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Acne scars in ethnic skin treated with both non-ablative fractional 1,550 nm and ablative fractional CO2 lasers: comparative retrospective analysis with recommended guidelines.
Alajlan AM, Alsuwaidan SN.
Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Fractional technology has changed the dermatologists view in how to treat acne scars in ethnic skin as a result of its favorable safety profile.
To evaluate the safety and efficacy of non-ablative fractional (NAF) 1,550 nm and ablative fractional (AF) CO(2) Lasers in the treatment of acne scars in ethnic skin.
In this retrospective analysis patients with acne scars who were treated with NAF 1,550 nm or AF CO(2) lasers from January 2008 until July 2009 were included. Evaluation was made through comparing pre- and postphotographs and physician global assessment. Patients' satisfaction rate was also recorded. Assessment of improvement was based on a quartile grading scale. Bleaching creams and oral antibiotics were routinely given after each session. Adverse effects were recorded. Follow up visits were scheduled at weeks 1 and 4 of each session and 12 weeks post-last session.
A total of 82 patients were recruited in the study. Forty-five patients treated with NAF 1,550 nm laser and 37 patients with AF CO(2) laser. Skin phototype was mainly type IV (III-V). An overall patient satisfaction was 71% for NAF 1,550 nm laser group and 65% for AF CO(2) laser group. Thirty-five percent and 37% of patients attained more than 50% improvement with NAF 1,550 nm and AF CO(2) lasers, respectively. Patients treated with NAF 1,550 nm laser had less down time. Transient post-inflammatory hyperpigmentation (PIH) was noted in 17% of patients treated with NAF 1,550 nm laser compared to 14% with AF CO(2) .
Both NAF 1,550 nm and AF CO(2) lasers are effective in treating acne scars in ethnic skin with good patient satisfaction rate and high safety profile. PIH decreased with routine use of prophylactic bleaching creams. Fractional laser resurfacing open a wide horizon for treating acne scars in ethnic skin. 2.Int J Dermatol. 2011 Oct;50(10):1179-94. doi: 10.1111/j.1365-4632.2011.05029.x.
Treatment of acne scarring.
Department of General Practice, Monash University, South Yarra, Victoria, Australia. firstname.lastname@example.org
Post-acne scarring remains a common entity despite advances in the treatment of acne. This represents limitations in our quality of therapy and a failure of public education. The level of severe scarring remains as much an ongoing challenge to prevent as well as manage.
This review will concentrate on the methods by which acne scarring may be improved and the available evidence for their utility. It will also rely on a grading scale of disease burden to classify patients and their ideal therapy. New therapies allowing treatment of scarring in areas other than the face will also be highlighted. Results: Tabulated treatment planning will present algorithms summarizing best practice in the treatment of post-acne scarring.
Post-acne scarring is being better managed. Grade 1 scars with flat red, white, or brown marks are best treated with topical therapies, fractionated and pigment or vascular-specific lasers and, occasionally, pigment transfer techniques. Grade 2 mild scarring as seen primarily in the mirror is now the territory of non-ablative fractionated and non-fractionated lasers as well as skin rolling techniques. Grade 3 scarring, visible at conversational distance but distensible, is best managed by traditional resurfacing techniques or with fractional non-ablative or ablative devices, sometimes including preparatory surgical procedures. Grade 4 scarring, where the scarring is at its most severe and non-distensible, is most in need of a combined approach. 3.Curr Probl Dermatol. 2011;42:40-7. Epub 2011 Aug 16.
Ablative skin resurfacing.
Chwalek J, Goldberg DJ.
two independent dermatologists evaluated clinical improvement using a quartile grading scale. nonablative resurfacing treatment for acne scarring.Source Skin Laser & Surgery Specialists of New York & New Jersey.1524-4725. 15.001) was observed on the acne scar scale from day 1 to 210. indications for ablative resurfacing. Post-treatment follow-up visits were performed 30 and 90 days after the last treatment. California. After one additional treatment session using the same protocol. 2.Dermatol Surg. overall improvement scores did. Peterson JD. The efficacy of autologous platelet rich plasma combined with ablative carbon dioxide fractional resurfacing for acne scars: a simultaneous split-face trial. The intensity of erythema was objectively measured using a chromometer at the same time intervals. 4. Patient satisfaction scores showed no significant change over time.02110. RESULTS A 72.x.1111/j. lasers. Immediately after resurfacing. which targets water resulting in tissue contraction and collagen formation. subcision. [Epub ahead of print] Evaluation of the Effect of Fractional Laser with Radiofrequency and Fractionated Radiofrequency on the Improvement of Acne Scars. MATERIALS AND METHODS: A split-face trial was conducted in 14 Korean participants with acne scars. The study was supported by Syneron. Source Dermatology Cosmetic Laser Associates of La Jolla. Autologous platelet-rich plasma (PRP) is known to enhance wound healing and has applications in many areas of medicine. dermabrasion. and infections. OBJECTIVES Our primary objective was to evaluate the improvement in acne scars and skin texture. Chung-Ang University. Korea. and 13. From day 30 to 210. Palm MD.3% decrease (p<. Guiha IC. Kim BJ. which may affect the daily lives of patients. Abstract BACKGROUND Options for acne scar reduction include peels.37(7):931-8. and possible side effects. Patients received five treatments at 30-day intervals.02). CO(2) and Er:YAG lasers emit infrared light. Goldman MP. 8. While ablative resurfacing has become safer.05). although this technique is associated with prolonged surgical site erythema and edema. All participants received one session of ablative CO(2) fractional resurfacing. dyspigmentation. 4. Abstract Ablative skin resurfacing has remained the gold standard for treating photodamage and acne scars since the development of the first CO(2) lasers. Clinicians utilizing ablative devices need to be aware of possible side effects in order to maximize results and patient satisfaction. USA. Epub 2011 Jun 2. facial halves were randomly assigned to receive treatment with autologous PRP injections on one side (experimental side) and normal saline injections on the other side (control side). respectively. 2011 Aug 11. Secondary objectives were determination of patient satisfaction and comfort and evaluation of scar pigmentation improvement.2011. NJ 07601. and pigmentation improved 68.1111/j.01999. Seoul.x. and pigmentation improved significantly according to investigator-rated assessment parameters. Mun SK. texture. This chapter reviews the background of ablative lasers including the types of ablative lasers. edema. The first ablative laser systems created significant thermal damage resulting in unacceptably high rates of scarring and prolonged healing. are capable of achieving significant improvements with fewer side effects and shorter recovery times. Hackensack. Lee JW. CONCLUSION This technology may be a useful. Newer devices. careful patient selection is still important to avoid post-treatment scarring. Kim MN. RESULTS: . Scarring.3% (p=. San Diego. although patient-evaluated overall improved scores increased 60% over baseline (p=. Abstract BACKGROUND: Ablative carbon dioxide (CO(2) ) fractional resurfacing is a promising therapeutic intervention for the treatment of acne scars.Dermatol Surg. mechanism of action. 66. and 30.2% (p<.001). Source Department of Dermatology. texture. College of Medicine. and other effects on days 0.7% (p<.2011. doi: 10. doi: 10. Kiripolsky MG. Although patient satisfaction scores did not improve.1524-4725. such as high-energy pulsed lasers and fractional ablative lasers. A novel device with a handpiece combining optical and radiofrequency (RF) energies along with a fractionated RF handpiece is available for nonablative resurfacing. OBJECTIVES: To evaluate the synergistic effects of autologous PRP with CO(2) fractional resurfacing for acne scars. 5. although not all are applicable in darker skin types. and surgical excision. investigator-rated changes in scarring. The participants were monitored for degree of recovery and resurfacing-associated adverse events. 6. 2011 Jul.001). fillers. including prolonged erythema.
A closeup front and 45-degree lateral photographs of both sides must be taken. Current treatment modalities.7 days on the control side and 8. Mumbai. Albert Szent-Gyorgyi Medical Center.9±1. and emollients may be prescribed for the dryness and peeling that could occur. Krupashankar DS. He/ she should possess a Master's degree or diploma in dermatology and should have had specific hands-on training in lasers. ANESTHESIA: Fractional laser treatment can be carried out under topical anesthesia with eutectic mixture of lidocaine and prilocaine.04).43(2):130-6. Abstract INTRODUCTION: Fractional laser technology is a new emerging technology to improve scars. Tome MA.1±1.0 days on the experimental side (p=.21031. This difference was confirmed using a chromometer (p=. ashrafbadawi@hotmail. This study .1±1.5 days on the control side and 6. Source Department of Dermatology and Allergology. chickenpox and surgical scars.5) (p=. doi: 10. either during postgraduation or later at a facility which routinely performs laser procedures under a competent dermatologist or plastic surgeon with experience and training in using lasers. This is especially true when attempting to treat large areas of acne scarring. Total duration of erythema was an average of 10.3±0. Participants were also assessed for duration of post-treatment crusting. Preoperative photography should be carried out in all cases of resurfacing. including deep dermal peels. Retrospective analysis of non-ablative scar treatment in dark skin types using the sub-millisecond Nd:YAG 1. desired effects and possible postoperative complications should be provided to the patient. DEVICES: Different fractional laser machines. 7. Hungary. are now available in India. Since parameters may vary with different systems. photoageing changes. Atteya A. A detailed understanding of the device being used is recommended. LASER PARAMETERS: There are different machines based on different technologies available. Goel A. dermatological conditions such as granuloma annulare has been reported. and fractional laser resurfacing and surgical techniques. are limited in skin types IV through VI due to increased risks of hyperand hypo-pigmentation. Source Cutis Laser Aesthetic Skin Solutions. 6. INDICATIONS: Common indications include resurfacing for acne. Morsy IA. The total duration of edema was an average of 7.1 days on the experimental side (p=. and skin color.1 days on the experimental side (p=. facial dyschromias. A sunscreen is mandatory.1002/lsm. PREOPERATIVE COUNSELING AND INFORMED CONSENT: Detailed counseling with respect to the treatment. Badawi A. Some machines can be used without any anesthesia or only with topical cooling or cryospray. location and type of lesion.7±0. The patient should be provided brochures to study and also adequate opportunity to seek information.4±2. No other adverse effects were observed in any participant. Physician needs to be familiar with these requirements before using the machine. non-ablative. Choice parameters depend on the type of machine. India.01).6±2.7) than on the control side (2.0 days on the control side and 5. Four months after the final treatment. dyspigmentation. fine lines. But further data are needed before adopting them for routine use in such conditions. striae and wrinkles. 2011 Feb. Sami N. periorbital and perioral wrinkles. The use of fractional lasers in stretch marks. Edema also improved faster on the experimental side than on the control side. a topical anesthetic prior to the procedure is recommended. University of Szeged. POSTOPERATIVE CARE: Proper postoperative care is important in avoiding complications. Aurangabadkar S.049). safe to use and has been used effectively for several clinical and cosmetic indications in Indian skin. ablative.com Abstract BACKGROUND: The use of lasers to treat atrophic scarring conditions in darker skin types presents a significant challenge to laser practitioners. Fractional lasers in dermatology--current status and recommendations.03).04).8±1. with different wavelengths. A detailed consent form needs to be completed by the patient. possible postoperative course expected and postoperative complications. FACILITY: Fractional lasers can be used in the dermatologist's minor procedure room for the above indications. Erythema on the experimental side improved faster than on the control side and was significantly less at day 4 (p=. Post-treatment edema and redness settle in a few hours to a few days. Omprakash HM.064 nm laser.All participants completed the study. The technique is easy. Mysore V. PHYSICIAN QUALIFICATION: Any qualified dermatologist may administer fractional laser treatment. with a mean of 6. Nischal KC. But for maximal patient comfort.047). Maharashtra. overall degree of clinical improvement was significantly better on the experimental side (2.Indian J Dermatol Venereol Leprol. both ablative and non-ablative.77(3):369-79.Lasers Surg Med. Consent form should include information on the machine. specific training tailored towards the concerned device at either the manufacturer's facility or at another center using the machine is recommended. melasma and other pigmentary conditions. CONCLUSIONS: Treatment with PRP after ablative CO(2) fractional resurfacing enhances recovery of laser-damaged skin and synergistically improves the clinical appearance of acne scarring. 2011 May-Jun.
Ho SG. non-treating and blinded physician. Department of Medicine.1002/lsm. Chan HH. Source Division of Dermatology. Abstract BACKGROUND AND OBJECTIVES: Non-ablative fractional resurfacing (NA FR) has been shown to be effective for photorejuvenation and acne scarring. 8. METHODS: A retrospective analysis was conducted of all patients (n = 22) who received sub-millisecond Nd:YAG laser treatments for atrophic scarring over a 6-month period. and 2 in pigment were observed (one-sample Wilcoxon signed rank test. but double the number of treatment sessions in Asian acne scar patients. delivering clinically and statistically significant results with reduced risk of pigment complications and patient discomfort. P < 0. pulse duration of 300-500 microseconds and repetition rate of 5-7 Hz. OBJECTIVE: To evaluate the safety and efficacy of a sub-millisecond 1. China. Previous studies indicated that density. CONCLUSIONS: NA FR was effective and safe in Asians.Lasers Surg Med. clinical efficacy could be maintained by increasing the total number of treatment sessions. All photographic images captured with the Canfield Visia CR system at baseline and follow-ups were assessed for clinical efficacy and complications by an independent.20976.2% with cross-polarized images compared to 6. Chan NP. Reviewers were asked to determine before and after photos and the degree of improvement in scarring.Lasers Surg Med. Degree of improvement was graded using a four-point scale: 0 = <25%. CA) versus four passes ('mini-NA FR') with comparable pulse energy and treatment level as 'full-NA FR'. the PIH risk was 18. An average of six treatments was performed on each patient approximately 3 weeks apart and the mean follow-up time after the final treatment was 9 months (range of 3-10 months). Chan HH.42(10):710-5. Patients had Fitzpatrick skin types III-VI and were treated for the indication of atrophic scarring using the fluence of 14-16 J/cm(2) . respectively.001). 1 = 25-50%. The objective of this retrospective study was to assess the efficacy and complications of eight passes of NA FR ('full-NA FR') with the 1. Department of Medicine. acne scarring. more than pulse energy. Hong Kong SAR.5 and 210. Yeung CK.550 nm erbium-doped fibre fractional laser (Fraxel SR laser system. Shek SY. China. Yeung CK. There was no statistically significant difference in clinical efficacy between three full-NA FR and six mini-NA FR treatments. the risk of PIH could be reduced.064 nm Nd:YAG laser for the treatment of atrophic scarring in Fitzpatrick skin types III-VI through retrospective photographic analysis. doi: 10. and post-inflammatory hyper-pigmentation (PIH) secondary to the acne or scarring condition. Improvement in skin texture. 9. Reviewers were highly consistent (inter-reviewer reliability) in identification of before and after photos (kappa of 0. University of Hong Kong. RESULTS: The total treatment densities for full-NA FR and mini-NA FR were 442. Solta Medical.5 MTZ/cm(2). Ho SG.001). For full-NA FR. Fractional ablative carbon dioxide laser resurfacing for skin rejuvenation and acne scars in Asians. By reducing the number of passes and the total treatment density.0% for mini-NA FR.88). Meanwhile. University of Hong Kong. 3 = 76-100%.064 nm Nd:YAG laser treatment is a safe and effective treatment for atrophic scarring in patients with darker skin types. Hayward. Shek SY. enlarged pores and overall pigmentation irregularity all reached statistical significance at last follow-up compared to baseline. .investigates the treatment of atrophic scarring with a non-ablative sub-millisecond-pulsed 1. 2010 Nov. 2010 Dec. CONCLUSIONS: Preliminary data collected in this retrospective study suggest that sub-millisecond 1. clinically and statistically significant median improvement of 2 in scarring. textural change. The use of non-ablative fractional resurfacing in Asian acne scar patients.42(9):615-23. MATERIALS AND METHODS: Forty-seven Asian atrophic facial acne scar patients who received full-face full-NA FR or mini-NA FR treatments between December 2005 and February 2009 were included. Source Division of Dermatology.064 nm Nd:YAG laser in darker skin types. 2 = 51-75%. RESULTS: Based on blinded photo assessments by three independent reviewers. Blinded photographic assessments were performed by three independent physicians using photos unlabeled for before and after and arranged in non-chronological order. Chan NP. 2. Hong Kong SAR. This difference was statistically significant (P < 0.3 in texture. was associated with post-inflammatory hyperpigmentation (PIH) in Asians.
laxity. enlarged pores. Standardized photographs using the Canfield Visia CR system® were assessed by two independent observers. overall pigmentation irregularity. CONCLUSION: . Efficacy assessments. Barolet D. USA. enlarged pores. imiquimod. in view of the high post-inflammatory rate and the statistically significant but only mild to moderate improvement after a single treatment as observed in this study. lasers.1% at 1 and 6 months post-treatment. Statistically significant improvements were seen for skin texture.Lasers Surg Med. Paghdal KV. Treating abnormal scars remains an important challenge. skin laxity. Improvement in skin texture. Montreal. Boucher A.5% and 11. Cohen G. ranging from silicone sheets. Medical and surgical management of keloids: a review. there is a need to review the current role of fractional ablative CO₂ laser treatment as compared to fractional non-ablative for skin rejuvenation and acne scar treatment in Asians. Canada. mean age 44. conducted up to a year post-treatment. RESULTS: Nine Chinese patients (skin types III and IV. 10. types and treatments for keloids and hypertrophic scars. 2010 Oct. The objective is to evaluate the efficacy and side effects of a new fractional CO₂ ablative device (Fraxel Re:pair) for skin rejuvenation and acne scars in Asians. Source RoseLab Skin Optics Research Laboratory. IL. clinical global assessment of digital photographs. Subjective improvement was assessed by patient questionnaires. respectively. The aim of this case series was to investigate the effectiveness of near infrared (NIR) light emitting diode (LED) treatment as a prophylactic method to alter the wound healing process in order to avoid or attenuate the formation of hypertrophic scars or keloids. Springfield.ca Abstract BACKGROUND AND OBJECTIVES: Hypertrophic and keloid scars result from alterations in the wound healing process. 2010 Aug.J Drugs Dermatol. whereas hypertrophic scars will stay contained to the original wound and may regress over time. 5. Allium cepa (onion) extract.Abstract BACKGROUND AND OBJECTIVES: Ablative fractional resurfacing (AFR) is a new modality for photorejuvenation and acne scars which combines carbon dioxide (CO₂) laser ablation with fractional photothermolysis. ligation. keloids may exhibit proliferative growth beyond the margins of the scar and will remain persistent. wrinkles. The post-inflammatory hyperpigmentation rate was 55. intralesional corticosteroid injections. No significant treatment-related adverse effects were reported. cryosurgery. Following scar revision by surgery or CO(2) laser ablation on bilateral areas. Safety was documented by adverse effects monitoring. spontaneous. Prophylactic low-level light therapy for the treatment of hypertrophic scars and keloids: a case series. In general. acne keloidalis nuchae (AKN) and sessile. 11.8) were included. non-ablative NIR LED (805 nm at 30 mW/cm(2)) for 30 days. ear lobe. and quantitative profilometry analysis using PRIMOS. and acne scars. and adverse effects were assessed up to 6 months post-treatment. RESULTS: Significant improvements on the NIR-treated versus the control scar were seen in all efficacy measures.fluorouracil. This review will discuss the pathogenesis. Division of Dermatology. daniel. However.42(6):597-601. Eighty-six percent of patients were overall satisfied to very satisfied with the treatment. MATERIALS AND METHODS: Nine patients underwent one full-face treatment. wrinkles. The authors will discuss the five different types of keloid: post-incisional. interferon-a and intralesional verapamil and surgical excision.barolet@mcgill. Source Southern Illinois University. STUDY DESIGN/PATIENTS AND METHODS: Three patients (age 27-57) of phototypes I-III with hypertrophic scars or keloids due to acne or surgery participated in this case series. Abstract Keloids and hypertrophic scars are abnormal responses to wound healing. Quebec. The energy levels ranged from 30-70 mJ with coverage between 30% and 45%. Shockman S.9(10):1249-57. CONCLUSION: Ablative fractional CO₂ laser resurfacing was overall safe and effective for skin rejuvenation and acne scars in Asians. one scar was treated daily by the patient at home with non-thermal. Many medical and surgical modalities have been studied in the treatment of these two entities. included the Vancouver Scar scale (VSS).
13.Possible mechanisms involved are inhibition of TGF-beta I expression. No other complications were observed. Post-inflammatory hyperpigmentation occurred in nine patients (7%) and lasted longer than 3 months in one patient (0.com Abstract INTRODUCTION: Ablative carbon dioxide resurfacing is the gold standard for treating atrophic acne scarring but is associated with prolonged recovery and many side effects. .8%). Istanbul. 300 microm. Singapore. Turkey. OBJECTIVE: To evaluate the clinical effects of resurfacing atrophic facial acne scars with the Er:YAG laser in the Turkish population. RESULTS: Clinical improvements in facial skin texture. pigmentary change. 2010 Apr. 14. CONCLUSION: Our study has shown that in Asians the fractional ablative carbon dioxide laser produces mild to moderate improvement in acne scarring with the advantage of a quick recovery period with minimal adverse effects. 2. Kutlubay Z. Changi General Hospital. All patients had erythema. aged 22-42 years. Walling HW.J Cosmet Laser Ther. METHODS: We undertook a prospective study whereby five Asian patients of skin phototype IV with moderate to severe atrophic acne scarring received two sessions of a fractional carbon dioxide laser 6-8 weeks apart. Mild to moderate postoperative acne flare-up occurred in 14 patients (11%). The patients had Fitzpatrick skin types ranging from II to V.9(1):66-7. both physically and psychologically. up to 500 microm.J Drugs Dermatol. >75% (excellent). Further studies in larger group of patients are needed to evaluate this promising technique. Source Lazerart Clinics. 2010 Jan. pulse width.5 ms. Photographs were taken before and 3 months after treatment.12(2):65-72. Treatment of atrophic facial acne scars with the Er:YAG laser: a Turkish experience. Wang YS. 2010 Apr.com Abstract BACKGROUND: Acne scars are extremely disturbing to patients. Fractional photothermolysis improves a depressed alar scar following Mohs micrographic surgery. degree of skin coverage. Schulz KK. Kwok C. To address these limitations. Tay YK. one: moderate improvement). acne scarring and dyschromia were noted in all patients. METHODS: A total of 128 patients. 28 J/cm(2). yishiw@hotmail. CONCLUSION: Er:YAG laser resurfacing is a safe and effective treatment modality for facial acne scars in the Turkish population who have darker skin tones. There was a 50. underwent laser resurfacing. Results were evaluated for the degree of clinical improvement. Photographic evaluation was done on the level of improvement according to a quartile grading scale: <or=25% (mild). Treatment parameters were: fluence. 12. penetration depth. which lasted for a mean of 6 days. Erythema occurred in all patients and lasted longer than 3 months in five patients (3. Fractional ablative carbon dioxide laser in the treatment of atrophic acne scarring in Asian patients: a pilot study.2% average clinical improvement. The treatment was well tolerated. 26-50% (moderate). Gokdemir G. Division of Dermatology. single pass. 20%. Source Department of Dermatology. all five subjects showed some clinical improvement (four: mild improvement. zekayikutlubay@hotmail. No other adverse effects were observed.9%). newer modalities employing the principle of fractional photothermolysis have emerged. This study assessed the safety and efficacy of the erbium:yttrium-aluminum-garnet (Er:YAG) laser on acne scars.J Cosmet Laser Ther. spot size. 51-75% (marked). Complete wound healing occurred between 6 and 8 days.12(2):61-4. RESULTS: At 2 months post-treatment. No patient experienced hypopigmention. and any adverse events.
4 days respectively and that of post-therapy erythema was 7. Kim YK. CONCLUSION: The 2940 nm fractional photothermolysis laser is safe and effective in the treatment of acne scarring. In post-treatment evaluations. Non-ablative 1550-nm erbium-glass and ablative 10 600-nm carbon dioxide fractional lasers for acne scars: a randomized split-face study with blinded response evaluation. denghui_1@hotmail. as well as an independent group of physicians each scored the atrophic scar improvement as significant. Source Department of Dermatology. treatment of facial scars resulting from Mohs micrographic surgery for cutaneous malignancy has not previously been reported. Coralville. METHODS: Twenty-six patients with moderate-to-severe atrophic scarring were treated with a 2940 nm-wavelength fractional photothermolysis laser.The Sixth People's Hospital of Shanghai.8 for CO(2) FS. both the patients treated.5 for FPS and 2.0 with the FPS and 7. split-face.J Eur Acad Dermatol Venereol. Fraxel SR laser) is a 1550 nm non-ablative erbium laser device with a variety of clinical applications. RESULTS: At 3 months after the treatment. Yan C.com Abstract OBJECTIVE: To evaluate the efficacy and safety of a 2940 nm fractional photothermolysis laser in the treatment of acne scarring in Chinese people. Yuan D. photoaging. Source Department of Dermatology and Cutaneous Biology Research Institute. METHODS: Eight patients with acne scars were enrolled in this study. 15. the scar was nearly imperceptible and has remained so eighteen months later. Abstract Fractional photothermolysis (FPT.0 with the CO(2) FS. At the completion of FPT. On each side treated by FPS and CO(2) FS. 2009 Nov. FPT has been used to treat photodamage.0 +/. OBJECTIVE: We compared the efficacy and safety of single-session treatments of FPS and CO(2) FS for acne scars through a randomized. Oh SH. Ding X. Kang JM. A 2940 nm fractional photothermolysis laser in the treatment of acne scarring: a pilot study in China. melasma. actinic keratoses and acne scarring. RESULTS: All patients had encouraging results. Deng H. Chung WS. .9 +/. Korea. We believe that our study could be used as an essential reference when choosing laser modalities for scar treatment.5 cm alar scar resulting from Mohs micrographic surgery for basal cell carcinoma with secondary intention healing. FPT was performed a total of five times at four-week intervals. Seoul. evaluator-blinded study.0 +/.0. We used a quartile grading scale for evaluations. Both skin elasticity and moisture content increased significantly after five treatments. 2010 Aug.3 and 7.8(11):978-80. Yonsei University College of Medicine. The mean VAS pain score was 3. China. Shanghai Jiaotong Universtiy.5 +/. Cho S. Abstract BACKGROUND: Non-ablative 1550-nm erbium-doped fractional photothermolysis systems (FPS) and 10 600-nm carbon dioxide fractional laser systems (CO(2) FS) have been effectively used to treat scars. We present the case of a 49-year-old woman with a depressed 0. She was treated with FPT initially eight weeks post-operatively.0. USA.24(8):921-5. Cho SB.5 and 11. the mean grade of improvement based on clinical assessment was 2.7 x 0. Kim DH. Lee SJ. To the authors' knowledge. IA 52241.2. the mean duration of post-therapy crusting and scaling was 2. Epub 2009 Dec 17.Source Town Square Dermatology.J Drugs Dermatol.2. 16.5 days respectively. Half of each subject's face was treated with FPS and the other half was treated with CO(2) FS. CONCLUSION: We demonstrated the efficacy and safety of single-session acne scar treatment using FPS and CO(2) FS in East Asian patients. Lin X. Shanghai.
Case study involving use of injectable poly-L-lactic acid (PLLA) for acne scars. Boston. NSSDERM@sadickdermatology. Source Massachusetts General Hospital. Kang JM. and post-therapy erythema lasted 2. The latest course of therapy consisted of seven treatment sessions during which injectable PLLA was administered serially into individual scars and depressions in the patient's nasolabial folds.17. USA. a 60-year-old white woman..6 days. seven had moderate improvements of 26% to 50%. Hypertrophic scarring of the neck following ablative fractional carbon dioxide laser resurfacing. Massachusetts. 2009 Dec.Dermatol Surg.8+/-4. Abstract BACKGROUND: The nonablative 1. Source Department of Dermatology at Weill Medical College of Cornell University. Yu T. RESULTS: Follow-up results revealed that one patient had clinical improvement of 76% to 100%. Korea. Harvard Medical School. the patient noted an observable improvement in her acne scars. She received touch-up injections 14 months after her seventh treatment. Sculptra) for the correction of acne scars in an adult patient. Nelson JS. Oh SH. 2009. Sadick NS. Tope WD. OBJECTIVES: To evaluate the efficacy and safety of the combined use of two treatment modes of an ablative 10. CA) were enrolled.com Abstract This report describes a novel use of injectable poly-L-lactic acid (PLLA. dermabrasion and trichloroacetic acid peels. The efficacy and safety of 10. Avram MM. Source Department of Dermatology and Cutaneous Biology Research Institute. Chung WS.600-nm carbon dioxide fractional laser for acne scars in Asian patients. METHODS: Twenty Korean patients with atrophic acne scars treated with a single session of Ultrapulse Encore laser (Lumenis Inc.41(3):185-8. New York. Kim YK.41(5):398. The patient. 18.550-nm erbium-doped fractional photothermolysis system (FPS) has been effectively used for scar treatments. Santa Clara. Lee SJ. but it seems that several sessions of treatment must be delivered to achieve satisfactory improvement. had previously been treated for acne scars with CO(2) laser resurfacing. Given the well-recognized difficulty in treating acne scars. Seoul. mavram@partners. The mean duration of post-therapy crusting or scaling was 6. nine had improvements of 51% to 75%. with only minimal swelling for 24-72 hours post-treatment and bruising at injection sites lasting 5-7 days. USA. mid-cheeks and chin. . as well as collagen. New York. The laser fluences were delivered to the scars using the Deep FX mode. and three had minimal to no improvements.3+/-3.0 days. calcium hydroxylapatite and hyaluronic acid dermal fillers. 19. Yonsei University College of Medicine. CONCLUSION: We suggest that CO(2) FS used with a combination of two different treatment modes may provide a new treatment algorithm for acne scars in Asians.Lasers Surg Med.35(12):1955-61. Six months after the seventh treatment session. These treatment approaches did not provide satisfactory improvement of the patient's acne scars. the results of this case suggest that injectable PLLA may provide an improved treatment modality for resolving acne scars.600-nm carbon dioxide fractional laser system (CO(2) FS) on acne scars.J Dermatolog Treat.20(5):302-7. 2009 Mar. Injectable PLLA was well tolerated.org Erratum in Abstract BACKGROUND: • Lasers Surg Med. Palmisano L. Additional treatment using the Active FX mode was performed throughout the entire face. 2009 Jul. Cho SB. Szachowicz E.
Zachary CB.Lasers Surg Med. Tournas JA. with moderate to severe acne scarring. Subjects also had improvement in their overall appearance. This report evaluates a fractional approach to CO(2) laser resurfacing for the treatment of moderate to severe acne scarring. underwent up to three treatments with an FDA IDE and IRB approved 10. OBJECTIVE: Five patients treated with the same fractional CO(2) laser technology for photodamage of the neck were referred to our practices 1-3 months after treatment. Edina. shortened downtime. Elkeeb L.0 kJ. Ortiz AE.Ablative fractional carbon dioxide (CO(2)) laser treatments have gained popularity due to their efficacy. HS is a potential complication of ablative fractional CO(2) laser resurfacing. Serosanguinous oozing resolved within 24-48 hours following treatment.550 nm laser to modify the wound healing milieu. she developed multiple vertical and horizontal hypertrophic scars (HS). At 2 weeks after CO(2) ablative fractional resurfacing. 21. Efficacy of the fractional photothermolysis system with dynamic operating mode on acne scars and enlarged facial pores. The papules in this case completely resolved with mild residual hypopigmentation after treatment with topical corticosteroids. Minnesota 55424. 20. Walgrave SE. We urge caution when treating the neck with this device and close attention to wound care in the postoperative period. One week later. These raised areas were treated with a non-ablative fractionated 1. All subjects were Fitzpatrick skin types I-V and 18-75 years of age. CONCLUSION: As with traditional ablative CO(2) laser resurfacing. Of the five cases. Oh SH. particularly on the neck. CONCLUSION: Fractional deep dermal ablation improves moderate to severe acne scarring. RESULTS: Histopathology for the first case confirmed the presence of a hypertrophic scar. Treatment parameters ranged from 20 to 100 mJ with total densities of 600-1. Minimal crusting was noted on the neck throughout the initial healing phase of 2 weeks. Abstract BACKGROUND AND OBJECTIVE: Pulsed carbon dioxide (CO(2)) laser devices are considered highly effective treatment options for skin resurfacing. Post-operative downtime was significantly decreased compared to traditional ablative resurfacing. the high risk for significant treatment complications following CO(2) resurfacing has warranted the development of new treatment modalities. The added benefit is a considerable reduction both in downtime and risk of complications when compared to traditional CO(2) ablative resurfacing techniques. RESULTS: Twenty-three out of 25 subjects sustained clinical improvement in the appearance of acne scarring at the 3-month follow-up visits according to study investigator quartile improvement scoring. Improvement of acne scarring was evaluated at 1 and 3 months post-treatment.600 MTZ/cm(2).41(2):122-7. Cho SB. 2009 Jan. USA. Source . HS failed to resolve in the second case to date after 1 month. The concept of fractional photothermolysis was developed to address the shortcomings of ablative and non-ablative device modalities. with a total treatment energy of 5. To date. The primary endpoint of the study was the overall improvement in the appearance of acne scarring. The first was treated under general anesthesia on the face and anterior neck at a pulse energy of 30 mJ (859 microm depth) with 25% coverage. No serious complications were reported.35(1):108-14.600 nm fractional CO(2) laser system. Approximately 3 weeks after treatment. which resolved in the majority of subjects within 13 months. two are discussed in detail. Evaluation of a novel fractional resurfacing device for treatment of acne scarring. With early diagnosis and appropriate treatment HS of neck skin may be reversible.Dermatol Surg. Source Zel Skin & Laser Institute. STUDY DESIGN/MATERIALS AND METHODS: Thirty subjects. three non-healing areas along the horizontal skin folds of the anterior neck were noted. All subjects had transient erythema. Zelickson BD. MacFalls HT. Each patient developed scarring. Lee JH. the neck was treated at a pulse energy of 20 mJ (630 microm depth) with 30% coverage of the exposed skin. scarring with fractional CO(2) lasers has not been reported. Lee KY. these areas had become thickened. distinct firm pale papules in linear arrays with mild hypopigmentation had developed along involved neck skin folds. She then experienced tightness on her neck. and decreased potential for scarring in comparison to traditional ablative CO(2) resurfacing. 2009 Feb. Epub 2008 Dec 4. Eleven days after treatment. Choi MJ. However. Skin biopsy was performed. Truitt AK. including pigmentation and rhytides. For the second patient.
to extract the contents of the blocked pilosebaceous follicle. We took a biopsy immediately after one treatment with the laser from one of the authors to assess the histologic effects of the laser on facial pores. Khunger N. Proper counseling is very important in the treatment of acne scars. Oberai C. Three sessions of FPS treatment were performed for acne scars and facial pores monthly. 22. Intralesional corticosteroids are indicated for the treatment of nodules. Gupta S. Prasad D.com Abstract Acne surgery is the use of various surgical procedures for the treatment of postacne scarring and also. Side effects. 2008 Aug. Nd:YAG laser. PHYSICIANS' QUALIFICATIONS: Any Dermatologist can perform most acne surgery techniques as these are usually taught during postgraduation. RESULTS: Follow-up results at 4 months after the last treatment revealed that. . Treatment depends on the type of acne scars.40(6):381-6. Standard guidelines of care for acne surgery. Khunger N. Patwardhan N. CRYOTHERAPY: Cryoslush and cryopeel are used for the treatment of nodulocystic acne. Abstract BACKGROUND: Current treatments for acne scars and enlarged facial pores have shown limited efficacy. and for facial pores. non ablative radiofrequency. of the 12 patients. Proper case selection is very important in ensuring satisfactory results. cysts and keloidal acne scars. 23.74 Suppl:S28-36. Krupashankar DS. However. Vedamurthy M. India. five demonstrated clinical improvements of 51% to 75% and three demonstrated improvements of 76% to 100%.Indian J Dermatol Venereol Leprol. including pain. However.and facial pore-treated areas. MATERIALS AND METHODS: Twelve patients with mild to moderate atrophic acne scars and enlarged pores were included in this study. and is useful for rolling scars. TCA chemical reconstruction of skin scars (CROSS) (Level C) is useful for ice pick scars. a patient may need more than one type of treatment. Glycolic acid. Safdarjung Hospital. Subcision is a treatment to break the fibrotic strands that tether the scar to the underlying subcutaneous tissue.Department of Dermatology and Cutaneous Biology Research Institute. Seoul. Buddhadev R. ACTIVE ACNE: Surgical treatment is only an adjunct to medical therapy. elevation and replacement are useful for depressed scars such as ice pick and boxcar scars. as adjuvant treatment for active acne. for acne scars. split-face design of our study. Superficial chemical peel is a process of applying a chemical agent to the skin. Yonsei University College of Medicine. and edema. were resolved within 1 week. five demonstrated moderate clinical improvements of 26% to 50% and three demonstrated improvements of 76% to 100%. IPL (Intense Pulsed Light). are associated with significant healing time and should be performed by dermatosurgeons trained and experienced in the procedure. salicylic acid and trichloroacetic acid are commonly used peeling agents for the treatment of active acne and superficial acne scars. pulse dye laser and light and heat energy machines have been used in recent years for the treatment of active inflammatory acne and superficial acne scars. Sachidanand S. Two blinded dermatologists who compared before and after photos based on a quartile grading scale conducted objective clinical assessments of acne scar. optimized. Collaborators (16) Mysore V. scar revisions need specific "hands-on" training in appropriate training centers. CONCLUSION: We suggest that the FPS may provide a new treatment algorithm in some cases with acne scars and enlarged pores. 2008 Jan. Surgery is indicated both in active acne and post-acne scars. Nonablative lasers and light therapy using Blue light. prospective studies should be conducted to fully assess the efficacy of FPS with dynamic operating mode. Joshipura S. Korea. Fillers are useful for depressed scars. Chatterjee M.Lasers Surg Med. Savant S. and nonablative methods such as microdermabrasion and nonablative lasers. which remains the mainstay of treatment. Shetty MK. Ablative methods cause significant postoperative changes in the skin. PDT (Photodynamic Therapy). certain techniques such as dermabrasion. Rao KH. FACILITY: Most acne surgery procedures can be performed in a physician's minor procedure room. IADVL Task Force. Source Department of Dermatology. Comedone extraction is a process of applying simple mechanical pressure with a comedone extractor. Resurfacing techniques include ablative methods (such as dermabrasion and laser resurfacing). OBJECTIVE: To evaluate the efficacy and safety of the fractional photothermolysis system (FPS) with dynamic operating mode on acne scars and enlarged pores. laser resurfacing. New Delhi. so as to cause controlled destruction of the epidermis leading to exfoliation. Considering the lack of placebo-controlled. full-face dermabrasion and laser resurfacing need an operation theatre in a hospital setting. Lahiri K. drniti@rediffmail. Punch excision techniques such as punch excision. post-treatment erythema.
Newer modalities using the principles of fractional photothermolysis (FP) create patterns of tiny microscopic wounds surrounded by undamaged tissue beneath the skin with an erbium-doped 1. A three-dimensional optical profiling system (Primos imaging) was used to generate a high resolution topographic representation of the acneiform scar in order to measure the depths of 10 scars from each cheek prior to the first treatment and 3 months after the last treatment. Re-epithelialization was complete by 4-6 days after treatment. Nine patients completed 6 months of follow-up. patients reported 34% improvement in their acne scarring at 3 months and 33% improvement at 6 months. Gonzalez MJ. is associated with an undesirable side effects profile. and risk of infection as well as potential pigmentary alterations. . we investigated the safety and efficacy of single-treatment. Sukal S. 1 week. resolving rapidly within the study period. RESULTS: Post-treatment side effects were mild to moderate and transient. RESULTS: On average. The plasma skin regeneration (PSR) system is a novel device that causes delayed ablation of the epidermis and controlled thermal modification to the underlying dermis. Hale E. atrophy. Improvement was determined by patient questionnaires and physician evaluation of digital photographs taken prior to treatment and at 3 and 6 months post-treatment.5-4. and scarring were graded as present or absent 3 days. treatable by a variety of modalities with varying degrees of success. Treatments were performed in an outpatient clinic setting. Abstract BACKGROUND AND OBJECTIVES: Acne scarring is a common and difficult to treat condition. Blinded physician ratings of patient photos demonstrated 19% improvement at 3 months and 34% at 6 months. These devices produce more modest results in many cases than traditional carbon dioxide (CO(2)) lasers but with fewer side effects and shorter recovery periods. New York.Successful treatment of acneiform scarring with CO2 ablative fractional resurfacing. minimal downtime alternative for the treatment of acne scarring.J Dermatolog Treat. Ross EV. Daniel D.Lasers Surg Med. oozing and crusting. San Diego. Bernstein LJ. and 3 months following each treatment. and overall satisfaction with appearance were graded on a quartile scale by subjects and investigators after each treatment and 1 and 3 months after the final treatment. No delayed onset hypo-pigmentation or permanent scarring was observed. Petechiae. atrophy. 2008 Feb. Geronemus RG. Ablative CO(2) laser resurfacing.0 J). lengthy recovery period. AFR treatments constitute a safe and effective treatment modality for acneiform scarring. USA. STUDY DESIGN/MATERIALS AND METHODS: Ten patients with acne scarring and Fitzpatrick skin types I-III were included in the study. Primos topographic analysis showed that all patients had quantifiable objective improvement in the depths of acneiform scars that ranged from 43% to 79. California. Source Dermatology Department. PSR has previously been shown to be a safe and effective treatment for facial rhytides and benign skin lesions. and no serious adverse events were encountered.8%. Abstract BACKGROUND: Acneiform scarring after severe episodes of acne is a common cosmetic concern. combines CO(2) ablation with a FP system.19(1):45-9. CONCLUSION: PSR appears to provide a safe and effective single treatment. All patients underwent a single PSR treatment with two high-energy passes (3. In this study. CONCLUSION: Successfully combining ablative technology with FP. Chapas AM. Additional studies are warranted to further demonstrate the safety and efficacy of this device. Treatment of acne scars using the plasma skin regeneration (PSR) system. 2008. while effective. and overall improvement were noted in all patients. USA. dyschromia. Sturgill WH. 1 month.9% with a mean level of improvement of 66. Source Laser & Skin Surgery Center of New York. 24. double-pass PSR for the treatment of acne scarring.550 nm laser. aged 28-58 years) with moderate to severe acne scars underwent two or three treatments with the AFR device at 1-2 months intervals. METHODS: Thirteen subjects (skin types I-IV. Uebelhoer NS.40(2):124-7. Brightman L. Post-treatment erythema and edema as well as improvements in texture. high-energy. NY 10016. Quartile grading scores correlating to at least 26-50% improvements in texture. Naval Medical Center San Diego. A novel ablative 30 W CO(2) laser device uses a technique called ablative fractional resurfacing (AFR). 25.
Manstein D. Hong Kong SAR. METHOD: A retrospective study of 37 Chinese patients who were treated with fractional resurfacing for acne scarring. with minimal downtime. 2007 Jun.and post-treatment for evidence of PIH. 2.000 MTZ) were associated with a lower prevalence of generalized PIH (7. each spaced 3-4 weeks apart.Fractional photothermolysis for the treatment of acne scars: a report of 27 Korean patients. Density may be of more important but further studies are necessary to determine this. Patients who underwent a high energy but lowdensity treatment (range of energy 7-20 mJ. Two independent observers assessed the photographs. Shin JW. average energy 16. USA). However.3 mJ. 51 sessions were low energy.Lasers Surg Med. low density. CA. Cooling to prevent bulk tissue heating is . Yu CS. The prevalence and risk factors of post-inflammatory hyperpigmentation after fractional resurfacing in Asians.1% vs. CONCLUSIONS: The 1550-nm erbium-doped FP is associated with significant patient-reported improvement in the appearance of acne scars. 1.000 MTZ) treatment.540-nm laser. RESULTS: FP led to marked improvement in the appearance of acne scars at 3 months post-treatment. China. Localized PIH occurred in the peri-oral area among patients who did not receive air cooling as an adjunctive therapy. University of Hong Kong. Source Division of Dermatology. Source Gowoonsesang Dermatology Clinic. Sixty-eight treatment sessions were high energy. 12. The aim of this study is to evaluate the safety and efficacy of FP in the treatment of acne scars in Asian patients. and moderate improvement in three patients (11%). erythema and edema. Shek S.hk Abstract BACKGROUND: Ablative laser resurfacing is considered to be the main therapeutic option for the treatment of wrinkles and acne scarring. Patients' selfassessed degrees of improvement were as follows: excellent improvement in eight patients (30%). In addition. Korea. Department of Medicine. Lee DH. and pigmentation was carried out. Lee HS. Fractional resurfacing is a new concept of skin rejuvenation whereby zones of micro thermal injury are generated in the skin with the use of a 1. Reliant Technologies. A prospective study of treatments of nine different density and energy levels that were applied to the forearms of 18 volunteers was also performed. Chung JH. OBJECTIVE: To assess the prevalence and risk factors of PIH that is associated with the use of fractional resurfacing in Asians. Lee JH. the difference was not statistically significant. Abstract OBJECTIVES: Atrophic post-acne scarring remains a therapeutically challenging condition despite various currently available technologies.39(5):381-5. Standardized digital photographs were obtained before each treatment and 3 months after the final treatment. average energy 8. The risk and prevalence of hyperpigmentation in darkskinned patients using this approach have not been studied. Chan HH. the patients' perceived degrees of improvement were assessed 3 months after the final treatment using a five-point grading scale. post-inflammatory hyperpigmentation (PIH) is a common adverse effect of laser resurfacing. pre.and post-treatment clinical photographs (from standardized and cross-polarized views) were taken using the Canfield CR system.2 mJ. METHODS: A total of 27 Korean patients (Fitzpatrick skin types IV or V) with moderate to severe facial acne scars received three to five sessions of FP treatment (Fraxel Laser. Clinical photographs were assessed pre. Ahn GY.4%) than those who underwent a low energy but high-density (range of energy 6-12 mJ. Wei WI. 26. Kim DH. However. Seoul. CONCLUSION: Both the density and energy of the treatment determines the risk of PIH in dark-skinned patients. high density. In all of the cases. Fractional photothermolysis (FP) is a novel concept of cutaneous resurfacing which induces noncontiguous microscopic thermal injury. significant improvement in 16 patients (59%). hhlchan@hku. in Asians. skin rejuvenation. Adverse events were limited to transient pain. Kono T. RESULT: In the retrospective study. 119 treatment sessions were performed.
Kunzi-Rapp K. as proved by temperature elevation and morphological changes in the upper dermis.1 and 3.to 12-month follow-up. and post-inflammatory erythema. and redness of the skin. Goldberg LH. USA. and no improvement in 31%. STUDY DESIGN/MATERIALS AND METHODS: An Erbium:YAG laser was used at a thermal mode with sub-ablative fluences of 2. Source Institute for Laser Technologies in Medicine and Metrology.also important.01) after one. Two treatments were applied 2 months apart. STUDY DESIGN/MATERIALS AND METHODS: Fifteen patients with inflammatory facial acne were treated with a combination of the 595-nm pulsed-dye laser and the 1. Histology and immunohistochemistry for pro-collagen expression were investigated. Drosner M.de Abstract BACKGROUND AND OBJECTIVES: To evaluate the efficacy and safety of a thermal mode Erbium:YAG laser several in-vivo morphological as well as clinical changes were monitored in a multi-center investigation.Lasers Surg Med.37(3):179-85. and 28 days after single pass treatment with Erbium:YAG thermal pulses.and post-operative discomfort was described as mild by the patients. fair in 25%. 2005 Sep.450-nm diode laser is safe and effective for the treatment of inflammatory facial acne. 27. Texas 77030.450-nm diode laser. fair in 20%. histological sections and immunohistochemistry demonstrated production of new collagen bundles. By using adequate parameters. and post-inflammatory erythema. Adverse effects were limited to mild. Photographs were taken before and at each follow-up visit and evaluated by three blinded independent reviewers. CONCLUSIONS: Thermal Erbium:YAG pulses can induce collagen neogenesis. RESULTS: All patients had reductions in acne lesion counts. At the 6. perioral rhytides or patients with post-traumatic or acne scars. 28. Glaich AS. 3. and no improvement in 0%. two. acne scarring.uniulm. 63% (P < 0. good in 25%. with follow-up at 1. 6.38(3):177-80. Cambier B. OCT. Patients described moderate-to-marked improvement in acne. karin.Lasers Surg Med. Source DermSurgery Associates. acne scarring. This study was designed to evaluate the efficacy and safety of the combined treatment with the 595-nm pulsed-dye laser and the 1. Houston. Jih MH. and 12 months post-treatment.Lasers Surg Med. CONCLUSIONS: The combination of the 595-nm pulsed-dye laser and the 1. Minimally invasive skin rejuvenation with Erbium: YAG laser used in thermal mode.450-nm diode laser for inflammatory facial acne. fair in 31%. Friedman PM. the improvement was excellent in 40%. transient erythema. acne scarring. 2006 Mar. . Patients' subjective response to treatment was evaluated regarding improvement in acne. Mean lesion counts decreased 52% (P < 0. and 84% (P < 0. and at 4. Dierickx CC. Intra. and no improvement in 0%. Optical coherence tomography (OCT) was performed before. The improvement of scars at 3-6 months follow-up was graded as excellent in 50%. good in 19%.01). Treatment of inflammatory facial acne vulgaris with combination 595nm pulsed-dye laser with dynamic-cooling-device and 1. oiliness. the risk of PIH in darkskinned patients can be significantly reduced. 29.38(10):899-907. 14. Abstract BACKGROUND AND OBJECTIVES: The 585-nm pulsed-dye laser and the 1. RESULTS: The improvement of rhytides at 1-3 months follow-up was graded as excellent in email@example.com diode laser have been found effective for the treatment of mild-tomoderate inflammatory facial acne. good in 40%. respectively.450-nm diode laser. University of Ulm. especially in small anatomical areas. Germany.1 J/cm(2) with parallel air cooling to treat either periorbital. 2006 Dec.01). and three treatments. This leads clinically to visible and long lasting reduction of wrinkles and scars after applying multiple passes with minimal side-effects.
and radiofrequency devices in Asian patients differs from their use in Caucasians in several respects. light sources. following treatment. STUDY DESIGN/MATERIALS AND METHODS: The disease spectrum is very different with pigmentary disorders being more commonly encountered in Asian populations. RESULTS AND CONCLUSIONS: The purpose of this article is to discuss the effective and safe use of lasers. with its higher epidermal melanin content. Source University of Hong Kong.hk Abstract BACKGROUND AND OBJECTIVES: The use of lasers. especially post-inflammatory hyperpigmentation (PIH). . Asian skin. hhlchan@hku. light sources. Hong Kong.Effective and safe use of lasers. is more likely to develop adverse reactions. light sources. Chan HH. and radiofrequency devices in the clinical management of Asian patients with selected dermatoses. and radiofrequency devices in the clinical management of Asian patients with selected dermatoses.
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