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Homework III

Prof.Sudad Saman
Hoa Le

1/explain the immune response process include all cell involved in this process:

The immune response is triggered by the presence of an antigen: the response


includes cell-mediated and antibody mediated defense.

T cell and cell –mediated immunity.


Foreign antigens must generally be processed by other cells (typically
macrophages) and incorporated into cell membranes (antigen presentation) before the
antigens can activate lymphocytes.
All body cells have membrane glycoprotein. The genes controlling their synthesis
make up a chromosomal region called the major histocompatibility complex (MHC). The
membrane glycoproteins are called MHC protein. Lymphocytes are not activated by lone
antigens but will respond to an antigen bound to either a class I or a class II MHC
protein.
Class I MHC proteins are in all nucleated body cells .class II MHC proteins are
only in antigen-presenting cells (APCs) and lymphocytes.
Whether a T cell responds to antigen held in Class I or II MHC proteins depends
on the structure of the T cell membrane. T cell membranes contain protein called CD
(cluster of differentiation) marker. CD 3 makers are present on all T cells.CD8 makers are
on cytotoxic and suppressor T cells.CD4 makers are on all helper T cells.
Cell-mediated immunity (cellular immunity) results from the activation of CD8 T
cell by antigens bound to Class I MHCs. When activated, most of the T cell divides to
generate cytotoxic T cells and memory Tc cells, which remain on reserve to guard
against future such attacks. Suppressor T cells depress the responses of other T cells and
of B cells.
Helper, or CD4, T cells respond to antigens presented by class II MHC proteins,
when activated; they secret lymphokines that help coordinate specific and nonspecific
defenses and regulate cell -mediated and immunity.

B cells and antibody- mediated immunity:


B cells become sensitized when antigens bind to their membrane antibody
molecules. The antigens are then displayed on the Class II MHC proteins of the B cells,
which become activated by helper T cells activated by the same antigen.
An active B cell may differentiate into plasma cells or produces daughter cells
that differentiate into plasma cells and memory B cell. Antibodies are produced by the
plasma cells.
An Antibody molecule consists of two parallel pairs of polypeptide chains
containing constants and variable segment.
When Antibody molecules bind to an antigen, they form an antigen-antibody
complex. Effect that appear after binding include neutralixation (antibody binding such
that viruses or bacterial toxins cannot bind); precipitation (formation of an insoluble
immune complex) and agglutination (formation of large complexes); opsonization
(coating of pathogens with antibodies and complement proteins to enhance
phagocytosis); stimulation of inflammation; and prevention of bacterial or viral adhesion.

The five classes of antibodies in body fluids are immunoglobulin


*G(IgG):responsible for resistance against many virus, bacterial toxins
*E(IgE),which releases chemicals that accelerate local inflammation
*D(IgD),located on the surfaces of B cells
*M(IgM)the first antibody type secreted after the antigen arrives
*A(IgA)found in glandular secretions

2/Define Opsonins:

Is a molecule that acts as a binding enhancer for the process of phagocytosis.


After the binding, bacteria, dead tissue cells and small mineral particles or example are
easily engulfed. The effect is called opsonization.

4/Explain what are protease inhitors:

Protease inhibitors are a class of medication used to treat or prevent infection


by viruses, including HIV and Hepatits C. Protease inhibitors prevent viral replication
by inhibiting the activity of HIV-1 protease, an enzyme used by the viruses to cleave
nascent protein for final assembly of new virons/

Protease inhibitors have been developed or are presently undergoing testing


for treating various viruses.

5/Explain what is a hapten, give example of some

Hapten is a small molecule that reacts with a specific antibody but cannot induce
the formation of antibodies unless bound to a carrier protein or other large antigenic
molecule. when attaching to large molecules, function of hapten is as complex antigens.

An example of a hapten is mentioned which is urusshiol, it is the toxin found in


poison ivy.

3/Draw and label Antibiotic molecule: