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ANTI-ULCER DRUGS

Brand Name: Axid (Nitzatidine) Indication: used to treat ulcers of the stomach and intestines and prevent them from coming back after they have healed. Action: an oral drug that blocks the action of histamine on stomach cells and reduces their production of acid Contraindication: Hypersensitivity to drug or other H2-receptor antagonists. Nsg Mgt: Take it with full glass of water

Brand Name: Carfate (Sucralfate) Indication: used to treat and prevent ulcers in the intestines Action: forms a coating over ulcers, protecting the area from further injury; helps ulcers heal more quickly Contraindication: hypersensitivity Nsg Mgt: on an empty stomach at least 1 hour before a meal, or as directed by your doctor

Brand Name: Cytotec (Misoprostol) Indication: for reducing the risk of NSAID (nonsteroidal anti-inflammatory drugs, including aspirin) induced gastric ulcers in patients at high risk of complications from gastric ulcer Action: protects the lining of the gastrointestinal tract by increasing the secretion of mucus in the stomach and by stimulating bicarbonate secretion in the duodenum Contraindication: Pregnant women Nsg Mgt: Taking Cytotec after meals and at bedtime may decrease the risk Do not take an antacid that has magnesium in it within 1 hour before or 2 hours after you take Cytotec . of diarrhea.

Brand Name: Pepcid (Famotidine) Indication: treatment of peptic ulcer disease (PUD) and gastroesophageal reflux disease (GERD) Action: inhibits stomach acid production Contraindication: Chest pain, pregnancy Nsg Mgt: can be taken with or without food.To prevent heartburn and acid indigestion, take famotidine 15-60 minutes before eating food or drinking beverages that can cause indigestion

Brand Name: Prilosec (Omeprazole) Indication: treatment of dyspepsia, peptic ulcer disease (PUD),gastroesophageal disease (GORD/GERD), laryngopharyngeal reflux (LPR) and Zollinger Ellison syndrome Action: blocks the enzyme in the wall of the stomach that produces acid Contraindication: Pregnant women, Lactating mother Nsg Mgt: should be taken with a glass of water on an empty stomach (i.e., at least one hour after eating), and you should not eat or drink anything except water for at least 30 minutes after taking it. reflux

ANTI-GOUT DRUGS
Brand Name: Probenecid (Colchicine) Indication: used to prevent gout and gouty arthritis in people who have frequent severe gout attacks Action: It inhibits the tubular reabsorption of urate, thus increasing the urinary excretion of uric acid and decreasing serum urate levels; It does have a prophylactic, suppressive effect that helps to reduce the incidence of acute attacks and to relieve the residual pain and mild discomfort that patients with gout occasionally feel. Contraindication: Cancer, cirrhosis, pregnancy Nsg Mgt: Administer without regard to meals. Administer wit Store tablets at controlled room temperature (59 to 86F)h food if GI upset occurs.

Brand Name: Colcrys (Colchicine) Indication: rheumatic complaints Action: reduction in crystallization of uric acid leading to a reduction in the inflammatory response Contraindication: advanced renal failure (including those on dialysis) Nsg Mgt: Colchicine can be taken with or without food.

Brand Name: Zyloprim (Allopurinol) Indication: used to treat gout and certain types of kidney stones. It is also used to prevent increased uric acid levels in patients receivingcancer chemotherapy Action: reducing the amount of uric acid made by the body Contraindication: hypersensitivity, haypertention, liver cirrhosis Nsg Mgt: Take this medication after a meal to reduce stomach upset

Brand Name: Benemid (Probenecid) Indication: used to treat gout and gouty arthritis Action: helps to remove excess uric acid from the body Contraindication: kidney stones, anemia, kidney problems Nsg Mgt: Drink plenty of water to prevent kidney stones while you are taking probenecid.

Brand Name: Anturane (Sulfinpyrazone) Indication: used to treat gout and gouty arthritis Action: reduces the amount of uric acid in your body by causing more uric acid to be passed out in your urine Contraindication: allergy, heartburn, kidney stones Nsg Mgt: To reduce the risk that kidney stones will form, drink at least 8 to 10 full glasses (8 ounces) of fluid every day, unless your doctor tells you not to.Take sulfinpyrazone with food, milk, or an antacid to lessen stomach upset.

ANTISECRETORY DRUGS

Brand Name: Omeprazole (Proton pump inhibitor) Indication: Dyspepsia, GERD, Peptic Ulcer disease, prevention of stress gastritis Action: act by irreversibly blocking the hydrogen/potassium adenosine triphosphatase enzyme system (the H /K ATPase, or more commonly gastric proton pump) of the gastric parietal cells. The proton pump is the terminal stage in gastric acid + secretion, being directly responsible for secreting H ions into the gastric lumen, making it an ideal target for inhibiting acid secretion. Contraindication: Hypersensitivity, liver disease Nsg Mgt: Take this medication without food
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Brand Name: Pirenzepine (Anti-muscarinics) Indication: Duodenal ulcel, diarrhea, COPD, irritable bowel Action: inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system,
cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial in the prevention of duodenal ulcer recurrence.

Contraindication: Glaucoma, prostatic hypertrophy, tachyarrhythmias/angina, gastric ulcer Nsg Mgt: inform pt that it may cause blurry vision and dizziness which may affect driving or opearating machinery

Brand Name: Misoprostol (Prostaglandin Analogues) Indication: used in treatment of duodenal and gastric ulcers Action: inhibiting the secretion ofgastric acid via G-protein coupled receptor mediated inhibition of adenylate cyclase, which leads to decreased intracellular cyclic AMP levels and decreased proton pump activity at the apical surface of the parietal cell Contraindication: suspected ectopic pregnancy, hepatic disease, hypersensitivity Nsg Mgt: ask for last menstrual period to assess if pregnant and to avoid abortion

Brand Name: Nexium (esomeprazole) Indication: GERD, duodenal ulcer, Zollinger-Ellison syndrome Action: blocking acid production in the stomach Contraindication: Hypersensitivity Nsg Mgt: Take this medication by mouth at least 1 hour before a meal

Brand Name: Ranitidine Bismuth Citrate Indication: active duodenal ulcers related to infection (H pylori) Action: Treating the infection may prevent your ulcer from reoccurring. Contraindication: drug allergies, liver disease, kidney disease Nsg Mgt: Take each dose with a full glass of water.

ANTI-ANXIETY DRUGS
Brand Name: Diazepam (Valium) Indication: Anxiety, preoperative sedation, conscious sedation Action: Depress the CNS, probably by potentiating GABA, an inhibitory neurotransmitter. Contraindication: Hypersensitivity, hepatic dysfunction Nsg Mgt: Monitor BP, PR,RR prior to periodically throughout therapy and frequently during IV therapy.

Brand Name: Buspar (buspirone hydrochloride) Indication: anxiety disorders or short-term relief of symptoms of anxiety Action: lacks antiseizure, sedative, or muscle relaxant properties Contraindication: Hypersensitivity, renal and liver impairment, lactation Nsg Mgt:
Assessment History: Hypersensitivity to buspirone, marked liver or renal impairment, lactation Physical: Weight; T; skin color, lesions; mucous membranes, throat color, lesions, orientation, affect, reflexes, vision examination; P, BP; R, adventitious sounds; bowel sounds, normal GI output, liver evaluation; normal urinary output, voiding pattern; liver and kidney function tests, urinalysis, CBC and differential Interventions Provide sugarless lozenges or ice chips Arrange for analgesic for headache or musculoskeletal aches.

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Brand Name: Ativan (Lorazepam) Indication: anxiety Action: enhancing the effects of GABA in the brain Contraindication: lactating mother, hypersensitivity, bradypnea, bradycardia Nsg Mgt: Take this medication by mouth with or without food

Brand Name: Alprazolam Intensol Indication: anxiety disorder Action: depressant activity varying from mild impairment of task performance to hypnosis Contraindication: hypersensitivity, angle glaucoma Nsg Mgt: Monitor BP, RR, PR

Brand Name: Luvox (Fluvoxamine) Indication: obsessive-compulsive disorder (OCD), Action: helping to restore the balance of certain natural chemicals (neurotransmitters such as serotonin) in the brain Contraindication: Pregnancy, lactation Nsg Mgt: Take this medication by mouth with or without food, usually once daily at bedtime, or twice daily

ANTI-PARKINSONIAN DRUGS

Brand Name: Carbidopa/ Levodopa Indication: used in combination to treat the symptoms of Parkinson's disease or Parkinson-like symptoms (e.g., shakiness,
stiffness, difficulty moving)

Action: Levodopa changes into dopamine in the brain, helping to control movement.Carbidopa prevents the breakdown of
levodopa in the bloodstream so more levodopa can enter the brain

Contraindication: glaucoma, asthma, heart aatack, liver disease Nsg Mgt: Take this medication by mouth with food

Brand Name: Pramipexole (Mirapex) Indication: Parkinsons disease, Restless legs syndrome Action: is a nonergot dopamine agonist with high relative in vitro specificity and full intrinsic activity at the D2 subfamily of
dopamine receptors, binding with higher affinity to D3 than to D2 or D4 receptor subtypes

Contraindication: Heart failure, Schitzophrenia, narcolepsy, pregnancy, lactation Nsg Mgt: Take this medication by mouth with or without food; You may fall asleep suddenly, even after feeling alert. Tell
your doctor if you have any problems with daytime sleepiness or drowsiness.

Brand Name: Ropinirole (Requip) Indication: to treat Parkinson's disease Action: This medication works by helping to restore the balance of a certain natural substance (dopamine) in the brain. Contraindication: sleep apnea, narcolepsy, pregnancy, lactation Nsg Mgt: Take this medication by mouth with or without food

Brand Name: Bromocriptine (Parlodel) Indication: Parkinson s disease Action: Bromocriptine works by stimulating dopamine receptors in the brain. Contraindication: GI bleeding, Liver disease Nsg Mgt: This medication often causes dizziness, especially just after the first dose. Lie down immediately after taking your
first dose to reduce the risk of injury from falling.

Brand Name: SYMMETREL (Amantadine Hydrochloride) Indication: Parkinsons disease/ syndrome Action: The drug has many effects in the brain, including release of dopamine and norepinephrine from nerve endings. It
appears to be a weak NMDA receptor antagonist[23][24] as well as an anticholinergic.

Contraindication: liver disease Nsg Mgt: This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity
that requires alertness or clear vision until you are sure you can perform such activities safely. Avoid alcoholic beverages.

DRUG STUDY
Submitted by:

MARGARET MAY LLAVOR BSN 4F