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FILARIASIS

By Micaela Yanez

OUTLINE
Introduction of Filariasis History  Transmission  Epidemiology  Progress of Lymphatic Filariasis  The Disease  Symptoms and Treatments
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WHAT IS FILARIASIS
A disease that affects humans and animals and is caused by nematode parasites of the order Filariidae.  Of the 100 described filarial parasites only 8 species cause infection in humans.  The 8 filarial parasites are classified by the location they inhabit in host

"  The "threadlike worm" that can cause lymphatic filariasis is a blood-dwelling filarial nematode.Cutaneous (of the skin)  Loa loa  Onchocerca volvulus  Mansonella streptocerca  2nd group.Lymphatic (Lymphatic system)  Wuchereria bancrofti  Brugia malayi  Brugia timori  3rd group. from the aschelminth phyla  3 known species:  Wuchereria bancrofti  Brugia malayi  Brugia timori  WHAT ARE THE DIFFERENCE?  Differences between W. B. reservoirs. symptoms.CLASSIFICATION OF FILARIAL PARASITES 1st group. . bancrofti. timori reside in epidemiology. malayi and B. but mainly species morphology.Body Cavity  Mansonella perstans  Mansonella Ozzardi  LYMPHATIC FILARIASIS "a parasitic disease caused by threadlike worms living in the human lymphatic system. vectors.

bancrofti that to B. malayi   .WUCHERERIA BANCROFTI well-documented most widespread cause of lymphatic filariasis  morphologically significantly different from the other species   Wuchereria bancrofti in a blood smear BRUGIA MALAYI Vector and reservoir Transmitted by Mansonia mosquitos  Animal reservoirs  Morphology differences   BRUGIA TIMORI Least common Least studied  More similar to W. malayi  Vector Anopheles barbirostris  No known animal reservoirs  Symptoms and morphology resembles B. malayi  Larger then B.

microfilariae 1876. it is Culex quinquefasciatus.HISTORY OF LYMPHATIC FILARIASIS  Timeline of discovery          2000BC Pharaoh Mentuhotep II 500 AD Nok civilization in West Africa Greek and Roman civilization 1588-1592 symptoms 1849.adult worm 1877. and Aedes Mansonia can transmit the infection in the Pacific and in Asia.symptoms 1863 and 1866. Anopheles Mansonia titillans Culex quinquefasciatus Aedes TRANSMISSION . depending on the geographic area. In Africa.transmission TRANSMISSION     A wide range of mosquitoes can transmit the parasite.life cycle 1900. the most common vector is Anopheles In the Americas.

& Bangladesh =70%  1/3 of infected live in India  1/3 of infected live in Africa  Remainder are in South Asia. Microfilaria of Brugia malayi. bottom image.  In Asia. top image.  Microfilaria of Wuchereria bancrofti. Nigeria. DPDx) . 80 countries 120 million infected  40 million seriously incapacitated or disfigured  India. Indonesia. (CDC Photos.EPIDEMIOLOGY Endemic in approx. the Pacific and South America   EPIDEMIOLOGY Most of the infections worldwide are caused by Wuchereria bancrofti. the disease can also be caused by Brugia malayi and Brugia timori.

DIAGNOSIS ICT Test X-Ray Detection  Blood Test   .PROGRESSION OF LYMPHATIC FILARIASIS 3 STAGES OF PROGRESSION * Prepatent Period * Incubation Period * Chronic Stage of Lymphatic Filariasis Adult W. bancrofti worms with the smaller male on the left and larger female on the right THE DISEASE  Elephantiasis The individuals above are all infected with W. bancrofti.

and Eradication   .PREVENTION AND TREATMENT there is no known vaccine or cure for lymphatic filariasis  Diethylcarbamazine (DEC) is a popular microfilaricide.  symptoms are often treated with antihistamines. and has been used in Mass Drug Treatment programs. Prevention. and antibiotics  ERADICATION Lymphatic filariasis is one of seven diseases worldwide that the WHO has targeted for eradication  Global Alliance to Eliminate Lymphatic Filariasis  REVIEW What is filariasis How its transmitted  Where its found  The disease  Treatment.

Louis. John." Medical Parasitology. and Piessens. W.REFERENCES  Center for Disease Control and Prevention. Missouri: Saunders Elsevier. 32:947/960. Missouri: Saunders Elsevier.. Petri Jr.. Melrose. David T. David T. 2006. Wayne D. 285-289. 9th ed. 2006. J. 274-285.cdc. and William A.gov/ncidod/dpd/parasites/lymphaticfilariasis/ Dreyer. Louis. 9th ed. 274-285. The Global Alliance to Eliminate Lymphatic Filariasis. and William A. "Brugia malayi. David T. St. Louis. Lymphatic Filariasis.filariasis. "Brugia timori. Parasitology Today. 9th ed. John. Figueredo-Silva. Noroes. "Wuchereria bancrofti .F. International Journal of Parasitology. Missouri: Saunders Elsevier.        . Lymphatic filariasis: new insights into an old disease. and William A. John. 2006. David T. Accessed online at http://www. J." Medical Parasitology. Petri Jr. "Wuchereria bancrofti . John. 2000. St. 16:545-550. Pathogenesis of Lymphatic Disease in Bancroftian Filariasis: A clinical Perspective. 2006. G. 2002. 287-289. Petri Jr.org/. Accessed April 2009 at http://www. Petri Jr. 2007. St. Louis." Medical Parasitology. Missouri: Saunders Elsevier. 9th ed." Medical Parasitology. and William A. St..