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Modul 2 1. Succinate dehydrogenase catalyses the dehydrogenation of succinate.

Malonic acid HOOC-CH2-COOH is used to interrupt the action of this enzyme. Choose the inhibition type: A. Non-competitive B. Limited proteolysis C. Allosteric *D. Competitive E. Dephosphorylation 2. There is an inhibited coagulation in the patients with bile ducts obstruction, bleeding due to the low level of absorbtion of a vitamin. What vitamin is in deficiency? A. Carotene B. E *C. K D. A E. D 3. In case of enterobiosis acrihine – the structural analogue of vitamin B2 - is administered. The synthesis disorder of which enzymes does this medicine cause in microorganisms? A. NAD-dependet dehydrogenases B. Cytochromoxidases C. Aminotransferases D. Peptidases *E. FAD-dependent dehydrogenases 4. The high level of Lactate Dehydrogenase (LDH) isozymes concentration showed the increase of LDH-l and LDH-2 in a patient's blood plasma. Point out the most probable diagnosis: *A. Myocardial infarction B. Acute pancreatitis C. Skeletal muscle dystrophy D. Viral hepatitis E. Diabetes mellitus 5. Hydroxylation of endogenous substrates and xenobiotics requires a donor of protons. Which of the following vitamins can play this role? A. Vitamin B6 B. Vitamin A C. Vitamin P *D. Vitamin C E. Vitamin E 6. A patient with abscess of the cut wound applied to the traumatological department. The wound was washed with 3% hydrogen peroxide to be cleaned from the pus. Foam was not observed. What caused inefficiency of the drug? A. Pus in the wound

which results in hemorrhagic syndrome. Activation of tissue thromboplastin D. Vasopressin D. Glucose *С. A man after 1. What vitamin deficiency can be the reason of this change: *A. Hypocalcemia B. Natriuretic . the inner membrane folded into cristae contain enzyme ATPase synthetase. The outer membrane is smooth. Vitamin K insufficiency 10. Golgi complex B. TIle increased secretion of what hormone caused such diuresis alteration? A. PP hypovitaminosis C. HNO3 D. Pyruvate concentration in the patient's urine has increased 10 times from ormal amount. Vitamin E Modul 3 1. Vitamin A E. Vitamin C D. The conjugated protein necessarily contains special component as a nonprotein part. Lysosomes E. Shallow wound *C. Fibrinogen deficiency *E.B.5 liters blood loss has suddenly reduced diuresis. Low concentration H202 E. What is the most posseble cause of hemorrhage of the child? A. Parathormone B. Inherited insufficiency erythrocyte's phosphatdehydrogenase 7. Choose the substance that can't carry out this function: A. AMP E. Centrioles *C. Vitamin B1 B. Vitamin B6 C. Mitochondria D. Cortisol E. Inherited insufficiency of catalase D. Ribosomes 9. ATP 8. Thiamine pyrophosphate B. These are: A. A 2-year-old child has got intestinal dysbacteriosis. Corticotropin *C. Oval and round organelles with double wall are seen at the electron micrograph.

Phosphoglucomutase 6. Periodic renal colics attacks are observed in a woman with primer hyperparathyroidizm. Hyperphosphatemia B.What substance is utilized in gluconeogenesis first of all in this case: A. CA2+ E. Adrenal glands B. Glutamate B. The gluconeogenesis is activated in the liver after intensive physical trainings . The formation of a secondary messengers is obligatory in membraneintracellular mechanism of hormone action. Galactosemia has been revealed in a child. What enzyme deficiency caused this illness? A. Amylo-1. Increasing of tissue blood supply *D.4. Point out the substance that is unable to be a secondary messenger: *A. Activation of oxidation reactions B. Glucose E. Pancreas . CAMP D. What mechanism from the below mentioned is considered to be the main mechanism of radioprotection? A. Concentration of glucose in the blood has not considerably changed. Hypercalcemia D. Hyperuricemia *C. The preventive radioprotector was given to a worker of a nuclear power station. Alanine 4. Hexokinase D. What organ of the internal secretion is affected on ldosteronism? *A. Ultrasonic examination revealed small stones in the kidneys.5-triphosphate 7. Increasing of respiration 5. Inhibition of free radicals formation E. Hyperkalemia E. Lactate D. Galactokinase *B. Diacylglycerol C. Inositol-3. Pyruvate *C. Glycerol B. What is the most plausible reason of the stones's formation? A. Some diseases reveal symptoms of aldosteronism with hypertension and edema due to sodium retention in the organism. Galactose-1-phosphate uridyltransferase C.6-glucosidase E.2. Hypercholesterinemia 3. Prevention of tissue's hypoxia C.

Clinically observed disproportional enlargement of hands. Thymus 11. thirst. He notes that he needed to buy bigger shoes three times. How will it be reflected in blood plasma? A. The B cells of endocrine portion of pancreas are selectively damaged by alloxan poisoning. Hypophysis D. Sensibilization *B. Patient with diabetes mellitus experienced loss of consciousness and convulsions after an injection of insulin. Parathyroid glands B. Ovaries 8.3 mmol/L . Joints dystrophy development *C. Increased sensitivity of the tissues to growth hormone E. A patient had been taking glucocorticoids for a long time. A 46 year-old patient has complained of headache. fatigue. Adrenal cortex D. Habituation 10. When the preparation was withdrawn he developed the symptoms of disease aggravation. What might be the result of biochemical blood analysis for concentration of sugar? A. feet. Cartilaginous tissue proliferation under growth hormone influence D. A 2-vear-old child experienced convulsions because of lowering calcium ions concentration in the blood plasma. Pineal gland E. Appearance of adrenal insufficiency C. B. What is the main reason of such disproportional enlargement of different parts of the body? A. The content of fibrinogen decrease 12. decreased blood pressure and weakness.C. pains in the spine and joints for the last 2 years. Joints chronic inflammation development 9. The level of sugar decreases C. The content of sugar increases E. superciliary arches. Increased sensitivity of the tissues to insulin . Hypophysis C. Hyperproduction of ACTH E. Function of what structure is decreased? *A. ose. What is the reason of this condition? A. 3. The content of globulins decreases B. Cumulation D. The content of albumins decreases *D. Testicle E.

Insulin *C. What hormone would you expect to find elevated in her scrum? A.0 mmol/L *D. Vasopressin *D. Glucose 14. Arterial pressure is low. Glycerin E. weight loss. The patient with diabetes mellitus has been delivered in hospital in the state of unconsciousness. Citrate B. Point it out: A. Mineralocorticoids 15. exophtalmos and irritability. Specify the substance that is used for the incomplete denaturation of hemoglobin: A.0 mmol/L C. Cholesterol esters B. 1. Ascorbic acid *C. Amino acids *E. Indicate which of the following substances can enhance the process of methylation during phospholipids synthesis? A. High fatty acids C. Toluene B.5 mmol/L E. Thyroxine D. Point substances. 10. The patient has acidosis. excessive sweating. There is only one hormone among the neurohormones which refers to the derivatives of amino acids according to classification. Thyroliberin 16. Somatotropin B. Synthesis of phospholipids is disordered under the liver fat infiltration. Sulfuric acid C. Monosaccharides D.ACTH E. 8. Ketone bodies Modul 4 1. Oxytocin C. Cortisol B. which accumulation in the blood results in these manifestations: A. 5.5 mmol/L 13.B. Melatonin E. Methionine D. Nitric acid . A 19-year-old female suffers from tachycardia in rest condition. A denaturation of proteins can be found in some substances.

Acetacetate 6. Ammonia E. Ornithine D. What are cerebrotoxical substances which accumulate in blood under hepar insufficiency? A. -CH3 B. Sodium hydroxide 2. Mononucleotide synthesis C. Autoantibody B. Different functional groups can be presented in the structure of L-amino acid's radicals.-CONH2 *C. Identify the group that is able to form ester bond: A. Translocation D. cramps. Processing B.*D. absence of reflexes. Urea E. IL-l C. Reparation *E. Necrosogenic substances *D. Biotin *B. -NH2 E. Indole C. recurrent (periodical) respiration. On which level does methotrexate hinder synthesis of the nucleic acids? A. What type of mutation took place in the DNA chain'? A. M-r S presents all signs of the hepatic coma: loss of consciousness. Ketonic body 5. Inversion C. Replication *B. What substances created in the intestines can cause endotoxemia? A. A patient with encephalopathy was admitted to neurological department. Butyrate E. Transcription D. Replication .-SH 4. Methotrexate (structural analogue of the folic acid which is competitive inhibitor of the dihydrofolatreductase) is prescribed for treatment of the malignant tumor. Deletion 3. Correlation of increasing encephalopathy and substances absorbed by the bloodstream from the intestines was revealed. disorder of heart activity.-OH D. Part of the DNA chain turned about 180 degrees due to gamma radiation. convulsion. Doubling E.

α-ketoglutarate *E. Thalassemia *B. Pyruvate D. Glycerin E. Uracil *E. Choose the minor nitrogenous base: A.l. Indicate which of the following substances can enhance the process of methylation during phospholipids synthesis? A. Dihydrouracil 8. Adenine B. Substitution of the glutamic acid on valine was revealed while examining initial molecular structure. Glucose Modul 5 1. Favism D. Lipoproteids D. Acid phosphatase C. Lactate 3. Hemoglobinosis 2. increased nail brittling and taste alteration. Cytosine C. For what inherited pathology is typical for this symptom ? A. General cholesterol E. Additive glycosaminoglycans B. What is the mechanism of the symptoms development? . Sickle-cell anemia C. Their increase of which blood values indicators could be the most significant in proving the diagnosis? *A. Nowadays about 50 minor bases have been found ill the t-RNA structure besides the main four nitrogenous bases. Citrate B.3-bisphosphoglycerate C. A worker has decreased buffer capacity of blood due to exhausting muscular work The increase of what acid substance in the blood can cause this symptom? A.7. Minkowsky-Shauffard disease E. Methionine D. R-glycosidase 4. Cysteine D.3-phosphoglycerate B. Ascorbic acid *C. A patient with hypochromic anemia has splitting and loss of hair. A 63-year-old woman developed symptoms of rheumatoid arthritis. Synthesis of phospholipids is disordered under the liver fat infiltration.

Maintaining the. Uroporphyrinogen 2 C. Marked increase of activity of MB-forms of CPK (creatinephosphokinase) and LDH-l was revealed by examination of the patient's blood. Deficiency of vitamin A *C. Rheumatism B. Maintaining the oncotic blood pressure E. The concentration of albumins in human blood sample is lower than normal. Point out the most probable diagnosis: *A. Coproporphyrinogen 3 D. Acute pancreatitis C. Viral hepatitis E. Deficiency of vitamin B12 5. Chronic glomerulonephritis was diagnosed in a 34-year-old patient 3 years ago. What blood function is damaged? A. What is the most probab1e pathology? A. Hyperaldosteronism C. Maintaining the Ph level B. Protoporphyrin *E.A. Miocardial infarction D. Maintaining the body temperature 10. Proteinuria 8. The patient with diabetes mellitus has been delivered in hospital in the state of . The high level of Lactate Dehydrogenase (LDH) isozymes concentration showed the increase of LDH-l and LDH-2 in a patient's blood plasma. Hyperosmolarity of plasma B. Heme B. Myocardial infarction B. Deficiency of iron-containing enzymes D. The accumulation of what compound in the skin can cause it? A. What caused the edema? A. Decreased production of thyroid hormones E. Decreased production of parathyrin B. Diabetes mellitus 6. Edema has developed within the last 6 monthes. Skeletal muscle dystrophy D. Hyperproduction of vasopressin *E. Uroporphyrinogen 1 9. Hepatitis *C. blood sedimentation system C. Liver disfunction of protein formation D. who suffers from congenital erythropoietic porphyria. This leads to edema of tissues. has skin photosensitivity. All answers are correct *D. Pancreatitis E. Cholecystitis 7. A patient.

Ketone bodies .unconsciousness. Amino acids *E. High fatty acids C. Monosaccharides D. Point substances. The patient has acidosis. Cholesterol esters B. which accumulation in the blood results in these manifestations: A. Arterial pressure is low.