DRUG NAME GENERIC NAME: Chlorpromazine BRAND NAME: Thorazine

CLASSIFICATION: Antipsychotics, Antiemetics

SUGGESTED DOSE Psychoses Adult: 25-50 mg repeated every 6-8 hr. Substitute with oral therapy as soon as possible. Child: 1-12 yr: 500 mcg/kg every 46 hr. Max: >5 yr: 75 mg daily; 1-5 yr: 40 mg daily. Elderly: Initially,1/3 -½ the normal adult dose. Intramuscular

CONTRAINDICATIONS •Hypersensitivity. •Cross-sensitivity may exist among phenothiazines. Should not be used in narrow-angle glaucoma. •Should not be used in patients who have CNS depression. •Coma •bone-marrow suppression •phaeochromocytoma •lactation INDICATIONS: Chlorpromazine is used virtually in all types of psychoses. It can be combined with other anti-psychotics. Chlorpromazine is also used to control anxiety or agitation in certain patients, to relieve a wide range of drug or disease induced vomiting, and in severe hiccups. Chlorpromazine is also used in the treatment of tetanus in combination with other drugs

SIDE EFFECTS: Blurred vision; constipation; dizziness; drowsiness; dry mouth; light sensitivity; nasal congestion. Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest or throat; swelling of the mouth, face, lips, or tongue); changes in breasts; changes in menstrual period; changes in vision; chest pain; chills; confusion; difficulty swallowing; difficulty urinating; drooling; extreme tiredness; fever; inability to move eyes; involuntary movements of the face, mouth, tongue, or jaw; jitteriness; lip smacking or puckering; mask-like face; muscle spasms of the face, neck, or back; prolonged or painful erection; puffing of cheeks; rigid muscles; seizures; shuffling walk; skin discoloration;

ADVERSE EFFECTS: •CNS: neuroleptic malignant syndrome, sedation, extrapyramidal reactions, tardivedyskinesia •CV: hypotension (increased with IM, IV) •EENT: blurred vision, dry eyes, lens opacities • GI: constipation, dry mouth, anorexia, hepatitis, ileus • GU: urinary retention • Hematologic: agranulocytosis, leucopenia • Skin: photosensitivity, pigment changes, rashes

NURSING RESPONSIBILITIES: 1. Assess mental status prior to and periodically during therapy. 2. Monitor BP and pulse prior to and frequently during the period of dosage adjustment. May cause QT interval changes on ECG. 3. The drug may be taken with or without food. 4. Observe patient carefully when administering medication. 5. Monitor I&O ratios and daily weight 6. Advise patient to take medication as directed. Take missed doses as soon as remembered, with remaining doses evenly spaced through out the day.

stiff arms or legs. tremors of hands. such as seizures. yellowing of the skin or eyes. disorientation or ataxia. extreme lethargy. weakness of arms or legs.sleeplessness. Instruct patient to report significant changes in neurological status. twitching or twisting movements. 10. Monitor cardiovascular status of the patient. Monitor kidney and liver function of the patient. sore throat. 7. 9. 8. . slurred speech.

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