“TIME IS BRAIN.


A Proposal for

THE UCLA BRAIN STROKE RESCUE PROGRAM
2010 Presented by
Professor of Radiology and Neurosurgery, David Geffen School of Medicine at UCLA Director, Leo G. Rigler Center for Radiologic Research Co-Director, UCLA Stroke Center and Program

Fernando Viñuela, M.d.

the brain loses 1. • In a typical acute ischemic stroke.1 minutes. 750.5 miles of myelinated nerve fibers every minute. The social impact upon families and the fiscal impact on our health care system are catastrophic. Seventy-three million Baby Boomers had an increased susceptibility to severe stroke the minute they received their AARP card. 14-billion synapses. yet innovations in this field have been few and far between. someone dies from one. • Every 45 seconds. • Stroke is the third leading cause of death and the leading cause of serious. . Our population is aging rapidly. Each year. In stroke. those risks increase exponentially.000 stroke survivors in the United States alone. age and vascular health are key factors. Every year.” One of the most miraculous moments in modern medicine is to open up a blocked vessel early enough. • The economic costs of stroke have been estimated to exceed $50 billion a year. and then restore the blood flow and watch the incapacitated stroke patient return to a completely normal state. when the damage has not yet been severe. and 7. long-term disability in the United States. someone in America has a stroke. and obesity is epidemic.400.9-million neurons. Every hour.UCLA BRAIN STROKE RESCUE PROGRAM DAVID GEFFEN SCHOOL OF MEDICINE AT UCLA “Time is brain. the brain suffering a stroke loses 200-million nerve cells and ages nearly four years. Who doesn’t have a friend or family member whose life has been affected by stroke? There are 4. time really does equal brain. While stroke strikes the population indiscriminately. making the need for “rescue” so relevant.000 people here have a stroke — 150.000 resulting in death. • Every 3.

With no stopping points along the way. knowledge. MISSION The mission of the UCLA Brain Stroke Rescue Program is threefold: 1. The UCLA Brain Stroke Rescue Program is about treating stroke faster and better. These 90 minutes are critical to saving the patient’s life. Our vision is to rescue people from the tragedy of stroke through a rapid treatment approach and multidisciplinary development of cutting-edge interventional and radiologic techniques.VISION The UCLA Brain Stroke Rescue Program represents an opportunity to make a valuable investment in your future and the future of the people you love. life-enhancing difference that our focus on rapid treatment can make. and functional imaging. and transportation to treatment. floor to floor. These groundbreaking investigations are made through a multidisciplinary collaboration of investigators from the disciplines of stroke neurology. addressing and helping to overcome the $50-billion annual impact of stroke. UCLA will serve as the model institution to assemble this kind of facility. is dedicated to developing new and pioneering ways to rescue people from the tragedy of stroke. recognition. stroke genomics. neuropathology. but is progressive after stroke. We appreciate your interest in joining with us to make the vision of the UCLA Brain Stroke Rescue Program a reality. with its multidisciplinary approach to treatment. There is a short therapeutic window for optimal treatment. 2 . emergency medicine. pre-hospital care. magnetic resonance physics. Neuronal damage is reversible early. vascular neurosurgery. and rehabilitation — can make a profound difference in a stroke victim’s outcome. the real-time STS will offer the very first direct route to lifesaving outcomes. over several blocks. and efficacy at all touch points along the way — from prevention. Research has shown that speed. Our program. there is currently no other entity dedicated to the comprehensive lifesaving. The program utilizes integrated research and education to discover and develop new. Creating the world’s first real-time Stroke Treatment Suite (STS) at Ronald Reagan UCLA Medical Center is the first step in an important journey. innovative therapies for acute ischemic and hemorrhagic stroke. While UCLA is allied with the few stroke organizations that exist. diagnostic and interventional neuroradiology. technology. To develop and build the first real-time Stroke Treatment Suite at Ronald Reagan UCLA Medical Center The capacity to diagnose and treat the cause of stroke without moving the patient — from room to room. post-treatment. or across town — saves approximately 90 minutes of transfer time.

The table will be moved to the 3T MRI-PET unit. aiming to remove the cerebral clot and reestablish normal brain circulation. The table will then be moved to the Zeego angio unit. and a state-of-the-art Zeego angiography unit. Patients will be transferred from the emergency room directly to the table located in the center of the STS.The dedicated STS will have a 3 TESLA (3T) magnetic resonance imaging–positron emission tomography (MRI-PET) unit. There is solid evidence that certain types of early changes on MRI are predictive of clinical outcome. PET is a nuclear medicine imaging technique that produces a 3-D picture of functional processes in the body. but the accuracy of the data could be improved substantially with access to real-time MRI-PET before. This new research information will be collected and reviewed by stroke neurologists. The UCLA Brain Stroke Rescue Program will allow UCLA neuroscientists to build upon this success. 3 . It will support the development of new devices and techniques used in emergency procedures to treat the cause of acute blockage of brain arteries eliciting an acute stroke. saving lives and thwarting disabilities. stroke remains one of the last unsolved. Dr. using interventional techniques. Stroke is a disease that progresses rapidly over the course of a few hours. when he developed the first Food and Drug Administration (FDA)-approved endovascular device for the mechanical treatment of acute stroke in 2000. The use of real-time imaging and therapy for patients with acute stroke will reveal new knowledge of brain responses immediately after the reestablishment of blood supply to the brain. matched with MRI. more detailed information is provided. One miraculous room at UCLA will enable the brain power within the program to revolutionize the approach to stroke treatment. The instant availability of an MRI-PET will help us decide whether further treatment is warranted and safe. neuro-intensivists. a rotating table. and an immediate endovascular procedure will be performed. during. and an emergency MRI-PET will show the status of the brain and identify brain tissue to be rescued. Real-time imaging allows us to instantly identify the activity in every artery of the brain. Another major advantage of the STS is the ability to perform serial scans to guide therapy. potentially fatal diseases. and neuroradiologists from the UCLA Brain Stroke Rescue Program. To develop new interventional techniques to reestablish rapid normal brain circulation in patients with acute ischemic stroke While there have been remarkable advances in the treatment of heart attacks and various forms of cancer. Pierre Gobin was a member of the UCLA Division of Interventional Neuroradiology. UCLA has been a pioneer in this area. 2. and after endovascular intervention. interventional neuroradiologists.

construction. The remaining funds will be used to purchase advanced neurointerventional devices and other specialized equipment to perform therapeutic procedures. GIVING OPPORTUNITIES Development & Construction of Real-time Stroke Treatment Suite $12 million A gift of $12 million will underwrite the development and construction of the STS and provide the funds to purchase and install the 3T MRI-PET unit and Zeego angiography unit. because of the delay. Real-time images will be the most important factor in the immediate management of the stroke. The funding for this 16-month project includes architectural and mechanical drawings. A time line and construction budget of $11. the images that are available to be used for evaluating stroke patients are not real-time and. Funding of Research $3 million Additional funding in the amount of $3 million will support cutting-edge research that will result in the development of new real-time MRI-PET techniques to assess brain responses during stroke and new interventional techniques to reestablish normal brain circulation.39 million is attached.3. and installation of the equipment. To develop new real-time MRI-PET techniques that will allow the accurate assessment of brain responses during and after the emergency reestablishment of normal circulation Currently. 4 . resulting in better outcomes for the patient. are not as effective for determining the best course of treatment.

Saver. David Geffen School of Medicine at UCLA and director of the UCLA Stroke Center and the UCLA Stroke and Vascular Neurology Program. clinical trial design. Fernando Viñuela received his M. Rigler Center for Radiologic Research. Co-Director Dr.D. and Peruvian Society of Neurosurgery. and neurocognitive consequences of stroke. Vascular Neurology. Co-Director Born in Mercedes. Jeffrey L. He completed his post-medical education at the University of Western Ontario. His work has been supported by grants from the National Institutes of 5 . degree from the University of Uruguay in December 1970. including the Japanese Society of Interventional Neurosurgery. Professor of Neurology. from 1974 to 1979. Viñuela is a founding member and president of the American Society of Interventional Neuroradiology. He has been awarded 40 industry and National Institutes of Health (NIH) contracts and grants on research related to his field of expertise. diagnosis. He arrived at UCLA in July 1986 as Professor of Radiology and Director of the Division of Interventional Neuroradiology and is also currently Professor of Neurosurgery. M. and Addiction Psychiatry. Saver’s research focuses on the prevention. World Federation of Interventional Neuroradiology. earned his medical degree at Harvard Medical School and completed his internship in Medicine and residency in Neurology at Brigham & Women’s Hospital. Russian Society of Neurosurgery. He is board-certified in Neurology. Fernando Viñuela. Uruguay. neuroimaging. Director of the Leo G. he is an honorary member of 19 scientific professional organizations.D. Jeffrey Saver. 1945.D. Dr. His fellowship in Cognitive Neuroscience was done at the University of Iowa Hospitals and Clinics and in Cerebrovascular Disease at Rhode Island Hospital. and treatment of stroke.ADDENDUM The UCLA Brain Stroke Rescue Program comprises some of the leading experts and innovators in the field of modern diagnosis and management of acute cerebral stroke. Among Dr. Canada. In addition. M. Dr. and Ibero-Latin American Society of Diagnostic and Therapeutic Neuroradiology. as well. Dr. he has presented 337 lectures on ischemic and hemorrhagic strokes at national and international meetings and has authored or co-authored 294 manuscripts in peer-reviewed journals and six book chapters focusing on ischemic and hemorrhagic strokes. and Co-Director of the UCLA Stroke Center and Program. Viñuela’s academic achievements to date. on April 5.

In particular.D. Liebeskind. FCCM. M. M.D.D. He also has been acknowledged for his accomplishments as chair of the California Stroke Work Group.D. Neuro-critical Care Neuronal Repair and Rehabilitation Paul M. Translational/Clinical Research S. Dr. M. Nestor Gonzalez.D. His work was instrumental in the Emergency Medical Service Commission’s passage of a new stroke destination policy in Los Angeles that recognizes primary-stroke-center status as a factor for selecting a receiving hospital for a stroke patient. Thomas Carmichael. Among his many accolades. Reza Jahan. Sidney Starkman.D. recently published research noting improved outcomes in hospitals. Pablo Villablanca. and division levels. Dr. M. Saver. He was recognized for his years of exemplary service to the AHA/American Stroke Association at the national. Gary R.D. He is the author or co-author of more than 175 research articles.D..D. who has served on several national AHA committees. a model document that will raise the standard of stroke care throughout the State of California. It is given to an individual who has demonstrated the most distinguished commitment and service to the AHA during the past fiscal year and over time. M. Medical Advisory Committees Chairman Education Jeffrey L. FAAN S.D. using the AHA’s Get With The Guidelines. Nestor Gonzalez. Saver. and Utah. Vespa.. Ph.D. Under his leadership. a stroke quality improvement program. Ph.D. National Institute of Neurological Disorders and Stroke.D. M. the members recently completed stroke system implementation recommendations. Bruce Dobkin.D.Health. Duckwiler. Ph. Saver was cited for his tireless efforts in establishing true stroke systems of care in Los Angeles over the last 10 years. 6 . Ph.. M.D. M. M. Nevada. M. David S.D. which covers California. in 2010. the American Heart Association (AHA). M. Telemedicine Therapeutic Innovations Latisha Ali. M. Imaging Developments Noriko Salamon. M.D. M. affiliate.. one of the top honors given by the AHA to volunteers in the Western States Affiliate..D. Thomas Carmichael. he was named Physician Volunteer of the Year. and the National Stroke Association. M.D. Satoshi Tateshima. J.

STROKE TREATMENT SUITE Stroke Treatment Suite 3T MRI-PET Stroke Treatment Suite 7 .

000 $11.000 $4.100.000 $7.390.000 $27.200.000 $900.„TIME IS BRAIN‰ Time Line Budget Month 1 Month 2 Month 3 Months 4 – 14 Month 15 Month 16 TOTALS UCLA Construction Initiate Project $27.100.000 $163.000.000 $2.000 Order MRI-PET & Zeego Install Equipment TOTALS 8 .000 $163.000 $4.000 Architectural & Mechanical Drawings Construction Seimen’s Healthcare Order equipment $4.100.

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