surface excess of ionic surfactants. Dynamics of Surfactant Self-Assemblies. CRC Press (2004). Hanser Pub. Rosen. F. Surfactants and Interfacial Phenomena (3rd edn. 3. Abe & J. Reference Books 1.26 Second Semester Che O 206 CHEMISTRY OF SURFACTANTS Credits: 4 Unit 1 Introduction (a) Characteristic Features of Surfactants: General structural features & behavior of surfactants. Text Books 1. Micelles. Unit 3 Mixed Surfactants Different types of mixed micelle. micellar structure and shape. 2. liquid/gas and liquid/liquid interfaces. classification of surfactants. hydrophobic/solvophobic interaction. Mixed Surfactant Systems. Rodenas treatment. R. (1999). R. Clint’s equation for cmc.

3. Unit 2 Powder Compact Reactions and Solid-State Defects Diffusion Model: Parabolic rate law. preparation. Magnetic moments. V. Vannilov. Jander’s rate equation. Unit 4 Magnetic and Optical Properties of Solids Behaviour of substances in magnetic field. 2. F. Prentice Hall of India (1979) Reference Books 1. J. X-ray diffraction method. Mechanism of ferro. E. mechanism of latent image formation. Kroger-Zeigler equation. Thermoelectric Effects: Seebeck effect. Organic Semicondutors and Biopolymers. Powder method – principles and uses. Electron diffraction. colour centre and information storage. Scattering of X-rays by crystals – systematic absences. Solid State Chemistry. Hannay. Frenkel defects. N. Tiley. silver iodide. Solid State Chemistry and its Applications. Configurational coordinate model. Buguslavski & A. Plenum Press (1988).27 Second Semester Che O 207 SOLID STATE CHEMISTRY Credits: 4 Unit 1 Solid State Reactions Preparative Methods: Vapor phase transport. Neutron diffraction. lithium iodide battery. GinstlingBrounshtein rate equation. consequences of non-stoichiometry.and antiferromagnetic ordering – super exchange. Unit 3 Solid Electrolytes Typical Ionic Crystals: Alkali metal halides (vacancy conduction).electrochemical methods. John Wiley (1987). W. Effects of temperature (Curie & Curie-Weiss laws). zone melting.Schottky defects. Hall Effect. Color centers: F-centre. R. silver chloride (interstitial conduction). photoconductivity of polymers. Whittaker. chemical vapour deposition. Defect Crystal Chemistry and its Applications. . Gutmann & L. Antistoke phosphors. Solid state Galvanic cell). Application of Solid Electrolytes. L.light sensitive crystals. Equilibria in non-stoichiometric solids. 3. B.E.β-alumina. Pergamon Press Oxford (1981).Bridgman & Stokbarger methods. John Wiley (1987). J. mechanism of conduction in organic semiconductors. Non-Stoichiometric Defects: Origin of non-stoichiometry. Lasers — ruby and neodymium. Luminescence and phosphors. Chapman and Hall. Fuel cells: electrochemical power generator (hydrogen-oxygen cell. halide and oxide ion conductors. Crystal growth . Crystallography. Solid Electrolytes . electron and hole centre. Lyons. 2. I. Conducting Organics: Organic conductors. The photographic process . preparation of thin films . Organic Semiconductors. R. West. Text Books 1 A. D. New York (1987). Characterization of Solids: Crystal diffraction of X-rays. Stoichiometric Defects: Equilibrium concentration of point defects in crystals .

Lewis Publishers. Unit 3 Experimental Techniques of Purification and Separation Solvent extraction: principles of extraction.). J. Coulometry and Conductance methods. Monk. waste water treatment. Text Books 1. exclusion chromatography. Potentiometry: Ion selective electrodes. Peterson Education (2000). choice of column and detector. Academic Press. applications .28 Second Semester Che O 301 Credits: 2 ENVIRONMENTAL AND ANALYTICAL CHEMISTRY Unit 1 Air and Water Pollution Air pollution – types and sources. Environmental Chemistry. J. London (1976). Willard. choice of mobile phase and detector. A. Wadsworth Publishing Company. Barnes and M. I. Atomic absorption spectrometry. Mendham. depletion of stratospheric ozone. Gas chromatography: Principles. Environmental Chemistry at a Glance. 2. De. Atomic fluorescence spectrometry. Moore & E. Pulford & H. E. Water pollution – types and sources. L. Vogel’s Textbook of Quantitative Chemical Analysis. Cyclic voltammetry. instrumentation. D. H. Environmental Chemistry (6th edn. Manahan. action of ion exchange resin. Amperometry. Merritt. C.). applications. R. Liquid chromatography: adsorption and partition chromatography. J. Reference Books 1. W. S. Atmospheric chemistry. Anodic stripping voltammetry. A. industrial and transport-related air pollution. London (1994). Environmental Chemistry (4th edn. 3. Dean & F. Global warming and its effects. H.A. 4. percentage extraction. column efficiency. Blackwell Publishing (2006). New Age International Limited (2006). physical and chemical water pollutants. California (1988). Thomas. A. P. 2. Flowers. Denney.). . HPLC (principles. equipment. K.L. Unit 2 Electrochemical and Spectral methods Polarography: Principle. 3. M. instrumentation and applications. Turbidimetry and Nephelometry. S. Settle. criteria of water quality. J. Fundamentals of Electroanalytical Chemistry. Moore. ion exchange equilibria. Instrumental Methods of Analysis (7th edn. applications. John Wiley & Sons (2001).

S. oxazepam.II (a) Antiinfective drugs: Mode of action and synthesis of sulphonamides. Medicinal Chemistry and Drug Discovery. Wolff. role of alkylating agents and antimetabolites in the treatment of cancer. (d) Antimalarial drug: Nitrogen heterocycles as antimalarial agents. antazoline. chincophan. Lednicer. ciprofloxacin. . (b) Cardiovascular drug: Classification. D. Vol-1. Synthesis of mechlorethamine. E. (c) Hypnotics and sedatives: SAR and mode of action. 2. Burger. Carcinolytic antibiotics and mitotic inhibitors. 5-bromouracil and 6-mercaptopurine. R. Anticancer action of cisplatin and taxol. S. John Wiley (1998). Strategies for Organic Drug Synthesis and Design. (d) Local anaesthetics: Classification. primaquine. Unit 2 Drug Types . Ed. Dimmock. verapamil. synthesis and mode of action of quinidine. alprazolam. promethazine and phenindamine. xylocaine.(2000). artemether and arteether. Goodman & Gilman. Mepacrine and pyrimethamine. 4. 5. Synthesis of diazepam. synthesis of chloroquine. cinchocaine and quinisocaine. Pandeya & J. daspone. (b) Antipyretic Analgesics: Classification and mode of action of antipyretic analgesics. Graham & Patrick.29 Third Semester Che O 302 MEDICINAL CHEMISTRY-II Credits: 2 Unit 1 Drug Types . thiopental sodium. M. Synthesis of paracetamol.I (a) Antineoplastic drugs: Cancer chemotherapy. SAR and mode of action. Introduction to Medicinal Chemistry (3rd edn. Synthesis of procaine. melphalan. barbiturates. methapyriline. Novalgin and mefenamic acid. OUP (2005). mepyramine.). Introduction to Drug Design. (c) Antihistamines: SAR and mode of action of H1-receptor antagonists. Pharmacological Basis of Therapeutics. α-eucaine and β-eucaine. pamaquine. their classification and mode of action. norfloxacin. New Age International. isoniazide. Synthesis of bromazine. Introductory idea on Artemisinin. chlorazepam. furazolidone. McGraw-HilI (2005). 3. John Wiley (1994). methyldopa and buphenine. Text Books 1.

Concentration quenching and excimer formation. Reference Books 1. A. Unit 2 Photophysical Processes in Excited State Types of photophysical pathways. University Science Books (1991). Buirks.E. Radiationless transitions. 2. Fluorescence emission. P. Absorption band shape and Franck-Condon Principle. . Fluorescence quenching. Redox potential and acidity constants of aromatic acids. Modern Molecular Photochemistry. Photophysics of Aromatic Molecules. Triplet state and phosphorescence emission. Exciplex formation. 2.30 Third Semester Che O 303 PHOTOCHEMISTRY Credits: 2 Unit 1 Physical Properties of Excited Molecules Nature of changes on electronic excitation. Excited state dipole moment. Quenching by foreign substrates. Blackwell Scientific. Oxford (1991). Wiley-Interscience (1969). Turro. origin of life. C. J. OUP (1996). Emission Spectra. Photochemistry. Gilbert & J. photosynthesis and mechanism of vision. Wayne. Wayne & R. J. N. Baggott. Text Books 1. Environmental effects on absorption and emission properties. Essentials of Molecular Photochemistry. Stern-Volmer equation.B. E. Unit 3 Applications of Photochemistry Importance of photochemistry. Potential energy diagram.

S. R. Inorganic Chemistry in Biology and Medicine. E. catalase and cytochrome P-450 Unit 3 Metalloenzymes Copper enzymes. Schwederski. Molybdenum enzyme: xanthine oxidase. Pt-DNA binding.Third Semester Che O 304 BIOINORGANIC CHEMISTRY Credits: 4 31 Unit 1 Scope of Bioinorganic Chemistry Inorganic elements in biological systems. transport. nucleotides. Cullen. Inorganic Aspects of Biological and Organic Chemistry.P. Vol. biology of calcium carriers.-I. Academic Press (1978). Dippard & J. Kaim & B. Text Books 1. Ochiai. Unit 4 Metals in Medicine Metal deficiency and disease. (1990). Viva Books Pvt.F. iron enzymes. Concepts and Models in Bioinorganic Chemistry. Kraatz & N. J. proteins. 4.W. Bioinorganic Chemistry. chelation therapy. arsenic and antimony as drugs. Gray. Bertini. 3. enzyme stabilization. biological defence mechanisms. John Wiley. B. Biochemistry: Distribution. Williams & J. New Trends in Bioinorganic Chemistry. S. E. Panima Publ. ferritin and transferrins. S. cells. James (eds. peroxidase. 4. A.R. superoxide dismutase. 5. Lippard. Addison. Bioinorganic Chemistry: Inorganic Elements in the Chenistry of Life. Dasilva. mercury. active transport of cations across membranes. biological roles. selenium and arsenic.). Biological Aspects of Inorganic Chemistry.J. role in muscle contraction. John Wiley (1977). N. toxicity of mercury. A. Metzler-Nolte (Eds. synthetic oxygen carriers. hemoglobin and myoglobin: molecular structures. Vitamin B12 and B12 coenzymes. heme proteins: magnetic susceptibility. Hughes. epr and electronic spectra. Bioinorganic Chemistry – An Introduction. Berg. model systems. Valentine. blood clotting and biological calcification Unit 2 Metalloporphyrins Structure and optical spectra. basic bioenergetics. Iron storage.. electronic and spatial structures. Progress in Inorganic Chemistry: Bioinorganic Chemistry.R. J.). ACS (1980).R. S. M. Martel. metals used for diagnosis and chemotherapy. Hanzlik. 3. Allyn and Bacon Inc. Academic Press (1976) Reference Books 1.R. 7. Principles of Bioorganic Chemistry. I. lead. Wiley (1981). cadmium. 2. classification of enzymes. zinc. Coenzymes. Ltd. Dolphin & B. H. 6. carboxy peptidase and interchangeability of zinc and cobalt in enzymes. beryllium. J. biologically important compounds amino acids. John Wiley (1994). Series. 38. (2004).P. D. (2005). (1977). copper. complexes of gold. biomineralization and siderophores. The Inorganic Chemistry of Biological Processes. Wiley (2006). Lippard & J. the sodium pump. M. N. R. Zinc enzymes: carbonic anhydrase. W. H. cytochrome oxidase and ceruloplasmin. Corpn. 2. thermodynamics and kinetics of oxygenation. carbohydrates and lipids. . ACS Symp. platinum complexes as anticancer drugs.

reversal of polarity. Unit 4 Steroids Biosynthesis of diterpenes. 2. their isolation and characterisation and biosynthesis of common plant products. Textbooks 1. alkene synthesis. One group C-C disconnections – alcohols and carbonyl compounds. cyclisation reactions. Synthesis of equlenins. Gilchrist. R. one group and two group C-X disconnections. (1992). amine synthesis. Synthesis of α-vetinone and total synthesis of β-eudesmol. chemoselectivity. yohimbine and tylophorine. Biosynthesis pathways for natural products using co-enzymes and enzymes.5-difunctionalised compounds. Rearrangements of santonic acid and thujospene. Academic Press. higher terpenes and steroids. 2. 1. synthesis and biosynthesis of common alkaloids: reticuline. Longman Scientific & Technical Publicns. Synthesis of selected natural products based on genetic classification – fatty acid derivatives and related compounds.βunsaturated carbonyl compounds. amine. Synthesis of hirsutene. methyl jasmonate. Strategies and Tactics in Organic Synthesis 4 & 5. K.3-difunctionalised compounds. trans-chrysanthemic acid. α. Two group C-C disconnections – Diels-Alder reaction. Natural Products Chemistry. 1.and sesquiterpenes. trans annular cyclisation of caryophyllene. Unit 2 Synthetic Strategies Synthons and synthetic equivalents. control in carbonyl condensations. pinene. cis juvenile hormone. . Wiley Eastern (1991). abietic acid. Unit 3 Terpenoids and Alkaloids General biosyntheses of mono. Michael addition and Robinson annelation. Lanosterol and caretonoids. K. Academic Press (2004) Reference Books 1. L. Heterocyclic Chemistry: Synthesis. exaltone and muscone.Third Semester Che O 305 NATURAL PRODUCTS CHEMISTRY Credits: 4 32 Unit 1 Natural Products and their Biosynthetic Pathways General classification of natural products. Retrosynthetic analysis. Miscellaneous transformations of steroid molecules. Heterocyclic Chemistry (2nd edn. Principle of protection of alcohol. T. synthesis of caryophyllene and isocaryophyllene. Common protecting groups. importance of order of events in organic synthesis. cyclo-pentato monoterpene lactones. Harmata. Nomenclature of steroids and synthesis of squalene. Vols. I and II. camphor and emitine. disconnection approach. Bansal. Reactions and Mechanisms. Corticosteroids. Degradation of diosgenin to progesterone and its synthesis.). Estrogens and total synthesis of non-aromatic steroids (progesterones). Synthesis of quercetin. Nakanashi. Synthesis and rearrangement of longifolene Structure. carbonyl and carboxyl groups. M. prostaglandins. regioselectiviity. functional group inter-conversions. use of acetylenes and aliphatic nitro compounds in organic synthesis. New York and London (1974). general biogenesis and synthesis of cis-jasmone.

Biochemical applications of environment sensitive fluorescent probes. mirror-image rule. Novel fluorophores: (i) quantum dots. high sensitivity DNA stains. characteristics of fluorescence emission Stokes shift. Reference Book 1. Springer (2006). John Wiley & Sons (1999). optical filters. sensing techniques based on (i) collisional quenching. Lakowicz.33 Third Semester Che O 306 Credits: 4 PRINCIPLES AND APPLICATIONS OF FLUORESCENCE SPECTROSCOPY Unit 1 Introduction Phenomenon of fluorescence: Jablonski diagram. (iii)electron transfer. Fluorescence standards Unit 2 Solvent and Environmental Effects on Fluorescence Solvent polarity effect. effect of solvent mixtures: specific and non-specific interactions. (ii) energy transfer. data collection. Derivation and application of Lipper-Mataga (LM) equation. B. Basics of time correlated single photon counting. Fluorescence quenching: mechanism & dynamics. temperature effects. monochromator. Additional factors that effect fluorescence emission. Resonance Energy Transfer. D. Time domain measurements: importance. Unit 3 Instrumentation for Fluorescence Spectroscopy Spectrofluorimeters: light source. Unit 4 Applications of Fluorescence Phenomena Fluorescence sensing: Mechanism of sensing. DNA technology – sequencing. . effect of viscosity. J. Fluorescence anisotropy. (ii) glucose sensors & (iii) protein sensors. Demidov. examples of (i) pH sensors. Molecular Fluorescence: Principles and Applications. Valeur. polarizers. R. photomultiplier tube. (ii) lanthanides and (iii) long-lifetime metal-ligand complex. Text Books 1. 2. analysis based on non-linear least square (NLSS) and maximum entropy method (MEM). lifetimes and quantum yields.A. Principles of Fluorescence Spectroscopy. Wiley-VCH (2001). Andrews & A. L. DNA hybridization. Radiative decay engineering – metal enhanced fluorescence.

M. F. Tata McGraw-Hill (1990). Roothaan equations. Einstein’s A and B coefficients. ELBS (1979).Hard sphere model. W. Basis set. Population analysis. Theory of Chemical Reaction Dynamics. spectroscopy Unit 4 Introduction to Chemical Reaction Dynamics Types of chemical reactions. Szabo & S. Text Books 1. Ostlund. L. Atkins. Koopman’s theorem. Hartree-Fock theory. The collinear arrangement. N. R. Kohn-Sham theory. (b) Density Functional Theory: Hohenberg-Kohn theorem. . Electron correlation. Reference Books 1. World Scientific (2000). Quantum Chemistry. exchangecorrelation functionals Unit 3 Applications Potential energy surfaces. Oxford Univ. Transition probabilities and rates.34 Third Semester Che O 307 COMPUTATIONAL QUANTUM CHEMISTRY Credits: 4 Unit 1 Many Electron Theory Indistinguishability of particles. selection rules. Harmonic oscillator model for diatom. 3. Atom-diatom interaction. thermochemistry and kinetics of simple chemical reactions. Unit 2 (a) Radiation-Matter Interaction: Time-dependent perturbation theory. CRC Press (1985). P. 2. Press (1986). weak interactions. Dynamics of Molecules and Chemical Reactions. Molecular Quantum Mechanics. semi-classical treatment of radiation-matter interaction. Baer. Reaction cross section and flux density. Pilar. 2. Antisymmetry principle and many electron wave function. Elementary Quantum Mechanics. Wyatt.

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