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01/11/2011

Obesity & Reproductive Disorders

Leny Budhi Harti Program Studi Ilmu Gizi Fakultas Kedokteran Universitas Brawijaya Malang, 1 Nopember 2011
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Obesity & Male Reproductive Disorders


Obese males usually express a characteristic hormonal profile described as hyperestrogenic hypogonadotropic hypogonadism.

Obesity & Male Reproductive Disorders

It is associated with a decrease in circulating androgen levels.

Leny Budhi Harti - Metabolic Syndrome

Leny Budhi Harti - Metabolic Syndrome

01/11/2011

Obesity & Male Reproductive Disorders

Obesity and Erectile Dysfunction 2


CVD

Obesity

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hypoandrogenism

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Proinflamatory cytokines

Endothelial dysfunction Erectile dysfunction NO pathway Erectile dysfunction


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Obesity & Female Reproductive Disorders

Obesity & Female Reproductive Disorders

Insulin resistance and compensatory hyperinsulinemia

PCOS (polycystic ovarian syndrome)


Anovulation, hyperandrogenism such as hirsutism, acne, and male-pattern hair loss
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01/11/2011

Obesity & Female Reproductive Disorders


In insulin resistance syndrome, excess insulin is capable of stimulating steroidogenesis, excessive androgen production from the theca cells and excessive oestrogen production from the granulosa cells of the ovaries.

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Adipokines
The ovary is a target organ for insulin. Insulin stimulates ovarian steroidogenesis in theca and granulosa cells, and enhances the stimulatory effect of LH through LH receptor upregulation Insulin also acts at the level of the pituitary, where it may enhance the sensitivity of the gonadotroph cells to the action of GNRH, further enhancing the stimulation of ovarian steroidogenesis
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01/11/2011

Summary

References
Dokras, Anuja. 2007. Plycystic Ovary Syndrome and the Impact of Obesity on Fertility. Hammoud, Ahmad O, et al. Obesity and Male Reproductive Potential. Journal of Andrology, Vol. 27, No. 5, September/October 2006. Copyright E American Society of Andrology Ramsay, Jane E., Greer ,Ian., Sattar, Naveed. Obesity and Reproduction. BMJ volume 333, December 2006 Brewer, Christopher J., and Adam H Balen. The Adverse Effect of Obesity on Conceprion and Implantation. Reproduction (2010) 140 347364 Kyrou, Ioannis., and Tsigos, Constantin. Chronic Stress, Visceral Obesity and Gonadal Dysfuntion. HORMONES 2008, 7(4):287-293 Ogbuji, C. Queen. Oesity and Reproductive Performance in Woman. African Journal of Reproductive Health Sept. 2010 (Regular Issue); 14(3)

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