In

two

volumes

...

Evaluation of Drug Activities: Pharmacometrics

Edited
The
and

by object
special

0. R. Laurence
of this book
is to pharmacological

and A. L. Bacharach
provide techniques a review used and a critical in the search discussion of general

has been called parison is made

activities as

pharmacometrics, a study is made between two or more substances

to therapeutic values. General

for new drugs. In what of a single substance or a comto determine relative biological
including method-

a guide

considerations,

ological principles in the first seven

kinds tising of drug

to be affected

and statistical procedures, are the subject of detailed discussion chapters. The other thirty-four chapters deal with the individual activity, as characterised by the nature of the target organ or tissue or by the pharmacological procedure involved. This guide for pracshould also enable biochemists, physiologists and others to

pharmacologists

perform pharmacometric evaluations An appendix gives the compositions

of which they have had no previous experience. of various organ bath solutions in current use.

(L186)

Volume

1: 1964, 456 pp., 95s./$1 5.00 Principles

CONTENTS:

Part I. General
D.

R. Laurence: First clinical Trials of Potential Drugs. John R. Vane: A Plan for Evaluating Potential Drugs. Chr. L. R#{252}mke and H. De Jonge: Design, Statistical Analysis and Interpretation. Annie M. Brown: Strain and Sex Differences in Response to Drugs. Chr. L. R#{252}mke: Some Limitations of Animal Tests. G. E. Paget and J. M. Barnes: Toxicity Tests. G. A. Deneau and M. H. Seevers: Drug Dependence.

Part II. Particular

Applications

H. 0. J. Collier: Analgesics. J. H. Weatherby: Local Anaesthetics. Erik Jacobsen: Tranquilisers and Sedatives. Graham Chen: Antidepressives, Analeptics and Appetite Suppressants. 0. F. J. Mason: Hypnotics and General Anaesthetics. James E. P. Toman and Guy M. Everett: Anticonvulsants. Vernon G. Vernier: AntiParkinsonian Agents. Edward F. Domino: centrally Acting Skeletal Muscle Relaxants. W. C. Bowman: Neuromuscular Blocking Agents. Theodore G. Brown and A. M. Lands: cardiovascular Activity of Sympathomimetic Amines. A. F. Green and A. 1. A. Boura: Depressants of Peripheral Sympathetic Nerve Function. A. L. A. Boura and A. F. Green: Antihypertensive Agents.

(L188)

Volume 2: February

1965, 444 pp., 90s./$1 4.00

CONTENTS:
F. Hobbiger: Anticholinesterases. J. L. Broadbent and W. A. Bain: Histamine Antagonists. H. L. Borison: Selective Brain Stem Depressants: Antiemetics, Antitussives, Antihypertensives, Antipyretics. D. D. Bonnycastie: Agents Acting on the Alimentary Tract. J. G. Widdi. combe: Drugs Affecting the Respiratory Tract. L. Golberg and L. E. Martin: Iron-containing Haematinics. M. J. Cross: Coagulants and Anticoagulants. William C. Holland and A. H. Briggs: cardioactive Agents. Michael Ginsburg: Diuretics and Antidiuretics. M. Schachter and J. Morley: Biologically Active Polypeptides. A. Jarrett: Dermatological Agents. G. K. Suchowsky: Oestrogens, Androgens and Progestagens. P. A. Desaulles: Adrenocorticoid Activity. C. M. Kagawa: Adrenocortical Antagonists. E. Tomich: Thyroxine Analogues (Thyroxine Antagonists and Thyromimetics). W. P. Vanderlaan, A. E. Jones and U. J. Lewis: Antithyroid Agents. Auguste Loubati#{232}res: Hypoglycaemic Agents. B. W. Fox and H. Jackson: Antifertility Agents. W. G. Spector and D. A. Willoughby: Antiinflammatory Agents. T. A. Connors and F. J. C. Roe: Antitumour Agents. Rodolfo Paoletti and Remo Fumagalfl: Blood Cholesterol Depressants. APPENDIX: ALPHABETICAL COMPOSITIONS GUIDE TO OF SOME CHAPTER ORGAN CONTENTS. BATH SOLUTIONS

MOLECULAR PHARMACOLOGY
The Mode of Action of Biologically
Edited

Active Compounds
1, 1964, 501 pp., $17.00 2, 1964, 280 pp., $10.00

by E. J. Ari#{235}ns
Volume Volume

Volume 3 of Medicinal Chemistry A Series of Monographs Edited by George deStevens

with
tion

MOLECULAR the biological

to

PHARMACOLOGY will be of interest activity of chemical compounds,

workers in the field of

to anyone including, pesticides,

dealing in addiphyto-

pharmacologists,

general

therapeutics,

chemotherapy

of infectious

diseases,

cancer

research,

pharmacology, olfaction, and related disciplines. The information in the volumes will also be of use for biochemists, physiologists, and endocrinologists using chemical compounds as tools in their research.

The authors approach fields on the basis of the of these pharmacodynamic logical object. Contents 0. K. deJongh, Part of

the pharmacological aspects of their specific physicochemical interaction of the molecules substances with the molecules of the bio1: Remarks on the Conception of Receptors

Volume
Some

Introductory

I: A Molecular Approach to General Pharmacology E. J. Ari#{235}ns, A. J. van Os, A. M. Simonis, G. and J. M. van Rossum Drug Transference: Distribution of Drugs in the Organism. Drug Transference: Drug Metabolism. Drug-Receptor Interaction: Interaction of One or More Drugs with One Receptor System. DrugReceptor Interaction: Interaction of One or More Drugs with Different Receptor Systems. The Relation Between Stimulus and Effect.
AUTHOR INDEX-SUBJECT INDEX.

Contents

of Volume

Part II: A Molecular M. C. J. Beets

2: Approach Basis

to Olfaction of Cancer Chemotherapy

Part
Part

Ill:

The

Molecular

P. Emmelot IV: Receptor Theory J. M. van Rossum

AUTHOR

in Enzymology
INDEX.
AP 1423

INDEX-SUBJECT

INSTRUCTIONS

TO

AUTHORS

Molecular action cal agent Suitable genetics, and for or of that

Pharrnaco!ogy
toxicity selectively are at the

will modifies those biology which

publish biologic describe to

the level.

results The

of term,

investigations drug,

that is defined

elucidate broadly, to

nmeehanisms include any

of drug chemi-

molecular

function. applications or of toxicologic the methods problems. of biochemistry, Also suitable are biophysics, reports of that

papers

molecular

pharmacologic

fundamental
ate basis

investigations
further upon of study underlying interest analysis of and or in action other different and drugs

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of the

although
molecular molecular

not

concerned
of are electronic, function; replication gene other

with
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drugs,
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Observations as other appropriate parameters and other and

provide
of for of on drug

an

immedi-

mechanism interactions,

phenomena, publication.

shed

no light
areas

Specific ture; drugs sis; of and olism; Short and

include drug of allosteric on

: stereochemical, and upon and transitions; cellular drug of he regulatory idiosyncrasies actions drug on molecules for their effects

architecbetween synthechanges in

conformation mechanism hormones teratogenesis; distribution

of receptors antibiotics

drug-enzyme and

interactions protein

macromolecules; structure,

transcription, drugs; chemical

growth-inhibitory

drug-induced

macromolecular

drug-induced
mechanisms; and properties between rapid They published drug

alterations
allergies; and functions biologic publication may contain investigations.

in metabolic
miitagenesis, selective of compartments. if their eXl)erimental subject

pathways;
carcinogenesis,

effects a single
metab-

pharmacogenetics, species; transport will and significant

toxicity

in
drug

organism

membranes;

Communications of material, the journal, or

considered are concise. upon

nmatter observations,

lies

within theo-

the
retical

scope

if they comment

Submission
published the cine, Editor, Palo Pharmacology, Alto, ty)ewritten in Prof.

of
English

nlanuscrij)ts.
only and Goldstein, University 94304. on is and spaced
X

Manuscripts should School Papers one side Three contain are not be Department of should of that have being sent

are to of Medibe paper the not

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when names

Avram Stanford California

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References

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described in them paper being subCommunicashould text list. time following, and be simould

elsewhere.

Observations in the reference

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style is to

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are set the

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of inmust abthe in

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in the order listed: (1) Title. (2) Names of authors, their laboratory and institution. (3) Running title. (4) Sunmmary. (5) Text. Footnotes should be referred to by superscript numbers and references
manuscript should by bered and numbers according in parentheses. to order of (6) References, in the numtext, citation

include

mathematical follow

of described

Chemistry,

cited

as in time following

exaimmple:

Instructions

Authors
240,
be names by may

and

Abbreviations
Drugs

(Vol.
must identified

No.

and Terminology 1, January 1965,

to name by the their text, in a

i)P. i-vi). generic or but footnote. may

chemical
be Abbreviations

referred throughout trade

1. T. Staehelin, H. Noll,
(7) Footnotes,

C. C. Brinton,
Nature numbered 199, 865

F. 0.
(1963).

Wettstein

and

according

to

order Figures.

of

be employed

if

they

appearance

in

time text.

(8)

Tables.

(9)