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CSIR life science syllabus

by ram nivas
The Joint CSIR-UGC 2 papers:

JRF/LS (NET) Examination shall comprise

duration: 2 ½ hours and maximum of 200 marks. 2 marks each question. (25×275×2)


Part -A: 40 General Science questions, attempt any 25 questions.

Part -B: 100 questions, attempt any 75 questions.

2 ½ hours duration and shall have a maximum of 200 marks (20×115×12)


This Paper shall consist of 39-45 short answer type questions requiring descriptive answers. Answer each question, on one page.

There shall be one compulsory question of twenty Marks. In addition to the compulsory question, the candidate is required to answer a maximum of 15 questions of twelve marks each.


mechanism of enzyme catalysis. D. molecules and chemical bonds. group transfer. Principles of biophysical chemistry (pH. Structure of atoms. Stabilizing interactions (Van der Waals. E. motif and folds). C. structure & function of biomolecules (carbohydrates.1. hydrophobic interaction. hydrogen bonding. isozymes. domains. coupled reaction. . Conformation of proteins (Ramachandran plot. 30 & 40 structures. colligative properties). proteins. oxidative phosphorylation. Principles of catalysis.Acids and vitamins). enzyme regulation. enzymes and enzyme kinetics. 20. glycolysis. N.). Bioenergetics. Composition. biological energy transducers. B. etc. electrostatic. G. MOLECULES & THEIR INTERACTION RELAVENT TO BIOLOG Y A. F. reaction kinetics. thermodynamics. buffer. lipids.

ion channels. I. electrical properties of membranes. lipid bilayer and membrane protein diffusion. osmosis. nucleus. lipids. interrupted genes. Golgi bodies. 2. DNA). structure & function of cytoskeleton and its role in motility. mitochondria. heterochromatin. transposons. C. Metabolism of carbohydrates. CELLULAR ORGANIZATION A. B-. J. peroxisomes. ion pumps. t-RNA. Membrane structure and function: Structure of model membrane. Structural organization and function of intracellular organelles: Cell wall. structure of chromatin and chromosomes. Z-. gene families. nucleotides and vitamins. lysosomes. . B. ER .Conformation of nucleic acids (A-. amino acids. euchromatin. micro-RNA). Stability of protein and nucleic acid structures. unique and repetitive DNA. plastids. H. Organization of genes and chromosomes: Operon. active transport. mechanism of sorting & regulation of intracellular transport. vacuoles. chloroplast.

and DNA damage and repair mechanisms. RNA editing. steps in cell cycle.translational modification of proteins. repair and recombination: Unit of replication. structure and function of different types of RNA. RNA synthesis and processing: Transcription factors and machinery. RNA polymerases. genetic code. their regulation. elongation and elongation factors. polyadenylation. 3. viruses. transcription activators and repressors. translational proof-reading. prokaryotic and eukaryotic D. B. formation of initiation complex. enzymes involved. splicing. aminoacyl tRNA synthetase. yield & characteristics.D. replication origin and replication fork. initiation factors and their regulation. translational inhibitors. post. Protein synthesis and processing: Ribosome. capping. and control of cell cycle. strategies of cell division. Microbial Physiology: Growth. C. FUNDAMENTAL PROCESSES A. fidelity of replication. stress response. E. tRNA-identity. elongation & termination. . Control of gene expression at transcription and translation level: Regulation of phages. extrachromosomal replicons. aminoacylation of tRNA. RNA transport. formation of initiation complex. RNA processing. Cell division & cell cycle: Mitosis and meiosis. DNA replication. termination.

second messengers. Cellular communication: Regulation of hema topoiesis. cell adhesion and roles of different adhesion molecules. therapeutic interventions of uncontrolled cell growth. C. . cell-cell fusion in both normal and abnormal cells. alteration of host cell behavior by pathogens. general principles of cell communication. virus-induced cell transformation. CELL COMMUNICATION & CELL SIGNALING Host parasite interaction: Recognition and entry processes of different pathogens like bacteria. viruses into animal and plant host cells. D. oncogenes. extracellular matrix. bacterial and plant two-component signaling systems. gap junctions. interaction of cancer cells with normal cells. cell surface receptor. 4. Cell signaling: Hormones and their receptors. Cancer: Genetic rearrangements in progenitor cells.gene expression. bacterial chemotaxis and quorum sensing. signaling through G-protein coupled receptors. tumor suppressor genes. B. pathogen-induced diseases in animals and plants. apoptosis. integrins. metastasis. A. virus-induced cancer. signal transduction pathways. regulation of signaling pathways. cancer and the cell cycle. neurotransmission and its regulation. role of chromatin in regulating gene expression and gene silencing.

blastula formation. 5. genomic equivalence and the cytoplasmic determinants. hypersensitivity & autoimmunity. determination & differentiation. inflammation. B and T cell epitopes. fertilization and early development: Production of gametes. Toll-like receptors. competence. B. immune response during bacterial (tuberculosis). parasitic (malaria) & viral (HIV) infections. Gametogenesis. Innate and adaptive immune system: Cells & molecules involved in innate and adaptive immunity. DEVELOPMENTAL BIOLOGY Basic concepts of development: Potency. antigens. morphogenetic gradients. gastrulation & formation of germ layers in animals. . stem cells. embryonic fields. MHC molecules. antigen processing & presentation.E. A. zygote formation. antibody engineering. primary & secondary immune modulation. cell fate & cell lineages. cell surface molecules in sperm-egg recognition in animals. induction. imprinting. mutants & transgenics in analysis of development. vaccines. establishment of symmetry in plants. congenital and acquired immunodeficiencies. cell-mediated effector functions. cleavage. seed formation & germination. antigenicity and immunogenicity. the complement system. monoclonal antibodies. antigen-antibody interactions. specification. B and T cell receptors. activation and differentiation of B & T cells. humoral & cell-mediated immune responses. commitment. structure & function of antibody molecules. generation of antibody diversity. embryo sac development & double fertilization in plants. embryogenesis.

transition to flowering. mechanisms of ETC. post embryonic development-larval formation. C. floral meristems and floral development inArabidopsis and Antirrhinum. eye lens induction. 6. E. photoprotective mechanisms. limb development & regeneration in vertebrates. amphibia and chick. CO2 fixation-C3. . differentiation of neurons. aging and senescence. B. axes and pattern formation in Drosophila. leaf development and phyllotaxy. SYSTEM PHYSIOLOGY ± PLANT Photosynthesis: LH complexes. organogenesis â¼³ vulva formation in Caenorhabditis elegans. shoot and root development. A.Morphogenesis & organogenesis in animals: Cell aggregation & differentiation in Dictyostelium. C4 CAMpathways. D. photorespiration. Respiration & photorespiration: TCA cycle. sex determination. Programmed cell death. Morphogenesis and organogenesis in plants: Organization of shoot and root apical meristem. metamorphosis. plant mitochondrial ET & ATP synthesis. alternate oxidase. environmental regulation of normal development.

C. E. transport & translocation of water. Stress physiology: Responses of plants to biotic (pathogen and insects) and abiotic (water. SYSTEM PHYSIOLOGY ± ANIMAL . through cells. stomatal movement. photoperiodism and biological clocks. amino acid biosynthesis. Solute transport & photoassimilate translocation: Uptake. F. G. across membranes. through xylem & phloem. mechanisms of resistance to biotic stress and tolerance to abiotic stress 7. Secondary metabolites: Biosynthesis of terpenes. ions. temperature and salt) stresses. physiological effects and mechanisms of action. mechanisms of loading & unloading of photoassimilates. breakdown and transport. solutes & macromolecules from soil. Plant hormones: Biosynthesis. D. Nitrogen metabolism: Nitrate and ammonium assimilation. storage. cryptochromes & phototropins. Sensory photobiology: Structure. phenols and nitrogenous compounds and their roles. H. function & mechanisms of action of phytochromes. transpiration.

immunity. gross neuroanatomy of the brain and spinal cord. blood pressure. haemostasis. blood volume. heart as a pump. Blood and circulation: Blood corpuscles. Sense organs: Vision. waste elimination. waste elimination. neural control of muscle tone and posture. exchange of gases. specialized tissue. E. plasma function. regulation of water balance. Nervous system: Neurons. neural and chemical regulation of all above. . body temperature â¼³ physical. cardiac cycle. hearing and tactile response. neural regulation. myogenic heart. anatomical considerations. blood groups. haemopoiesis and formed elements. central and peripheral nervous system. acid-base balance. Cardiovascular System: Comparative anatomy of heart structure. micturition. ECG â¼³ its principle and significance. chemical. F. Respiratory system: Comparison of respiration in different species. acclimatization. action potential. haemoglobin. blood pressure. transport of gases. neural and chemical regulation of respiration. blood volume. B.A. Excretory system: Comparative physiology of excretion. kidney. urine concentration. urine formation. electrolyte balance. Thermoregulation: Comfort zone. D. G. C. blood volume regulation.

3. Voet and Voet Biochemistry. Stryer Biochemistry. Reference Books for CSIR-Life science Posted Date: 27 Jun 2010 Responses: 3 Total Posted By: Manohar Joshi Member Level: Diamond Points: 2 CSIR has been changed the syllabus of NET JRF and We analyzed the syllabus quite precisely and its seems that many advanced are of research has been included. Although it will be the first exam by new syllabus. Stress and adaptation Digestive system: Digestion. Books: 1. Biology by Campbell Reece UNIT 2 For A. I.H. Syllabus has been splited into ten units.B. Chapter 29 Eukaryotic gene regulation from Voet and Voet. 2. energy balance. Here we are highlighting important resources.C. .D : Lodish Molecular Biology . Unit 1. absorption. we would strongly recommend below guidelines. BMR.

if we want to solve many questions. E Kuby and Pressoctt UNIT 5 Developmental biology by gilbert Albert Lodish and voet has good chapter on development biology. Read precisely and solve all the questions. For A-D Lodish and Voet UNIT 4 A Presscot. UNIT 6 Plant Physiology : Buchanan and for some topics consult Voet and Voet UNIT 7 Animal Physiology : An Ebook by wikipedia found to be really important.For E : Presscott Microbiology UNIT 3 This unit is most important. This topic will not covers too many questions. UNIT 9 Biology by Reece NCERT Book of 11 and 12 Biology by Raven UNIT 10 . Go for any basic book. Griffith and Benjamin. But there are many printed books are also available. B-D Lodish. Gardner. good for review or introduction. UNIT 8 This is another important unit which students should get command.

Question banks: Solve the question and try to understand the concepts Review and Lecture notes : Good for revision Ebooks : There are plenty of ebooks are available. at http://biobooke. UNIT 13 Segel Biochemical Calculation Wilson and Walker Instrumentation Old and Primrose : RDT TA Brown : RDT For Stats and Bioinfo we have notes.Ecology by smith and smith Ecology by PD Sharma Good Ecology Notes UNIT 11 We dont have any good reference. Use ItuneU and an Ipod to download the videos and audio English Improvement : Its most important to write correctly to get good marks . Other Important Resources Podcast : listen and watch the video and audio podcast from University sites. We would appreciate if somebody can recommend some good books. All we rely on notes from various sources and electronic forms.