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  • Pathophysiology of Colon Cancer

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    Jeff Alviz
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    Colon cancer is more common in older adults over 62 and those with a family history of oropharyngeal cancer or exposure to radiation. High salt diets, lack of exercise, alcoholism, and smoking are modifiable risk factors. Colon cancer begins as benign adenomatous polyps in the colon that can develop into malignant tumors and spread rapidly if left untreated, causing weight loss, bleeding, bowel obstruction, and eventually invasion of lymph nodes and distant metastases leading to organ failure and death.

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    Colon Cancer Pa Tho Physiology

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    Colon cancer is more common in older adults over 62 and those with a family history of oropharyngeal cancer or exposure to radiation. High salt diets, lack of exercise, alcoholism, and smoking are modifiable risk factors. Colon cancer begins as benign adenomatous polyps in the colon that can develop into malignant tumors and spread rapidly if left untreated, causing weight loss, bleeding, bowel obstruction, and eventually invasion of lymph nodes and distant metastases leading to organ failure and death.

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    Attribution Non-Commercial (BY-NC)
    Download as DOC, PDF, TXT or read online from Scribd
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    3K views1 page

    Pathophysiology of Colon Cancer

    Uploaded by

    Jeff Alviz
    Colon cancer is more common in older adults over 62 and those with a family history of oropharyngeal cancer or exposure to radiation. High salt diets, lack of exercise, alcoholism, and smoking are modifiable risk factors. Colon cancer begins as benign adenomatous polyps in the colon that can develop into malignant tumors and spread rapidly if left untreated, causing weight loss, bleeding, bowel obstruction, and eventually invasion of lymph nodes and distant metastases leading to organ failure and death.

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    PATHOPHYSIOLOGY OF COLON CANCER

    Predisposing factors: Old age, 62 years old Non-white race Family history of oropharyngeal cancer Radiation exposure

    Modifiable risk factors: High-salt diet Sedentary lifestyle Alcoholism Smoking

    Abnormal growth of tissue from the oropharynx

    Adenomatous polyps Benign Untreated\ignored Malignant

    Aggregation of adenomatous polyps in the colon

    High Malignancy

    Protooncogenes are changed to oncogenes

    Enlargement of tumors

    Abnormal cells/cancer cells grow and divide rapidly High energy utilization by the cancer cells Weight loss

    Lower and upper gastrointestinal bleeding

    Lumen obstruction

    Cancer cells proliferates in the superficial lining of the colon Cancer cells has grown through the wall but not the lymph nodes

    Occult blood in stool

    Bowel Obstruction

    Cancer invades the lymph nodes Constipatio n Abdominal pain Abdominal distention Vomiting Metastases to distant sites, other organs such as liver, lungs

    Metastases to distant sites, other organs such as liver, lungs

    Multiple destruction of organs/ MODS

    DEATH

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