Grant assessment (Asia ARVO 2011) 5 areas Significance – how impt is disease or tx to human health?

Feasibility – likely to be impediments? Why is it impt? Specific aims, Background and significance How innovative

What are you going to do? Research methods How you will likely overcome impediments

CV, collaborators, envt, resources Translation – more fields Importance Hypothesis or need for data Potential research is creative and novel Relevant to funding agency Broad impluications Topical subject Neglected areas High health benefit

Order: 1. Overview (aims/deigns/significantsce) a. Currently unavailable data b. Test x major hbypotheses c. Could lead to advances that could stimulate techniques for other imaging 2. Specific aims: likely papers a. ½ page b. Broadly define long term objective c. Specific and achievable d. Significance and implications e. Hypothesis – important to current field with biological rationale. f. Will improve understanding of either aetiology, r/f or patho of dz g. Opening statement then specific aims. “Specifically, we aim to evaluate the following” Aim & Hypothesis for each

Highlight conflicting results from diff studies e. Preliminary vs current c.3. negative makes less clear f. Overview b. Population c. Measurement of outcome d. d. Sample size and power determinations Points 40% preliminary background. Positive findings support. Summary Clinical trials: endpoint determination based on dz progression? Vision? How defined? Eg. supportive pilotdata. consider measurement issues Sample size considerations Tolerable type 1 = 5% Tolerable type 2 = 20 Power of study to detect differences Calculate when sample size fixed – ask stats person! Role of pilot studies What you have done to support the grant Demonstrate collaborators abilities to complete proposal Budget considerations . Introduction: describe disease and statement g. power. Research plan and methods – overview. Directions of field and gaps in knowledge. Measurement of variables of interest e. specific methods. Known vs unknown b. Structure: i. timeline 6. logMAR instead of Snellen Use state of the art methods Measurements of other variables – don’t overload. include confounders and effect modifiers. stats methods and study a. what is missing a. Make clear links between existing data and proposed study 4. 40% methods 20% translation of information Describe selection of source material 5. Background – what is known. Study operations f.

- Justify every person listed as to what they will do and for how long Tie budget to study schedule and time line Hypothesis: does your proposed study translate? Research – does it read well? Sentence structures. Sequency easy to follow? Conclude well? Young investigators: get onto other people’s grants.Inadequately powered to meet the objective . never delete without acknowledging deletion d. Revision letter to EIC and section editor 2.Authors answer question different to one they posed . How to respond to difficult review/rejection (Salmna Quereshi) Criteria Content is new Improves on an earlier work Interesting or topical Covers a neglected or emerging topic Contradicts earlier work Provides perspective on or reviews a topic Rejection . State in revision letter explaining why not b. Respond quickly e. 6 causes . Improve other aspects of paper esp language to improve clarity – highlight changes in pink. Ignore legitimate criticisms and resubmit elsewhere without modeification 4. Provisional acceptance a.Repearts .Topic already well known .Poorly written Responses 1. Root cause analysis prior to submission elsewhere b. Prepare vision later with each of the reviewes and section editors and EIC criticisms addressed sequentially and clearly b. Have criticisms in bold and responses underneath c.Methods and results don’t support the conclusion . Don’t i. Non revisable a. Reject without resubmission a. Clearly highlighted in discussion the weaknesses in manuscript 3.Fatally flawed .Not interested .

References to commonly cited articles iv. impt: simple clear and brief. Readership and EIC preferences. Cinclusion relevant to hypothesis. Title and abstract are v. avoid detailed stats. Failure of reconnaissance (lit r/v) b. Methods and introduction are more impt than discussion ii. Avoid abbreviation always e. Lack of awareness of previously published papers in journal iii. Design failure i. title should engage readers iii. . Under powered ii. Outcome measures changed during course iii.a. Simple active language iv. Outcome measure is invalid surrogate for clinical outcome d. focus ii. Failure to execute i. Failure of situational awareness i. Manuscripts are perishable c.

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