OBAT ANESTESI 1. Safol 1 cc = 10 mg Dosage: Induction of general anesth Adult Titrate 40 mg every 10 sec until onset of anesth.

Adult <55 yr 1.5-2.5 mg/kg. Childn >8 yr 2.5 mg/kg slow IV until onset of anesth. Maintenance of general anesth Adult 4-12 mg/kg/hr or 25-50 mg repeated bolus inj. Childn >3 yr 9-15 mg/kg/hr. Sedation during intensive care 0.3-4 mg/kg/hr. 2. Ephedrine 1cc= 1 amp/aplus 4cc= 10mg Dosis: Oral Diabetic neuropathic oedema Adult: 30-60 mg tid. Child: Intravenous Reversal of spinal or epidural anaesthesia-induced hypotension Adult: 3-6 mg or up to 9 mg in a 3 mg/mL soln given as slow Inj repeated every 3-4 min, as needed. Max Dosage: 30 mg. 3. Fentanyl® Premed 100 mcg IM 30-60 mins prior to surgery. Adjunct to regional anesth 50-100 mcg IM/slowly IV over 1-2 mins when additional analgesia is required. Post-op (recovery room) 50-100 mcg IM, may be repeated in 1-2 hr as needed. As analgesic supplement to general anesth Low dose: 2 mcg/kg. Moderate dose: 2-20 mcg/kg. High dose: 20-50 mcg/kg. As anesth agent 50-100 mcg/kg. 4. atropine Parenteral Premedication in balanced anaesthesia Adult: 300-600 mcg IM/SC 30-60 minutes before anaesthesia. Alternatively, 300-600 mcg IV immediately before induction of anaesthesia. Child: >20 kg: 300-600 mcg; 12-16 kg: 300 mcg; 7-9 kg: 200 mcg; >3 kg: 100 mcg. Doses to be given via IM/SC admin 30-60 minutes before anaesthesia. Parenteral Organophosphorus poisoning Adult: 2 mg IV/IM, every 10-30 minutes until muscarinic effects disappear or atropine toxicity appears. In severe cases, dose can be given as often as every 5 minutes. In moderate to severe poisoning, a state of atropinisation is maintained for at least 2 days and continued for as long as symptoms are present. Child: 20 mcg/kg given every 5-10 minutes. Parenteral

6-1 mg IV/IM/SC. 6. repeated every 2 hr. For prolonged action: 9 mg (1. Child: As sulfate: Instill 1 or 2 drops of a 0. Rate: 5-40 drop/min.04 mg/kg body weight. with a further dose given 1 hr before the procedure. puerperal bleeding 0. repeated once after 2-10 min if necessary. May be repeated at intervals of not <2 hr. Syntocinon® Induction of labour IV infusion: 1 u/100 mL.000) can be admin.8 ml) of a 0. Ophthalmic Eye refraction Adult: Instill 1 drop of a 1% solution bid for 1-2 days before the procedure. Max Dosage: 0.5-1% solution up to 4 times daily. followed by 50 mg every 2 hr if needed. Methergin® Active management of 3rd stage of labor 0. up to 3 times daily. Max total: 90 mg/dental sitting.125-0. Bucain® Percutaneous infiltration anaesthesia Adult: 0. in lactating women preferably for not >3 days. 5. lochiometra. 3rd stage of labour 510 iu IM or 5 iu slow IV Caesarian section 5 iu intramurally after delivery. Intravenous Bradycardia Adult: 500 mcg every 3-5 minutes. 7.25 mg orally or 0. Subinvolution.25% solution is typically used. Injection Peripheral nerve block .5% solution with adrenaline (1:200. Max single dose: 150 mg with or without adrenaline.Poisoning or overdosage with compounds having muscarinic actions Adult: 0.5-1 mL IM.5-1 mL IV. Incompatibility: Incompatible with hydroxybenzoate preservatives.5% soln (or 1 drop of a 1% solution) bid for 1-3 days before the procedure. Uterine atony/hemorrhage 1 mL IM or 0. Child: As sulfate: Instill 1-2 drops of a 0. Delivery under general anesth Recommended dose: 1 mL. Ophthalmic Inflammatory eye disorders Adult: Instill 1-2 drops of a 0.5% soln (or 1 drop of a 1% solution) up to tid.5-1 mL IM following delivery of the head or anterior shoulder or immediately after child delivery. Total: 3 mg. or on a single occasion 1 hr before the procedure.

to be given 24 hr after chemotherapy.5% solution. Injection Caudal block Adult: In surgery: 37. then continuous IV infusion of 1 mg/hr for up to 24 hr or by further 2 . With analgesia during labour: 15-30 mg (6-12 ml) of a 0. Sotatic® Oral Adult 10 mg or 1-2 tsp 3 times daily. Max single dose: 150 mg with or without adrenaline. 8. Radiotherapy-induced nausea & vomiting 8 mg orally 8 hrly.25% solution or 30-60 mg (6-12 ml) of a 0. before the end of surgery.25% solution or 50-100 mg (10-20 ml) of a 0. Childn <6 yr Max dose: 0. 9. With analgesia during labour: 25-50 mg (10-20 ml) of a 0. Injection Retrobulbar block Adult: 15-30 mg (2-4 ml) of a 0. 1st dose should be taken 1-2 hr before radiotherapy. Post-chemotherapy antiemetic Adult 0.5% solution. followed by 50 mg every 2 hr if needed. Injection Sympathetic nerve block Adult: 50-125 mg (20-50 ml) of a 0. Cedantron® Oral Prevention of post-op nausea & vomiting Initially 1 tab 1 hr before anaesth. followed by 2 doses of 1 tab 8 hrly. Inj Treatment of postop nausea & vomiting 4 mg IM as single dose or slow IV inj.25% solution or 50-100 mg (10-20 ml) of a 0.75% solution.5 mg/kg body wt/day 4 times daily for 6 days. Childn & adolescents Max dose: 0.5 mg (5 ml) of a 0. Inj Treatment of delayed gastric emptying Adult 10 mg by IV inj over 1-2 min. Highly emetogenic chemotherapy Initially 8 mg by slow IV inj or 15 min infusion immediately before chemotherapy.25% solution. Injection Lumbar epidural block Adult: In surgery: 25-50 mg (10-20 ml) of a 0. Childn 6-14 yr 2.5-5 mg by IV inj.5% solution.5% solution. Prevention of vomiting due to chemotherapy 1-2 mg/kg body wt IV over >15 min.25% solution or 75-150 mg (15-30 ml) of a 0.25% solution or 25 mg (5 ml) of a 0.5-75 mg (15-30 ml) of a 0.75% solution.1 mg/kg body wt/day as a single dose.1 mg/kg body wt by IV inj.Adult: 12.5% solution. to be given 30 min before chemotherapy.5 mg/kg body wt/day in 3 divided doses. ≤6 yr 0. Prevention of vomiting before surgery 10-20 mg IM over 1-2 min. In non-obstetric surgery: 75-150 mg (10-20 ml) of a 0.

Parenteral Moderate to severe acute pain Adult: As hydrochloride: 25-100 mg IM/SC inj or 25-50 mg by slow IV inj repeated after 4 hr. Less emetogenic chemotherapy 8 mg by slow IV inj or 15 min infusion immediately before chemotherapy or 8 mg orally 1-2 hr before chemotherapy followed by 8 mg orally 8 hrly for up to 5 days. Alternatively. repeat after 1-3 hr if needed. IV inj: Neonates and children ≥12 yr: 0. Renal impairment: Dose reductions may be necessary. Elderly: As hydrochloride: 50 mg every 4 hr. 12-18 yr: 25-50 mg every 4-6 hr if needed. Repeat dose every 4-6 hr if needed.5-2 mg/kg. pethidine Oral Moderate to severe acute pain Adult: As hydrochloride: 50-150 mg every 4 hr if needed. Child: As hydrochloride: SC/IM: 2 mth to 12 yr: 0. Hepatic impairment: Dose reductions may be necessary.doses of 8 mg by slow IV inj or 15 min infusion 4 hr apart. Parenteral Obstetric analgesia Adult: As hydrochloride: 50-100 mg by IM/SC inj as soon as contractions occur at regular intervals. Either regimen is then followed by 8 mg orally 12 hrly up to 5 days. Repeat dose every 4-6 hr if necessary. Hepatic impairment: Dose reductions may be necessary. Child: As hydrochloride: Children 2 mth to 12 yr: 0. Intramuscular Preoperative medication Adult: As hydrochloride: 25-100 mg IM/SC given 1 hr before surgery. Renal impairment: Dose reductions may be necessary. Renal impairment: Dose reductions may be necessary. IM/SC doses may be given every 2-3 hr if needed. 10.5-1 mg/kg IV inj every 10-12 hr if needed in those up to 2 mth and every 4-6 hr if needed in older children. . 12-18 yr: 50-100 mg. ≥1 mth: Loading dose: 1 mg/kg by IV inj followed by 100-400 mcg/kg/hr via continuous IV infusion adjusted according to response. Renal impairment: Dose reductions may be necessary. Elderly: 25 mg every 4 hr. 12-18 yr: 20-100 mg. Hepatic impairment: Dose reductions may be necessary. Max: 400 mg in 24 hr.5-2 mg/kg. Child: As hydrochloride: 1-2 mg/kg given 1 hr before surgery.

Syringe incompatibility: Pentobarbital. heparin. doxorubicin liposome. titrate infusion rate according to response. 1-2 mg/kg infused at 0. IV inj: Dilute with water for inj to a concentration of 5-10 mg/ml.5-13 mg/kg. do not inject in the same syringe. minocycline. furosemide. phenobarbital.5 mg/kg as IV inj. amphotericin B cholesteryl sulfate complex. Parenteral Postoperative pain Adult: As hydrochloride: 25-100 mg IM/SC inj every 2-3 hr if necessary. Alternatively. Child: 1-4. cefoperazone. Usual dose to produce 5-10 minutes of anaesthesia: 2 mg/kg over 60 seconds. Surgical anaesthesia is produced within 30 sec of the end of inj. Admixture incompatibility: Aminophylline. ketamine Intravenous Induction of anaesthesia Adult: 1-4. morphine. imipenem/cilastatin. thiopental.5-2 mg/kg as IV infusion.9% to required volume. Incompatibility: Y-site incompatible with idarubicin. may use with diazepam to prevent emergence reactions. 0. heparin. amobarbital.Hepatic impairment: Dose reductions may be necessary. 11. allopurinol. Usual dose to produce 12-25 minutes of anesthesia: 10 mg/kg. cefepime. morphine. phenytoin. Hepatic impairment: Dose reductions may be necessary. Alternatively. Intravenous Adjunct to anaesthesia Adult: As hydrochloride: 10-25 mg by slow IV inj. Reconstitution: IV infusion: Dilute with glucose 5% or sodium chloride 0. Surgical anaesthesia is produced within 30 sec of the end of inj and lasts for 5-10 min if 2 mg/kg is given over 60 sec. pentobarbital. Renal impairment: Dose reductions may be necessary. Maintenance: Achieve with 10-45 mcg/kg/min. Incompatibility: May form precipitates with barbiturates. floxacillin. Intramuscular Induction of anaesthesia Adult: 6. Hepatic impairment: Dose reductions may be necessary.5 mg/kg/minute. Renal impairment: Dose reductions may be necessary. .5 mg/kg as IV Inj.

Further. Usual range: 2. Childn >7 yr 150 mcg/kg. further small doses should be injected IV.5-7. Premedication Before an Operation: IV: For Sedation in Diagnostic or Surgical Interventions Carried Out Under Local Anesthesia: The initial dose is 2. The dose is 10-15 mg IV. IV injections must be given slowly (approximately 2.5 mg 5-10 min before the beginning of the operation. IM: Patients Suffering From Pain Before an Intervention: Administration alone or in combination with anticholinergics and possibly analgesics. then 30-200 mcg/kg/hr.5 mg. Premed 70-100 mcg/kg IM 30-60 min before surgery. The dose and the intervals between doses vary according to the individual reaction of the patient. Induction 200-300 mcg/kg by slow IV. the latter should be administered first so that the sedative effects of Dormicum can be safely titrated on top of any sedation caused by the analgesic. Maintenance of Anesthesia: IV: For maintenance of the desired level of unconsciousness. Usual dose: 5 mg. particularly if the patient is in poor general oral condition or of advanced age. Roculax® . the special factors relating to each patient being taken into consideration. 14. according to age and general condition of the patient. In cases of severe illness. Fortanest® Sedation 2 mg by IV inj over 30 sec followed after 2 min by increments of 0. the initial dose must be reduced to 1-1.12. When Dormicum is given with potent analgesics. doses of 1 mg may be given as necessary. the dosage should be determined with caution.5 mg. Dormicum® respiratory function.5-1 mg if sedation not adequate. A sufficiently deep level of sleep is generally achieved after 23 min. Adults: 0. Induction of Anesthesia: IV: As an induction agent in inhalation anesthesia or a sleepinducing component in combined anesthesia.07-0. The drug takes effect about 2 min after the injection is started. Sedation of patients in ICU Initially 30-300 mcg/kg by IV infusion over 5 min.1 mg/kg IM standard dosage about 5 mg. 13.5 mg in 10 sec for induction of anesthesia and 1 mg in 30 sec for basal sedation).

when the volatile agents have reached the tissue concentrations required for this interaction.2 mg/kg.1 mg/kg body weight. The method of anesthesia.3-0.10. In patients undergoing cesarean section. the expected duration of surgery. Infusion After an initial 0.075-0.6 mg/kg body weight is used for rapid sequence induction of anesthesia.6 mg/kg/hr as a continuous infusion.6 mg/kg body weight. The maintenance doses should best be given when twitch height has recovered to .1-0.6 mg/kg. 16. Esmeron® As with other neuromuscular-blocking agents.2 mg/kg body wt as IV bolus.6 mg/kg. the following dosage recommendations may serve as a general guideline for tracheal intubation and short to long lasting muscle relaxation.Endotracheal intubation 0. Maintenance: 0. adjustments with Esmeron should be made by administering smaller maintenance doses at less frequent intervals or by using lower infusion rates of Esmeron during long lasting procedures (>1 hr) under inhalational anesthesia (see Interactions). since a 1 mg/kg dose has not been investigated in this patient group.6 mg/kg body weight. Consequently.125 mg/kg body wt.3-0. A dose of 1 mg/kg body weight is recommended for facilitating tracheal intubation during rapid sequence induction of anesthesia. the method of sedation and the expected duration of mechanical ventilation. Inhalational anesthetics do potentiate the neuromuscular-blocking effects of Esmeron. becomes clinically relevant in the course of anesthesia. This potentiation however. after which adequate intubation conditions are established within 60 sec in nearly all patients.15 mg/kg body weight. Notrixum® Adult IV 0.5-0. it is recommended to only use a dose of 0. If a dose of 0. the possible interaction with other drugs that are administered concomitantly. in the case of long-term inhalational anesthesia this should be reduced to 0. it is recommended to intubate the patient 90 sec after administration of rocuronium bromide. the dosage of Esmeron should be individualized in each patient.6 mg/kg bolus dose. Tracheal Intubation: The standard intubation dose during routine anesthesia is 0. after which adequate intubation conditions are also established with 60 sec in nearly all patients.6 mg/kg body wt. In adult patients.6-1. Maintenance Dosing: The recommended maintenance dose is 0. Maintenance: 0. and the condition of the patient should be taken into account when determining the dose. 15. neuromuscular block may be maintained by administration of 0.0750. Endotracheal intubation 0. Full block prolongation 0. ICU patients Maintenance of neuromuscular block: 11-13 mcg/kg/min. Childn Initially 0.3-0.2 mg/kg body wt as intermittent IV inj. The use of an appropriate neuromuscular monitoring technique is recommended for the evaluation of neuromuscular block and recovery.

Children: Children (1-14 years) and infants (1-12 months) under halothane anesthesia manifest similar sensitivity to Esmeron as adults.25% of control twitch height.5 mg/kg/hr depending on nature and extent of organ failure(s).3-0.3-0.075-0. The infusion rate should be adjusted to maintain twitch response at 10% of control twitch height or to maintain 1-2 sequences to TOF stimulation.3-0. concomitant medication and individual patient characteristics. Clinical duration is shorter in children than in adults.6 mg/kg/hr during the 1st hr of administration.6 mg/kg body weight should be considered for rapid sequence induction of anesthesia in patients in which a prolonged duration is expected. and the recommended infusion rate is 0. A large between-patient variability in hourly infusion rates has been found in controlled clinical studies. the recommended maintenance dose for these patients is 0. which will need to be decreased during the following 6-12 hrs. Elderly Patients and Patients with Hepatic and/or Biliary Tract Disease and/or Renal Failure: The standard intubation dose for geriatric patients and patients with hepatic and/or biliary tract disease and/or renal failure during routine anesthesia is 0. with mean hourly infusion rates ranging from 0. individual dose requirements remain relatively constant. A dose of 0. . according to the individual response. In adults under IV anesthesia. the infusion rate required to maintain neuromuscular block at this level ranges from 0. Onset of action is faster in infants and children than in adults. The recommended initial infusion rate for the maintenance of a neuromuscular block of 80-90% (1-2 twitches of TOF stimulation) in adult patients is 0. start administration by infusion.6 mg/kg body weight. Continuous monitoring of neuromuscular block is recommended since infusion rate requirements vary from patient to patient and with the anesthetic method used. the infusion rate ranges from 0.6 mg/kg body weight and when neuromuscular block starts to recover.4 mg/kg/hr. To provide optimal individual patient control. doses should be reduced taking into account a lean body mass. Overweight and Obese Patients: When used in overweight or obese patients (defined as patients with a body weight of ≥30% above ideal body weight). or when 2-3 response to train of four (TOF) stimulation are present. Dosage should always be titrated to effect in the individual patient.1 mg/kg body weight.3-0. Regardless of the anesthetic technique used. Thereafter. and under inhalational anesthesia.2-0. Continuous Infusion: If Esmeron is administered by continuous infusion. Administration up to 7 days has been investigated. There are no data to support recommendations for the use of Esmeron in neonates (0-1 month). followed by a continuous infusion as soon as twitch height recovers to 10% or upon reappearance of 1-2 twitches to TOF stimulation.6 mg/kg body weight is recommended. it is recommended to give a loading dose of 0.6 mg/kg/hr. monitoring of neuromuscular transmission is strongly recommended.4 mg/kg/hr (see also Continuous Infusion). Dosing to Facilitate Mechanical Ventilation: The use of an initial loading dose of 0.

There are no data to support dose recommendations for the facilitation of mechanical ventilation in pediatric and geriatric patients. . 17. Incremental doses: 30-50 mcg/kg body wt IV. Administration: Esmeron is administered IV either as a bolus injection or as a continuous infusion (see Instructions for Handling under Cautions for Usage). Farelax® Maintenance of neuromuscular block 0. Ecron® Intubation & subsequent surgical procedures Initially 80-100 mcg/kg body wt IV.6 mg/kg/hr as continuous infusion.1-0. 18.

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