JORNADAL, MABELLENE G.

3DMT

AUTOIMMUNE DISEASES

SPECIFICITY

DISEASE
Hashimoto’s thyroiditis Graves’ disease Pernicious anemia cells Addison’s disease Type I diabetes mellitus MG MS Autoimmune hemolytic anemia Idiopathic thrombocytopenic purpura Goodpasture’s syndrome RA Scleroderma SLE

TARGET TISSUE
Thyroid ThyroiD Gastric parietal Adrenal glands Pancreas Nerve-muscle synapses Myelin sheath of nerves Red blood cells Platelets Kidney, lungs Joints, lungs, skin Skin, gut, lungs, kidney Skin, joints, kidney, brain, heart, lungs

Organ-Specific


Systemic

OTHER AUTOIMMUNE DISEASES
DISEASE
Addison’s disease Autoimmune hemolytic anemia Autoimmune thrombocytopenic purpura Crohn’s disease Disseminated encephalomyelitis Pernicious anemia Poststreptococcal glomerulonephritis Rheumatic fever Scleroderma Sjögren’s syndrome

ORGAN OR TISSUE
Adrenal glands Red blood cells Platelets Intestines Central nervous system Stomach Kidney Heart Connective tissue Eyes, mouth

IMMUNOLOGIC MANIFESTATIONS
Antibody to adrenal cells Antibody to red blood cells Antiplatelet antibody Inflammatory infiltrate of T and B cells: mechanism unknown Sensitized T cells Parietal cell antibody, intrinsic factor antibody Streptococcal antibodies that cross-react with kidney tissue Streptococcal antibodies that cross-react with heart tissue Antinuclear antibodies: anti-Scl-70, anticentromere antibody Antinuclear antibodies, RA factor antisalivary duct antibodies, antilacrimal gland antibodies Activation of T lymphocytes

Sarcoidosis

Multisystem granulomas, pulmonary manifestations

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