Manufacturer Distributor Contents Indications

Claris Lifesciences Macropharma Corp Ketoanalogues & amino acids Prevention & therapy of damages due to faulty/deficient protein metabolism in chronic renal insufficiency in connection w/ limited protein food of 40 g/day (for adults) & less. Click to view Ketolog detailed prescribing infomation Adult ”70 kg 4-8 tab tid. Click to view Ketolog detailed prescribing infomation May be taken with or without food

Dosage Administration

Contraindications Hypercalcemia, disturbed amino acid metabolism. Click to view Ketolog detailed prescribing infomation Special Precautions Adverse Drug Reactions Hereditary phenylketonuria. Pregnancy & lactation. Click to view Ketolog detailed prescribing infomation Hypercalcemia. View ADR Monitoring Website

Drug Interactions Ca-containing drugs eg acetolyte; tetracycline. View more drug interactions with Ketolog Storage Description Mechanism of Action MIMS Class ATC Classification View Ketolog storage conditions for details to ensure optimal shelf-life. View Ketolog description for details of the chemical structure and excipients (inactive components). View Ketolog mechanism of action for pharmacodynamics and pharmacokinetics details. Other Drugs Acting on the Genito-Urinary System G04BX - Other urologicals ;

In case of hereditary phenylketonuria. May be taken with or without food Hypercalcemia. Tablets may be taken during meals. Ensure the sufficient supply with calories. Use in pregnancy: No experience has been made so far with the application in pregnancy. food should contain ”40 g/day of protein ie. it has to be taken into account that Ketolog contains phenylalanine. Dosage Administration Contraindications Special Precautions . Duration of Use: Ketolog tablets are given as long as the GFR is between 5 and about 15 mL/min. The serum calcium levels should be monitored regularly. should be swallowed whole. Administration: For oral use. Use in children: No experience has been made so far with the application in pediatry. Adults (70 kg/body weight): 4-8 tablets 3 times daily during meals. disturbed amino acid metabolism. Simultaneously for adults. Ketolog should be taken during meals to allow proper absorption and metabolism into the corresponding amino acids. generally in patients with glomerular filtration rate (GFR) between 5 and about 15 mL/min.Manufacturer Distributor Contents Indications Claris Lifesciences Macropharma Corp Ketoanalogues & amino acids Prevention and therapy of damages due to faulty or deficient protein metabolism in chronic renal insufficiency in connection with limited protein food of ”40 g/day (for adults).

calcium-2-oxo-3phenylpropionate ( -ketoanalogues to phenylalanine. calcium salt) 86 mg. calcium salt) 101 mg.25 mmol Storage Description . L-threonine USP 53 mg. L-histidine USP 38 mg. Click to view ADR Monitoring Website Simultaneous administration of medicaments containing calcium (eg. Keep in a cool and dry place. calcium salt) 68 mg. Do not take drugs together with Ketolog that form sparingly soluble compounds with calcium (eg. L-tyrosine USP 30 mg.Adverse Drug Reactions Drug Interactions Hypercalcemia may develop. L-tryptophan USP 23 mg. tetracyclines) in order not to interfere with absorption. calcium salt) 59 mg. acetolyte) may lead to pathological increases of the serum calcium level or intensification. As the uremic symptoms improve under Ketolog. calcium-3methyl-2-oxo-valerate ( -ketoanalogues to isoleucine. a possible administration of aluminum hydroxide should be reduced. total nitrogen content 36 mg. calcium salt) 67 mg. L-lysine-acetate USP 105 mg. calcium-3-methyl2-oxo-butyrate ( -ketoanalogues to valine. Shelf-Life: 24 months. View more drug interactions with Ketolog Store at temperatures not exceeding 30°C. calcium 1. Each tablet of Ketolog contains: Calcium-4methyl-2-oxo-valerate ( -ketoanalogues to leucine. calcium-DL-2hydroxy-4 (methylthio) butyrate ( hydroxyanalogue to methionine. Pay attention to a reduction of serum phosphate.

there is an increase in the plasma level of ketoanalogues. It should nevertheless be noted that. In the plasma a simultaneous increase in levels of the ketoanalogue and the corresponding amino acid show that transamination of the ketoanalogues are very rapid. In normal individuals.equivalent to 0. No specific study on ketoacid excretion has been performed to date. and that the post-absorptive kinetics seems to be distributed very early in the development of the disease. Mechanism of Action Pharmacokinetics: The plasma kinetics of amino acids and their integration in metabolic pathways are well established. These levels reach values that are approximately 5 times higher than the initial level. Gastrointestinal absorption is thus very rapid. it is probable that exogenous intakes are very rapidly integrated into metabolic cycles. . in uremic patients.05 g. Ketoacids follow the same catabolic pathways as the classical amino acids. Rx Presentation/Packing Film-coated tab x 100's.Other urologicals . the plasma disturbances do not seem to depend on digested amino acid intake. MIMS Class ATC Classification Poison Schedule [?] Other Drugs Acting on the Genito-Urinary System G04BX . Peak levels are reached within 20-60 min and normal levels are reached again after 90 min. Due to natural pathways of disposal of -ketonic acids in the organism. 10 min after oral ingestion.

magnesium and phosphate. Indications of Ketosteril   Protein energy malnutrition Prevention and treatment of conditions caused by modified or insufficient protein metabolism in chronic renal failure Contraindications of Ketosteril     Allergy and hypersensitivity to any content of this drug Hypercalcemia Disturbed amino acid metabolism Caution use for patietn with phenylketonuria Dosage of Ketosteril   Four to eight tabs TID 1 tab/5kg body weight/day . Reduces ion concentration of potassium. Essential amino acids Therapeutic Actions of Ketosteril Normalizes metabolic process. promotes recycling product exchange.Generic Name: Essential Amino Acids Brand Name: Ketosteril Classifications: Ketoanalogs.

Adverse Reactions of Ketosteril  Hypercalcemia may develop Nursing Considerations of Ketosteril    Evaluate for any contraindications Take drug as prescribed Warn the patient about possible side effects and how to recognize them Give with food if GI upset occurs Frequently assess for hypercalcemia   .