You are on page 1of 23

Diseases of the Liver in farm

animals

By
Dr. Ali H. Sadiek
Prof. of Internal Veterinary Medicine and Clinical
Laboratory Diagnosis

Dept. of Animal Medicine


Faculty of Veterinary Medicine
Assiut University- Assiut, EGYPT

E-mail: Sadiek59@yahoo.com

Ali Sadiek 1
Function of liver
• Maintenance of normal blood sugar by
providing the source as glycogen.
• Synthesis of some of the pl. proteins.
• The formation and excretion of bile salts
and excretion of bile pigments.
• The formation of prothrombin.
• Detoxification and excretion of many
toxic substances.

Ali Sadiek 2
Ali Sadiek 3
Liver Diseases
• Primary diseases of the liver
occurs rarely in farm animals
except as a result of food
poisonings and Fatty liver.
• Liver dis. occurs secondary to
generalized disease process or by
spread from another organs e.g.
Lung abscess, T.B. RVF, etc.

Ali Sadiek 4
Liver Diseases
Liver diseases either:
• Localised: T.B. Cysts, Abscess
• Diffused: Hepatitis or hepatosis.
• Inflammatory or Non Inflam.

Ali Sadiek 5
Signs of liver and billiary disease
1- Jaundice
2- Nervous signs.
3- Edema.
4- Dig. Troubles (Diarrhea/constipation)
5- Photosensitization.
6- Hemorrhagic diathesis.

Ali Sadiek 6
Signs of liver and billiary disease

7- Abd. Pain.
8- Change of Liver size.
9- Displacement of liver.
10- Rupture of liver.
11-Black liver in sheep.
12- Anorexia, vomition, emaciation,
anemia
Ali Sadiek 7
Jaundice
• It is a clinical sign in which yellowish
staining of tissues and membranes,
especially elastic tissue.
• It is clinically detected clinically in
the sclera & other visible m. m.
• It is often arises in diseases of the
liver and billiary system and other
disease e.g. hemolysis of RBCs or
hemorrhage.
• It is classified as: Prehepatic, hepatic
nad posthepatic jaundice.
Ali Sadiek 8
Classification of jaundice:
A) Pre-hepatic (Hemolytic Jaundice):
1- Bacterial toxins (Bacillary Hb urea and
leptospirosis).
2- Babesia and Anaplasma.
3- Viruses (Equine anaemia virus).
4- Immunological reactions.
5- chronic copper toxicity.
6- Lead toxicity.
7- Onion posoning.
Ali Sadiek 9
Classification of jaundice:
B) Hepatic causes: (Hep. jaundice)
1-Toxic hepatitis (phosphorus, arsenic).
2-Infectious hepatitis (salmonell., leptosp.,
listeriosis and inf. Eq. anaemia ).
3-Parasitic hepatitis (Massive liver fluck.
Migration of ascaris larvae).
4-Nutritional hepatitis (Deficiency of cystine
and thiamine & Methionin deficiency
5-Congestive hepatitis.
Ali Sadiek 10
Classification of jaundice:

C) Post hepatic causes: (Obstructive)


Obstruction of bile duct by :
• Calculi,
• Tumors
• Abscess.
• Fasciola

Ali Sadiek 11
Bottle jaw

Ali Sadiek 12
Jaundice in a horse's oral mucosa.

Ali Sadiek 13
Numerous flukes of Fasciola hepatica observed in
the bile ducts and liver parenchyma of a cow

Ali Sadiek 14
Photosensitization

Ali Sadiek 15
Teats are "burned" and Burned" muzzle, discharges
painful from inflamed eyelids
Ali Sadiek 16
Photosensitization
white of the eye" is yellow or
icteric, an indication that liver
damage may be present

Ali Sadiek 17
Normal liver and fatty liver

Ali Sadiek 18
Hydatid cysts in bovine liver. Watery cysts in liver

Ali Sadiek 19
Multiple abscesses in the calf
liver as a result of an umbilical
infection

Abdominal edema caused by


liver disease

Ali Sadiek 20
Echinococcosis. E. granulosus
cysts in the liver

parasitic lesion &


mineralization sheep
liver
Ali Sadiek 21
Principals Treatment of liver diseases
1)Treat the original cause if it is known.
2)In biliary congestion, give purgatives:
R (for horses) Aloes 18.00
Calomel 4.00
one bolus per os
R (for cattle)
Magnesium sulphate 60.00 gm
Sodium bicarbonate 30.00 gm
Sodium citrate 10.00 gm
given orally as a drench in suffecient
water for 5 successive days.
.
Ali Sadiek 22
Principals Treatment of liver diseases
3) Atropin sulphate i.m. (1/4 - 1/2 grain for the
horse and 0.001 - 0.002 grain for dogs) to
dilate the bile duct .
4) Flush the liver with large quantities of
glucose
5) Oral and parentral calcium injection.
6) Multivitamins daily.
7) Easily digest. laxative food (boiled linseed
and little fodder for horses and cattle &
barley water for dogs).
8) Lipotrophic factors should be given as
choline

Ali Sadiek 23