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Indications and Dosages Respiratory tract, GI tract, skin, soft tissue, bone, and joint infections and otitis media caused by Escherichia Coli and other coli form bacteria, group A betahemolytic streptococci, Haemophilus influenza, Klebsiella, Moraxella catarrhalis, Proteus morabilis, Streptococcus pnemoniae and staphylococci. Adults: 250 mg to 1 g P.O every 6 hours or 500 mg every 12 hours; maximum, 4 g daily. Children: 25 to 50 mg/kg P.O. in divided doses, maximum 4 g daily.
Contraindications and Cautions Contraindications to patients hypersensitive to cephalosporin. Used cautiously in patients hypersensitive to penicillin and patients with renal impairment. In pregnant and breast feeding woman, used catiously.
Adverse reactions CNS: dizziness, headache, malaise, paresthesia. GI: abdominal cramps and anal pruritus, anorexia, diarrhea, dyspepsia, glossitis, nausea, oral candidiasis, pseudomembranous colitis, tenesmus vomiting GU: candidiasis, genital pruritus, vaginitis
333 mg.Hematologic: anemia. May cause false positive urine glucose determination with copper sulphate test. May increase eosinophil count. urticaria. May decrease neutrophil and platelet counts. transient netropenia Respiratory: dyspnea Skin: maculopapulara and erythematous rashes. eosinophilia. 750 mg Oral suspension – 125 mg/ 5 ml. bilirubin and LDH level. Other: hypersensitivity reaction Effects on lab test results May increase ALT. usually bactericidal. alkaline phosphatise. thrombo cytopenia. 500 mg . Available forms: Capsule – 250 mg. AST. Actions Chemical effect: inhibits cell wall synthesis. 500 mg. May decrease haemoglobin level and hematocrit. 250 mg/ 5 ml Tablets – 250 mg. promoting osmotic instability. Therapeutic effect: hinders or kills susceptible bacteria.
Max: 24 mg/day.g.Chlorphenamine Indications Dosage Listed in Dosage. Total max: 40 mg/day. hypertension. tinnitus. dizziness. pylori duodenal obstruction. Food Interaction For caution against potential drug-food interactions . muscular weakness.. lactation. sedation. PO Allergic conditions 4 mg 4-6 hrly. tightness in chest. drowsiness. renal and hepatic impairment. GI upsets. epilepsy. BPH. headache. angle-closure glaucoma. neonates. Drug Interactions Potentiates sedative effect of psychotropic drugs e. opiod analgesics. Potentially Fatal: CV collapse and respiratory failure. Click to view chlorphenamine Dosage by Indications Administration May be taken with or without food. Adverse Drug Reactions CNS depression. hypotension. barbiturates. paradoxical CNS stimulation. or increased appetite.. anorexia. euphoria. IV/IM/SC Adjunct in anaphylactic shock 10-20 mg. Pregnancy. dryness of mouth. click to view chlorphenamine . hypnotics. lassitude. Contraindications Hypersensitivity. Special Precautions Elderly. bladder neck obstruction. prostatic hyperplasia. epigastric pain. dysuria. urinary retention. Interaction with alcohol could be dangerous (sedation/excitation). anxiolytics and antipsychotics. blurring of vision. May affect performance of skilled tasks.
pharmacology and pharmacokinetics and toxicology .Chlorphenamine .Pregnancy Category (US FDA) Category B: Either animal-reproduction studies have not demonstrated a foetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect (other than a decrease in fertility) that was not confirmed in controlled studies in women in the 1st trimester (and there is no evidence of a risk in later trimesters)... Belongs to the class of . ATC Classification R06AB04 . Mechanism of Action MIMS Class For details of the mechanism of action. click to view chlorphenamine Antihistamines & Antiallergics substituted alkylamines used as systemic antihistamines.