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2011 FASEB Summer Re search Conferences Proteases in Hemostasis and Vascular Biology June 12-17, 2011

2011 FASEB Summer Research Conferences

Proteases in Hemostasis and Vascular Biology

June 12-17, 2011

Carefree, Arizona

Co-Organizers:

Jay Degen Cincinnati Children’s Hospital / University of Cincinnati Cincinnati, OH James Huntington University of Cambridge Cambridge, UK

Sunday, June 12, 2011

4:00PM – 9:00PM

6:00PM – 7:00 PM

7:00PM – 8:30 PM

8:30PM – 10:00PM

FASEB Office open for Registration

FASEB Opening Reception

Buffet Dinner

Keynote Speakers

Sidney Strickland Rockefeller University “Fibrin and Alzheimer’s Disease: The Clot Thickens”

Russell F. Doolittle University of California, San Diego, CA “Evolving insights in coagulation”

The Clot Thickens” Russell F. Doolittle University of California, San Diego, CA “Evolving insights in coagulation”

Monday, June 13, 2011

7:30AM – 9:00AM

Session 1:

9:00AM – 12:00PM

9:00AM – 9:10AM

9:10AM – 9:40AM

9:40AM - 10:10AM

10:10AM –10:25AM (15 min)

10:30AM – 11:00 AM

11:00AM – 11:30AM

11:30AM – 12:00PM

12:00PM – 1:00PM

Free Time

3:00PM – 4:00PM

4:00PM – 6:00PM

6:00PM – 7:00PM

Session 2:

7:00PM – 10:00PM

7:00PM - 7:30PM

7:30PM – 8:00PM

8:00PM – 8:15PM (15 min)

8:15PM – 9:00PM

9:00PM – 9:30PM

9:30PM – 10:00PM

Breakfast

Platelet Activation, Endothelial Cells and the EC Interface Chair: Paula Tracy, University of Vermont

Welcome to FASEB

Skip Brass, University of Pennsylvania “Novel regulators of platelet activation”

Leslie Parise, UNC Chapel Hill “Platelet activation mechanisms and sickle cell disease”

TBN Hot Topic selected from submitted abstracts

FASEB Sponsored Coffee Break & Group Photo

Mark Ginsberg, University of California, San Diego “Endothelial cell-cell junctions and vascular permeability”

Mark Kahn, University of Pennsylvania “Platelet signaling and the regulation of lymphatic vascular development”

Lunch

Meet-the-Expert Session: “Things you wish someone told you earlier about grants”

Poster Session 1

Dinner

Biochemistry and Cell Biology of Proteases, Receptors and Inhibitors Chair: Steven Olson, University of Illinois

James Huntington, Cambridge University ”Protease and Serpin Contortionism

Paul Bock, Vanderbilt University “Bacterial activators of prothrombin and plasminogen”

TBN Hot Topic selected from submitted abstracts

Break

Rodney Camire, CHOP/University of Pennsylvania “Basic and translational advances along the common pathway”

TBN

Break Rodney Camire, CH OP/University of Pennsylvania “Basic and translational advances along the common pathway” TBN

Tuesday, June 14, 2011

7:30AM – 9:00AM

Session 3:

9:00AM – 12:00PM

9:00AM - 9:35AM

9:35PM –10:05AM

10:05AM – 10:20AM (15 min)

10:20AM – 11:00AM

11:00AM – 11:30AM

11:30AM – 12:00PM

12:00PM – 1:00PM

Afternoon free for activities

6:00PM – 7:00PM

7:00PM – 8:00PM

Session 4:

8:00PM – 10:00PM

8:00PM - 8:35PM

8:35PM – 9:10PM

9:10PM – 9:25PM (15 min)

9:25PM – 10:00PM

Wednesday, June 15, 2011

7:30AM – 9:00AM

Breakfast

Novel Protease Systems and Mechanisms Coupling Proteases to Disease Chair: Thomas Bugge, NIH/NIDCR

Toni Antalis, University of Maryland “Membrane-associated serine proteases”

Stephen Weiss, University of Michigan “Membrane-associated MMP in development and disease

TBN Hot Topic selected from submitted abstracts

FASEB Sponsored Coffee Break

Thomas Bugge, NIH/NIDCR “Matriptase-mediated pro-HGF activation in squamous cell carcinoma”

Joseph Palumbo, University of Cincinnati, CCHMC “Regulation of proteases at the endothelial cell-tumor cell interface in metastasis”

Lunch

Dinner

Stuart Stone Lecture Sriram Krishnaswamy, Children’s Hospital of Philadelphia “Dissection of the Continuum: Prothrombin activation and the fate/function of thrombin intermediates”

fXIII- and fXI-dependent events in vivo Chair: David Gailani, Vanderbilt University

Andras Gruber, Oregon Health and Science “Role of proteases factor XII and XI in pathological events”

Break

TBN Hot Topic selected from submitted abstracts

Thomas Renné, Karolinska Institutet “Roles of factor XII for coagulation and inflammation”

Breakfast

abstracts Thomas Renné, Karolinska Institutet “Roles of factor XII for coagulation and inflammation” Breakfast

Session 5:

9:00AM – 12:00PM

Proteases and vascular biology Chair: Patricia Andrade-Gordon, Johnson & Johnson

9:00AM - 9:35AM

9:35PM –10:10AM

10:10AM – 10:25AM (15 min)

10:25AM – 10:50AM

10:50AM – 11:25AM

11:25AM – 12:00PM

12:00PM – 1:00PM

Free Time

4:00PM – 6:00PM

6:00PM – 7:00PM

7:00PM – 7:15PM

Session 6:

7:15PM – 10:00PM

7:15PM - 7:45PM

7:45PM – 8:15PM

8:15PM – 8:45PM

8:45PM – 9:15PM

9:15PM – 9:30PM (15 min)

9:30PM – 10:00PM

Thursday, June 16, 2011

7:00AM – 9:00AM

Session 7: 9:00AM – 12:00PM

JoAnn Trejo, University of California, San Diego “Mechanisms underlying differential protease signaling through PARs”

TBN

TBN Hot Topic selected from submitted abstracts

FASEB Sponsored Coffee Break

Nigel Mackman, UNC Chapel Hill “TF- and PAR-mediated events in vivo”

Hugo ten Cate, Maastricht University “Thrombin and thrombomodulin in vessel wall disease”

Lunch

Poster Session 2

Dinner

Business Meeting

Integrated Systems Controlling Vascular Permeability Chair: Shaun Coughlin, UCSF

Shaun Coughlin, UCSF “Control inflammation-induced vascular permeability”

Wolfram Ruf, Scripps Research Institute “TF activation and cell signaling”

Li Zhang, University of Maryland “APC signaling and integrin CD11b”

Break

TBN Hot Topic selected from submitted abstracts

TBN

Breakfast

Proteases in Inflammation and Host Defense Chair: Hartmut Weiler, Blood Center of Wisconsin

abstracts TBN Breakfast Proteases in Inflammation and Host Defense Chair: Hartmut Weiler, Blood Center of Wisconsin

9:00AM - 9:35AM

9:35AM –10:10AM

10:10AM – 10:25AM (15 min)

10:25AM – 10:50AM

10:50AM – 11:25AM

11:25AM – 12:00PM

12:00PM – 1:00PM

Afternoon free for activities

6:00PM – 7:00PM

Session 8:

7:00PM – 10:00PM

Hartmut Weiler, Blood Center of Wisconsin “Regulation of inflammatory systems by activated Protein C”

TBN

TBN Hot Topic selected from submitted abstracts

FASEB Sponsored Coffee Break

Matthew Flick, University of Cincinnati, CCHMC “Engineered forms of pro/thrombin and inflammatory disease”

TBN

Lunch

Dinner

Protease Engineering and Therapeutics Chair: Charles Craik, UCSF

7:00PM - 7:35PM

Edwin Madison, Catalyst Biosciences “Redirection of protease specificity to therapeutically significant targets”

7:35PM – 7:50PM (15 min)

TBN Hot Topic selected from submitted abstracts

7:50PM – 8:25PM

Jeffrey Weitz, McMaster University, Canada “Therapeutic advances in the arms race for fIIa- and fXa-targeted anticoagulants”

8:25PM – 8:50PM

Break

8:50PM – 9:25PM

TBN

9:25PM – 10:00PM

Katherine High, University of Pennsylvania/HHMI “Realizing the vision of gene therapy”

Friday, June 17, 2011

7:30AM – 8:30AM

Session 9:

9:00AM – 12:00PM

9:00AM - 9:35AM

9:35AM – 10:00AM

10:00AM – 10:25AM

10:25AM – 11:00AM

Breakfast

Proteases Targets in Neurobiology Chair: Katerina Akassoglou, Gladstone, UCSF

Katerina Akassoglou, Gladstone, UCSF “Hemostatic factors in CNS inflammatory disease”

TBN

FASEB Sponsored Coffee Break

Daniel Lawrence, University of Michigan

factors in CNS inflammatory disease” TBN FASEB Sponsored Coffee Break Daniel Lawrence, University of Michigan

“Protease action in the neurovascular unit and stroke”

11:00AM – 11:05AM

12:00PM

Closing Comments Departure Boxed Lunches Available

END OF CONFERENCE

For additional information contact:

FASEB Summer Research Conferences 9650 Rockville Pike Bethesda, MD 20814 Arizona@faseb.org http://src.faseb.org

FASEB Summer Research Conferences 9650 Rockville Pike Bethesda, MD 20814 Arizona@faseb.or g http://src.faseb.org