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Dextromethorphan:

()

5 2553

dextromethorphan d-3-methoxy-N-methylmorphinan
(DXM) 4 2553
DXM 50

DXM
2546 DXM
2548
DXM 4x100

.. 2005 (USFDA)
DXM 5
DXM DXM


DXM

DXM

DXM

DXM
DXM
15-30 mg 4-6 120 mg

(euphoric effect)

DXM
DXM dextrorotatory stereoisomer methylated derivative levorphanol
analog codeine medulla
threshold opiate -receptor
DXM
DXM 15-30
5-6 DXM cytochrome P-450 (CYP) isoenzyme
2D6 dextrorphan N-methyl-D-aspartate receptors (NMDA
receptors antagonist) phencyclidine (PCP) (euphoria)
(hallucinations) 5-HT receptors
lysergic acid diethylamide (LSD)
DXM NMDA receptors
dextrorphan phencyclidine enzyme
CYP 2D6 ( genetic polymorphism)
DXM 7-10 DXM
dextrorphan dextrorphan
phencyclidine

DXM




DXM 15-30 mg 4-6


120 mg
100-200 mg (euphoric
effect)

400 mg
(hallucination) (vivid imagination)
phencyclidine ketamine 6
DXM 600 mg

DXM DXM
dextromethorphan Robitussin-DM Vicks formula 44 D
2543 Cincinati Poison Control Center
(dextromethorphan 30 mg
chlorpheniramine 4 mg) LSD
DXM
CCC, robo, red devil, poor mans PCP, DXM Dex
DXM
DXM

DXM (HBr) DXM


DXM
4-5 DXM


8 16 (-= 2-60
) 8 1-2
8-16
DXM
DXM DXM
DXM 1500 mg
24-48

DXM

DXM


National Guideline Clearinghouse
- decontamination
1 1

- (sedative) naloxone
pure opioid receptor antagonist opioid overdose
- benzodiazepine
40 hyperthermia

DXM ... .. 2510

(non-prescription
drug) DXM
Illinois DXM
DXM

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