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1 Ribograma Introdution 2 Corporate Strategy 3 Business Plan 4 Contact
1 Ribograma Introdution 2 Corporate Strategy 3 Business Plan 4 Contact
1 Ribograma Introdution 2 Corporate Strategy 3 Business Plan 4 Contact
1
Ribograma Introdution
2
Corporate Strategy
3
Business Plan
4
Contact
A.   Ferreira-Alemão MD Ph D
A.   Ferreira-Alemão MD Ph D
A.   Ferreira-Alemão MD Ph D

A. Ferreira-Alemão MD PhD

RIBOGRAMA :

RIBOGRAMA:

The repeated records of those quantities of free ribosomes, establishes a graphic curve (RIBOGRAMA) that
The repeated records of those quantities of free ribosomes, establishes a graphic curve (RIBOGRAMA) that

The repeated records of those quantities of free ribosomes, establishes a graphic curve (RIBOGRAMA) that represents the degree of a malignant tendency, which above a certain level of concentration, allows to say that the cells in a tissue (of the colon and rectum, e.g.) can be considered in the process of developing carcinoma in the colon- rectum mucosa, before any macroscopic viewing (endoscopy). "

FREE AND MEMBRANE RIBOSOMES RNA DNA FREE RIBOSOMES MEMBRAN E RIBOSOMES CYTOPLAS CELLULAR NUCLEUS M
FREE AND MEMBRANE RIBOSOMES RNA DNA FREE RIBOSOMES MEMBRAN E RIBOSOMES CYTOPLAS CELLULAR NUCLEUS M
FREE AND MEMBRANE RIBOSOMES
RNA
DNA
FREE
RIBOSOMES
MEMBRAN
E
RIBOSOMES
CYTOPLAS
CELLULAR NUCLEUS
M

biomolecular basis of the cellular machinery

ROUGH ENDOPLASMIC RETICULUM

Free ribosomes are generally assumed to synthesize intracellular proteins (internal economy of the cell), whereas bound ribosomes synthesize proteins intended for secretion (exportation)."

biomolecular basis of the cellular machinery MEMBRANE RIBOSOMES Schematic three-dimensional rough endoplasmic reticulum,
biomolecular basis of the cellular machinery MEMBRANE RIBOSOMES Schematic three-dimensional rough endoplasmic reticulum,

biomolecular basis of the cellular machinery

MEMBRANE RIBOSOMES

basis of the cellular machinery MEMBRANE RIBOSOMES Schematic three-dimensional rough endoplasmic reticulum,

Schematic three-dimensional rough endoplasmic reticulum, showing the synthesis of proteins destined for export by ribosomes attached to membranes reticulum(signal sequence). !

biomolecular basis of the cellular machinery CONTROL OF PROTEIN SYNTESIS Upstream side ! Downstream side
biomolecular basis of the cellular machinery CONTROL OF PROTEIN SYNTESIS Upstream side ! Downstream side

biomolecular basis of the cellular machinery

CONTROL OF PROTEIN SYNTESIS

Upstream side ! Downstream side !
Upstream side !
Downstream
side !
! !
!
!

The protein synthetic capacity of a cell is dictated by a number of processes such:"

Tumor Markers !
Tumor Markers !

mRNA availability; !

efficiency of translation; !

availability of translation factors;"

number of ribosomes "

biomolecular basis of the cellular machinery THE RIBOSOME AS THE COMMON ELEMENT IN THE CELLULAR
biomolecular basis of the cellular machinery THE RIBOSOME AS THE COMMON ELEMENT IN THE CELLULAR

biomolecular basis of the cellular machinery

THE RIBOSOME AS THE COMMON ELEMENT IN THE CELLULAR BIOMOLECULAR PROCESS

2. (Tumor Markers) !
2.
(Tumor Markers) !

1. The evidence accumulated to date indicates that overall the protein synthetic capacity is determined by the number of free ribosomes, which function as an informative sensor of the protein synthesis. !

a

hallmark of agressive malignant neoplasms, which requires a general increase in protein synthesis and a specific increase in the synthesis of replication-promoting proteins. !

Increased

cell

proliferation

is

3. Ribosome synthesis, or biogenesis, is a complex process dependent on the coordinated synthesis of approximately 85 ribosomal proteins, four ribosomal RNA (rRNA) and their subsequent processing and assembly into mature ribosomes.!

biomolecular basis of the cellular machinery THE RIBOSOME AS THE COMMON ELEMENT IN THE CELLULAR
biomolecular basis of the cellular machinery THE RIBOSOME AS THE COMMON ELEMENT IN THE CELLULAR

biomolecular basis of the cellular machinery

THE RIBOSOME AS THE COMMON ELEMENT IN THE CELLULAR BIOMOLECULAR PROCESS

CELL CYCLE

MALIGNANT TRANSFORMED CELL HYPERPLASIA CELL HYPERPLASIA NORMAL CELL CELL NORMAL CELL INTERPHASE MITOSIS
MALIGNANT
TRANSFORMED
CELL
HYPERPLASIA
CELL
HYPERPLASIA
NORMAL
CELL
CELL
NORMAL
CELL
INTERPHASE
MITOSIS
INTERPHASE
MITOSIS
G
S
G
M
G
S
G
M
1
2
1
2
9,3
8,0
2,0
0,7
9,3
8,0
2,0
0,7
Hours "
Hours "
It has been shown in polyoma 

virus-transformed cells that one of the key 

mechanisms for the loss of control of protein 

PRO
MET
ANA
TEL
25,2
2,1
2,1
12,6
Minutes"
FREE RIBOSOMES
QUANTITY !

synthesis is an inability to decrease ribosome number, which correlated with proliferation of transformed cells in fresh media without addition of serum growth factors (Stanners et al., 1979). !

biomolecular basis of the cellular machinery RIBOGRAM CONCEPT S   From the subjective nature, relatively
biomolecular basis of the cellular machinery RIBOGRAM CONCEPT S   From the subjective nature, relatively

biomolecular basis of the cellular machinery

RIBOGRAM CONCEPT

S From the subjective nature, relatively of the amount of free ribosomes, a diagnosis of malignancy is made just under the idea of the constancy property that consists of an great increase of free ribosomes in cells that are in a process of multiplication without self control, as in the case of malignant cells; "

S

A malignant cell

has a very high free ribosomes density

that is a fundamental aspect of its phenotype; "

 

S

So, naturally, to describe the quantities of free ribosomes it is necessary to create a language reproducible, not subjective, with mathematical translation, through a graphic curve that we

call RIBOGRAMA."

biomolecular basis of the cellular machinery RIBOGRAM CONCEPT
biomolecular basis of the cellular machinery RIBOGRAM CONCEPT

biomolecular basis of the cellular machinery

RIBOGRAM CONCEPT

biomolecular basis of the cellular machinery RIBOGRAM CONCEPT
biomolecular basis of the cellular machinery RIBOGRAM CONCEPT Legend : ! smt = every 6
biomolecular basis of the cellular machinery RIBOGRAM CONCEPT Legend : ! smt = every 6

biomolecular basis of the cellular machinery

RIBOGRAM CONCEPT

basis of the cellular machinery RIBOGRAM CONCEPT Legend : ! smt = every 6 months; A,
basis of the cellular machinery RIBOGRAM CONCEPT Legend : ! smt = every 6 months; A,

Legend: ! smt = every 6 months; A, B, C, D = Concentration levels of free ribosomes "

biomolecular basis of the cellular machinery RIBOGRAM CONCEPT
biomolecular basis of the cellular machinery RIBOGRAM CONCEPT

biomolecular basis of the cellular machinery

RIBOGRAM CONCEPT

biomolecular basis of the cellular machinery RIBOGRAM CONCEPT
biomolecular basis of the cellular machinery RIBOGRAM CONCEPT
STATISTICS
STATISTICS
STATISTICS
The RIBOGRAMA method can represent a brand- new generation of " molecular biomarker for use

The RIBOGRAMA method can represent a brand- new generation of " molecular biomarker for use in very early diagnosis, and even to orientate the therapeutic, helping the drug testing for treatments like ADC (Antibody Drug Conjugates), in the same fashion of the antibiograme. "

COLORECTAL CANCER ( CRC ) PREPARATION AND COUNTING OF FREE RIBOSOMES

COLORECTAL CANCER (CRC)

PREPARATION AND COUNTING OF FREE RIBOSOMES

COLORECTAL CANCER ( CRC ) PREPARATION AND COUNTING OF FREE RIBOSOMES
RIBOGRAMA is an objective and quantitative method that provides an unique service to HealthCare Providers
RIBOGRAMA is an objective and quantitative method that provides an unique service to HealthCare Providers

RIBOGRAMA is an objective and quantitative method that provides an unique service to HealthCare Providers worldwide. The method is qualified to deal within all business sectors of the worldwide HealthCare, from the sole practice physician to the largest chain of hospitals. "

"

The advantages of RIBOGRAMA METHOD over other noninvasive tests of cancer of the colon and rectum are the evident twelve "factors nice" that by themselves provide a good patient compliance and a preference for determining the health professionals, because there are no false positives or false negatives, since they are considering charges of ribosomes of cells isolated from the colorectal mucosa. "

"

The colorectal cancer represents one of the biggest incidences of human cancer in the western

The colorectal cancer represents one of the biggest incidences

of human cancer

in the western type of life and cocked food. "

"

This research project has strong potential in the following fields : "

public health, "

medico-hospitalar practice, "

clinical and laboratorial research, "

food industry, "

veterinary, "

oncologic research, "

pharmaceutical industry and "

clinical trials research etc., "

The method has great medical and financial impact, firstly, by now, in the lowering significantly the morbidity and mortality of the colorectal cancer disease, in the world, and, after, with other organs and systems. !

•   To be the leading independent Cancer research Lab in Portugal •   To
•   To be the leading independent Cancer research Lab in Portugal •   To
•   To be the leading independent Cancer research Lab in Portugal •   To
To be the leading
independent
Cancer research
Lab in Portugal
To build a Portu-
guese recognized
brand
•   To be a caring pharmaceutical company helping to enhance health trough quality products
To be a caring
pharmaceutical
company helping
to enhance health
trough quality
products
Ribograma kept and maintained in spite of the difficulties it went through, a framework of
Ribograma kept and maintained in spite of the difficulties it went through, a framework of
Ribograma kept and maintained in spite of the difficulties it went through, a framework of

Ribograma kept and maintained in spite of the difficulties it went through, a framework of high quality human resources, which has allowed it to continue to produce and actively work towards the goal of meeting all the requirements of APIFARMA pro forma to ensure the achievement of Best Practices Manufacturing.

Quality assurance - a pharmacist

Regulatory Affairs - a pharmacist

Head coach - a pharmacist

Quality control - a pharmacist and a chemical engineer

Microbiology - a biologist

Administrative Services - a receptionist / secretary, an accountant, 1 billing clerk

Production - 10 employees

Others - two helpers for cleaning, a doorman, a maintenance operator

Directors - 4 directors

Because aspire to both understand & improve how research is undertaken " Particularly interested in
Because aspire to both understand & improve how research is undertaken " Particularly interested in
Because aspire to both understand & improve how research is undertaken " Particularly interested in

Because aspire to both understand & improve how research is undertaken "

Particularly interested in how the few influence the many to accomplish bold goals "

Cancer research Lab in Portugal "

Center & Department "

Institution-wide "

Clients, employees, and our community will recognize RIBOGRAMA as a firm with: Corporate culture centered
Clients, employees, and our community will recognize RIBOGRAMA as a firm with: Corporate culture centered

Clients, employees, and our community will recognize RIBOGRAMA as a firm with:

Corporate culture centered on the core values of professionalism, fairness, integrity, trust, diversity, excellence, and teamwork

Leaders who combine vision and practical experience with integrity

who combine vision and practical experience with integrity Commitment to supporting diversity in our workforce

Commitment to supporting diversity in our workforce

Obsession with quality in everything we do

These values differentiate RIBOGRAMA from the many other independent Cancer Research Lab in Portugal firms in the market today.

We trust our staff to make decisions and to act based on values. RIBOGRAMA values are not just words, but embody everything we do.

The information contained in this document has been compiled in good faith by Global Partner
The information contained in this document has been compiled in good faith by Global Partner

The information contained in this document has been compiled in good faith by Global Partner Consulting.

Participants should take note, however, that some of the information contained in this document is based on information provided to Global Partner Consulting by other entities as well as external sources and has not been independently verified by Global Partner Consulting.

Participants should not rely on any material contained in this document as a statement or representation of fact, but should satisfy themselves as to its correctness by such independent investigation as they or their legal or financial advisers see fit.

No liability for negligence or otherwise is assumed by Global Partner Consulting for the material contained in this document/ presentation.