PCB3063.

01 JFadool Fall 2011

Syllabus General Genetics Fall 2011 PCB 3063 Section 01 Department of Biological Science College of Arts and Sciences The Florida State University Lecture: M W F 1:25 pm Room:KIN 1024. FINAL EXAM: Dec 16, Friday 7:30 - 9:30 a.m. Instructor: James M. Fadool Phone: 644-3550 Office: 3018 KIN Email: jfadool@bio.fsu.edu Office Hours: Tu 12:30-2:30; Or by appointment. Recitation: M, 515-615, KIN 1024 (Strongly Recommended) TA: Mailin Sotolongo-Lopez Phone: 850-645-3348 Office: 3022 KIN Email: msoto@bio.fsu.edu Office Hours: Thursday 12:30-2:30 Recitation: M, 515-615, KIN 1024 (Strongly Recommended) TEXT: Genetics Essential: Concepts and Connections Author: Benjamin Pierce Publisher: Freeman ISBN-10: 1-4292-5720-2 This is an exciting time to be a geneticist. The human genome project, gene therapies, computer resources and computational methods and the ever-growing methodologies for manipulating genes have propelled a field fundamental to all areas of biology. The role of genetics and the impact upon society as a whole and its infiltration into our culture cannot be understated. For example, how many of you attended any one of a number of campus forums highlighting the recently published non-fiction book, "The Immortal Life of Henrietta Lacks," by Rebecca Skloot? The objective of this course is to provide undergraduate students with an understanding of the fundamental concepts of genetics and molecular biology. Apart from being a required course for majors in Biological Science and strongly recommended for others interested in careers in medicine or allied health professions, genetics shapes our understanding of human health and disease, evolution, agriculture, conservation biology and yes even political affairs. The transmission of genetic material from one generation to the next is what makes biology truly unique amongst the natural sciences. The classical experimental investigations illustrate the development of the scientific method and the evolution of genetics as a field of study. The principles of human genetics, methods in molecular biology and the lessons from cancer biology demonstrate the applications of genetics to our understanding of health and disease in society.

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The lecture material is divided into 2 general areas, Transmission Genetics and Molecular Genetics. The reading assignments are intended to prepare the students for the lectures. When reading, you should focus on the goals as outlined in the text and familiarize yourself with the terminology. More so than many areas of biology, analytical skills and problem solving are fundamental to an understanding of transmission genetics. The recommended problems in the back of each chapter highlight the important points of study and the applications of the lecture material. The solutions to several questions will be reviewed in the help session held each week. Although attendance is not compulsory, it is strongly encouraged. Grade Policy: There will be three one-hour exams, each worth 20% of the final grade, and a final exam, worth 40% of the final grade. The hour exams will emphasize material covered in that quarter of the course, but students are responsible for all course material presented to that date. The final exam will be cumulative with a section devoted to the latest class material and others that specifically address topics from the first 3 sections of the course. Quizzes covering the reading material, lecture material, or recommended problems will be given at the beginning of class on a regular but unannounced basis. The most obvious goal is to encourage each student to come to class prepared for lecture and having reviewed previous material. Genetics covers a broad range of principles from inheritance and probability to molecular biology and its applications. Preparation is essential. A second goal is to provide students with samples of the types of questions and depth of understanding to be expected on the Exams. The average on the quizzes count as bonus point and will be factored into the hourly exam score for that section of the course. There will be no make-up quizzes as these will be graded immediately following administration. There will be no extra credit, so take advantage of the opportunity offered by the quizzes to improve your grade. There is no roundingup of averages. Grade Scale: A 93-100 A- 90-92 B+ 87-89 B 83-86 B- 80-82 C+ 77-79 C 70-76 C- 65-69 D 60-64 F Below 60 Attendance at lectures should not be viewed as unnecessary. There is no substitute for the interaction between the instructor and students. Questions during lecture are actively encouraged. Furthermore, supplemental information, not present in the text, may be provided. Likewise, it is expected that students will study the assigned material in the text as all requisite information cannot be presented in lecture. Attendance at Lecture Exams is required. University Attendance Policy: Excused absences include documented illness, deaths in the family and other documented crises, call to active military duty or jury duty, religious holy days, and official University activities. These absences will be accommodated in a way that does not arbitrarily penalize students who have a valid excuse. Consideration will also be given

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to students whose dependent children experience serious illness. Academic Honor Policy: The Florida State University Academic Honor Policy outlines the Universitys expectations for the integrity of students academic work, the procedures for resolving alleged violations of those expectations, and the rights and responsibilities of students and faculty members throughout the process. Students are responsible for reading the Academic Honor Policy and for living up to their pledge to . . . be honest and truthful and . . . [to] strive for personal and institutional integrity at Florida State University. (Florida State University Academic Honor Policy, found at http://dof.fsu.edu/honorpolicy.htm.). The Academic Honor System of The Florida State University is based on the premise that each student has the responsibility (1) to uphold the highest standards of academic integrity in the student's own work, (2) to refuse to tolerate violations of academic integrity in the university community, and (3) to foster a high sense of integrity and social responsibility on the part of the university community. (Florida State University Academic Honor Policy, found at http://dof.fsu.edu/honorpolicy.htm.)

Americans With Disabilities Act: Students with disabilities needing academic accommodation should: (1) register with and provide documentation to the Student Disability Resource Center; and (2) bring a letter to the instructor indicating the need for accommodation and what type. This should be done during the first week of class. This syllabus and other class materials are available in alternative format upon request. For more information about services available to FSU students with disabilities, contact the: Student Disability Resource Center 874 Traditions Way 108 Student Services Building Florida State University Tallahassee, FL 32306-4167 (850) 644-9566 (voice) (850) 644-8504 (TDD) sdrc@admin.fsu.edu http://www.disabilitycenter.fsu.edu/ Free Tutoring from FSU For tutoring and writing help in any course at Florida State University, visit the Academic Center for Excellence (ACE) Tutoring Services comprehensive list of tutoring options - see http://ace.fsu.edu/tutoring or contact tutor@fsu.edu for more information. High-quality tutoring is available by appointment and on a walk-in basis. These services are offered by tutors trained to encourage the highest level of individual academic success while upholding personal academic integrity. Syllabus Change Policy Except for changes that substantially affect implementation of the evaluation (grading) statement, this syllabus is a guide for the course and is subject to change with advance notice.

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READING ASSIGNMENTS AND PROBLEM SETS This is a tentative Schedule. Listed are the assigned readings and problems in the back of each chapter. The overall topics and order of lectures are subject to change. Please Note Exam Dates. WEEK 1 Aug 29 Introduction; History of Genetics Chpt 1: 1,4,5,11-15,21,26 Aug 21 Review Cell Cycle Review Chpt 2:1,3,4,6-13,16,18-23 Sept 2 Mendelian Principles Monohybrid Cross Chpt 3: 1-6,8,12,13-21 WEEK 2 Sept 5 **Labor Day HOLIDAY** Sept 7 Mendelian Principles Dihybrid Cross Chpt 3: 9,10,24,25 Sept 9 Probability & Human Pedigrees Chpt 3:30-32 WEEK 3 Sept12 Chi square analysis Chapter 3: 11,28,29 Sept 14 Modifications of Mendelian Ratios & X-Linkage Chpt 4:1-4, 12,13,15,16,17,19,20 Sept 16 Sex Determination & Dosage Compensation Chpt 4 cont WEEK 4 Sept 19 Codominance, Multiple Alleles; Chpt 4:6,7 Sept 21 Additional Gene Interactions Chpt 4:8,9,21-24,26,27,30 Sept 23 Two or More Gene Interactions Chpt 4 cont WEEK 5 Sept 26 Additional Gene Interactions; Extranuclear DNA Chpt 4:10,31 Sept 28 Wrap-up Sept 30 EXAM I Chpt 1-4 WEEK 6 Oct 3 Linkage in Eukaryotes Chpt 5, 1-5, 9-12, 14, Oct 5 Linkage Chpt 5:6,7,15,18a,18b,19a Oct 7 Complete Linkage and 3-point crosses WEEK 7 Oct 10 Cytology Chpt 7, All Key terms, problems 1,4-7,9,10, 13,14,16 Oct 12 Cytology Chpt 7; 18,19,27. Oct 14 Cancer & Chromosome Variation, Chpt 15.2,15.3 WEEK 8 Oct 17 Quantitative Genetics Chpt 16,terms from lecture;1,2,4,8; 12-16,19. Oct 19 Quantitative Genetics Try several from section 16.4

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Oct 21 Complete Quantitative Genetics and Q&A WEEK 9 Oct 24 EXAM II Oct 26 DNA AS Hereditary Material Chpt 8; also review Bacterial and Viral Genetics Chpt 6, pp13943,153-54 Oct 28 DNA AS Hereditary Material Chpt 8 WEEK 10 Oct 31 Continue DNA; Replication Chpt 9 and online material Nov 2 Replication Chpt 9 Nov 4 Complete Replication WEEK 11 Nov 7 Replication, Recombination and Chromosomes Chpt 9 Nov 9 RNA structure and function Chpt 10 sections 1-3 Nov 11 **Veterans Day HOLIDAY** WEEK 12 Nov 14 Transcription and RNA Polymerases, Chpt 10 section 1-3 Nov 16 Transcription and RNA processing Chpt 10 Nov 18 No Class: Homecoming Weekend WEEK 13 Nov 21 **EXAM III** Nov 23 **THANKSGIVING HOLIDAY** Nov 25 **THANKSGIVING HOLIDAY** WEEK 14 Nov 28 Translation; Genetic Code Chpt 11 Nov 30 Translation; Machinery Chpt 11 Dec 2 Regulation of Gene expression Chpt 12 WEEK 15 Dec 5 Gene Mutation and repair Chpt 13 Dec 7 Population Genetics Chpt 17 Dec 9 Population Genetics and Review WEEK 16 Dec. 16 Friday FINAL EXAM 7:30am-9:30am