Osmania University

Syllabus for M. Pharmacy (Pharmaceutical Chemistry)
(w.e.f. academic year 2009-10)

Faculty of Technology, Hyderabad

Scheme of Instruction and Evaluation for M. Pharmacy (Pharmaceutical Chemistry) I – Semester Subject Code Subject / Paper Theory / Practical Instruction Hours per week Evaluation Duration of External Examination Practical 70 70 Interna l External 3 3

Theory M PCH.T.1.101 M PCH.T.1.102 M PCH.T.1.103 M PCH.T.1.104 M PCH.P.1.105 M PCH.P.1.106 M PCH.T.1.107 M PCH.1.108 Pharmaceutical Analytical Techniques Advanced Pharmaceutical Organic Chemistry – I Advanced Medicinal Chemistry – I Advanced Chemistry of Natural Products Pharmaceutical Analytical Techniques Advanced Chemistry of Natural Products Entrepreneurship Management (SAIL) Seminar Theory Theory 4 4 − − 30 30

Theory Theory Practical Practical Tutorials −

4 4 − − 2 − 18

− − 6 6 − 8 2 0

30 30 30 30 A/B/C/D 50 230

70 70 70 70 − 6

3 3

6 −

420

Scheme of Instruction and Evaluation for M. Pharmacy (Pharmaceutical Chemistry) II– Semester
Subject Code Subject / Paper Theory / Practical Instruction Hours per week Evaluation Duration of External Examination Practical 70 Interna l External 3

Theory M PCH.T.1.201 Intellectual Property Rights & Regulatory Affairs Advanced Pharmaceutical Organic Chemistry – II Advanced Medicinal Chemistry – II Theory 4 − 30

M PCH.T.1.202 M PCH.T.1.203

Theory

4

30

70

3

Theory

4

30

70

3

1.T.206 M PCH.1. Pharmacy (Pharmaceutical Chemistry) Semester III and IV DISSERTATION – Original research work carried out by the candidate under the guidance of regular teaching faculty/visiting faculty of the department should be submitted in a bound form. Fail .1. Dissertation viva-voce Grade A/B/C/D/F Dissertation report Grade A/B/C/D/F A: Excellent B.205 M PCH.P.208 Drug Screening Methods & Biostatistics Advanced Pharmaceutical Organic Chemistry – II Advanced Medicinal Chemistry – II Scientific and Technical Writing (SAIL) Seminars Theory 4 − 30 70 3 Practical − 6 30 70 6 Practical Tutorials − 2 6 − 30 A/B/C/D 70 − − 6 − − 18 8 2 0 50 230 − 420 − SAIL: Self assess Instrumentation Learning Scheme of Instruction and Evaluation for M.204 M PCH.1. Evaluation of the dissertation shall be done by external and internal examiners appointed by the university. Good D: Fair F.T.207 M PCH.M PCH.T.1. Very good C.P.

Instrumentation. Difference and derivative spectra. (Attenuated Total Reflectance). Interpretation of IR spectra. instrumentation in HPLC. Woodward-Fieser rules for caculating absortion maximum for unsaturated hydrocarbons. Instrumentation (components and their significance). derivatisation methods. and supercritical fluid chromatography (SFC). instrumentation. b) Infra-Red Spectroscopy: Interaction of infrared radiation with organic molecules and it’s effects on bonds. mass spectrum and its characteristics. molecular ion. fragmentation processes. effect of conjugation. Interpretation of PMR spectra. flash chromatography. column selection. shielding and deshielding. isoelectric focusing (IEF). .101 Sessional: 30 Examination: 70 Period/Week: 4 Duration of Exam: 3 hrs Nature of Exam: Theory UNIT – I a) UV-Visible Spectroscopy: Basic principles. normal and reversed phase packing materials. solvent and pH. fragmentation patterns and fragment characteristics in relation to parent structure and functional groups.Dispersive IR spectrophotometers and Fourier transform spectrophotometers. Sample handling for IR spectroscopy. applications and limitations. Liquid chromatography: Comparison of GC and HPLC. gel permeation chromatography. Relative abundances of isotopes and their contribution to characteristic peaks.spin coupling. metastable ions. column efficiency parameters. SDS gel electrophoresis and blotting techniques. Concept of chromophore and auxochrome. continous electrophoresis (preparative) and capillary electrophoresis.T. fragment ions. b) Radio immunoassay and ELISA: Principle. efficiency parameters. mobile phase selection. UNIT – III Mass Spectrometry: Basic principles and instrumentation (components and their significance). UNIT – IV Chromatographic Techniques: Classification of chromatographic methods based on mechanism of separation and their basic principles. Brief introduction about Carbon-13 NMR and 2D NMR Spectroscopy.1. interaction of electromagnetic radiation with matter and its effects (electronic transitions). spin. Ionization techniques. zone electrophoresis (ZE). signal multiplicity phenomena in high resolution PMR. Brief note on ATR. applications in pharmaceutical analysis.PHARMACEUTICAL ANALYTICAL TECHNIQUES M PCH. isotachphoresis. chiral chromatography. Absorption spectra of organic compounds and complexes illustrating the phenomenon and its utilization in qualitative and quantitative studies of drugs including multicomponent analysis. Chemical shifts concept. instrumentation (components and their significance). spin-spin decoupling. applications in pharmaceutical analysis. Instrumentation and applications of HPTLC. instrumentation and applications of moving boundary electrophoresis. solvents. ion exchange chromatography. Gas chromatography: Instrumentation. UNIT – II Nuclear Magnetic Resonance Spectroscopy: Fundamental principles of NMR. UNIT – V a) Electrophoresis: Principles.

Settle FA. I & II. Conners KA. McGraw Hill Book Company. Introduction to spectroscopy. Crouch. 6. 4th ed. Organic spectroscopy: Principles and Applications. New Delhi. Goel Publishing house. Vyvyan JA. 2005. 6th ed. William Kemp. Meerut. Willard HH. 2006. Schirmer.. Principles of instrumental analysis. 2007. Webstar. CRC Press. GW. 8. Haryana.. Sharma BK. 1985. 3. CBS Publishers & distributors. Instrumental methods of chemical analysis. 25th Ed. 3rd ed.. New Delhi. Florida. 2008. Modem methods of pharmaceutical analysis. Holler. Narosa publishing house Pvt Ltd.. Vol. Skoog. 3rd ed.. 2nd ed. John Wiley & Sons. New Delhi.. Organic spectroscopy. Pavia DL. 2004.. 11. AH. CBS Publishers & Distributors. Instrumental methods of analysis. 7 th ed. Jag Mohan.Recommended Books: 1. Baba Barkha Nath printers. A Text book of pharmaceutical analysis. Singapore. Lampman GM. 5. Stenlake. Kriz GS. 2005. JB. RM. 10.. Silverstein. Beckett. 2nd ed. 2006. Palgrave. 2000. FX. Instrumental methods of chemical analysis. Practical pharmaceutical chemistry.. Brookescole publishers.. ADVANCED PHARMACEUTICAL ORGANIC CHEMISTRY – I . 7. John Wiley & Sons (Asia) Pvt.. California. Ewing. DA. 1986. 4th ed. RE. SR. FJ. 9. 5th ed. Singapore. New York. 4.. Dean JA.. 2004. Merritt LL. Spectrometric identification of organic compounds. 6th ed. Part I & II. 2. Ltd. New York.

Ege S.M PCH. 1999. Organic chemistry. Part. nitrenes/ nitrenium ions. 5th ed. Advanced organic chemistry: reactions. 6. UNIT – V Molecular Rearrangements: 1. mechanisms and structures. 5th ed. 2007. Finar IL. terminology and mechanism with suitable examples. Cis/Trans. Recommended Books: 1. New Delhi: Pearson Education. generation. Wothers P.Villager rearrangement and rearrangement of hydroperoxides. UNIT – III Mechanisms of Organic Reactions: Electrophilic (addition and substitution). Curtius rearrangement. Advanced organic chemistry.benzilic acid rearrangement. Nomenclature – D. 2. 7. sequence rules. 8. Carbon to carbon migration: Wagner. Carey FA. Finar IL. Delhi: Dorling Kindersley (India) Pvt. Morrison RT. UNIT – II Reactive Intermediates: Definition. carbocations. Carrruthers W. Delhi: Oxford University Press. Organic Chemistry-stereochemistry and the chemistry of natural products. structure and reactivity of free radicals. allenes and spiranes. Beckmann rearrangement and Lossen rearrangement. Delhi: A. Ltd. New York: Springer. elimination and free radical (addition and substitution) reactions. 6th ed. Warren S. Delhi: Dorling Kindersley (India) Pvt. Nucleophilic (addition and substitution). 4th ed. cycloaddition and sigmatropic reactions-introduction. 2003.B.T. S. Stereochemistry of biphenyls. 4. 2007. Organic chemistry. Singapore: John Wiley & Sons. Pinacol-pinacolone rearrangement and Benzil. 4th ed. 2006. Ltd. Boyd RN. vol 2. Greeves N. carbenes. Stereochemistry of organic compounds. E-Z isomerism resulting from double bonds. 2007.T. Carbon to nitrogen migration: Hoffmann rearrangement.Meerwin rearrangement.B: Reactions and synthesis. Organic Chemistry. 2006. 6th ed. Organic chemistry. Delhi: John Wiley & Sons. Asymmetric Synthesis and stereoselective synthesis. monocyclic compounds. 2. 3rd ed. UNIT –IV Pericyclic Reactions: Electrocyclic. 10. Skyes P. L and R. carbanions. 3.S.102 Period/Week: 4 Sessional: 30 Duration of Exam: 3 hrs Examination: 70 Nature of Exam: Theory UNIT – I Stereochemistry: Elements of symmetry-plane of symmetry. Wilen SH. fused ring systems. Publishers & Distributors. Eliel EL. kinds of molecules displaying optical activity. Delhi: Cambridge University Press.nomenclature. center of symmetry. vol 1. Racemic modifications and methods of resolution of racemic mixtures. 5. Carbon to oxygen migration: Bayer. Claisen rearrangement. 9. Clayden J. March J. 5th ed. 2008 3.1. 2001. alternating axis of symmetry and simple axis of symmetry. Modern methods of organic synthesis. Delhi: Pearson .I. stability. A guided book to mechanism in organic chemistry. Sundberg RJ.

5th ed. Sierra M.103 Period/Week: 4 Sessional: 30 Duration of Exam: 3 hrs Examination: 70 Nature of Exam: Theory . 3rd ed. New York: Academic Press. Vol I. Roland EL. New Delhi: New Age International (P) Ltd Publishers. Patrick G. Macomber R. Ahluwalia VK. Nasipuri.T. Organic chemistry. Singapore: Thomson Asia Pte Ltd. Delhi: Rajkamal Electric Press.Education. 17. Fergusson LN. 19. Organic chemistry. 2006. 2007. 1st ed. India: Delhi: Oxford University Press. 18. Orbital symmetry: a problem solving approach. 2nd ed. 2008. 2006. ADVANCED MEDICINAL CHEMISTRY – I M PCH. Alan PM. Organic chemistry. 12. 2007. 14. Gallego MG. 2002.A. New Delhi: Viva Books private Limited. 13. 2000. Organic reaction mechanisms. Textbook of organic chemistry. Organic chemistry. New Delhi: East-West Press Private Limited.1. 2001. Loudon GM. Kolkata: Narosa Publishing house. Mc Murry J. 11. New Delhi: Viva Books Private Limited. 16. Organic reaction mechanisms. Stereochemistry. 4th ed. 15.

Pharmaceutical Chemistry. UNIT – III Targets for the development of following chemotherapeutic agents: antiulcer. Volume-1-6. The organic chemistry of drug design and drug action. editor. 2nd ed. New Delhi: John Wiley & Sons. 11. Istvan T. Testa B. Theories of drug-receptor interactions: 1) occupancy theory. New York: A wiley-interscience publication. New York: Marcel Dekker. 21st ed. 2005. New Jersey: John Wiley & Sons. 1988. Block JH. New York: Taylor & Franscis. extraction of active principles from natural sources. 6th ed. . New Delhi: Wolters Kluwer and Lippincott Williams & Wilkins. Lemke TL.UNIT – I Theoretical aspects of drug action: Introduction. Gyorgy K. Silvermann RB. Williams DA. Jenner P. Lednicer D. 2005. 2003. 8. 3) induced fit theory. I-X. selection or synthesis of soft and hard drugs. John Wiley & Sons. choice and function of pro-moiety. Kleemann A. Foye’s principles of medicinal chemistry. 2007. 5) topographical and stereo chemical considerations. Recommended Books: 1. Andrejus K. 2008. 5. 9. The organic chemistry of drug synthesis. New Delhi. analgesic. 3. 12. 6. Burger’s Medicinal Chemistry and Drug Discovery. vol. Mitscher LA. 7. antiangiogenesis and antihypertensive agents. Hansch’s comprehensive medicinal chemistry. Wilson and gisvold’s textbook of organic medicinal and pharmaceutical chemistry. molecular modification of known drugs. 6) Ion channel blockers.. editor. 4) macro molecular perturbation theory. bioreversible derivatives for various functional groups. I & II. brief account on various forces involved in drugreceptor complex. editor. UNIT – IV Biotransformation of drugs: Enzymes responsible for biotransformation. 2004. 6th ed. 1988. and rational drug design. Ariens EJ. antifungal. Abraham DJ. Noida: Academic Press. 1973. Delhi: Rajkamal Electronic Press. editor. 2. random screening. UNIT – V Genesis of new drugs: Serendipity. Beale JM. 10. Vol 1-6. 2004. Vol-I. Drug design vol. microsomal and nonmicrosomal mechanisms. types of receptors. 2005. 2nd ed. UNIT – II Design and application of prodrugs: Prodrug concept. Drug metabolism: chemical and biochemical aspects. 4. 2) rate theory. editor. Hansch C. Strategies of Drug design: A guide to biological activity. 1976. Molecular pathomechanisms and new trends in drug research. antiinflammatory. 2009. Baltimore: Lippincott Williams & Wilkins. London: Academic press (Elsevier). Roth HJ. applications of the pro-drug approach. 11th ed. Case history of drug development – cimetidine. Factors influencing enzyme induction and inhibition. William AP. Lippincatt Willams & Wilkings. New York: Ellis Horwood Limited. Remington: The science and practice of pharmacy. Phase-I and phase-II transformations with suitable examples. 13. Drug synthesis. Essentials of Medicinal Chemistry.

15. Strategies of drug design. Essentials of medicinal chemistry. Purcell. ADVANCED CHEMISTRY OF NATURAL PRODUCTS M PCH. Korolkovas.14.T.104 Period/Week: 4 Sessional: 30 Duration of Exam: 3 hrs Examination: 70 Nature of Exam: Theory .1.

8. 2003. Kundli: Replika Press Pvt. 2006. stereochemistry of steroids. Nagasampagi BA. Organic chemistry-natural products. semi synthetic derivatives.UNIT – I Natural products as leads for new drugs: Introduction/history. editor. Advanced organic chemistry-reactions. From opium: morphine-structural elucidation. Bhat SV. and cardiovascular agents. From vinca rosea: vincristine and vinblastine . structural modifications. nomenclature. Edinburgh: Saunders. 6th ed. 2004. Lemke TL. Recommended Books: 1. secondary. Boyd RN. Beale JM. Steroids by Fischer & Fischer. vol 1-15. vol 1-2. and structure. Delhi: Pearson education Pvt. Block JH. Delhi: Dorling Kindersley (India) Pvt. 2004. New Delhi: Wolters Kluwer/ Lippincott Williams & Wilkins. Meerut: Goel Publishing House. Roche VF. tertiary and quaternary structure of proteins. and uses. 30th ed. 2006. New Delhi: Narosa Publishing House. 2003. 6. 12. 6 th ed.. editor. Textbook of pharmacognosy. structural modifications and therapeutic uses of steroidal anti-inflammatory agents and antifertility agents. 2001. 5th ed. Chemistry of natural products. 10. Foye’s principles of medicinal chemistry. Baltimore: Lippincott Williams & Wilkins. Trease and evans pharmacognosy. 6th ed. Pelletier SW. Williams DA. 15th ed. Zito SW. Evans WC. 11. Abraham DJ. Ltd. Organic Chemistry. UNIT – III Steroids: Introduction. UNIT – V Miscellaneous compounds: Structure. 3. 11th ed. Jerry M. general methods of synthesis of peptides. 2005. structural modifications and uses. Morrison RT. Agrawal OP.. London: Pergamon. Chemistry of natural products 7. Finar IL. mechanisms. UNIT – IV Polypeptides and proteins: introduction and general methods of separation. . Ataur Rahman. Ltd. chemistry of insulin. approaches to discovery and development of natural products as potential new drugs selection and optimization of lead compounds for further development with suitable examples from antibiotics.structural modification. 2. From Rauwolfia: Reserpine-structural eludication. general methods of degradation and end group analysis. Ltd. Wallis TE. New Delhi: CBS Publishers & Distributors. 4th ed. CNS. UNIT – II Alkaloids: Introduction and general methods of structure elucidation. 2002. Structures. mechanism of action and therapeutic uses of a) taxanes b) camptothecin c) artemisicin e) ginkolides and f) gymnemic acids. vol 1-6. Primary. Burger’s medicinal chemistry and drug discovery. 2008. Sivakumar M. 9. Alkaloids-chemical & biological perspectives. Organic Chemistry-stereochemistry and the chemistry of natural products. Source and structure elucidation of cholesterol and diosgenin. Singapore: John Wiley & Sons. 5th ed. 2007. Wilson and gisvold’s textbook of organic medicinal and pharmaceutical chemistry. 5. 13. development of morphine analogues and morphine antagonists. vol 2. 4.

UV/Visible spectrum scanning of a few organic compounds for UV. New Delhi. 26th ed. Effect of solvents and pH on UV spectrum of drugs. Rodwell VW. 2005.1.14. PHARMACEUTICAL ANALYTICAL TECHNIQUES M PCH. Delhi: Rajkamal electric press. Murray RK. 15. Harper’s Illustrated biochemistry. vol.absorption and correlations of structures (5 compounds) and isosbestic point in case of mixtures. Granner DK. Remington: The science and practice of pharmacy. New Delhi: Mc Graw Hill.. I & II. (2 experiments) 3.Spectrophotometer in formulations. Rama Rao AVSS. Mayes PA. 2. 16.P. Estimation of multicomponent formulation by UV. 2004. A text book of biochemistry.105 Sessional: 30 Examination: 70 Period/Week: 6 Duration of Exam: 6 hrs Nature of Exam: Practical List of Experiments: (Minimum of 8 experiments shall be conducted) 1. 2003. 9th ed. 21st ed. Lippincatt Willams & Wilkings. (2 .

Any other relevant experiments based on theory. Curcumin from turmeric powder. 5. Practical pharmacognosy. Part II. 2005. Tannic acid from myrobalan. 3.experiments) 4. 2005.P. 12th ed. ADVANCED CHEMISTRY OF NATURAL PRODUCTS M PCH. Myristicin and trimyristicin from nutmeg. New Delhi: Elsevier. Natural products: a laboratory guide. 4. Interpretation of drugs by IR spectra. References: 1. (2 experiments) 6. Experiments based on the application of derivative spectroscopy. Practical pharmacognosy. Pune: Nirali Prakashan. MASS) structural elucidation of at least 5 compounds. d. i. 2. Shah Prakashan. IR. Experiments based on HPLC (Isocratic and Gradient elution) techniques. Strychnine from Nux vomica seeds. Isolation of casein from milk.106 Period/Week: 6 Sessional: 30 Duration of Exam: 6 hrs Examination: 70 Nature of Exam: Practical List of Experiments: (Minimum of 8 experiments shall be conducted) 1. f. Ahmedabad: B. Kokate CK. Pharmacognosy & phytochemistry. 7. 3. (2 experiments) 5. 2nd ed. 2004. Khandelwal KR. Rangari VD. Lysozyme from albumen. 4. Degradation and characterization of degradation products of a) Piperine b) Atropine and c) Caffeine. Shah and Qadry’s pharmacognosy. New Delhi: Vallabh Prakashan. Nashik: Career Publications.1. Any other relevant experiments based on theory. Hesperidin from orange peel. Qadry JS. e. Raphel I. g. Piperine from black pepper b. NMR. . (4 experiments) 8. Workshop of spectroscopy: (UV. 2. Isolation and characterization of the following natural products: a. c. h. Separation of natural products through column chromatography. Extraction and estimation of carvone from caraway seeds. Lycopene from tomatoes. 5. S.

• To orient and impart knowledge towards identifying and implementing entrepreneurship opportunities.ENTREPRENEURSHIP MANAGEMENT Subject Code: M PCH. • To develop management skills for entrepreneurship management.T. .1. • To Sensitise and motivate the students towards entrepreneurship management.107 Grade: A/B/C/D Periods/week: 2 Examination: -Nature of Exam: Tutorials Exam Duration: -Course Objectives: • To provide conceptual inputs regarding entrepreneurship management.

Patel VC.finance. Ahmedabad: EDII. problems. site and manpower. . UNIT – IV: GROWTH STRATEGIES AND NETWORKING .C. .Role of enterprise in national and global economy . . Entrepreneurship-starting. raw material. self awareness. enterprise feasibility study.Entrepreneurial competency – Concepts. New Delhi: NIESBUD.Profitability and control measures.Entrepreneurial motivation – dynamics of motivation.Future Growth – Techniques of expansion and diversification. interpersonal skills. schemes of assistance. 1995.Concept need and process in entrepreneurship development. 4. Akhauri MMP. Peters MP. Hisrich RD.Government policies and schemes for enterprise development . factors affecting entrepreneur'’ role. Meredith GG.al. . UNIT – III: LAUNCHING AND ORGANISING AN ENTERPRISE . . resource mobilisation and implementation.requirements and understanding the process of entrepreneurship development. Hisrich RD. Brush CG.Types of enterprise – Merits and Demerits . monitoring and evaluation.Need for diversification .Concept and dynamics .Feedback.Project work – Feasibility report. Joint venture.Developing Entrepreneurial competencies . 3. 1982. co-ordination and feasibility study UNIT –V: PREPARING PROJECT PROPOSAL TO START ON NEW ENTERPRISE .Resource mobilisation . demands and challenges . 5. Planning. Practice of Entrepreneurship.Costing and marketing management and quality control. Recommended Books: 1. technology. Geneva: ILO.UNIT – I: CONCEPTUAL FRAME WORK: . 1990. vision strategies .Enterprise selection. market assessment. . .Institutional support in enterprise development and management UNIT – II: THE ENTREPRENEUR . Women entrepreneurship-developing new entrepreneurs. SWOT Analysis. Health & Company. 2. et.Environment scanning – Information.Methods. assertiveness.Performance appraisal and assessment .. Toranto: D. creativity. 1987. The women entrepreneurs. developing and managing a new enterprise. . achievement. Entrepreneurship for women in India. USA: Inwin. INC. sources. 1996.

copyrights. fundamental principles.INTELLECTUAL PROPERTY RIGHTS AND REGULATORY AFFAIRS M PCH. source of patient information. silent features. impact on globalization. . objectives. scope. functions. status. objectives. impact on developing countries. scope. Patents.1. structure. prospectives. UNIT – II GATT and WTO: GATT – historical. trade related aspects (TRIPS).T. patent processing and application.201 Period/Week: 4 Sessional: 30 Duration of Exam: 3 hrs Examination: 70 Nature of Exam: Theory UNIT – I Patents and Intellectual Property Rights (IPR): definition. trademarks. WTO-objectives. membership and withdrawal. India-tasks & challenges. international and regional agreements. dispute settlement.

2004.. and 2.wipo.6-dicyano-1. www.4-benzoquinone (DDQ).T. ANDA. Laws and drugs. U and Y. New drug approval process. UNIT – IV Related Quality Systems: Objectives and guidelines of USFDA. UNIT – II Mechanism and applications of reactions and reagents: a. c. Good manufacturing practices for pharmaceuticals. Recommended Books: 1.fda. Guarino RA. harmonizing formulation development for global filings.. New York. Law of drugs in India.int . Hussain.org . sodium borohydride. Marcel Dekker Inc. New York. Micheal addition. 2001. WHO and ICH. ADVANCED PHARMACEUTICAL ORGANIC CHEMISTRY – II M PCH. 2. CTD. handling and maintenance including electronic documentation.. n-bromo succinamide (NBS). b. NDA. 5. 4th ed. 6. Claisen ester condensation. vol 109. lithium aluminium hydride (LAH). 5th ed. Websites: www. Das P. Willing SH. Marcel Dekker Inc. Law Publishers. Das G. protocols. 3. UNIT – V Documentation: Documentation types related to pharmaceutical industry. Protection of industrial property rights. Witting reaction. vol 139. d.org .org .. www.3-dichlro-5. Introduction to ISO series.cder. www. Mannich reaction.UNIT – III Regulatory Affairs: Indian context – requirements and guidelines of GMP. dealing with post-approval changes – SUPAC.202 Period/Week: 4 Sessional: 30 Duration of Exam: 3 hrs Examination: 70 Nature of Exam: Theory UNIT – I Synthetic Reagents and Applications: Lead tetra acetate (LTA). 4. Original Laws published by Government of India.ich. understanding of drugs and cosmetics act 1940 and rules 1945 with reference to schedule M. 7. .1. DCC (Dicyclohexyl carbodimide). Katju SN. osmonium tetraoxide.

Unit process in organic synthesis. editor. 5th ed. 2003. Roth HJ. New Delhi: Tata McGraw Hill Publishing Comapany Limited. Berlin: Berkhauser Verlag. photolithography. mechanisms and structures. Green Chemistry. 2002. 4th ed. Groggins PH. consecutive vs convergent synthesis. 3. March J. Organic Chemistry. Modern methods of organic synthesis. Advanced organic chemistry. UNIT – V Combinatorial Chemistry: Introduction. Hilgenfeld R. Boyd RN. ethylcyano acetate. 5th ed. Part. 4. New York: Ellis Horwood Limited. 2001. 7. A guide book to organic synthesis. and applications. Patrick G. Organic chemistry. Hansals VAS. Singapore: John Wiley & Sons. 2006.B: Reactions and synthesis. diethyl malonate. Wuts PGM. strategic bond approach-preliminary scan. Sundberg RJ. Pharmaceutical Chemistry. streamlining the process. Mackie RK. Smith MB. 6th ed. 15. 2007. Vol-I. 2000. 1988. Greene TW. investigative approach. 8. Kleemann A. 6th ed. Recommended Books: 1. New York: Springer. 2004. 2nd ed. Greeves N. limitations of combinatorial chemistry. 9. Morrison RT. New York: Taylor & Franscis. 6. Organic chemistry. 10. Delhi: Dorling Kindersley (India) Pvt. New Jersy: John Wiley & Sons. 4 th ed. 2. UNIT – IV Synthetic Strategies: Introduction to disconnection approach. Carrruthers W. deconvulution techniques. Advanced organic chemistry: reactions. Introduction. Molecular pathomechanisms and new trends in drug research.e. New Jersy: Prentice Hall Private Limited. 2007. Ltd. 13. Hillish A. 11. 5th ed. 2006. Coldham I. Drug synthesis. planning and designing of combinatorial synthesis. A brief account on Green Chemistry: principles. development and scale up. Organic chemistry. solid phase techniques. New Delhi: Tata McGraw Hill Publishing Comapany Limited. synthetic route selection. 16. A guided book to mechanism in organic chemistry. New Delhi: Pearson Education. 12. identifying strategic bonds in rings. . 2. 5. Carey FA. Delhi: Cambridge University Press. 2007. tagging. Wothers P. UNIT – III Development & scale up of process for the manufacture of new pharmaceuticals: 1. parallel synthesis. Istvan T. 14. Delhi: Oxford University Press. optimization of synthetic routes-yield improvement. various strategic approaches in retro synthesis. criteria in disconnection of strategic bonds. Finar IL. Delhi: Pearson Education. Modern methods of drug discovery. 2003. Skyes P. Greene’s protective groups in organic synthesis. 2003. mixed combinatorial chemistry. vol 1. Synthetic applications of ethyl aceto acetate. 1977. 4th ed. Gyorgy K. Warren S. New Delhi: Viva Books Private Limited. Organic synthesis. 2007. Clayden J.

Methods used to correlate physico chemical parameters with biological activity: Hansch analysis. UNIT – II Rational Drug design: Quantitative structure activity relationship (QSAR): Physico chemical properties: hydrophobicity. Molecular modeling: Molecular mechanics.T. modeling ligands for known receptors and unknown receptors. Topliss scheme. steric factors-Taft’s steric factor (Es). Virtual screening: concept. verloop steric parameter. other physico chemical parameters. molecular graphics based drug design and mathematical methods. molar refractivity. quantam mechanics. electronic effects.1. 2. 3D QSAR. Free and Wilson approach.ADVANCED MEDICINAL CHEMISTRY – II M PCH. planning a QSAR study. focused screening libraries for lead identification. drug likeness screening. structure based virtual screening and applications. UNIT – III .203 Period/Week: 4 Sessional: 30 Duration of Exam: 3 hrs Examination: 70 Nature of Exam: Theory UNIT – I Computer aided drug design (CADD): 1. bioisosteres. pharmacophore screening.

2007. Silvermann RB. 6. New York: Taylor & Franscis. 1988. • Xanthine oxidase inhibitors. 2005. structure and life cycle of viruses. Hansch’s comprehensive medicinal chemistry. editor. 13. New York: Ellis Horwood Limited. 11. 9. 5. Lemke TL. 7. Hansch C. 1973. John Wiley & Sons. editor. Vol 1-6. Baltimore: Lippincott Williams & Wilkins.Enzyme Inhibitors: A detailed study of the following types of enzyme inhibitors. 3. I-X. editor. 2nd ed. 6th ed. Thomas Nogardy. 2004. UNIT – IV Anti Viral Agents: Viruses. 4. 10. related drugs and their pharmaceutical significance. 8. • HMG Co A reductase inhibitors. Oxford University Press. UNIT – V Chemotherapy of Cancer: Molecular biology of caner: introduction. • Phosphodiesterase (PDE) inhibitors. Recommended Books: 1. Delhi: Rajkamal Electronic Press. .herpes. Drug synthesis. biochemical basis of cancer. Noida: Academic Press. Molecular pathomechanisms and new trends in drug research. 11th ed.G. An introduction to medicinal chemistry. and RNA viruses – HIV. Synthease (Cyclooxygenase and Lipoxygenase) inhibitors. Andrejus K. Beale JM. Strategies of Drug design: A guide to biological activity. • P. Foye’s principles of medicinal chemistry. SAR and mechanism of action of anticancer agents. 3rd ed. Introduction to principles of drug design-Harwood academic press. Roth HJ. 2008. chicken pox. 2004. antiviral agents used against DNA viruses. Ariens EJ. antitumor antibiotics. antimetabolites. • Angiotensin convertin enzyme (ACE) inhibitors. A biochemical approach. influenza. Wilson and gisvold’s textbook of organic medicinal and pharmaceutical chemistry. Abraham DJ. London: Academic press (Elsevier). Essentials of Medicinal Chemistry. 6th ed. Vol-I. Williams DA. Kleemann A. editor. Medicinal chemistry. A brief account on cancer chemotherapy and drug resistance. New Delhi: Wolters Kluwer and Lippincott Williams & Wilkins. New Delhi: Oxford University Press. alkylating agents. Gyorgy K. The organic chemistry of drug design and drug action. 12. Pharmaceutical Chemistry. Purcell. Patrick GL. Istvan T. viral diseases. 2. 2003. 1988. 2009. Block JH. Strategy of drug design. editor. 2006. types of cancer. New Delhi: John Wiley & Sons. Burger’s Medicinal Chemistry and Drug Discovery. Smith & Williams. Drug design vol. William AP. New Jersey: John Wiley & Sons. 2nd ed. 14.

Bioassay: Different types: dose effect relationships. F-test. In vivo screening methods: Antihypertensive. (iii) Independence in contingency tables. assay construction.DRUG SCREENING METHODS AND BIOSTATISTICS M PCH. Chi-square test of (i) Variance of a normal population (ii) Goodness of fit. 2. 2-way and 3-way classification. UNIT – II Design of experiment: Principles of randomization. Method of least squares. calculation of LD50. cardiotonic. and screen construction-assay design. bioassay design. process control.204 Period/Week: 4 Sessional: 30 Duration of Exam: 3 hrs Examination: 70 Nature of Exam: Theory UNIT – I Bio-statistics: Regression and correlation: Linear regressions.T. significance of correlation coefficient. Statistical quality control. UNIT – IV 1. replication and local control. UNIT – III High throughput screening: introduction. correlation coefficients. ED50 – Probit analysis. homogenous and non homogeneous biochemical assays and cellular assays. . multiple regression tests of significance: testing hypotheses. completely randomized block of the above designs in pharmaceutical research. T-test. control charts. and anticancer and diuretic drugs. tests of significance based on normal distribution.1. rank correlation. acceptance sampling – sampling plans. antiarrythmic. Analysis of variance: 1-way.

New Delhi: Jaypee Brothers Medical Publishers (P) Ltd. Alder HL. 4-benzylidene-2-methyloxazol-5-one (or) azalactone c. p-amino benzyl alcohol from p-amino benzaldehyde using sodium borohydride. and antifertility drugs. New Jersey: John Wiley & Sons. 2nd ed. Abraham DJ. Schiff base by microwave irradation h. Recommended Books: 1. Pharmaceutical statistics. 2007. 8. antiepileptic.3-diphenyl quinoxaline e. 2. 7. 2. 2004 . Fernandes PB. n. Benzanilide by bechmann rearrangement b. Roesseler EB. m. 2006. Fundamentals of applied statistics. β-dimethylamino propiophenone hydrochloride (mannich base) j. Kapoor VK.3-dione) l. 2007. Bon C. 6th ed. biology and chemistry. New York: Reinhold Publishers Corporation. Biostatistics. 2-phenyl indole k.1. 10.205 Period/Week: 6 Sessional: 30 Duration of Exam: 3 hrs Examination: 70 Nature of Exam: Practical List of Experiments: (Minimum of 8 experiments shall be conducted) 1. Seethala R. 12th ed. 9. Mumbai: Himalaya Publishing House. Bolton S. New York: CBS Publishers & Distributors. anti-inflammatory.P.UNIT – V In vivo screening methods: Analgesic. 4th ed. New York: Marcel Dekker Inc. 5. 4th ed. 2008. Saunders and Fleming. vol 1-6. New Delhi: Sulttaan Chand and sons. 2nd ed. Freemann and company. 3-bromo cyclohexene from cyclohexene using NBS. N-(m-nitrobenzyl)aniline from m-nitrobenzaldehyde d. ethyl acetoacetate and urea in presnce of CaCl2 catalyst. 1984. Introduction to probability and statistics.ADVANCED PHARMACEUTICAL ORGANIC CHEMISTRY – II M PCH. 2008. 2004. Vogel H and Volgel WH. g.5-dimethyl cyclohexane-1. Drug screening methods. 3. antidiabetic. Germany: Springer. Cinnamic acid by perkin reaction i. 4. Gupta SC. 2. 3. 2002.5-dicarboxylic acid from benzoic acid (hydrogenation).4-dihydropyrimidin-2(1H)-one from benzaldehyde. Hand book of drug screening. Biostatistics. San Francisco: WH. Mathematics and statistics for use in pharmacy. Dimedone (5. Cyclohexane-2. 1H-indole-3-carbaldehyde f. Arora PN. 6. Drug discovery and evaluations-pharmacological assays. . editor. Gupta SK. Synthesis and characterization of the following drugs: a. Any other relevant experiments based on theory. Lewis AE. Burger’s Medicinal Chemistry and Drug Discovery. Malhan PK.

Drug synthesis. Hanaford AJ. Singapore: Longman Singapore Publishers P Ltd. Mann FG. 2005.206 Period/Week: 6 Sessional: 30 Duration of Exam: 3 hrs Examination: 70 Nature of Exam: Practical List of Experiments: (Minimum of 8 experiments shall be conducted) 1. 4th ed. New York: A wiley-interscience publication. Tatchell AR. ADVANCED MEDICINAL CHEMISTRY – II M PCH.P. 2004. 4th ed. 2006. 2004. Lednicer D. Part 1: Small scale preparations. Tatchell AR. New Delhi: Orient Longman. New York: Ellis Horwood Limited. Smith PWG. 3. 3. Volume-1-6. Bansal RK. 4. paracetamol from p-aminophenol 2. Elementary practical organic chemistry. Saunders BC. New Delhi: New Age International (P) limited. 2. Isoniazid h. 3. Kleemann A.References: 1. 2nd ed. Vogel’s textbook of practical organic chemistry. Mitscher LA. Furniss BS. . Phenacetin b. 5th ed. Pharmaceutical Chemistry. Practical organic chemistry. Determination of partition coefficient of any medicinal compound by shake flask method. Tolbutamide f. 2. Furniss BS. References: 1. 6. Hanaford AJ. Elementary practical organic chemistry. 4th ed. Laboratory manual of organic chemistry. Roth HJ. New Delhi: CBS publishers and distributors. Practical organic chemistry. Sulphasalazine i. 2005. Uramil e. Smith PWG. The organic chemistry of drug synthesis. Antipyrin c. 5th ed. Mann FG. Phenothiazine g. 5. 2005. Saunders BC. Synthesis and characterization of the following drugs: a. Vogel’s textbook of practical organic chemistry. 2nd ed.1. 1989. 2005. Advanced Practical Medicinal Chemistry. New Delhi: Orient Longman. Kar A. aspirin from salicylic acid j. Vogel A. Benzocaine d. New Delhi: CBS publishers and distributors. Vol-I. 1989. Part 1: Small scale preparations. Singapore: Longman Singapore Publishers P Ltd. Any other relevant experiments based on theory. 1988. 4. New Delhi: New Age International (P) limited. Vogel A.

207 Grade: A/B/C/D Periods/week: 2 Examination: -Nature of Exam: Tutorials Exam Duration: -Course Objectives: • To be able to appreciate and understand importance of writing scientifically.T. Advanced Practical Medicinal Chemistry. 2005. sources. SUB TITLES. 2003. monographs.Articles in journals. • To develop competence in writing and abstracting skills. review articles. SCIENTIFIC AND TECHNICAL WRITING Subject Code: M PCH. bibliographies. Column Head. 8. Laboratory manual of organic chemistry. Box Head Appendices: use and guidelines. United States Pharmacopoeia. New Delhi: New Age International (P) limited. Reflecting and Re- . • To write either a draft research proposal or a chapter of dissertation. 7. 4th ed. London. conceptual outline. Controller of Publication. tabulating information. Indian Pharmacopoeia. ILLUSTRATIONS Tables as systematic means of presenting data in rows and columns and lucid way of indicating relationships and results. sentence outlines and combination of topic and sentence outlines UNIT – III: DRAFTING TITLES.1. Inc. 6. Bansal RK. . British Pharmacopoeia. UNIT – I: COLLECTION AND EVALUATION OF INFORMATION Identification.Different forms of scientific and technical writing. 1996. Stab Column. British Pharmacopoeia Commission Office. research notes and reports. How to formulate outlines: The reasons for preparing outlines • as a guide for plan of writing • as skeleton for the manuscript Kinds of outline: topic outlines. Formatting Tables: Title. Spanner Head.5. dissertations. UNIT – II: WRITING AS A MEANS OF COMMUNICATION . Drafting. Kar A. classifying information under fact/opinion. New Delhi: New Age International (P) limited. The Writing process: Getting started. summarizing a text and presenting sequence of topics in different forms. United States Pharmacoepial Convention. USA. 2006. Use outline as a starting device. searching information. Body stab. 2008. Delhi. 9. TABLES.

clarity. .reading.Drafting and Re-drafting based on critical evaluation UNIT . Integrating research: a guide for literature reviews.Clear organization . Dunn FV. 1984.Clearly state the question to be addressed . Review of Literature.Budgeting.Presenting pilot study/data . Content. Results and Discussion. Checking: Organization. 3. New York: Sage. et al. Headings. available infra-structure and recourses . specificity of method . California: Sage.Outcome of study and its implications . Brevity and Precision in writing . Clarity and Grammar. validity internal consistency and objectivity during writing each of the above parts. UNIT – V: WRITING FOR GRANTS .Research proposal. 1984. 3th ed. continuity.Executive summary Recommended Books: 1. 2nd ed.IV: PARTS OF DISSERTATION/RESEARCH REPORT/ARTICLE Introduction. Washington: APA. Cooper HM. clarify. Disserninating research: changing Practice.Emperial and theoretical conceptualization .Rationale and importance of the question being address . 1990. Ask questions related to: content. Methodology. APA: Publication Manual of Americal Psychological Association.. 2.

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