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WEEK 6 1-5 APRIL 2012 CARDIOVASCULAR SYSTEM (MODULE 11) Pyhsiology of microcirculation 1. What is meant by vasomotion? A.

Circulating blood through the systemic capillary system B. Continous rate of flow of blood through the capillaries C. Intermittent contraction of metarterioles and precapillary spichter D. The number of partially and totally closed capillaries 2. Choose the correct function of capillaries: I. Keep normal venous return II. Local autoregulation that regulate arterial blood pressure and the blood flow III. Site of exchange between blood and external environment IV. Keep normal cardiac output A. I & II B. I, II & III C. III & IV D. All of the above 3. All of the following are correct regarding the exchange across the capillary wall EXCEPT: A. Bulk flow of water and solutes from interstitial fluid into the plasma is called filration B. Diffusion is kinetic movement of material from the area of high concentration to low concentration C. Starling forces is consist of the plasma colloid osmotic pressure and the capillary pressure D. Large substance produce high osmotic pressure inside the capillary wall since it cannot pass through the wall 4. Capillary pressure is affected by the following factors: I. Visceral characteristics II. High Arterial blood pressure III. Venous pressure IV. Dilatation and constriction of arterioles A. I & II B. I, II, & III C. I, III & IV D. All of the above

QMU CVS 2012

5. Choose the correct way of transportation of molecules across the capillary wall A. Slit pores: Large quantities of water and solutes B. Pinocytosis : glucose C. Fenestrae : protein D. Transcellular transport : O2 & CO2 HEART FAILURE DRUGS 1 6. Choose the right answer about the sign and symptom for the congestive heart failure A. Dyspnoea B. Orthopnoea C. Dependent oedema D. All of the above 7. What is the goal of treatment of congestive heart failure? A. To relieve the symptoms B. Delay cardiac remodelling C. All of the above D. None of the above 8. Which of the following is not the cardiovascular system symptom of digitalis toxicity? A. Complete heart block B. Fatigue C. Conversion of atrial flutter to fibrillation D. Ventricular tachycardia and fibrillation 9. All of the following answer is true about the factors and interactions predisposing to toxicity except A. Quinidine B. Hypothyroidism C. Hyperkalaemia D. Hypoxia 10. Choose the main cardiac effect of digitalis drug A. Increase force of contraction B. Impaired A-V conduction C. Decrease cardiac oxygen demand D. Bradycardia 11. Choose the correct value of filtration pressure and reabsorption pressure of the capillary respectively A. 11 mmHg, 9 mmHg B. 40 mmHg, 29mmHg C. 9 mmHg, 11 mmHg D. 29 mmHg, 40 mmHg

QMU CVS 2012

12. Choose the correct differences between filtration and diffusion I II III IV Diffusion occurs in both directions while filtration is movement of fluid out of the capillaries Filtration is movement of fluid out of capillaries at venous end Diffusion rate is more than filtration rate by about 15 000 folds, normally Diffusion is a less important mechanism for transport of nutrients between interstitial fluid and plasma

A. I and II B. I and III C. II and IV D. III and IV 13. Which of the following is the definition of oedema? A. Normal increase in the volume of interstitial fluid B. Normal increase in the volume of protein in interstitial fluid C. Abnormal increase in the volume of interstitial fluid D. Abnormal increase in the volume of protein in interstitial fluid

14. Increased capillary permeability results in edema. Choose the correct causes of increased capillary permeability I II III IV Extremes of temperature Hypoxia Capillary dilation Nutritional deficiency

A. I, II and III B. I, II and IV C. I, III and IV D. All of the above True or False 15. Lymphatic system removes interstitium albumin and other macromolecules that escapes from microcirculation.

QMU CVS 2012

Heart failure drugs

16. Which drug is given during intermittent acute exacerbations of cardiac heart failure as in some cases of cardiogenic shock? A. Amrinone B. Milrinone C. Dobutamine D. Atenolol 17. Which drug is given to inhibit metabolism of cAMP? A. Dobutamine B. Amrinone C. Spironolactone D. ACEI 18.Which drug is given to prevent angiotensin production and decreasing the norepinepherine and aldosterone? A. Dobutamine B.ACEI C. B-blocker D. Nitrates 19.All the following are the humoral compensatory mediators responsible for perpetuating cardiac remodelling except? A. Aldosterone B. Norepinephrine C. Angiotensin II D. Angiotensin I 20.All the following are the effect of diuretic except? A. Decrease preload B. Useful in dyspnea C. Causes hyperkalemia D. Causes hypokalemia ANSWERS 1 2 3 4 5

C 146 D 147 A 148 C 148 D 148

6 7 8 9 10

D 272 C 272 B 274 C 274 A 274

11 12 13 14 15

A 151 B 152 C 153 D 153 T 154

16 17 18 19 20

C B B D C

QMU CVS 2012

QMU CVS 2012