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Bicol College COLLEGE OF NURSING Daraga, Albay

Course Code: NCM 106 Course Description: Care of Clients with in Inflammatory and Immunologic Disorders Units: Time: 1:00-5:00 General Course Objectives: Successful completion of this course will promote the general student learning outcomes listed below. The student will be able to:
1. Describe the general concepts of disease processes and factors associated with

disease causation.
2. Identify the function of basic cellular structures, determining the sequelae of

selected cellular malfunctions.
3. Describe the responses of the body to injury and immunologic challenge. 4. Discuss the etiology, pathogenesis, and treatment modalities of frequently

occurring diseases. Specific Course Objectives: Upon successful completion of the course the student will be able to:
1. Describe and understand the common diseases and disorders of the human

body systems.
2. Discuss the pathophysiologic changes that occurs as a result of cellular injury. 3. Analyze the role of the immune system in disease processes. 4. Describe the pathophysiologic changes that occur in selected disease processes 5. 6. 7. 8.

for each body system. Correlate the cellular and system changes that occur in selected disease processes with common presenting clinical manifestations. Define the common treatment modalities and procedures associated with various disease processes. List the categories of pathogenic organisms and the effects these organisms have on the human body. Describe events related to common disorders, major disease processes, and outline the inflammatory response events.

Course Content:

A. Anatomy and Physiology of the Immune System 1. Functions 2. Characteristics/ Properties a. Self versus non self recognition b. Antibody production c. Self regulation d. memory 3. Components of Immune System Bone marrow a. Thymus gland b. Spleen c. Lymph nodes d. Tonsils and adenoids

a antigen recognition 1. Response stage 4. Allergy v. Immunity a.c types of antibodies c. Lifestyle factors viii. Immunodeficiencies i. Immune Response/ Three Means of Defense 1. Assessment of Immune Function a. HIV infection tests ix. Humoral/ antibody response 1. Diagnostic examination i. Pathophysiology of the Development of the Cells of Immune System C. Disorders/ diseases vi.b role of antibodies 1. Hypersensitivity test vii. Types 1. Immune System Disorders a. Acquired/ artificial b. Phagocytic cell function test v. ANA titer determination x. Infection and immunization iv. Nutrition iii. Phagocytic immune response 2. Medications and blood transfusions vii. Recognition stage 2. Complement component test vi. Proliferation stage 3. Gender ii. Health history i. Specific antigen-antibody tests viii. stages of immune response 1. Psychoneuroimmunologic factors b. Physical examination c. Leukocyte and lymphocyte count ii. Anti-DsDNA antibody test D. Cellular immunity test iv. Skin testing xi. Effector stage 4. Natural/ innate 2. Primary  Defect on Phagocytic Cells  Hyperimmunoglobulinemia E (HIE) syndrome / Job Syndrome  Chronic Granulomatous Disease (CGD  Defect on B-Lymphocytes  Bruton agammaglobulinemia/ Bruton’s disease/Sex linked Agammaglobinemia  Hypogammaglobulinemia or Common Variable immunodeficiency (CVID)  Defect on T-Lymphocytes  Di George’s syndrome or Thymic hypoplasia  Chronic Mucocutaneous Candidiasis . Humoral immunity test iii.B.

Secondary  AIDS b. Defect on B and T-Lymphocytes  Severe Combined Immunodeficiency disease(SCID)  Ataxia telangiectasia  Nezelof’s Syndrome  Wiscott-Aldrich Syndrome  Defect on Complement System  Angioneurotic edema  Paroxysmal nocturnal hemoglobinuria (PNH) ii. Autoimmune Diseases  Systemic Lupus Erythematosus  Rheumatoid Arthritis  Myasthenia Gravis  Multiple Sclerosis  Hashimoto Thyroiditis d. Hypersensitivity  Types of Allergens  General Etiologic Factors  Hereditary  Congenital  Contact  Factors Related to the Degree of Allergic Response  Chemical Mediators of Hypersensitivity  Primary mediators o Histamine o Eosinophil chemotactic factor of anaphylaxis o Platelet activating factor o Prostaglandin o Basophil kallikrein  Secondary mediators o Bradykinin o Serotonin o Heparin o Leukotrienes  Four Types of Hypersensitivity Reactions  Type I (Anaphylactic)/Immediate Reaction  Allergic rhinitis/Hay fever  Atopic dermatitis  Dermatitis Medicamentosa/ Drug Reactions  Urticaria  Angioneurotic Edema  Hereditary Angioedema  Food Allergy  Latex Allergy  Type II (Cytotoxic) Reactions  Blood transfusion reaction  RH incompatibility  Type III (Immune Complex) Reaction  Serum Sickness  Systemic Lupus Erythematosus . Gammopathies  Multiple Myeloma c.

 Acute Glomerulonephritis  Arthus Reaction  Type IV (Cell-Mediated)/ Delayed Reactions  Tuberculosis  Contact dermatitis  Transplant rejection .