Modifiable Factors Non Modifiable Factors

Smoker Male
Sedentary Lifestyle Hereditary
Drinking alcohol

Low acid secretion predisposes to gastric cancer by several mechanisms,

including impaired absorption of vitamin C and overgrowth of salivary and
intestinal bacteria within the stomach. By contrast, proximal gastric cancer (at
the gastro-esophageal junction) is associated with normal acid output.

H. Pylori Arises from the mucous lining of the stomach

Colonizing of Bacteria in the stomach

Perforation / Hemorrhage

Stage 1

Loss of appetite Indigestion or burning sensation Abdominal Discomfort

(heartburn)

Weight
Presence of Palpable Mass
 Stage 2

Some tumors penetrate, ulcerate, and spread

along tissue planes

Weakness Invades the wall of the stomach Fatigue