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Board on Health Sciences Policy

Request for Nominations Committee on a Review of the California Institute for Regenerative Medicine
The Institute of Medicine (IOM) is searching for experts in the scientific, technical, and medical professions to be considered for a study committee titled Committee on a Review of the California Institute for Regenerative Medicine. The California Institute for Regenerative Medicine (CIRM) has requested that the IOM provide an independent assessment of CIRM's programs, operations, strategies, and performance since its inception in 2005. Specifically, the IOM committee will review and address the following questions: CIRM's initial processes What can be learned from the history and process of building consensus in the public and scientific communities to support the inception and work of CIRM? CIRM's programmatic and scientific scope Does CIRM have the portfolio of projects and grant opportunities necessary to meet its scientific goals? How can CIRM improve upon its existing array of programs? What additional programs and initiatives are recommended to meet its goals? Does CIRM's scientific strategic plan address the range of relevant issues in regenerative medicine? CIRM's organizational and management systems Are the internal organizational and management systems (in particular the board and working group structures and operations, the peer review system, the conflict of interest guidelines, and the grants management system) effective in working toward the institute's scientific goals? Are the systems that are in place scientifically and ethically valid and rigorous? Do they achieve the level of transparency and the level of stakeholder and scientific community involvement needed to meet the institute's public responsibilities and scientific goals? CIRM's funding model Has the funding model for CIRM had an impact on the work of the institute? What are the advantages of CIRM's model for covering long-term costs of medical research? Could aspects of this funding model serve as a paradigm for other states or countries? CIRM's intellectual property policies What are the strengths and weaknesses of CIRM's policy for sharing revenue generated by intellectual property? How does this model compare to the model governing federally-supported research? The principal objective of this review is to ensure that all aspects of CIRM's operations are functioning at peak performance. The committee is asked to provide recommendations regarding short-, medium-, and long-term actions that could improve the performance of CIRM. The IOM seeks to appoint a committee of approximately 14 members with expertise in (but not limited to) stem cell research, developmental biology, bioethics, research administration, financial structures for biomedical research, program evaluation, economics and finance, business administration, and intellectual property.

500 Fifth Street, NW Washington, DC 20001-2721

Phone: 202 334 1755 Fax: 202 334 1329 E-mail: astith@nas.edu www.iom.edu/hsp

Please provide by Friday, August 5th, names of any persons you think the IOM should consider for this important task. Please send your nominations (name, description of expertise, contact information) to Adrienne Stith Butler, Ph.D., study director, via email (astith@nas.edu) or fax (202-334-1329). Suggestions are sought for qualified individuals in all sectors of the scientific and technical community. Service on the study committee is open to scientists and other experts working for a government agency or other sponsor of this project if (1) they have relevant scientific and technical expertise needed to accomplish the committees task, and (2) their service will not appear to compromise the independence and objectivity of the study. The IOM is committed to increasing the participation of under-represented minorities in all phases of its work. The excellence of the members of its study committees is crucial to its work. Your assistance in identifying potential committee members especially from under-represented minorities is greatly appreciated.