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Diseases of the Liver in farm


Dr. Ali H. Sadiek
Prof. of Internal Veterinary Medicine and Clinical
Laboratory Diagnosis

Dept. of Animal Medicine

Faculty of Veterinary Medicine
Assiut University- Assiut, EGYPT


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Function of liver
• Maintenance of normal blood sugar by
providing the source as glycogen.
• Synthesis of some of the pl. proteins.
• The formation and excretion of bile salts
and excretion of bile pigments.
• The formation of prothrombin.
• Detoxification and excretion of many
toxic substances.

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Liver Diseases
• Primary diseases of the liver
occurs rarely in farm animals
except as a result of food
poisonings and Fatty liver.
• Liver dis. occurs secondary to
generalized disease process or by
spread from another organs e.g.
Lung abscess, T.B. RVF, etc.

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Liver Diseases
Liver diseases either:
• Localised: T.B. Cysts, Abscess
• Diffused: Hepatitis or hepatosis.
• Inflammatory or Non Inflam.

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Signs of liver and billiary disease
1- Jaundice
2- Nervous signs.
3- Edema.
4- Dig. Troubles (Diarrhea/constipation)
5- Photosensitization.
6- Hemorrhagic diathesis.

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Signs of liver and billiary disease

7- Abd. Pain.
8- Change of Liver size.
9- Displacement of liver.
10- Rupture of liver.
11-Black liver in sheep.
12- Anorexia, vomition, emaciation,
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• It is a clinical sign in which yellowish
staining of tissues and membranes,
especially elastic tissue.
• It is clinically detected clinically in
the sclera & other visible m. m.
• It is often arises in diseases of the
liver and billiary system and other
disease e.g. hemolysis of RBCs or
• It is classified as: Prehepatic, hepatic
nad posthepatic jaundice.
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Classification of jaundice:
A) Pre-hepatic (Hemolytic Jaundice):
1- Bacterial toxins (Bacillary Hb urea and
2- Babesia and Anaplasma.
3- Viruses (Equine anaemia virus).
4- Immunological reactions.
5- chronic copper toxicity.
6- Lead toxicity.
7- Onion posoning.
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Classification of jaundice:
B) Hepatic causes: (Hep. jaundice)
1-Toxic hepatitis (phosphorus, arsenic).
2-Infectious hepatitis (salmonell., leptosp.,
listeriosis and inf. Eq. anaemia ).
3-Parasitic hepatitis (Massive liver fluck.
Migration of ascaris larvae).
4-Nutritional hepatitis (Deficiency of cystine
and thiamine & Methionin deficiency
5-Congestive hepatitis.
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Classification of jaundice:

C) Post hepatic causes: (Obstructive)

Obstruction of bile duct by :
• Calculi,
• Tumors
• Abscess.
• Fasciola

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Bottle jaw

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Jaundice in a horse's oral mucosa.

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Numerous flukes of Fasciola hepatica observed in
the bile ducts and liver parenchyma of a cow

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Teats are "burned" and Burned" muzzle, discharges
painful from inflamed eyelids
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white of the eye" is yellow or
icteric, an indication that liver
damage may be present

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Normal liver and fatty liver

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Hydatid cysts in bovine liver. Watery cysts in liver

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Multiple abscesses in the calf
liver as a result of an umbilical

Abdominal edema caused by

liver disease

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Echinococcosis. E. granulosus
cysts in the liver

parasitic lesion &

mineralization sheep
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Principals Treatment of liver diseases
1)Treat the original cause if it is known.
2)In biliary congestion, give purgatives:
R (for horses) Aloes 18.00
Calomel 4.00
one bolus per os
R (for cattle)
Magnesium sulphate 60.00 gm
Sodium bicarbonate 30.00 gm
Sodium citrate 10.00 gm
given orally as a drench in suffecient
water for 5 successive days.
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Principals Treatment of liver diseases
3) Atropin sulphate i.m. (1/4 - 1/2 grain for the
horse and 0.001 - 0.002 grain for dogs) to
dilate the bile duct .
4) Flush the liver with large quantities of
5) Oral and parentral calcium injection.
6) Multivitamins daily.
7) Easily digest. laxative food (boiled linseed
and little fodder for horses and cattle &
barley water for dogs).
8) Lipotrophic factors should be given as

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