This action might not be possible to undo. Are you sure you want to continue?
This exam consists of 27 questions worth a total of 100 points. All questions are multiple choice and there is one best answer for each question. Record your answers on the scantron sheet. Answer only once for each question or you will be automatically marked wrong. Use a #2 pencil. Name_________________________ Peoplesoft ID#__________________________
065 0. none of the above 2. A wild-type chromosome can be represented as ABC * DEFGH and from this a chromosomal aberration arises that can be represented as ABC * DEFGGH ( * = centromere). What is the frequency of the heterozygotes (fA/a)? a. Sampling errors (e. b. Incomplete dominance b.1. 0. c.500 0. the maintenance of discontinuous variation within a population c.07 0. Migration e. Founder’s Effect) c. heterozygous advantage d. pericentric inversion. In a large randomly mating population of Mexican Red knee Tarantulas.0049). the stability of the allele structure within a large randomly mating population from one generation to the next b. c. paracentric inversion 4. b. All effect allele frequencies 3. In this population. Hardy-Weinberg Equilibrium refers to a. there are two alleles at a single gene that control the number of red spots found in the adult – a dominant 16 spot allele and a recessive 8 spot allele. d. deletion.93 . 0..13 0. e. Mating Patterns d.g. the absence of selection e. e. translocation. d. This is known as a: a.49 % of the adult Millipedes have 8 spots (fa/a =0. duplication. Which of the following does NOT affect Allele frequencies in a Hardy-Weinberg Equilibrium: a.
0. 500 e. 0.7 What would be the frequency of the Beta Thalassemia mutation at equilibrium (Hint the mutation frequency is = 1. 0.77 c.18 e. The frequency of this disease. the frequency of carriers is: a. 0.01 WAa = 1 WAA = 0. 700 c. In Greece. also known as Cooley’s Anemia. 0.23 b.5. the mean seed weight is 100 mg. Beta Thalassemia is an autosomal recessive human disorder in which there is a reduced production of hemoglobin.01 b. What is the additive genetic variance of this trait? a. None of the above Q 7-9: In a population of pumpkins. this disease is occurs in about 1 in every 100 births. Not enough data . Assuming Hardy-Weinberg equilibrium for this trait. is an example of balancing polymorphisms. 0. s2d =205 7. This is a life threatening disorder for infants as it results in severe anemia and requires lifelong transfusions. 0. Thus.53 d. similar to the sickle cell anemia mutation. 0. you begin a selective breeding program. You select seed that average 140 mg as parents for a selective breeding program. the heterozygotes may display a greater fitness than either of the two homozygotes in the presence of mosquitoes carrying a species of Plasmodium.09 c. 1000 d. is very high in people from the Western Mediterranean area. 400 b. Let us imagine that the relative finesses are: Waa = 0. s2e = 95.014 e.10 d.the wild type allele frequency)? a. s2g =605. 0. It is thought that the Beta Thalassemia mutation.81 6. Since a major supplier of pumpkin seeds will pay double for seeds that weigh 125 mg.
0. Dissociation Transposable elements: a. 0. All of the above.7833 b. The Nucleotide Excision Repair system relies on: a. Transcription Factor IIH (TFIIH) d.8.86 d. are enzymes b. 0. are non-autonomous d. 111. A retrotransposon such as the copia element of Drosophila: a. resistance cells were produced by environmental mutagens e. What is the mean weight of the next generation of pumpkin seeds? a. all of the above .7 c. Does not generate mutable loci e.29 c. the proof reading capabilities of DNA polymerase III b. require reverse transcriptase c.57 e. can induce transposition of Activator elements 11.01 9. What is the Broad Sense heritability (H2) for this trait? a. Encodes for Capsid proteins c. Salvador Luria and Max Delbruck designed the fluctuation experiment to show that: a. 125 e. 12. Encodes an reverse transcriptase d. resistant cells were produced by phage infection b. resistant cells were selected by phage infection c.9 d. 100 b. 0. phage infection did not have any effect on resistant cells d. 122. 0. found throughout the human genome e. 140 10. a photolyase c. none of the above 13. DNA ligase IV e. Transposes through an RNA intermediate b.
d. An inversion of part of the chromosome in line 1 gave rise to the version in line 2. Unequal crossing-over led to the productions of lines 3 and 1. e. 16. In maize. b. Amorph 15. This gait is much more comfortable to the rider and will be prized in the equestrian community. which have the following gene orders on chromosome 3: 1: a b c i h g k j d e f l 2: a b c i h g f e d j k l 3: a b c d e f g h i j k l Which of the below is true? a. You have identified the following mutation: Wild type: ATG CTC AGT CTT Amino Acids: Met Leu Ser Leu Mutation: ATG CTT Amino Acids: Met Leu a. e. Hypermorph d. b. You find that by placing this mutation over a deficiency of the locus. c. All of the above are false. there are three different breeding lines. In breeding studies you realize that this smooth gait is caused by a single dominant mutation. A deletion led to the production of line 1 from line 2. the gate becomes smoother. Neomorph b. An inversion in part of the chromosome in line 3 gave rise to the chromosome in strain 1. c. You have discovered a mutant Andalusian horse with a very smooth lateral four beat gait similar to the Paso Fino breed. Antimorph c.14. Hypomorph e. This mutation is most likely a: a. d. Horses with two wild type copies in addition to the mutation have a rougher gate. This mutation is a: Insertion Nonsense mutation Frameshift mutation Transversion Silent Mutation AGT CTT Ser Leu GTT Val GTT Val TGG TAA Trp Stop TGG TAA Trp Stop .
but the narrow sense heritability is zero d. a & d 22. 18. The norm of reaction refers to: a. characterize the phenotypic variance generated by different environments c. the variation of phenotypes in a population b. the phenotypic response of a given genotype to different environments e. determine the number of loci that regulate a quantitative trait d. If a clonal population (all individuals with the same genotype) displays large variation for height. generates a four-stranded DNA molecule b. 243 c. there is significant environmental variance for this population e. each with 2 alleles? a. To phenocopy is to: a. How many homozygous genotypes are produced by 6 loci. heritabilities in both broad and narrow senses for height in this population equal zero b. the narrow sense heritability is positive. the broad sense heritability is positive. Which of the following are necessary for evolution by natural selection to be effective? . 64 e. 16 d. the role of the dominance genetic variance in broad sense heritability c. 81 b. is a test to establish genetic dominance d. is capable of branch migration c. generate a dominant phenotype due to the loss-of-function of a gene. but the broad sense heritability is zero c. the movement of the population mean after selection d. to produce a specific phenotype by extra-genetic means b. to generate a second mutation with a gene that reverses the phenotype e. A Holliday Junction: a. a & b e. 256 21.17. none of the above 20. none of the above 19. then: a.
II. I. II. III. per population. Competition for resources so that not all organisms can survive. D. E. V. I and IV. II. connect average population genotype of two populations – allowing a direct comparison between populations. In a sequencing reaction containing everything required for normal DNA synthesis plus a mix of deoxy-ATP and dideoxy-ATP. B. III. III. IV. fix) in the population does not depend on population size. III. Opposite some G nucleotides on the template strand. Neutral mutations occur at an approximately constant rate.e. C. Neutral mutations must be common. D. E. connect population fitness to the average population phenotype. IV. B. V. III only. What is the underlying design of a fitness (adaptive) landscape? They: A. V. Neutral mutations occur at an approximately constant rate. Opposite some T nucleotides on the template strand.I. A. IV. where will reactions terminate? A. B. The ratio of beneficial to neutral mutations is approximately constant. D. B. The probability that a given neutral mutation will reach a frequency of 1 (i. C. V. connect average population genotype to the complete phenotype of each genotype. Opposite some C nucleotides on the template strand. II. Variation in a population so that some individuals are better adapted than others. What combination of factors combine such that neutral mutations fix at an approximately constant rate? I. I. per individual. I. III. IV and V 25. Opposite some A nucleotides on the template strand. II and V. E. . A. connect average population genotype to population fitness. III. C. fix) in the population is proportional to population size. All of the above. 24. IV. 23. IV. D. I. Dideoxy-ATP will not terminate a growing DNA strand. The number of species present must increase over time. Useful traits will be inherited by offspring.e. C. E. The probability that a given neutral mutation will reach a frequency of 1 (i. I. I and II. II.
Any region of DNA on the Ti plasmid is called T-DNA. but the bacteria don’t seem to be expressing the protein.26. All of the above 27. E. The human gene may have introns that are not spliced out in bacteria B. The region of DNA transferred from the Ti plasmid to a plant genome. What could be wrong? A. What color test do you have? A. Yellow D. The human gene may have a promoter sequence not recognized by the bacterial transcription machinery. Green C. Blue B. You are trying to clone a human gene into a bacterial vector so that you can use bacteria to produce large amounts of the protein the gene encodes. What is T-DNA? A. Pink . B. 28. The region of DNA transferred from the Ti plasmid to another bacteria. You have cloned the gene OK (you checked using Sanger sequencing). E. C. C. D. The region of DNA acquired by the Ti plasmid from a plant genome. Any region of DNA that would provide a benefit to Agrobacterium tumefaciens if transferred to a plant genome. The human gene may lack a Shine-Dalgarno sequence necessary for efficient translation in bacteria. The human protein may need post-translational modification before being functional D.