The inorganic component of dental hard tissues consists of crystalline hydroxyapatite (HAP) and has been the focus

of extensive studies in biomineralization. Dental enamel is exposed to constant demineralization and remineralization within the oral environment, and an imbalance between these processes can result in the conditions of dental erosion or dentine hypersensitivity, or both. This study demonstrates the novel use of electrospun mats of amorphous calcium phosphate (ACP)/poly(vinylpyrrolidone) (PVP) nano- and micro-fibres as hydrogel mats that guide and promote in vitro remineralisation of dental enamel in the presence of fluoride. The procedure results in in situ transformation of the spherical ACP phase at the surface of the enamel to produce a contiguous overlayer of crystalline fluoridated hydroxyapatite, ca. 500 nm in thickness. We also show that similar methods can be developed for the effective occlusion of the porous array of channels present in dentine tubules when exposed to the ACP/PVP electrospun mats. Together, these studies suggest a new approach for the specific engineered regeneration of enamel and alleviation of dentine hypersensitivity and a general strategy for metastable mineralization of a range of substrates.

Take from manipal

Compend Contin Educ Dent. 2011 Jul-Aug;32(6):26-33; quiz 34, 36.

The role of remineralizing agents in dentistry: a review.
Rao A, Malhotra N.


depending upon the microenvironment around the tooth. . Manipal University. Mangalore. Minimal intervention dentistry (MID) focuses on the least invasive treatment options possible in order to minimize tissue loss and patient discomfort. These agents are part of a new era of dentistry aimed at controlling the demineralization/ remineralization cycle.Department of Pedodontics and Preventive Dentistry. One of the key elements of a biological approach is the usage and application of remineralizing agents to tooth structure (enamel and dentin lesions). Abstract Minimal intervention is a key phrase in today's dental practice. Manipal College of Dental Sciences. India. advocating a biological or therapeutic approach rather than the traditional surgical approach for early surface lesions. MID's first basic principle is the remineralization of early carious lesions. Concentrating mainly on prevention and early intervention of caries. This article details the various agents that enhance and/or promote remineralization and discusses their clinical implications.