This action might not be possible to undo. Are you sure you want to continue?
July 8, 2011
Review finds improved survival in clinical trials of vitamin D3 supplementation
A lengthy review published on July 5, 2011 in The Cochrane Library reveals that supplementing older individuals with vitamin D3 is associated with reduced mortality over a two year average period. Goran Bjelakovic of the University of Nis in Serbia and his European associates selected 50 randomized trials involving vitamin D supplementation, which provided a total of 94,148 participants for their analysis. Most of the trials analyzed the effect of supplementation on bone mineral density, falls and fractures. The subjects' average age was 74, and 79 percent were female. The median length of supplementation with vitamin D was two years. Dr Bjelakovic and his colleagues uncovered a significant benefit for supplementation with vitamin D3, but not for other forms of the vitamin, on improving survival over the course of the trials. "A Cochrane meta-analysis published only a couple of years ago found that there was some evidence for benefit, but it could not find an effect on mortality," commented Dr Bjelakovic, who is affiliated with the University of Nis' Department of Internal Medicine Gastroenterology and Hepatology. "We were, however, aware that more trials had been published and wanted to assess the effects of vitamin D when you added all the data together." "Our analyses suggest that vitamin D3 reduces mortality by about 6%," he concluded. "This means that you need to give about 200 people vitamin D3 for around two years to save one additional life." Because there were fewer trials involving other forms of the vitamin included in the current analysis, the apparent absence of a survival benefit for these forms needs to be taken with caution. "We need to have more randomized trials that look specifically to see whether these forms of vitamin D do or don't have benefits," Dr Bjelakovic stated. "Previous reviews of preventive trials of vitamin D have not included as much information and have not examined the separate influence of different forms of vitamin D on mortality," he added. "By taking data from a larger number of trials we have been able to shed much more light on this important issue."
Along with calcium, vitamin D is the nutrient that most people recognize as important for bone health (Holick 2007). But, even today, few people understand the powerful and complex ways that vitamin D acts to promote not only bone health, but the way the entire body handles calcium, both in healthy and in undesirable ways (Holick 2007). Vitamin D triggers absorption of calcium from the intestine and deposition of calcium in bone — and also removal of calcium from blood vessel walls. Conversely, insufficient vitamin D intake results in depletion of calcium from bones — and increased deposition of calcium in arterial walls, contributing to atherosclerosis (Celik 2010, Tremollieres 2010).
Weight Loss Sale
Achieve your weight loss goals this summer!
More than 13. current scientific evidence suggests a minimum target threshold for optimal health is over 50 ng/ mL or 125 nmol/L (Aloia 2008. or calcidiol). Now you can combat these changes with DNA Repair Cream by Cosmesis®. Skin tone eventually loses its luster.00 CR Mimetic Longevity Formula 60 vegetarian capsules Item #01429 $23. which of course makes fractures still more likely (Bischoff-Ferrari 2009. Vitamin D deficiency is defined as a serum 25(OH)D level of less than 50 nmol/L. To obtain the many health benefits of Vitamin D.00 Optimized Saffron with Satiereal® 60 vegetarian capsules Item #01432 $18. Super CLA Blend with Sesame Lignans 120 softgels Item #00818 $36.000 Life Extension® members have had their vitamin D level checked. The optimal dose of vitamin D has been hotly debated in recent years.00 Super CLA Blend with Guarana and Sesame Lignans 120 softgels Item #00819 $14. Pterostilbene is a compound structurally similar to resveratrol and can also be found in grapes. so it is vital to check which set of units a lab is using. or 30 ng/dL (Bischoff-Ferrari 2007. Get started today with these science-based formulations that deal with the molecular factors that keep the weight on. Janssen 2010). The firm. as well as the bark of some trees. blueberries.lef. Note that this measure is reported in two different units. An innovation in skin care. Results may vary. and other small fruits. this formula PTEROPURE™ CAPSULES Like resveratrol. Heaney 2008). Face and neck become noticeably dry and wrinkled instead of refreshed and vibrant. . pterostilbene belongs to a class of compounds called phytoalexins.00 Optimized TryptoPure® Plus 90 vegetarian capsules Item #01202 $24.60 $42. A validated measure of total body vitamin D status in blood is serum 25-hydroxy vitamin D (also known as 25 (OH)D. increasing the risk of falling. the visible effects of aging on your appearance are always the same. 2009). which are naturally produced by plants when under attack by pathogens such as bacteria or fungi. The dose of vitamin D required to achieve the neuroprotective and other non-bone related effects are substantially higher than those required simply to achieve good calcium absorption (Bischoff-Ferrari 2007). or less than 20 ng/dL. Use them alone or in combination for a multi-pronged attack on fat.70 $28.00 LuraLean® Caps 120 vegetarian capsules Item #01470 $14.40 These supplements should be taken in conjunction with a healthy diet and regular exercise program. Experts recommend a higher level of 75 nmol/L. nmol/L and ng/dL. Vitamin D dosage as high as 5000 to 8000 IU per day may be required to achieve a minimum target level for optimal health in aging individuals (Life Extension Magazine January 2010).org/weightloss DNA REPAIR CREAM Whether you're a man or a woman. http://www. Pfeifer 2009.00 $39.Vitamin D deficiency (or insufficiency) also causes muscle weakness and neurological deficits.00 $36.00 $12. health-focused individuals.00 $40. supple look of your younger years begins to fade. The results from these tests provides important information about achieved vitamin D blood levels in a large group of dedicated. DawsonHughes 2005. They’re priced right now at savings that will trim your budget and jumpstart your weight loss program.
org Sign up for Life Extension Update For Customer Service inquiries. Inc. two key ingredients that help restore your skin's youthful glow.com or call 1 800 678 8989. Teprenone has a molecular structure similar to vitamin K. please refer to Life Extension copyright policy. Inc. pTeroPure™ is the authentic pterostilbene used in clinical studies and is the only material licensed for high-dose application in dietary supplements. while caprylic acid occurs naturally in palm and coconut oils: topical ingredients dermatologists have relied on for years to help men and women enhance their skin's appearance. . If you have questions or comments concerning this issue or past issues of Life Extension Update. You should not stop taking any medication without first consulting your physician. *These statements have not been evaluated by the Food and Drug Administration. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. These products are not intended to diagnose.S. or if you have or suspect you might have a health problem. All Contents Copyright © 1995-2011 Life Extension Foundation All rights reserved. cure or prevent any disease.lef. TryptoPure® is a registered trademark of Ajinomoto Company. Department of Agriculture. send them to ddye@lifeextension. This exciting product is based on a licensed patent from the University of Mississippi and the Agricultural Research Service.features teprenone and caprylic acid. treat. You should consult with a healthcare professional before starting any diet.com or call 954-202-7716. before taking any medication. exercise or supplementation program. www. Satiereal® is a registered trademark of INOREAL. which is the principal intramural scientific agency of the U. International Patents Pending. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. please email customerservice@lifeextension. Life Extension Update s s s Higher vitamin D levels associated with increased survival among older women over a 6 year period Large study links poor vitamin D status with greater risk of dying over 8 year period AMA journal meta-analysis finds vitamin D supplements linked with reduced risk of dying over a six year period What's Hot s s s Vitamin D supplementation helps prevent nursing home falls Vitamin D plus calcium reduces falls in women Vitamin D supplements recommended for elderly women Life Extension® Magazine s s Startling findings about vitamin D levels in Life Extension® members Guarding against the dangers of vitamin D deficiency LuraLean® is a registered trademark of AHD International LLC. pTeroPure™ is a trademark of ChromaDex. For copyright permission.
This action might not be possible to undo. Are you sure you want to continue?
We've moved you to where you read on your other device.
Get the full title to continue reading from where you left off, or restart the preview.