PRO ARGI-9

PRO ARGI-9 is the KEY CODE to TURNING ON YOUR BODY’S “METABOLIC SWITCH”

PRO ARGI-9 PROTOCOLS Daytime Night-Time Fat-Burning Athletes
PRO ARGI-9 IS BACKED BY A REGISTERED FEDERAL GOVERNMENT PATENT and TWO DECADES OF L-ARGININE RESEARCH Copyright 2006

L-ARGININE
The amino acid L-arginine is considered the most potent Nutraceutical ever discovered, due to its powerful health

properties, and is referred to by scientists as the “Miracle Molecule.” The remarkable properties of L-arginine were validated by the 1998 Nobel Prize in Medicine, and since then have created a frenzy of interest in the Pharmaceutical and Nutraceutical fields. Columbia University refers to L-arginine as the “Magic Bullet” in human health. Over 10,000 L-arginine citations have been compiled by Columbia University researchers in their quest to document the benefits of this simple amino acid. It is now taught to medical students at the Columbia University College of Physicians and Surgeons. The Nobel Prize landmark discovery of the functions of nitric oxide (NO) highlighted the fact that without NO, human life would be impossible. Even more revolutionary was the irrefutable evidence that L-arginine is the sole NO molecule in the human body. Twenty years ago, the idea that a simple and humble amino acid could change the face of medicine would have been dismissed. Now, physicians, researchers, and scientists are embracing the effectiveness of L-arginine and its use has become mainstream.

FORMS OF L-ARGININE: Creating Safe L-Arginine Formulas

Incorrect ingredients in L-arginine products will block L-arginine’s entry into the body as a free form amino acid. If L-arginine is not properly formulated, it will not elevate serum levels of L-arginine, will not cross the Blood-Brain-Barrier (BBB), and will not provide health benefits. L-arginine products that are founded on metabolic mistakes do not metabolize correctly, and are therefore ineffective. It is unwise to use any L-arginine product without first ascertaining its Length of Use (history and use in humans), the formulator of the product, the Patent-status, the form of L-arginine used, the exclusion of L-arginine antagonists, and its ultimate Isoform Pathway via inclusion of a “Blind Amino Acid Rider.” It is mandatory that the form of L-arginine be bound to a Blind Amino Acid Rider, and formulated by an L-arginine expert with a background in safe arginine Isoform Pathways. The L-arginine-nitric-oxide signaling pathway is probably the most complicated facet of biochemistry. In creating an efficacious formula, the form of L-arginine used will dictate the quality of the product. If the form of arginine used in a formula is not appropriate, the product will not work, and can exhibit side effects. The L-form (left-handed) of arginine is acceptable for human use, while the D-form (right-handed) is not. The D-form of L-arginine is an example of an unacceptable form of L-arginine, though there are many other unacceptable forms, including L-Arginine antagonists. Antagonists are agents that directly compete with L-arginine and: • Block L-Arginine health benefits

• Prevent L-Arginine metabolism • Negate L-Arginine’s ability to cross the Blood-Brain-Barrier • Cause potential serious health problems (including damage to sperm and mortality) Antagonists are listed below: Unacceptable L-Arginine Formulas

UNACCEPTABLE L-ARGININE FORMULAS
ARGININE HCL
In studies where the HCL form of L-arginine has been used, metabolic acidosis and alterations in electrolytes have been documented. Not recommended for human use. Arginine HCL is the form that was used in the tragic Johns Hopkins/JAMA clinical trial that caused mortalities. (www.ArginineAnswers.com).

ARGININE PYROGLUTAMATE
Not recommended for human use. Mechanism of action in the body is entirely speculative according to the Physician’s Desk Reference (PDR).

ARGININE KETOGLUTARATE and ALPHA-KETOGLUTARATE (AKG)
Researchers and physicians caution that Alpha-ketoglutarate is not recommended for human use.

HIGH GLYCEMIC L-ARGININE
High glycemic L-arginine formulas are not effective and are contraindicated for use in humans. High glycemic formulas include those that contain: maltodextrins, glucose, glucose polymers, sugar (sucrose), honey, high fructose corn syrup, fructose corn syrup, flavors made with maltodextrins, sweeteners without caloric impact, and any high glycemic raw material. Any of these ingredients block arginine transport and metabolism and are contraindicated in L-arginine formulas.

NUTRIENTS & SUPPLEMENTS
Foods, drinks (other than water), nutrients, vitamins, herbs, minerals, and supplements also block L-arginine. Therefore, they must be taken separately from L-arginine formulas. DIRECTIONS for REGIMENS are explained below, which outline specific timing.

CAPSULES, TABLETS, SPRAYS, LIQUIDS FORMULAS CONTAINING LESS THAN 5,000 mg for DAYTIME USE, and LESS THAN 10,000 mg FOR NIGHTTIME USE FORMULAS WITHOUT A BLIND AMINO ACID RIDER FORMULAS THAT CONTAIN COMPETING AMINO ACID L-LYSINE
One of the most prominent formulating mistakes related to L-arginine antagonism is the inclusion of Lysine. L-lysine is a direct antagonist of Larginine, though it is frequently seen in L-arginine formulas. L-lysine is added to L-arginine for the purpose of mitigating the herpes reaction of body sores (see Herpes Simplex Virus below), as L-arginine can reactivate the herpes simplex virus (HSV) if it is improperly formulated. Formulas containing L-arginine with L-lysine do not work, and are the result of improper formulating. Dietary disproportions of amino acids can alter the flux of specific amino acids across the Blood-Brain-Barrier (BBB), and the Lysine/Arginine antagonism is an example of this alteration. A plethora of clinical studies have proven that L-arginine and L-Lysine are antagonistic.

PROTEIN

OR

ANY

ASPIRIN
Aspirin is a known antagonist to arginine, and cannot be taken within 2 hours of taking L-Arginine. Aspirin can be beneficial and is frequently recommended by a physician. If your physician has recommended aspirin, take it separately from L-arginine.

L-ORNITHINE
L-ornithine has been clinically proven to be an antagonist of L-arginine and disrupts L-arginine transport. L-ornithine is contraindicated in any L-

arginine formulas, and specifically in products geared to the athlete. Lornithine should be avoided by bodybuilders, powerlifters, and all other athletes, as well as persons desiring to increase muscle mass, because ornithine is a non-protein amino acid. Ornithine is not anabolic and is not used to make protein in the human body, whereas arginine does make protein and is anabolic.

L-CITRULLINE
According to multiple independent studies, L-citrulline is not an appropriate ingredient in an L-arginine formulation. The use of Citrulline in an Larginine formulation can cause inherent problems, including depletion of Larginine.
• Endogenous NOS inhibitors reduce the enzyme sensitivity to L-arginine. These inhibitors include, NG, NG-dimethyl-L-arginine, L-citrulline, argininosuccinic acid and agmatine. Intracellular L-citrulline, an NOS product, is a potent inhibitor of NOS so that the cells may need extra L-arginine to compete with L-citrulline inhibition.

The Arginine Paradox (Folia Pharmacol. Japan Vol. 119 7-14:2002 Department of Pharmacology, Teikyo University School of Medicine):
Lee J, Ryu H, Ferrante RJ, Morris SM Jr, Ratan RR. Translational control of inducible nitric oxide synthase expression by arginine can explain the arginine paradox. Proc Natl Acad Sci U S A 2003;100:4843-8. P. Roy. Recent trends in the nitrergic nervous system.2005. In. Journal of Pharmacology; P. Roy, G. Venkat Ramana, M. Naidu, P. Usha Rani Thomas G, Ramwell PW. Nitric oxide, donors and inhibitors. In: Bertram G Katzung, editor. Basic and Clinical Pharmacology. United States: McGraw Hill; 2004.p.313-8. Chandran S, Sridhar N, Veeranjaneyulu A. Nitric oxide: concepts, current perspectives and future therapeutic implications. Indian J Pharmacol 1998;30:351-66.

PRO ARGI-9

TWO DECADES OF L-ARGININE RESEARCH
Pro Argi-9 is an L-arginine formula backed by over 20 years of research and a registered Patent. Pro Argi-9 is the result of the entire body of work conducted by Dr. Ann de Wees Allen, with two-decades of documented safe L-arginine use in humans. Pro Argi-9 represents the First Generation of safe and effective Larginine, as Pro Argi-9 is the first L-arginine product proven to be safe in humans long-term. Pro Argi-9 is also the only L-arginine product to be used safely in humans over a 23-year period (since 1983). PRO ARGI-9 LEGAL CLAIMS Per FDA and FTC Federal government law, in order to legally make claims related to any L-arginine product, substantiation (definitive proof) of said claims is mandatory. It is illegal to make a “claim” without prior documentation.

“Pro Argi-9 is the only L-arginine product researched over a 20 + year period with documented substantiation of long-term safety, efficacy, and proof of claims”

Legal Claims for PRO ARGI-9

All “Legal Claims” herein stated (1-15) are solely related to the Pro Argi-9 Patent, as awarded to Dr. Ann de Wees Allen, the exclusive inventor and Patent-holder of Pro Argi-9. Each of the fifteen (15) claims for Pro Argi-9 have been submitted and analyzed by FDA and FTC regulatory attorneys and are allowed under the Dietary Supplement Health and Education Act of 1994. Said claims have been determined to meet the legal requirements of “Dietary Supplement Structure/Function” claims per government regulations, as related to Dr. Allen’s Patent for L-arginine, and upon review of the Patent’s documentary evidence and clinical substantiation spanning a two-decade period of more than 23 years, including broad use of safety in humans. The following claims are unique to the Pro Argi-9 Patent and evidential documents submitted since 1983, and may not be used for any other product or patent, under penalty of law. Basis for Claims: 2 + decades of L-arginine research Safe use by over 250,000 human subjects Safe use in humans over a longer period than any other L-arginine product (since 1983) Over 100,000 pages of documentation Only L-arginine that contains a Rider for Blind Amino Acids Only Certified Low Glycemic L-arginine product

PRO ARGI-9 LEGAL CLAIMS

Legal Claims as related to L-arginine PRO ARGI-9 Patent :

1. Enhances muscle mass 2. Supports muscle growth 3. Stimulates muscle development 4. Supports hypothalamic response 5. Aids in decreasing body fat 6. Is an antioxidant 7. Helps maintain healthy blood sugar levels 8. Is more well tolerated than L-arginine alone * 9. Helps boost energy 10. Is rejuvenative 11. Helps promote healthy sexual performance 12. Is an adaptogen 13. Growth hormone: Helps provide the building blocks necessary for the body to maintain its own healthy growth hormone levels 14. Helps produce Nitric Oxide (NO) 15. Stimulates production of human anti-aging mechanisms in persons over 23

These claims may be viewed at www.ProArgi9.com * See explanation at www.ArginineAnswers.com

PRO ARGI-9 Claims & Protocols
The Pro Argi-9 Protocols align the claims (1-15) with the appropriate method of use.

CLAIM
1. ENHANCES MUSCLE MASS:

PROTOCOL
Night-Time

2.

SUPPORTS MUSCLE GROWTH:

Night-Time

3.

STIMULATES MUSCLE DEVELOPMENT:

Night-Time

4.

SUPPORTS HYPOTHALAMIC RESPONSE:

Night-Time

5.

AIDS IN DECREASING BODY FAT:

Night-Time and Fat-Burning

6.

IS AN ANTIOXIDANT:

All Protocols

7.

HELPS MAINTAIN HEALTHY BLOOD SUGAR LEVELS: All Protocols

8.

IS MORE WELL TOLERATED THAN L-ARGININE ALONE: All Protocols

9.

HELPS BOOST ENERGY:

All Protocols

10.

IS REJUVENATIVE:

All Protocols

11.

HELPS PROMOTE HEALTHY SEXUAL PERFORMANCE: All Protocols

12.

IS AN ADAPTOGEN:

All Protocols

13. GROWTH HORMONE: Helps provide the building blocks necessary for the body to maintain its own healthy growth hormone levels: Night-Time

14.

HELPS PRODUCE NITRIC OXIDE (NO):

All Protocols

15. STIMULATES PRODUCTION OF HUMAN MECHANISMS IN PERSONS OVER AGE 23:

ANTI-AGING

Night-Time

PRO ARGI-9 Regimens

Since L-arginine is both Dose-Dependant and TimingDependent, the benefits derived from taking Pro Argi-9 are based on the amount taken (Dose-Dependent) and the time it is taken (Timing-Dependent). Therefore, there are four (4) different PROTOCOLS for achieving dose-related and time-related benefits from Pro Argi-9. Each of the four (4) PROTOCOLS is attained by following a specific REGIMEN as follows:

• DAYTIME • NIGHT-TIME • PREFERENTIAL FAT-BURNING • ATHLETES

DAYTIME PROTOCOL & REGIMEN
The DAYTIME PROTOCOL is appropriate for:

Claim 6. Claim 7. Claim 8. Claim 9. Claim 10. Claim 11. Claim 12. Claim 14.

Antioxidant Helps maintain healthy blood sugar levels Is more well tolerated than L-arginine alone Helps boost energy Is rejuvenative Helps promote healthy sexual performance Is an adaptogen Helps produce Nitric Oxide (NO)

DIRECTIONS FOR THE DAYTIME REGIMEN AMOUNT: One level scoop of Pro Argi-9 contains 5 grams (5,000 mg) of Elemental L-arginine, the therapeutic dose required for Daytime use. Use one (1) level scoop of Pro Argi-9 mixed with 8 ounces of water. Do not use flavored or enhanced water, do not use juice, use only plain water, either tap water or bottled water. TIMING: Take 1 scoop (mixed in water) in-between meals. Do not take with meals or within ½ hour of meals or snacks. May be taken 1-3 times per day as desired or as directed by a physician. CONTRAINDICATIONS: L-arginine products may NOT be used by persons under age 23 without express instruction from an attending physician. Pregnant and nursing women may not use any L-arginine product. Do not take L-arginine with L-Citrulline or any other amino acid or proteins.

NIGHT-TIME PROTOCOL & REGIMEN
The NIGHT-TIME PROTOCOL is strictly for use by persons over age 23 because they have stopped growing (long-bone

growth). You cannot use any L-arginine product at bedtime or night-time in persons who are under age 23, as they are still producing growth hormone (GH), and growth factors. Using Pro Argi-9, or any other L-arginine product to increase height will not work, as total height is genetically controlled and cannot be altered. For persons over age 23, the NIGHT-TIME PROTOCOL is appropriate for: Claim 1. Claim 2. Claim 3. Claim 4. Claim 5. Claim 6. Claim 7. Claim 8. Claim 9. Claim 10. Claim 11. Claim 12. Claim 13. Enhances muscle mass Supports muscle growth Stimulates muscle development Supports hypothalamic response Aids in decreasing body fat Is an antioxidant Helps maintain healthy blood sugar levels Is more well tolerated than L-arginine alone Helps boost energy Is rejuvenative Helps promote healthy sexual performance Is an adaptogen Growth hormone: Helps provide the building blocks necessary for the body to maintain its own healthy growth hormone levels Claim 14. Helps produce Nitric Oxide (NO) Claim 15. Stimulates production of human anti-aging mechanisms in persons over 23 DIRECTIONS FOR THE NIGHT-TIME REGIMEN

AMOUNT: Two level scoops of Pro Argi-9 contain 10 grams (10,000 mg) of Elemental L-arginine, the therapeutic dose required for Night-Time use. 25 total grams of Pro Argi-9 contain 10 g of pure L-arginine.

Two (2) level scoops of Pro Argi-9 mixed with 8 ounces of water or any preferred amount of water. Some people wish to use a smaller amount of water at bedtime to avoid night-time urination. The amount of water used is not important, as long as the 2 scoops are mixed thoroughly. Do not pre-mix Pro Argi-9 with water and let it sit for more than 10 minutes. Do not use flavored or enhanced water, do not use juice, use only plain water, either tap water or bottled water. TIMING: Take 2 scoops (mixed in water) 30 minutes prior to SLEEP. Example: Dinner 8 PM, take Pro Argi-9 11 PM, go to
sleep at 11:30 PM.

Pro Argi-9 Night-Time Regimen must be taken on an empty stomach. You cannot eat for 2-3 hours prior to taking the Night-Time dose, or the product will not work (accessing the BBB and Delta sleep cycle is mandatory). Do not take within 2-3 hours of meals or snacks or drinks other than water. May be taken only one (1) time per day at bedtime.
CONTRAINDICATIONS: L-arginine products may NOT be used by persons under age 23 without express instruction from an attending physician. Pregnant and nursing women may not use any L-arginine product. Do not take L-arginine with L-Citrulline or any other amino acid or proteins.

PREFERENTIAL FAT-BURNING PROTOCOL

The FAT-BURNING PROTOCOL is primarily for persons who wish to use Pro Argi-9 as an adjunct to reducing excess adipose body fat. Claim 5. Aids in decreasing body fat

It is also appropriate for: Claim 6. Is an antioxidant Claim 8. Is more well tolerated than L-arginine alone Claim 9. Helps boost energy Claim 12. Is an adaptogen MECHANISM FOR PREFERENTIAL FAT-BURNING When Pro Argi-9 is used as a drink prior to and during exercise, it triggers a relative shift in substrate utilization from carbohydrate to FAT. The biochemical mechanism by which Pro Argi-9 Preferentially triggers Adipose Tissue Fat-Burning (ATFB) is a result of the unique combination of Trutina Dulcem bonded to the Elemental Pro Argi-9 L-arginine molecules in a low glycemic matrix. No other Arginine product worldwide can produce Preferential Fat Burning. Pro Argi-9 taken as a drink prior to and during exercise reduces the weight of abdominal (retroperitoneal) and epididynal adipose tissue fat tissues (45 and 25 % respectively).
(Preferential Fat-Burning continued)

Pro Argi-9 increases adipose tissue fat expression of genes aligned with glucose oxidation and fatty acid oxidation by 120 % to 800 %

via Heme Oxygenase-3, PPARC-1, NOs-1, and AMP-A Protein Kinase. An ideal exercise for this mechanism is using a treadmill @ 70 % VO2max. Alternatively, fast walking or light jogging will also trigger the appropriate VO2max. DIRECTIONS FOR PREFERENTIAL FAT-BURNING REGIMEN

AMOUNT: One level scoop of Pro Argi-9 contains 5 grams (5,000 mg) of Elemental L-arginine, the therapeutic dose required for the FatBurning Regimen. Use one (1) level scoop of Pro Argi-9 mixed with 8-12 ounces of water. Do not use flavored or enhanced water, do not use juice, use only plain water, either tap water or bottled water. TIMING: Take 1 scoop Pro Argi-9 and mix in 8-12 ounces of water. You may place 1 scoop in your sports bottle, add water, and shake to dissolve. Drink the entire contents prior to and during exercise. not take with meals or within ½ hour of meals or snacks. Do not use any sports drink within 2 hours of using the Fat-Burning Regimen – water only. May be taken 1-2 times per day prior to exercise.
Do

CONTRAINDICATIONS: L-arginine products may NOT be used by persons under age 23 without express instruction from an attending physician. Pregnant and nursing women may not use any L-arginine product. Do not take L-arginine with L-Citrulline or any other amino acid or proteins.

PROTOCOL for ATHLETES
The PROTOCOL for ATHLETES is designed for the professional, competing, world-class, and/or serious athlete. Persons under age 23 may not use this Regimen.

This Regimen is designed to increase muscle mass and muscle mitochondria, increase strength, reduce adipose tissue body fat, and to shorten recouperation time. Benefits of specific interest to athletes are bolded. For persons over age 23, the ATHLETE’S REGIMEN is appropriate for: Enhances muscle mass Supports muscle growth Stimulates muscle development Supports hypothalamic response Aids in decreasing body fat Is an antioxidant Helps maintain healthy blood sugar levels Is more well tolerated than L-arginine alone Helps boost energy Is rejuvenative Helps promote healthy sexual performance Is an adaptogen Growth hormone: Helps provide the building blocks necessary for the body to maintain its own healthy growth hormone levels Claim 14. Helps produce Nitric Oxide (NO) Claim 15. Stimulates production of human anti-aging mechanisms in persons over 23 DIRECTIONS FOR ATHLETES REGIMEN Human Maximum Performance Serious Results for Serious Athletes Claim 1. Claim 2. Claim 3. Claim 4. Claim 5. Claim 6. Claim 7. Claim 8. Claim 9. Claim 10. Claim 11. Claim 12. Claim 13.

Directions for Athletes taking Pro Argi-9 are very precise, and must be followed to the letter in order to obtain maximum benefits. After two decades of working with hundreds of World-Class athletes, our advanced L-Arginine research and Protocol has been finely-tuned, and is considered the most successful in the entire sports industry. Reaching Human Maximum Performance in sports requires that an athlete maximize his/her genetic and individual physical potential. This requires working one-on-one with: • A skilled nutritional/biochemical expert trained in State-ofthe-Art methodologies in sports performance. • A trainer that is highly skilled in sports physiology.

PERIMETERS DIRECTLY TIED TO ATHLETIC ABILITY: 1) Genetics/Heredity 2) Somatotype 3) Individual Biochemistry 4) Food Program 5) Nutritional Supplementation 6) Age 7) Focus & Drive (Mental/Brain/Physical) 8) Training 9) Performance Hormone Levels GAINING ‘THE EDGE” Without an “Edge” the athlete is doomed to mediocrity. The “Edge” is gained by going beyond the barriers required of normal persons, and achieving Human Maximum Performance. All of the nine (9) perimeters outlined above must be addressed in order to

reach Human Maximum Performance. Trial and Error do not work in the highly competitive field of sports. The utilization of Pro Argi-9 in a Human Maximum Sports Performance program addresses # 5) and # 9) of the 9 Perimeters: 1) Genetics 2) Somatotype 3) Individual Biochemistry 4) Food Program 5) Nutritional Supplementation 6) Age 7) Focus & Drive (Mental/Brain/Physical) 8) Training 9) Performance Hormone Levels

PERFORMANCE HORMONE LEVELS An athlete’s ability to perform is largely dependent on his/her hormone levels. The most important sports performance hormones (in males and females) are testosterone and Growth Hormone. Athletes with genetically low testosterone or Growth Hormone (GH) levels will not be able to compete at a high level. Suboptimal levels of performance hormones result in ultimate failure in the professional and competitive sports arena.

In humans, the primary function of Performance hormones is to provide: • GENERATION OF NATURAL ANABOLIC HORMONES • INCREASED MUSCLE MASS

• • • • •

DECREASED ADIPOSE TISSUE BODY FAT INCREASED INTERNAL THERMOGENESIS INCREASED STRENGTH & STAMINA REDUCED INCIDENCE OF INJURY IMPROVED HEALING TIME

Many athletes turn to illegal steroids, and synthetic testosterone and GH to increase their performance abilities. These drugs are illegal and dangerous, and reduce lifespan. They are also unnecessary. There are legal and safe methods for naturally and legally increasing performance hormones in humans. Normal humans produce very high amounts of performance hormones, such as testosterone and GH, during ages 15-18. After age 23, production of these hormones decrease, and continue to descend as age progresses. At age 30, the decline begins to affect sports performance. Though the brain, via the hypothalamus/pituitary axis, “turns off” its production of performance hormones as age progresses (beginning at age 23), this axis can be re-instated in a natural and legal methodology in humans. The brain is completely able and capable of re-instating the same performance hormones as those found in a teen-ager. It requires precise dosing and timing, and the ability of L-arginine to cross the Blood-Brain-Barrier (BBB). If L-arginine does not cross the BBB, there is no re-instation or release of performance hormones. Therefore, athletes cannot take L-arginine in a form that is incapable of crossing the Blood-Brain-Barrier (BBB). FORMS OF L-ARGININE THAT DO NOT CROSS THE BLOOD-BRAIN-BARRIER

(For complete list see: Unacceptable L-Arginine Formulas) • Capsules or tablets • Sprays or liquid • High Glycemic formulas (any formula that contains glucose, glucose polymers, sugar, sucrose, maltodextrins, honey) • Less than 10,000 mg (10 g) of elemental L-arginine • Formulas without a Blind Amino Acid Rider • Formula that contain protein or competing amino acids • Formulas with no/low carbohydrates • HCL Arginine or • Formulas taken at incorrect BBB access-times • Formulas taken with or near food/drink (other than water) • Formulas that contain high glycemic flavor systems • L-Lysine: Unlike L-arginine, L-Lysine does not improve whole
muscle strength or size, and is therefore a substandard amino acid for athletes and persons desiring to increase size and power output from muscle tissue and muscle mitochondria.

ATHLETES AMOUNT: In order to elicit any Performance Hormone response from the brain, including Growth Hormone and Testosterone, a minimum of 10,000 mg (10 grams) is required. Anabolic, anti-aging, and sports

performance benefits only occurs when 10 grams of pure elemental L-arginine is ingested in a low glycemic format with no competing proteins, amino acids, maltodextrins, or sugars. The appropriate dose for most Athletes is 2 scoops of Pro Argi-9. 10 grams of L-arginine = 2 level scoops of Pro Argi-9 2 level scoops of Pro Argi-9 contain 10 grams (10,000 mg) of Elemental L-arginine. 3 level scoops contain 15 grams (15,000 mg) of Elemental L-arginine. These are the therapeutic doses required for the Athlete Regimen (2-3 scoops, depending on the size of the individual). When mixing Pro Argi-9, do not use flavored or enhanced water, do not use juice, use only plain water, either tap water or bottled water. Biochemically speaking, de-ionized water is the best form of water available (not distilled or spring water). Selecting Appropriate Serving Size Athletes can decide how many servings to take depending on personal goals and overall size. Start by taking 1 serving the first night and then increase to 2-3 servings, if desired, over a period of a few days. See Contraindications for exemptions.

ATHLETES TIMING: Take Pro Argi-9 30 minutes prior to sleep on a totally empty stomach. A totally empty stomach means nothing taken but water 2-3 hours prior to taking Pro Argi-9. You must take Pro Argi-9

thirty (30) minutes prior to sleep because L-arginine must cross the Blood Brain Barrier (BBB) during Delta sleep. In ATHLETES, if you have anything in your stomach for two hours prior taking Pro Argi-9, it is not going to work, and will be a waste of time, money and effort. Athletes only produce significant amounts of growth hormone (GH) two times in a 24-hour period: 1) During specific sleep cycles 2) During intense exercise (not aerobics), such as lifting weights and resistance exercise Therefore, athletes can take Pro Argi-9 (at GH doses/2+ scoops) twice per day, while the non-athlete should not.

TIMING for # 1)

SLEEP CYCLE

Take 2-3 scoops Pro Argi-9 and mix in ½ - 1 cup water. Use enough water for the powder to go into solution. If the water is cold, it may take a minute for solubility. Take at bedtime (on a totally empty stomach for 2 hours) 30 minutes prior to sleep. Do not pre-mix the product and let it sit for more than 15 minutes.

Do not take with meals or within ½ hour of meals or snacks. Do not use any sports drink within 2 hours of using the Athletes Regimen – water only. Ingesting food, amino acids, or proteins with or near this product is not in any way harmful, it simply will negate the benefits.

TIMING for # 2)

INTENSE EXERCISE

Athletes may take an optional 1-2 servings 30 minutes prior to intense exercise on an empty stomach. Intense exercise is defined as lifting weights or resistance exercise (not aerobic exercise). If taking Pro Argi-9 30 minutes prior to sleep is problematic, the athlete may instead utilize TIMING # 2 (Intense Exercise). In general, athletes should not eat close to bedtime, as it interferes with the body’s natural cycles and production of anabolic muscle building. ATHLETES SUGGESTIONS If an athlete is not accustomed to taking large doses of L-arginine, a slow-start program may be acceptable. In persons not accustomed to taking large doses of L-arginine, soft stools or mild diarrhea may occur. This is a normal reaction to high-dose Larginine. In said cases, reduce the amount taken until normal stools return. Start off the first night with one scoop which is 5 grams of Larginine. For 2-3 nights just take one scoop. Then go up to 2 scoops, which is 10 grams of elemental Larginine. Take 10 grams per night at bed time for about 3 weeks to a month. The body should then be accustomed to large doses of Larginine.

INCREASED DOSES DIRECTIONS for MALE ATHLETES electing to use more than 10 grams of L-arginine at bedtime:

After working up to 10 grams (without diarrhea), athletes may elect to start taking 15 grams (3 scoops) per night at bed time. • Stay at 3 scoops for one month. • Compare the results with those of the 10 gram dose. If the athlete is getting better results at 10 grams per night versus 15 grams per night, stay at 10 grams per night. More is not always better - If you’re not getting better results at 15 grams go back to 10 grams. FEMALE ATHLETES Female athletes should stay at 10 grams.

CONTRAINDICATIONS: L-arginine products may NOT be used by persons under age 23 without express instruction from an attending physician. Pregnant and nursing women may not use any L-arginine product. Do not take L-arginine with L-Citrulline or any other amino acid or proteins. Non-athletes should not take more than 10 g L-arginine at one time.

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