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Influenza Essay Introduction = Biology of the virus - RNA based - mode of action/mechanisms and vaccines or drug targets

. = History of epidemics = How virus spreads = How virus might mutate/become infective to humans = Epidemiology/Biological Issues Time-frame (response to epidemic / preparation) Clinical efficacy/ manufacturing time frames = pros/cons of vaccines and drug based treatments = Manufacturing Issues supply issues = plant location/ spare capacity = timescale of manufacturing rel. to epidemic timeframe distribution = workers plan in epidemic Social Planning Issues Informing public eg stay home army/police law and order health workers and manufacturers / key workers vaccination International Issues border control monitoring of epidemics even in remote areas international agreements to assist/allow distribution of medicine Ethical Issues Conclusion http://virology-online.com/general/Replication.htm - replication http://pathmicro.med.sc.edu/mhunt/RNA-HO.htm - replication http://www.who.int/csr/disease/swineflu/laboratory18_12_2009/en/index.html - resistance. http://www.who.int/csr/disease/avian_influenza/country/cases_table_2009_12_30/en/index.html - Cumulative Number of Confirmed Human Cases of Avian Influenza A/(H5N1) Reported to WHO http://www.who.int/csr/disease/avian_influenza/avian_faqs/en/ - Pandemic definition http://www3.interscience.wiley.com/cgi-bin/fulltext/120718156/HTMLSTART?CRETRY=1&SRETRY=0 - Pandemic history http://www.cdc.gov/ncidod/eid/vol12no01/05-0979.htm - Spanish Flu pandemic http://www.fao.org/avianflu/en/clinical.html - epidemiology http://www.naturalnews.com/017503.html - Avian Influenza outbreak history http://www.influenzareport.com/ir/ai.htm - avian outbreak history - table http://biotech.about.com/b/2009/05/05/flu-vaccine-production-a-primitive-process.htm - number of eggs needed for vaccine manufacture. http://www.sciencedaily.com/releases/2009/12/091209193506.htm - bioreactors instead of eggs. http://www.cidrap.umn.edu/cidrap/content/influenza/avianflu/biofacts/avflu_human.html

(1) http://www.who.int/csr/disease/swineflu/laboratory08_01_2010/en/index.html WHO, 8 Jan. 2010 [Accessed 10 Jan. 2010]

gov/ncidod/eid/vol12no01/05-0979.htm . Dec. 2010] (3) http://www. Journal of Applied Microbiology. 11. 8 May 2006 [Accessed 2 Jan.pdf . 30 Dec.W. 2010] . Taubenberger and David M. 2008.ScienceDaily. Pages 572-579 (7) WHO.com/press_archive/press2005/flu_backgrounder. 2009 [Accessed 11 Jan.gsk.int/csr/disease/avian_influenza/avian_faqs/en/ . 2005 [Accessed 10 Dec 2009] (5) http://www. 5 Dec. 2009 [Accessed 3 Jan.(2) http://www. Potter. 2010] (8) http://www.WHO. Volume 91. 2006 [Accessed 10 Dec 2009] (6) C.com/releases/2009/12/091209193506. Jan. [Accessed 11 Jan.cdc.int/csr/disease/avian_influenza/country/cases_table_2009_12_30/en/index.htm . A history of influenza.sciencedaily. H5N1 avian influenza: timeline.who. Morens.GSK.html – WHO.Jeffery K. 2010] (4) http://www.who.

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