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PIm. 342C/142P Exam II - Fall2002

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142:

(6) Iy The vinegarsoldin grocerystores(andsomeretailpharmacies) usually3Vowlv acetic is J acid. Giventhatth" Ku andMW of aceticacidare 1.8x 10-5 60 g/mole,whatis the and
pH of Vinegar?

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(4) ?a-.Ephedrine a weaklybasiccornpound is with pKu = 9.36. Whatis the K6 for ephedrine?'

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FK*:* Pk* + pk u
--l:l--=q.3b $ Tk u

'tu.rn =ffi'1
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(4) b. Write a chemical reaction with equilibrium constantequal to the yaiue calculatedin

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f ' u = a " ? qx l b 5

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B) df A pediatrician a2Vo solution drugD in a flavoredsyrup. Drug D asksyou to prepare of is a weakacidwith pKn= 6.4, intrinsic solubilityof 0.006M, intrinsicpartition coefficientof I0.2, andMW of I87.2 g/mole. You hayethreesyrups available:orange, grape, cherrywhich arebufferedat pH2.8,6.0,and7.8,respectively. and Which syrupor syrupscouldyou use? Showwork andlogic whichjustifiesyour answer. _I

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Any compoundwhich producesOI{- when placed'inwatermust be a base.

whosepIL i. lbsstlan 7 mustbe an acid. Any compftnd

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(rather acidic) will A basic compound bemoresoluble basic in than "likedissolvefllike.'l solutions because |{ + F{r,'""rf# l*1 i-iodL) Theconjug#acid;if Y""i. uuiBi,l stbea strong acid.
pair. A buffer must contain a conjugate-acid/conjugate'base You can make a buffer by mixing hydrochloric acid and sodium acetate.
j

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HC! + l'/aAc d

Whentitratinga weakbasewith a strongacid,theequivaleffiint is whenthepH = 7. reached

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the Increasing pH will increase solubilityof a weaklyacidica;f=-€-the the aqueou-slhase increased. is

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T o/'F ) The igtriasic partition coefficient of a basic drug increaseswhen the pH of ffi4 .
to Adding acid to a bufferedsolution wili alwayscausethe pH to decrease some extent.

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(3)-b. identifyiqlany conjugate (box)in thereactionyou acid(circle) and/orconjugate base w" wroteabove'
(3) c. _The equilibrium constaatfor your reaction is:

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noneofthe above.

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(4) b. to Write an equation which corresponds the graphabove.

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Choosethe bestanswer: The equation in part (b) applies to

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Atropine is a basewith pIQ = 9.65. Computethe Ku, write a balancedreaction correspondingto that K., idettify4conjugate acid(s) and cor{ugate base(s)with circle(s) and box(es)as done in ciass.

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(5) 8, The iahinsic solubilityof Phenobarbikl(a weakacid) is 0.005M. Given that theI! andmolecular weightof Phenobarbital 3.9 x 10-8 ?32.?3g/mole,what is the are and solutionwhich couldbe formulatedat pH 8.3? /nost concenffated

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Aspirin (ASA) undergoes l*-order degradation salicyclicacid (Se). ro

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10. Sulfisoxizole a weaklyaciddrug with Ku= 1.0x 10-5.Define(in termsof equiiibrium is
concentrations) following termsfor sulfisoxizole: the

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= intrinsicpartitioncoefficient

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g(gfi thefollowing giaphsshowing muchdetail asI did in class Also'forsulfisoxizole, as chemical andindicate predominant the specie(s) present variouspoints. at

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'j (3)a. { vs.pH i (3)b. K.* vs. pH

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'I{ vs.pH

with L " @ d . titrationof sulfisoxizole 0.1 M NaOH
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te (9 12'a, Followingthei.v. administration a 100mg of dose drug-X an adultmalepatient, of to plasma samples collectedat 3 hours andThourspost-administration. are Laboratorv I analy_sis the samples of yieldsf concentrations 15.2 yg/ml anclI0.l pglml."Given of fl \that the eliminationof drug-N known to occurasa L$-order is process, write an equation with numerical (andproperunits)which describes coefficients the concentration drug-fi in plasmaasa functionof time. of

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"volumeof plasma,') volumeof distributioa(pretend: fothis patient?
What is the

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