Acknowledgement

I take immense pleasure in presenting my gratitude towards Mr. Umesh Trivedi, owner of Nulife Pharmaceuticals for giving me an opportunity to work with their prestigious organisation. I am greatful and thankful to my guide and mentor Mr. Avinash Salunkhe for his continuous guidance and advice, without whose support I wouldn't have been able to complete this project and learn so well. He guided me with the steps and procedures to conduct the survey and corrected me for my mistakes. I extend my heart felt thanks to my college director, Dr.Thomas Mathew for his support and also I would like to thank one of the most important person who guided me throughout this project, my college guide Prof. Simmi Prasad. I thank her for her continuous guidance and mentoring regarding the progress and development of my project. I thank all those chemists and doctors who gave their valuable time for my survey and provided me with valuable and correct information. Lastly I would like to thank my family members and my friends for their support and valuable suggestions during the course of the project.

Gor Rachit Vijay

Study on antihistamine/ Rachit V Gor

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Table of Contents
Sr. No 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 Content Executive Summary List of Charts List of Figures Company profile Department profile Project Introduction Need for Study Objectives Research Methodology Data Collection and Research design Analysis of Data and Result Findings and Interpretation Recommendations and Conclusion Implementation and Future Scope References Page No. 3 4 5 6 7 8 10 11 12 13 17 22 24 28 29

Study on antihistamine/ Rachit V Gor

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the brands that are available in the Mumbai market and sold largely are studied via secondary as well as primary research. But some antihistamines show sedation as side effects and so it is required to introduce a product in the market with lesser side effects and better results. Thus the main aim of the project was to study the drug and give suggestions for the introduction of a new brand of antihistamine in the market. indications and the mechanism of actions of different antihistaminic drugs in the market. Thus. the market for antihistamine is too large. Suggestions and recommendations were provided for the improvement in the existing brand and suggestions were provided for the launch of a new brand in the market. Also.EXECUTIVE SUMMARY Histamines are the natural amines that are produced in the body and their action causes inflammation. So. with 3generations of drugs in the market and number of brands. project focuses on collecting secondary data regarding the side effects. it is vey important to understand the drug in detail along with its market share and the preferability of particular drug in different medical indications. Also. The reasons were identified for a particular existing brand to be sold in the market more than other brands by primary research of doctors and chemists in the Mumbai region. Study on antihistamine/ Rachit V Gor Page 3 . it is very important to study the trend in the market and to create a unique and different brand in the market. itching and allergic sensations and so antihistamines play an important role in preventing this allergic actions and give relief.

List of Charts: Sr no. 1 2 3 4 5 6 7 8 9 10 11 Content Chemist survey Reasons Chemist survey Drug Cetrizine Chemist Survey Drug Levocetrizine Chemist Survey Drug Fexofenadine Chemist survey Drug Ketotifen Doctor’s survey Reasons Doctor’s Survey Indications Doctor’s survey Drug Cetrizine Doctor’s survey Drug Levocetrizine Doctor’s survey Drug Fexofenadine Doctor’s Survey Drug Ketotifen Pg no 17 17 18 18 18 19 19 20 20 21 21 Study on antihistamine/ Rachit V Gor Page 4 .

1 Antihistamine reaction: an overview 9 Study on antihistamine/ Rachit V Gor Page 5 . Content Pg No.List of Figures: Sr No.

N. At present Nulife has product line focusing on  Dermatology  E.Company Profile: Nulife Pharmaceuticals Ltd: As said that service to mankind is service to God. Expansion is the need of the hour and so is Nulife pharmaceutical taking various major steps to increase its product line. Nulife's three tier quality management system assures consistent quality products and has been proud winner of Rajiv Gandhi Quality Excellence Award for three consecutive years. Mr.T  Ophthalmology  Pediatrics It also has ayurvedic preparation using the natural products that could help to heal the ailments of the people. competitive and committed member of global healthcare industry. Jayantilal Trivedi established "Nulife pharmaceuticals" in 1973. Be seen and felt as ethical organization Organization devoted and committed to customer service. The company's Vision is     Emerge as quality producer. Study on antihistamine/ Rachit V Gor Page 6 . visible. Having this phenomenon in mind and with an intention to help people fight with the various diseases. customer satisfaction and social responsibility. Emerge as one of the benchmarked companies in healthcare industry.

Under the Guidance of Mr. the designing of the products and the promotional strategies are worked on for the development of the company. Marketing department of the company plays a major role in the overall development and extension of the product line and introducing new products in the market. Avinash Salunkhe the company is on the path of progress with zeal and hard work. J.Department: Marketing Dept. Study on antihistamine/ Rachit V Gor Page 7 . Trivedi. A. the management of Nulife is taking the company on the path of progress. Umesh Trivedi. The new strategies planned for the betterment of the sales of the products. The owner and son of Late. PMT group of company is enthusiastic and creative finding new ways and methods of marketing the product. Under the guidance of Mr.

is a pharmaceutical drug that inhibits action of histamine by blocking it from attaching to histamine receptors. Thus. and as such do not cause drowsiness.INTRODUCTION: A histamine antagonist. Sedation is a common side effect. It has been discovered that these H1-antihistamines are actually inverse agonists at the histamine H1-receptor. H1 antihistamines are used to treat symptoms of allergy. second generations antihistamines do not cross the blood brain barrier. Allergens are the elements that a Study on antihistamine/ Rachit V Gor Page 8 . are also used to treat insomnia. H1 antagonists are used to treat allergic reactions. there are blockers for each histamine receptors. the body releases chemicals. also known as H1 antihistamines. the term antihistamine refers only to H1 antagonists. such as runny nose and watery eyes. rather than antagonists that means they bind to the receptors similar to histamine and show inverse actions. Mechanism: When a person with allergic infection breathes in an allergen such as pollen or dust. and some H1 antagonists. However. including histamine. Clinically. commonly referred to as antihistamine. such as diphenhydramine and doxylamine. Classification: Antihistamines / Histamine antagonists H1 antagonists H2 antagonists H3 antagonists H4antagonists 1st 2nd 3rd Genera Genera Generation tion tion H1 Antagonist: In common use.

In other words. Study on antihistamine/ Rachit V Gor Page 9 . As seen in the figure the release of histamine and other chemicals cause allergic reactions and thus. antibody IgE that is attached to the mast cells in the body releases histamine from the mast cells into the human body. when an allergen enters the body. and mucus production. itching sensation. swelling. Histamine acts as inflammatory mediator and causes inflammation or we say swelling. This causes allergy symptoms such as itching.person is allergic to. by blocking the histamine receptors antihistamines heal the allergic reactions.

such as pollen. with 3generations of drugs in the market and number of brands. they have a huge market with many competitors. Allergies are caused by a body's excessive type I hypersensitivity response to allergens. Hence. such as runny nose and watery eyes. Mumbai. Hence. so it is very important to study the market trend and the users of the product. what is their requirement from a brand. it is very important to study the psychology of these mediators. introduction of new generation of drugs that have lesser sedation is the need of the people and we need to study the new generation antihistamine that can be used to treat allergy with lesser sedation. can be used for itching and swelling or inflammatory reactions in the body. Study on antihistamine/ Rachit V Gor Page 10 . there is a need to conduct a market survey on the antihistaminic Drugs in the Mumbai market. Even though the end users the customers or patients the mediators that means the doctors and the chemists play a major role. So.Need For Study: H1 antihistamines are used to treat symptoms of allergy. Thus. antihistamines are the drugs that prevent from allergic reactions. So. it is very important to study the trend in the market and to create a unique and different brand in the market. being a huge market with many people and many doctors. So there is need for the study of these antihistamines in Mumbai region which has a large market segment. As most of the antihistamines are non prescription and generic products. But the H1 antagonists used for allergic reactions have a common side effect of drowsiness and sedation. it is very much required to study the trend that could help to introduce the new product and study the product in detail. The market for H1 antihistamine is too large. the project was conducted. Without proper study it is not possible to introduce a brand in the market as there are many competitors for the brand.

To conduct a survey to study the brands of the antihistamine drugs those are preferred by the doctors in the Mumbai region.Objectives:        To understand the concept of Antihistaminic drugs and its mechanism of action in the body. To conduct a survey regarding the drugs or the brands those are preferred by the chemists in the Mumbai region. To conduct a survey about the various generic and branded products of antihistamines available in the market. To provide recommendations and suggestions for the introduction of new product in the market. To study the reason why a particular brand is preferred To collect ideas and suggestions that could help to improve the market of antihistamine drugs. Study on antihistamine/ Rachit V Gor Page 11 .

DESCRIPTIVE RESEARCH     It helps to understand the problem in detail. Thus.RESEARCH METHODOLOGY RESEARCH TYPE  EXPLORATORY  DESCRIPTIVE EXPLORATORY RESEARCH    The primary objective of exploratory is to provide insight into and understanding of. Study on antihistamine/ Rachit V Gor Page 12 . the problem confronting the researcher. It gives the description of the problem and also the decription about characteristics of the drug molecule. exploratory and descriptive research design helps to identify the problem and find solution for the same. the combination of both. secondary helps to explore the conditions and to come out or identify the problem. Thus the exploratory research helped to identify the need to introduce a new anti histamine drug in the market. Thus descriptive type of research study is carried out Thus. Primary and secondary data is collected to describe the problem clearly and to get proper results for the problem.

if required were collected. their mode of action. a survey was conducted of 65chemists in the Mumbai region and information regarding the why a particular drug is preferred was studied. So. Please mention the name of any other brand preferred in the market. a short survey of 10chemists was carried out to understand which all are the brands that are available for antihistamines in the market. This information was very valuable as it helped a lot in devising the recommendations and suggestions. This gave an idea about how vast is the product line of antihistaminic drugs that are available in the market. now was the time to understand the actual market. please mention__________________________________ 3. followed by '2' preferred lesser compared to 1. followed by '3'. Once I got acquainted with in general antihistaminic drugs. etc.Data Collection and Research Design: Initially as per the objectives it was required to understand the concept of antihistamines. Name of the Chemist/Medical Store:________________________________ Which is Top moving Antihistaminic Brands for each Drug? Rate the Brand names from 1 to 4. please mention_________________________________ 2. the various side effects were studied and the various pharmacological indications were studied. It also gave an idea about the packaging of the drug and also about the pricing of the brands that is available in the market. Cetrizine: Alerid ( ) Cetariv ( ) Cetzine ( ) Cetrizet( ) If any other brand. Now as the basic knowledge was acquired about the antihistamine. 1. Also. Levocetrizine Levocet ( ) Levorid ( ) Ekon Xl( ) Glencet( ) If any other brand. and lastly '4' for least sold among the four. Also. '1' being the most sold. The questionnaire was prepared and it is as follows. suggestions regarding the betterment in case of services or product. so a secondary research was conducted and data was collected from books and from the internet regarding the various antihistaminic molecules discovered. Fexofenadine: Study on antihistamine/ Rachit V Gor Page 13 .

What is the reason? _____________________________________________________________________ _____________________________________________________________________ Please give some suggestions regarding the packaging/ Presentation of these brands of antihistaminic Drugs to improve the brand value of that brand? _____________________________________________________________________ _____________________________________________________________________ Thus. primary research design was used to collect the information from the chemists and then it was reported appropriately. Study on antihistamine/ Rachit V Gor Page 14 .Allegra ( ) Fexigra ( ) Allegix( ) Altiva ( ) If any other brand. please mention__________________________________ 4. Ketotifen Ketasma ( ) Asthafen ( ) Tritofen ( ) Zerosma ( ) If any other drug brand which is fast moving? DRUG _____________________ _____________________ _____________________ BRAND _________________________ __________________________ __________________________ Why do you prefer this Brand of drugs? Doctor's prescribe it more Chemist's offer/ Bonus offer Better company service/ M. R visit Other If Other.

1. Levocetrizine Levocet ( ) Levorid ( ) Ekon XL ( ) Glencet ( ) If any other brand. if any required was studied. The questionnaire for the doctor's survey is a s follows. followed by '3'. Fexofenadine: Allegra ( ) Fexigra ( ) Allegix( ) Altiva ( ) If any other brand. Hence. followed by '2' preferred lesser compared to 1. and lastly '4' for least prescribed among the four. Cetrizine: Alerid ( ) Cetariv ( ) Cetzine ( ) Cetrizet ( ) If any other brand. Suggestions regarding improvement in the brand value of the products. please mention___________________________________ In what indication do you prefer Antihistaminic medicine? _____________________________________________________________________ If any other brand of Antihistamine which is most prescribed? DRUG _____________________ _____________________ BRAND _________________________ __________________________ Why do you prefer this Brand of antihistamine medicine? Study on antihistamine/ Rachit V Gor Page 15 . Also.As doctors play an important and vital role in the sale of any drug. Their views for a particular brand the reason for its preference were studied. '1' being the most prescribed/ dispensed. a survey of 50doctors was conducted in the Mumbai region regarding the antihistaminic drugs. please mention___________________________________ 4. Name of the Doctor : _________________________________________ Which is Top moving Antihistaminic Brands for each Drug? Rate the Brand names from 1 to 4. Ketotifen Ketasma ( ) Asthafen ( ) Tritofen ( ) Zerosma ( ) If any other brand. please mention___________________________________ 2. it was very much important to consider and understand the psychology of the doctors regarding the antihistaminic drugs. in what indications are these drugs prescribed was studied. please mention___________________________________ 3.

if any. What is the reason? _____________________________________________________________________ _____________________________________________________________________ Please give suggestions. regarding the packaging/ presentation of these brands of antihistaminic medicines to improve the brand value of that brand? _____________________________________________________________________ _____________________________________________________________________ Study on antihistamine/ Rachit V Gor Page 16 . R. Visit Lesser Side Effects Patient Psychology Cost Effective If Other.M.

Analysis of Data and Results: The data collected through the chemists survey was compiled and represented in the form of pie charts and it is represented as follows. Percentage Doctor's prescription 23% 6% 23% 15% Better Company Service/ MR visit Good Result Doctor's prescription and Offer 33% Chemist's offer/ Bonus Offer Preference of Cetrizine 0.5 1 0. Study on antihistamine/ Rachit V Gor Page 17 .5 3 Cetariv Alerid Cetzine 5 Cetrizet Other The following charts show the preference of particular brand of Drug. The reason why a particular brand is preferred is represented as.

the charts shown above give a brief idea about the preferences of the brands on a 10 point scale as they are preferred by the chemists in the Mumbai region.5 1.5 0 7 0 Ketasma Asthafen Tritofen Zerosma Other Thus.2 0.5 Allegix Altiva Allegra 8 Other Preference of Ketotifen 1. Study on antihistamine/ Rachit V Gor Page 18 .Preference Of Levocetrizine Levocet 1 0 1 0 Ekon XI 8 Glencet Levorid Other Preference of Fexofenadine Fexigra 0.3 1 0.

Percentage M R Visit 33% 19% Lesser Side effect and better result 3% 7% Patient Psychology 38% Cost effective M R visit and effectiveness The following chart gives an idea as to in what Indications mostly the antihistaminic drugs are prescribed by the doctors. which is drawn from the doctor’s survey that was conducted. Study on antihistamine/ Rachit V Gor Page 19 . Indication 10% 15% 5% Allergic Rhinitis 70% Eye Allergies All Allergies Bronchial Asthma Thus. The following chart represents the reasons why a particular brand is prescribed more by the doctors. the results shown from the Doctor’s survey are represented as follows.Now. the above chart tells us in detail about the diseases that can be diagnosed by the use of the antihistamines in the market.

5 3 Cetariv Alerid Cetzine 5.4 0.5 0. Preference of Cetrizine 0.5 1 Ekon XI 7 Glencet Other 0 Levocet Levorid Study on antihistamine/ Rachit V Gor Page 20 .Now.5 Cetrizet Other Preference Of Levocetrizine 1.6 0. the following charts show the preference of the brands prescribed by the doctors for a particular drug molecule.

Preference of Fexofenadine 0.5 0.5 0. this information helps to understand the market trend and combining the results and analyzing it properly we understand how can an antihistaminic brand create an image in the market.2 7 Other Tritofen Zerosma 0 Ketasma Asthafen Thus.3 1. the above charts display the preference of the doctors for the antihistaminic brands on a 10 point scale.5 0 1 Fexigra Allegra Allegix Altiva 8 Other Preference of Ketotifen 1. Thus. Study on antihistamine/ Rachit V Gor Page 21 .

Study on antihistamine/ Rachit V Gor Page 22 . So. So. Also. in case of the chemist’s survey. Like in one case a patient felt better with cetzine. it was seen that doctor’s prescription played a very important role in the sale of antihistamines in the market. in case of some chemists better results shown in the past for few patients are being considered as a reason for dispensing medications to such patients. it can be seen from the graphs that the main reason for doctor’s prescribing particular brand of medicines is better result with lesser side effects. this proves that services provided by the company should be accompanied with the results shown by a particular brand of drug to improve the brand value and create a strong and lasting image in the minds of the doctors. M.prescription category as compared to those in the prescription medicines category. the offers provided to the chemists and also the services that the company provides to the chemist play a vital role in the sale of such brands of drugs. Also. Now.Findings and Interpretations: Thus. while other with alerid. So. As seen that there are more antihistaminic drugs in the non. Patient psychology as to they get used to a particular brand plays an important role. to introduce a new brand in the market. even though both being brands of cetrizine antihistaminic drugs. company services and the chemist offers play vital roles in the sale of the drug.R visit plays a very important role in the doctors getting acquantained with the drug and prescribing them. in case of generic drugs the general practitioners dispense those to the patients. Also. Also. we need to promote it and create an image in the minds of the doctors so that they can prescribe the drug. cost effectiveness is one of the reasons for prescribing a particular brand. Also.

it can be interpreted from the survey and the analysis that is carried out on the results obtained from the survey that the market for antihistamines is very huge with around 15. Thus. the survey has helped to gather various points or may say various areas where we are required to work on to be competitive and emerge as a brand in the market. Study on antihistamine/ Rachit V Gor Page 23 . Thus.20 H1 antihistaminic drugs each having many different brands.Thus. Thus. it proves the very important role of the chemists in the sale of the antihistamines. we came to the suggestions and recommendations based on the survey result. and so sustain in such a market it is very important to be competitive and to show the uniqueness of our brand.

The price should be fixed accordingly. So levoctrizine. said "Economies of Scale". used in itching of eyes in the form of small bottles. Generic drugs can be dispensed in the package of 500 tablets or say 1000 tablets that decreases the cost and which is preferred by the general practitioners in private as well as government hospitals and dispensaries. Also. we can introduce cheaper but better quality of product in this drug category. Blister packaging is the most preferred for tablets and capsules as they are cheaper and also none of the drug is light resistant so the efficiency won't be reduced. Thus. As. 20 as Glencet of Glenmark is sold at Rs.18. the more being produced the lesser be the cost of production. Also.50. It must be available with a dispenser and so it must be priced in between Rs. while in fexofendine Allegra is the world famous brand. Study on antihistamine/ Rachit V Gor Page 24 .50 based on the cost of production and marketing. 120. ketotifen are the drugs that should be focused to introduce a new brand in the market. Ketotifen which is used in eye allergies and marketed by novartis as Zaditor can be introduced in the market as eye lotion.Recommendations and Conclusions: As observed in the survey there are many generic and branded products of cetrizine as a drug. So we need to introduce a new brand we can introduce in case of drug Levocetrizine with better effects in blister packaging as it is comparatively cheaper source of packaging. also levocetrizine has levocet as major brand. It can also be dispensed in bottles but the quantity should be more like 50tablets a bottle. so bulk packaging will help to sell the products at cheaper rate. 100 as we can see Sun pharma sells it at a price of Rs. terfenadine. We can price it around Rs. azelastine which is used in the form of nasal spray for nasal allergies. new brands can be introduced in market in this particular drug category of second as well as third generation of H1 antihistaminic as they show lesser sedation and better effects. We would have a competitive edge in case of this drug. 30 to Rs. The price should be near Rs.

Thus. 14. 10tablets . Study on antihistamine/ Rachit V Gor Page 25 . 200. packaging was suggested to the company the two drugs being Levocetrizine and ketotifen.Rs.00 Bulk packaging for 500tablets . 21. Drug: Levocetrizine: Brand Name: NuLcet. 350.00 Promotion strategy: We need to adopt push strategy as we need to push the brand in the market by mass marketing.Rs.00 In the form of 30ml syrup.00 Bulk packaging for 1000tablets. We need to meet general practitioners and provide them with bulk packages of the brand.Also. combinations of drugs are required to be used that could overcome the side effects that are produced by a particular group of antihistaminic drug. 30.Rs.00 20tablets . Slogan: Allergies and watery eyes and nose get nil as the null set (empty set) Packaging: 5 mg tablets in blister packaging/ strip packing of. The chemists should be provided with better company services so that they can sell more of the generic products and the doctors to be offered better services so that they can prescribe the particular brand and take more of bulk packing.Rs. on the basis of the survey and the various results obtained 2 new products along with the pricing. 20.Rs.Rs.00 Capsules 10tablets.

these are the suggestions provide to the company for the introduction of the new brand named Nulcet that contains levocetrizine. Running nose and eyes. We can conduct health check in collaboration with a dispensary or a general practitioner and thus promoting our brand in the market as antiallergic.We explain them the importance of being cheaper then the other brands and the only available in the form of bulk packaging. Also do we provide them with incentives that would motivate them to sell. which is a potent antihistaminic drug that show broad aspect of growth in future. Brand is required to be positioned in the minds of doctors and chemists as cheaper brand that empties allergies and systems of cold from the body. Study on antihistamine/ Rachit V Gor Page 26 . We need to also focus on chemists and provide them some offers that could instigate them to keep and sell the brand initially. LOGO: Nulcet Uses: Allergies. itching skin Thus.

40 Marketing and Promotional strategies to be adopted: The medicine is required to be introduced in the market with intensive and aggressive marketing strategy. along with allowing them to undertake check ups where the brand can be promoted. harsh for allergies That’s Nukfen potent antiallergic Packaging: 10ml bottle. Brand Logo: Nukfen Study on antihistamine/ Rachit V Gor Page 27 . Also.Rs. ENT doctors can be focused on to promote the brand. schemes should be provided to the chemist. DRUG: Ketotifen Brand Name: Nukfen Slogan: Soothing for eyes.The second drug that is recommended is ketotifen and the various issues or the parameters that are studied for the drug are as follows. with gifts for the doctors motivating them to introduce in the market.

Implementation and Future Scope: Considering the vast market of antihistamine and the margin or the area it provides to expand. antihistamines have a very good scope of enhancing in the market. Thus. with around 15-20 drug molecules and many brands of this drugs. introducing a new brand in the market is required to be implemented in the company policy. So. Study on antihistamine/ Rachit V Gor Page 28 . considering the suggestions provided by the doctors and the chemists the new brand could be a potential competitor in this competitive market of antihistaminic drugs.

Beale John. Clinical Pharmacology by Tripathi K.References:       Organic Medicinal and Pharmaceutical Chemistry by Block John.com    Survey of 10 chemists Survey of 65 chemists from Dahisar To Andheri Survey of 502 doctors from Dahisar to Goregaon Study on antihistamine/ Rachit V Gor Page 29 .com www.google.D.com Pharmacology by Satyanarayan Web MD.wikipedia. www.

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