Thymidine synthesis Purines dUMP 5.

10 Methylene THF Tryptophan Arginine BH4 ALUM Tyrosine glycine THF Methionine

glycine

MAT
SAMe DMG

Guanido AC Creatine Creatinine

Pyruvate

SHMT

serine

mercury lead
B12

MTRR BHMT
TMG

methylation SAH adenosine

DNA, RNA Protein, lipids

MTR

SAH

Acetyl CoA oxaloacetate aspartate

Ornithine

ACAT
citrate UREA AMMONIA

NOS
LEAD

DHPR
BH2

MTHFR
5 Methyl THF

AHCY
Homocysteine

2 BH4

fumarate

Kreb’s Cycle

isocitrate α-ketoglutarate

OTC

CBS VDR
cystathionine

succinate NADH/FADH

Serotonin

Dopamine NorEp SAMe AMMONIA Cysteine + , α-ketobutyrate taurine glutathione

MAO A
Citrulline + NO Neuronal Damage 1 BH4 HIAA

COMT
HVA

SAH

Peroxynitrite 0 BH4

COMT
VMA

SAH

Microglial Activation

Super Oxide

“When the need is for energy and not for cysteine, homocysteine is metabolized to Alpha-Ketobutyrate, NH3 and H2S.”
Text of Biochemistry with Clinical Correlations, Devlin 2002

GST SOD G6PDH
glutamate gaba

SUOX

cortisol

ACE
Angiotensin I Angiotensin II

Yasko Methylation Pathway
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GAD

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