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LSEB407, 24 Cummington St., Phone: 3-3443, 3-3444 e-mail: jenwelin@bu.

edu Teaching Fellow: Shirley-Eva Sanchez LSEB 412 : 24 Cummington St., Phone: 3-6963 e-mail: sanchs@bu.edu

Class Time

Lecture: MTW: 9 - 11:30. (PHO201) Discussion: MW: 11:30-12:30 Neuroscience, 4th ed; Purves, et al. Lin: T: 11:30-12:30 TF: By Appointment Midterm 1: 30% Midterm 2: 25% Final: 30% Discussion attendance & participation (Mandatory): 15% BI108, BI203 (or equivalents with permission of instructors)

Textbook: Required Office Hours

Grading

Pre-requisites

Date 1 7/5

Topic Introduction Electrical Signals of Nerve Cells Voltage-Dependent Membrane Permeability Channels and Transporters Channels and Transporters Synaptic Transmission Synaptic Transmission Neurotransmitters, Receptors and Their Effects Molecular Signaling within Neurons Synaptic Plasticity Synaptic Plasticity; Review midterm1 The Somatic Sensory System Pain Vision: The Eye Vision: The Eye Central Visual Pathways The Auditory System The Vestibular System The Chemical Senses Lower Motor Neuron Circuits and Motor Control Upper Motor Neuron Control of the Brainstem and Spinal 12 7/27 Cord Review 13 8/1 Midterm2 Modulation of Movement by the Basal Ganglia Modulation of Movement by the Cerebellum Eye Movements and Sensory Motor Integration The Visceral Motor System Sleep and Wakefulness Early Brain Development Construction of Neural Circuits Modification of Brain Circuits as a Result of Experience Repair and Regeneration in the Nervous System Final

Chapter 1 2 3 4 4 5 5 6 7 8 8

Discussion ND

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Crick

Francis Crick, The Astonishing Hypothesis (1994)

Sydney Brenner .

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it would be very convenient and very economical from the point of view of analytical effort if all the nerve centres were made up of a continuous intermediary network between the motor nerves and the sensitive and sensory nerves. nature seems unaware of our intellectual need for convenience and unity. Britannica Reticular theory . by almost unanimous approval. Unfortunately. and very often takes delight in complication and diversity. I found myself unable to follow the current of opinion. Neuron doctrine Ramón y Cajal. Camillo At this point. I must declare that when the neuron theory made. this was the existence of the formation which I have called the diffuse nerve network. while I shall come back to this question later. because I was confronted by one concrete anatomical fact. its triumphant entrance on the scientific scene.Golgi. Santiago True.

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(C) Epithelial cell. (B) Developing neuron: red: actin.Localized protein distribution in neurons: (A) culture neuron: red:tau. Green: tubulin. . Green: tubulin. red: actin. (D) astroglia cell. red: actin.

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CNS: astrocytes and oligodendrocytes PNS: Schwann cells .

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CNS: astrocytes and oligodendrocytes PNS: Schwann cells .

Specific protein micrglia Myelin: red Green: channels at node of Ranvier .Astrocytes red: astrocyte specific protein Oligodendrocytes green: oligo.

definitions and mental pictures of various parts of a neuron • 2. Distribution of molecules can be very localized.• Cellular level • 1. .

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Important definitions: Divergence and convergence Local circuit neurons (interneurons) Projection neurons .

(Afferent) (Efferent) .

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Extracellular recordings record record record record .

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intracellular recordings .

. time scale of AP and PSP. excitatory and inhibitory synaptic potentials. efferent. ms. afferent. def. excitatory and inhibitory synapses. intracellular and extracellular recordings. 5. 3. interneurons 2.• • • • • • Circuitry level: 1. 4.

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*Gray matter * * X .

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. not labeled.Blockage of Medullary branch of vertebral artery.

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not labeled.Blockage of Medullary branch of vertebral artery. .