Abbreviations

A atrial AR – allergic reaction AB resistance antibiotic resistance Al salts aluminium salts Mg magnesium salts ARF – acute renal failure Adm administer Angioedema (swelling of face, eyes, lips, tongue and trachea that can interfere with breathing). ACH SE – anticholinergic effects: OH, 4 can’t: cant’see/pee/shit/spit (dry mouth, constipation, blurred vision, photosensitivity, dry eyes) impotence, HPT, tachycardia 7Ds: disorientation, dizziness, digestion problems (N/V), drowsiness, dancing (involuntary muscle spasms), dilated pupils.) BBB – blood brain barrier BC bradycardia BL bleeding b/f before BF blood flow BP – blood pressure BPH – benigh prostatic hypertrophy BS - blood sugar CA cancer CNS – central nervous system CSR – central serous retinopathy CON constipation CK - creatinine CVS cardiovascular system cretinism (growth & mental retardation). DIZ - dizziness DM – diabetes mellitus DTR – deep tendon reflexes DROW drowsiness dis – disorder/disease DN depression DUMBELLS: D, urination, miosis or muscle weakness, bronchorrhea (mucus running), bradycardia, emesis. EB virus – Epstein Barr virus Elect imb electrolyte imbalance Esp especially EGFR – Epithelial Growth Factor receptors EF ejection fraction EPS – extra pyramidal SE (restlessness/anxiety/spasms face & neck) G- gram negative bacteria G+ gram positive bacteria GERD – Gastroesophageal reflux disease GID gastrointestinal discomfort. GIU gastrointestinal upset Inj injection I&O input output HA – headache HB heart block HF – heart failure HTN – hypertention HPT - hypotension HSV – herpes simplex virus HG - hyperglycemia HPG - hypoglycemia HIT – heparin induced thrombocytopenia ICP – intracranial pressure IOP intraocular pressure MG myasthenia gravis MRSA – methicillin-resistant enterococcus MI –myocardial infarction myxedemia (intolerance to cold, lethargy, poor appetite, constipation)

NOT for contraindicated NFC – not for children C> 6 children older than 6 years NMS – neuroleptic malignant syndrome (severe EPS, hyperpyrexia (fever), autonomic dysfn) N/V/D – nausea/vomiting/diarrhea OCD – obsessive compulsive disorder OH – orthostatic /postural hypotension OJ orange juice PVC premature ventricular contraction PE – pulmonary embolism PID – pelvic inflammatory disease PN – peripheral neuropathy PUD - ulcer disease Preg X pregnancy category X PS photosensitivity RD respiratory depression RF – renal failure RD respiratory depression

Suppr suppression SOB – shortness of breath S&s signs & symptoms SED sedation SLUDGE: salivation, lacrimation, urination, D, GI upset, emesis. salicylate poisoning (aspirin): tinnitus>hearing loss, sweating, HA, DIZ TIA – transit ischemic attack TC tachycardia

u/o urine output URI – upper respiratory infection UR - urinary retention UC ulcerative colitis V ventricular VRE – vancomycin resistant enterococcus VEGRFvascular endothelial growth factor receptors Vit vitamin VF ventricular fibrillation VT ventricular tachycardia VZV varicella zoster virus WG – weight gain WL – weight loss

KT – kidney toxicity KD- kidney damage KDis kidney disease LT – liver toxicity LD – liver damage L Dis Liver disease LOC – level of consciousness

↑ increased ↓ decrease/decreased/reduce > Followed by , cause,
therefore

Drugs Table w classes/use/MOA/SE/AE/nursing applications/prefixes/roots/suffixes
Prefix, root, suffix -caine Subclass/category Drug class In alphabetic order examples Use, MOA, SE/AE, notes, nursing applications

Local anesthetic agents

Anesthesia Care

Ester

Chloroprocaine (Nesacaine)

Ester

Cocaine

For regional anesthesia. Block conduction of pain impulses in specific area (parenteral). No loss of consciousness. Used for dental work, minor surgery, labor & delivery, diagnostic procedures, skin & mucous membrane (topical).SE: CNS excitation-seizures →RD → unconsciousness, HPT & cardio suppr, AR, can prolong labor, risk of fetal BC & CNS depression, spinal HA, UR. For local infiltration, peripheral nerve block, epidural anesthesia. Blocks more sensory than motor nerves. Little systemic toxicity. Onset: rapid 6-12 min, duration: short acting 45-60 min. For topical anesthesia only, rarely used for other due to

Ester Amide

Tetracaine (Pontocaine) Lidocaine (Xylocaine)

Amide

Mepivacaine (Carbocaine)

Amide Amide

Bupivacaine (Marcaine, Sensorcaine) Ropivacaine (Naropin)

systemic toxicity and addictive potential. Provides vasoconstriction. May cause severe↑HR & BP. Used primarily for nasal intubations & nasopharyngeal surgery. Onset: rapid, duration: intermediate acting. Onset: slower 7-10 min, duration: long acting. Topical/Spinal block, not FDA approved in peds. For topical anesthesia/local infiltration. IV regional, peripheral nerve block, spinal & epidural block. Blocks motor & sensory nerves equally. Onset: rapid 5-15 min, duration: intermediate/depends on the dose & additives: 45-180 min & longer. For local infiltration, peripheral nerve/epidural block. Does not cause vasodilation. Onset: rapid to intermediate 3-20 min, duration: intermediate acting 120-200 min. For local infiltration, peripheral nerve block, spinal & epidural block. Onset: slower 5-15 min, duration: long 3-10 hrs. For epidural block. Onset: intermediate to fast. Duration: long acting, not as long as bupivacaine.

Neuromuscular blocking agents
Paralytic Depolarizing agents

Anesthesia Care
Succinylcholine (Anectine) Muscle relaxant for surgeries, ideal for short procedures, intubation. Onset: rapid 30-60 sec, duration: short 3-5 min, no reversal agents available. SE: look for BC, myalgia, MH trigger. Route of elimination: pseudochlinesterase (plasma cholinesterase). AE: hyperkalemia. If rigidity&↑T (NMS): antidote: Dantrolene (Dantrium) to slow metabolic activity of muscles. Duration: intermediate 45 min. Route of elimination: Hofmann elimination (hepatorenal independent degradation occurring spontaneously within plasma at a normal body T and PH) SE: slight histamine release, CV stability. Duration: intermediate 40-60 min. Route of elimination: Hofmann elimination. SE: no histamine release, CV stability. Duration: intermediate 20-40 min. Route of elimination: Hepatic. SE: no histamine release, CV stability. Duration: intermediate/dose dependent 12-67 min. Route of elimination: hepatic. Onset rapid to intermediate. SE: histamine release, ↑pulmonary vascular resistance. Rare use. Duration: long 60-85 min. Route of elimination: renal. SE: no histamine release, vagolylic, TC. Rare use. Duration: long 100 min. Route of elimination: renal. SE: min to no histamine release, CV stability.

Nondepolarizing agents

Atracurium (Tracrium)

Cis-atracurium (Nimbex) Vecuronium (Norcuron) Rocuronium (Zemuron)

Pancuronium (Pavulon) Doxacurium (Nuromax)

Reversal agents for nondepolarizing muscle relaxants
-stigmine
Anticholinesterase drugs

Anesthesia Care

Neostigmine (Prostigmin)

Physostigmine Pyridostigmine

To improve muscle tone in MG, in anesthesia to reverse effects of non-depolarizing muscle relaxants. For UR (from general anesthesia) Parasympathomimetic that acts as reversible acetylcholinesterase inhibitor. Strong muscarinic effects. Onset: 6-8 min, duration: 60 min, usual dose o.5-2.5 mg IV. SE: dysrhythmias BC> cardiac monitoring is essential.

Anticholinergic drugs

Atropine 2.0 mg IV

Glycopyrrolate (Robinul) 1.0 mg IV

General Inhalation Anesthetics

Anesthesia Care

Ocular SE: HA, eye brow pain, blurred vision, retinal detachment (rare). Anticholinesterase drugs stimulate muscarinic receptors leading to BC, excessive salivation & bronchoconstriction. Given to counteract the SE of anticholinesterase drugs. Atropine rare use for reversal, onset: rapid, duration: 40 min. SE: tachydysrhythmias common, may cause central cholinergic syndrome as drug crosses BBB. Onset: slower, duration: 80 min. SE: lower incidence of dysrhythmias, slow change in HR, does not cross BBB. Produces loss of consciousness & sensation, relaxed muscles, memory loss. For surgical anesthetic, diagnostic procedures, cardiological procedures, pain relief, muscle relaxation. SE: HPT, RD & cardiac depression, malignant hyperthermia (muscle rigidity,↑body T, up to 43° C (109.4° F), LT, aspiration of gastric contents, risk of toxicity to OR personnel.

Inhalation Anesthesia

Anesthesia Care
Halothane
Malignant Hyperthermia is a complication of general anesthesia using Halothane can occur during induction or after. Signs: TC, dysrhythmias, muscle rigidity, v in O2 sats. Telemetry is essential to detect! For: along with inhalation anesthetics, induces & maintains anesthesia, causes amnesia, conscious SED, Ketamine used for children. Produce loss of consciousness & eliminates pain response. SE: RD& cardiac depression, HPT, bacterial infection, psychological reactions in children <15 & adults <65, hallucinations, dreams, mental confusion. Induction & maintenance of general anesthesia, SED for mechanically ventilated adults. Short acting. Is not analgesic>opioids (fentanyl) can be combined w propofol to alleviate pain. SE/AE: HPT (vasodilation), transient apnea, pain @ inj site> Tx w lidocaine; dystonia (neuro movement dis), euphoria, priapism (erect penis) NOT for RD, benzo use. Inhalation general anesthetic (human/veterenerian). Affects nerv system> anesthesia (unconsciousness), muscle relaxation,↓pain sensitivity by altering tissue excitability. SE:

Anesthetics

Anesthesia Care

General anesthetics Hypnotic agent

Propofol IV

-ane

General anesthetics Halogenated agents

Cyclohexane Isofluorane (Ethane)

HA, tremors, convulsions. Cyclohexane: mild eye& skin irritant>flush eyes w water. AE: Malignant hyperthermia. -caine Local anesthetics Bupivacaine Tetracaine (Pontocaine) Lidocaine (Xylocaine) Mepivacaine Procaine (Novocain) Cocaine
For dental/minor surgical/labor-epidural/diagnostic procedure. ↓pain by blocking conduction of pain impulses in a circumscribed area. No loss of consciousness. SE/AE: CNS excitation (seizures followed by RD>unconsciousness), HPT, cardio suppr >BC, HB, cardiac arrest (spinal anesthesia), AR (procaine), prolonged labor & delivery/fetal BC (cross placenta), spinal HA, UR (spinal anesthesia). Lidocaine is given w epinephrine to v risk of systemic toxicity. Toxic effects of local anesthesia can cause seizure activity!!! To reverse: neostigmine (Prostigmin). neostigmine

curonium Neuromuscular

Vecuronium (Norcuron)

Probiotics↓colitis and restore normal flora. Ceftriaxone (Rocephin): NOT if allergy to penicillin Reversal agent Post Anesthesia Care Naloxone (Narcan) IM/IV/endotracheal tube Opioids Post Anesthesia Care Morphine 2mg Fentanyl (Sublimaze) 25 mcg Sufentanil (Sufenta) Alfentanil (Alfenta) Remifentanil (Ultiva) Hydromorphone (Dilaudid) 0. Gold standard in pain management. AR/SOB > Anaphylaxis. C. KT. Duration depends on dose & route. Onset <30 sec. Initial loading dose must be followed by continuous infusion. #1 choice for most infections (URI. dysrhythmias w high doses. Broad spectrum. seisures. Onset 1-3 min IV. Watch for chest wall rigidity w IV. surgical prophylaxis (1 gen. Older: ototoxicity. interfere w Vit K: cause excessive BL (DDI w warfarin). holes). RD. G. staph&strep). SE: hypersensitivity.anaerobic rd th meningitis (3 gen). NOT for immunocompromised. peak effects 20 min. resp arrest.blocking agent Pancuronium Pipecuronium Rocuronium (Prostigmin): use w caution in bronchial asthma AE: bronchiolar constriction. Dilute 0.↑resistance to B lactamase. vaginal yeast infection. Duration 1-2 hrs.4 mg (1 amp) w 9 ml of NS (0. Onset 60-90 sec IV. used to diagnose and treat it AE: can develop if received a dose less than 4 hr prior to adm of the med during surgery. Greater spectrum of drug’s activity does not ↑effectiveness. 7. thrush. Duration 30-60 min. G. Take at least 1 hr b/f or 4 hr after iron and antacid (absorption). 500-1000 x more potent than morphine. bronchospasm. Kerufox) 3rd gen: Cefdinir (Omnicef) Cefixime (Suprax) Ceftriaxone (Rocephin) 4th gen: Cefepime (Maxipime) CefCeph- Cephalosporins .anaerobic (2 gen). PSEUDOMEMBRANOUS COLITIS. UTI. No max dose. SE (fewer): anaphylaxis. AE: AR (angioedema. For induction & maintenance of anesthesia. SE: GIANT: GI N/V/D. use w caution in cardiovascular disease AE: card dysrhythmias. Caution in Seizures AE. SE: GI D. Morphine 10 mg=1. KT. thrombophlebitis. thrombocytopenia PSEUDOMEMBRANOUS COLITIS. Extremely short ½ life. nd G+.04mg/ml) & adm ½ ml per dose for desired effect. hyperkalemia. weakness. ↑ability to reach CNS (SE). itching.BC. LRI. Never adm by non-anesthesia personnel. KD. st bactericidal. Kefzol) Cephalexin (Biocef. 1-4 gen. 100 more x potent than morphine. HG. AE: KD. “Disulfiram reaction” w alcohol. difficile. wound infection). Onset 5-10min IV. Prevent bacteria from forming cell walls (make the wall loose. 1/10 as potent as fentanyl. Caution in MG. Keflex) 2nd gen: Cefoxitin (Mefoxini) Cefuroxime (Ceftin. most G+/some G-. Ceftriaxone (Rocephin) if urticaria & dyspnea>stop IV to prevent anaphylaxis. DIZ.5 mg IV/PCA/Epidural Cell wall synthesis inhibitors (bactericidal) Anti-Bacterial drugs -cillin Penicillin Amoxicillin (Amoxil) Amoxicillin/Clavulanate (Augmentin) has shield to protect B lactam! 1st gen: Cefazolin (Ancef. High potency. Onset 30 sec-2 min. N of opioids. ↑killing power against G-. We do not have cell walls>safe (preg)! More broad spectrum. AB resistance: inactivated by B lactamase like penicillins.5 x stronger than morphine. G-/+ (4 gen).5mg hydromorphone. Also: alternative in pts w mild allergy to penicillin. ↑bronchial secretions. rash)>anaphylaxis. 10 x more potent than morphine. Reverses SED. potential BL.

Tobramycin sulfate: DO NOT take w NSAIDs (Ibuprofen) can cause KT. hypersensitivity>rash/pruritis/parethesia/urticaria. HA. mid-ear infection. UTI. NOT for C<8 years/preg (prevents normal bone growth+teeth)! suprainfection: PSEUDOMEMBRANOUS COLITIS /yeast infections. TACH. cellulitis. KD suprainfection. MRSA. DO NOT mix together in the same solution. ↑ICP. rash. diabetic foot ulcer. VRE. SE: thrombophlebitis. broad spectrum: G+/G-. SE: N/V AE: CNS ototoxicity(hearing loss). AE: v liver fn. oral contracep). flushing. KD. Gentamicin (Gentamicin)AE: proteinuria/↑BUN due to KD/KT. pneumonia. For mixed infections (G+/G-. loss of appetite. Not for LD. infusion reactions (rashes. tingling/numbness feet/hands) nd 2 choice. for allergic to penicillins/cephalosporins. DO NOT take w tyramine food!!! AE:↓WBC. AE: AR. serious drug interaction (Digoxin. CNS changes (confusion. fever. Stop bacteria making folic acid. lethargy. Streptomycin: neurologic dis (peripheral neuritis. Use cautiously w KD. peritonitis.↓metabolism. AE: ototoxicity. “red man” syndrome (give it slowly). resist to B lactamase and otherMDR organisms. N/V/D. cardiac AF. DO NOT take w milk (no absorp) Clindamycin (Cleocin): bacteriostatic/bactericidal w high doses G+. thrombophlebeitis @ IV site. cardiac arrest). N/V/D. SE: N/V/D.stop growth. does not kill. Bacteriostatic/Bactericidal for UTI. ONLY for pt w healthy immune system. Ototoxicity when taking w Loop diur. aerobic infections. SE: N/D.AE: dysrhythm (sudden death). Narrow spectrum: G-. sore tongue. HTN (vasoconstriction). Bactericidal/bacteriostatic depending on blood levels of drug & bacteria type. aerobi/anaerobic). thrombophlebitis. KD/LD/LT.-enem Carbapenems Ertapenem (Invanz) IV Imipenem/cilastatin (Primaxin) IV Parenteral: Vancomycin (Vancocin) -mycin Monobactams Very broad spectrum. warfarin. Bacteriostatic. For acne (topical. optic nerve dysfn. combined w penicillin synergistic. infectious D. Protein synthesis inhibitors (bacteriostatic & bactericidal) -micin -mycin Aminoglycosides Anti-Bacterial drugs Gentamicin (Gentamicin) Streptomycin (Tx of TB) Tobramycin sulfate -mycin Macrolides Oral & IV: Azithromycin (Zithromax) Oral: Clarithromycin (Biaxin) -mycin -cycline Tetracyclines Doxycyclines (Vibramycin) Tetracycline (Tetracon) Minocycline (Minocin) -mycin Others Oral & parenteral: Clindamycin (Cleocin) Linezolid (Zyvox) Metabolism inhibitors (bacteriostatic) Anti-Bacterial drugs Bactericidal. treat some nonbacterial infections. abd pain PS> Avoid SUN! LT (lethargy/jaundice). For allergic to penicillins /cephalosporins. give slowly by IV (too fast: shock. SE: site irritation. CDAD. . For serious infections: MRSA. Broad spectrum: G+/Gaerobic. neuromuscular blockade> RD. Linezolid (Zyvox): reserved for severe/life-threatening infections not responding to other AB drugs (G+). pneumonia. Broad spectrum (G+/G-). SE: N/V. Therapeutic peak levels 30-40 mcg/ml. KT. v WBC. HPT). hypersensitivity. NOT if allergy to penicillin Resistance to B lactamase. PS>avoid SUN! yellow/brown tooth discoloration & hypoplasia of tooth enamel. seizures). damage to optic nerve.

darkened urine. dry mouth. PS>avoid SUN. suprainfection (thrush/yeast infection). Slow viral reproduction by stopping viral DNA production. Bactrim) DNA synthesis inhibitors (bactericidal) -floxacin Fluoroquinolones Anti-Bacterial drugs See below See below Inhibit growth by preventing synthesis of folic acid. safer. w warfarin>toxicity. PN. HA. bactericidal. ↑caffeine and theophylline effects (seizure. AE: form crystals in kidney> kidney stones & RF>↑fluid to prevent. numbness of extremities (PN). hypersensitivity> report vesicular crusty rash>STEVENJOHNSON syndrome. Common virus: antiviral drugs. worsen glaucoma. AE: serious heart dysrhythmias QT elongation (esp. For influenza A viral infection. RTI. N/V. DIZ. (Antihistamine SE)SE: DIZ. AE: leukopenia. SE: HA. neutropenia. skin rash. Older: Met. SE: Phlebitis/inflame @ inf site-adm slow! KDhydration! Granulocytopenia. Stop viral reproduction by inhibiting the release of virus into resp epithelial cells to multiply. malaise (not feeling well). infectious D. SE: AR (more serious if IV). HA.Sulfonamides Trimethroprim Combination Sulfadiazine Trimethroprim (Trimpex) Trimethroprim/Sulfametho xazole (SMX-TMP. SE: HA. achilles tendon rupture (older on steroids). hypokalemia). Steven-Johnson syndrome. for skin infections. N/V. itchiness. suicidal thoughts in mentally ill. Inhibit production of DNA. bactericidal. Take w large glass of water & food. DN. CNS toxicity. hallucinations. change in taste. seizures. AE (amantadine): affects CNS.↑bilirubin) hepatitis. infection). Virustatic. bone marrow suppr (anemia. cardiac arrest) Cipro: NOT for <18 years. vaginitis caused by trichomonas vaginalis (STD). gonorrhea! Prevent & treat anthrax! SE: PHOTOTOXICITY> Avoid sun! rash. fast irregular HR. DIZ. Older: can Ciprofloxacin (Cipro) Levofloxacin (Levaquin) Moxifloxacin (Avelox) -dazole Antiprotozoa Metronidazole (Flagyl) Common Virus Antiviral therapy AntiViral drugs -ciclovir -cyclovir -tadine Acyclovir Valacyclovir Amantadine Rimantadine . blurred vision. kernicterus (jaundice. fever. inhibitors +thiazide diuretics= anemia & BL Bactrim: drink 8-10 glasses of water to prevent KD from crystalluria. NOT if taking aluminum-containing antacids or dairy products (absorption). For PID & pseudomembranous colitis caused by Clostridium difficile. metallic taste in the mouth. VZV. blood dysgrasias. retard viral growth. abd pain. NOT for pts w Hx of caffeine/theophylline/steroids/amiodarone NOT for <18 years: retard growth. AE: v kidney fn: deposits if not hydrated> KD&KF> ↑fluid intake. N/V/D. UR. Monitor for “Sulfa” allergies & G6PD deficiency – blood dis in black/Mediterranean males (RBC breakdown). HSV1/2. N/D. CMV. Take exactly as prescribed to prevent recurrence and resistance. UTI. For EB virus. Anaerobic. burning urination. thrombocytopenia – take baseline CBC/platelets! Reproductive toxicity. changed BS. Broad spectrum. SE: N/V/D. KT. NO alcohol>disulfiram reaction. ataxia. preventing bacterial reproduction. OH. NOT for preg. Ramatadine has fewer nerv system SE.

Take 1 hr b/f or 2 hrs after antacids. RIPE drugs for TB! . damage heart/ears. AE: PN. ↑RI (bact pneumonia ). given in “cocktails” (multidrug).cells. Suppresses viral action and reproduction. LT. fever. Protease –clipper. DIZ. cough. liver dysfn (oseltamivir) AE: breathing problems. lactic acidosis. DN. hepatomegaly/fatty liver. HG. Peds: take as part of HAART. blood test & sputum culture. attack human immune system (CD4+. HG. Hep A&C. HA. SE: rash>STEVEN-JOHNSON syndrome. CA. Take w food. AE: teratogenic> preg– DO NOT touch the drug! bone marrow suppr. Prevent viral replication & release of viral particles. CON. HA. droplet/aerosol transmission. confusion. west Nile virus. hypersensitivity reaction. GIU w fatty/fried foods (pancreatitis). LT. Disrupt HIV reproduction by binding to the reverse transcriptase to prevent it from converting viral RNA to DNA. Combination drug therapy works w strict adherence. LD/KD. SE: reaction @ inj site. trouble sleeping. SE: HA. LT. vivid dreams/nightmares. Drug resistance common due to missed drug doses. Be alert to AR. trouble sleeping. HIV. swine flu. SE: N/V/D. Inhibit the enzyme integrase. HIV infected people NOT always have AIDS! AIDS pts have HIV infection. AE: AR(rash>anaphylaxis). SE: suppr bone marrow> can cause anemia>monitor Hg. DIZ. rash. LT. Older: PN. For refractory VI. seizures (zanamivir). To treat & prevent influenza A&B. SE: N/V/D. WG. muscle aches. If HIV: DO NOT breastfeed!!! Block CCR5 receptor on CD4+ T. fatigue. For HIV pts who r on HAART begin to have↑viral load. flu-like symptoms.-vir- Ribavirin -mivir Oselamivir (Tamiflu) Zanamivir Retrovirus Antiviral therapy AntiViral drugs Entry Inhibitors Fusion Inhibitors -vir -dine NRTIs Nucleoside Analog Reverse Transcriptase Inhibitors Abacavir (Ziagen) Zidovudine (Retrovir) -navir NNRTIs Non-Nucleoside Analog Reverse Transcriptase Inhibitors Integrase Inhibitors Amprenavir Indinavir Nelfinavir Ritonavir Protease Inhibitors Rifa- AntiTubercular drugs worsen HF &↑edema. AE: HPT. depletion of WBC> limit exposure to infection. interact w many drugs & food. pain/irritation @ inj site. SE: muscle aches & pain. chills. ↑lipid levels. some contain sulfa. DN. HG. Most antiretroviral drugs are recommended for HIV + preg women (cross placenta). Older: OH Block viral docking protein from fusing w host cell. N/V. Integrase – inserter of viral DNA into human DNA. virustatic. LT. active TB by chest X-ray. PN w long term use. thrombocytopenia>uncontrolled BL in pts w hemophilia. AE: anemia. slowing viral reproduction. helper/inducer T-cell). Take 1 hr b/f/2 hrs after antacids. N/V/D. Take st within 48hr of onset of 1 symptoms!! Retrovirus uses RNA as its genetic material. GIU. SE: D AE: anemia (report). Retrovirus: antiretroviral drugs. very slowgrowing bacteria. RHABDOMYOLYSIS>report. D. Stop spreading virus in the resp tract by inhibiting the enzyme neuraminidase. GIU. flu-like symptoms. AE: DM/HG. Inhibit reverse transcriptase & viral DNA production. HPT. AE: LT. Use 2 forms of birth control. difficulty sleeping. HA. difficulty sleeping. HA. TB caused by Mycobacterium tuberculosis. some impair electrical conduction (HB). combine w interferon to treat RSV in peds w chronic Hep C.

Rifa- First line therapy First line therapy First line therapy First line therapy Rifampin (RIF) Isoniazid (INH) Pyrazinamide (PZA) Ethambutol (EMB) Bactericidal/bacteristatic. For Tx malaria. muscle weakness & hypotonia. hypokalemia. nightmares. N/V/abd pain. hard to rid. bone marrow suppr. RA. ergosterol. SE: GIU. DVT. N/V. TC &HTN>BC &HPT. Cr=3 reduce dose. insomnia. PN. More SE/AE than antibacterial. difficulty concentrating. KT. NOT for bone tumors/hyperthyroidism/KD AntiParasitic drugs -quine Antiparasitics Chloroquine Hydroxychloroquine AntiFungal drugs -azole Azoles Fluconazole (Diflucan) Ketoconazole (Extina) Clotrimazole (Lotrimin) Nystatin Amphotericin B (Fungizone) Terbinafine (Lamisil) Butenafine (Lotrimin Ultra) Flucytosin (Ancobon) Anidulafungin (Eraxis) Polyenes Allylamines Antimetabolites Echinocandins -fundin Drugs for Bone Disorder -calciCalcium & vit D supplements Calcium carbonate (Tums) Calcium acetate (PhosLo) Calcium chloride Calcium gluconate Calciferol Calcitrol Ergocalciferol Raloxifen (Evista) SERMs Selective estrogen receptor modulator Bisphosphonates Alendronate sodium (Fosamax) For female to prevent & treat postmenopausal osteoporosis & prevent spinal fractures. infusion reactions (1-3 hrs after). LE. PN in malnourished/DM/alcoholism Report if jaundice. For hypocalcemia. ergosterol. PN. LT. Fungus – tough/thick cell walls. Report swelling/redness in calf/SOB. hypokalemia. SE: LT. thrombophlebitis. pruritis. PS. SE/AE: hypercalcemia (>10. HA. Lamisil AE: anemia. SE: enlarged breasts in MEN. No Grapefruit. SUN sensitivity>use sunscreen! For histoplasmosis. NOT for infants/NFC. PN. deficiency of parathyroid hormone/vit D/dietary calcium. AE:PN. Target plasma membrane. lethargy & confusion. AE: Infusion reaction (fever &chills). OH. “shake & bake” ↑ calcium blood levels cause the parathyroid hormone to release calcitonin. ↑uric acid (gout) SE: ^uric acid (gout) AE: Optic neuritis (high doses). DVT.5). To live & reproduce: intact plasma membranes & cell walls (phospholipids & ergosterol). yeast infection) & deep (internal organs). SE: taste changes. Suppr immune system. Fungizone AE: LD/KD. sore throat. SE: REDDISH-ORANGE URINE/body fluids. AE: LT. severe rashes. HA. to protect against beast CA. hypokalemia>dysrhythmias. Antifungal drugs damage cell membranes & cell walls to prevent fungus reproduce/kill it. Infections for toenails/fingernails require systemic drugs. GIU. thrombophlebitis. Target plasma membrane. GIU. Target plasma membrane. ergosterol. hot flashes. UR. For prophylaxis of postmenopausal osteoporosis. AE: anemia. AE: anemia. blurred vision. FI: superficial (thrush. Drink at least 3 L water to prevent gout. monitor Cr/2nd day. Older: ↑risk for DVT. Glucan synthesis inhibitor. not topical. CON. alopecia. SE/AE: ↑risk PE/DVT. bone marrow supp. SE: acne. Soft contact lenses will become discolored. male osteoporosis.SE: LD/KD/KT. Piaget’s dis of bone & hypercalcemia of . Block protein production. LD/KD. Take for 6 months as prescribed! Avoid alcohol.

hypokalemia. v bone resorption by inhibiting the activity of osteoclasts in osteoporosis. blood dyscrasias (thrombocytopenia. agranulocytosis. drink full glass of water. Aurothioglucose SE/AE: Toxicity (severe pruritis. DMARDs III Minor nonbiologic & biologic -sone -solone Glucocorticoids NSAIDs Prednisone (Deltasone) Prednisolone (Prelone) Aspirin Ibuprophen Diclofenac (Voltaren) Indomethacin (Indocin) Meloxicam (Mobic) DMARDs slow joint degeneration & progression of RA. bone marrow suppr. ↑renal calcium excretionby inhibiting tubular resorption. w intranasal route: nasal dryness& irritation. fluid retention. LT (jaundice). DMARDs II Major Biologic DMARDs slow joint degeneration & progression of RA. Cytotoxic SE/AE: ↑risk infection (fever/sore throat). GI ulcers. rashes) Cyclosporine SE/AE:↑risk of infection (fever/soar throat). N/V/abd pain. hepatic fibrosis. aplastic anemia). blood dyscrasias. avoid lying down after taking!!! (to prevent esophagitis) For postmenopausal osteoporosis. Sulfasalazine SE/AE: N/V/D. osteoporosis.SE/AE: esophagitis. hirsutism. N/V/CON/dyspepsia. Antimalarial agents SE/AE: Retinal damage>blindness. discontinue if BL/fever. Biologic response modifiers SE/AE: site irritation. bone marrow suppr. rashes STOMATITIS) KT (proteinuria). AE/SE:↑risk of infection. . adrenal suppr.↓# & action of osteoclasts> inhibit bone resorption. Miacalcin) RA Drugs DMARDs I Disease modifying antirheumatic drugs Major Nonbiologic Bone & Joint conditions Drugs Cytotoxic: Methotrexate (Rheumatrex Ieflunomide (Arava) Antimalarial agents: Hydroxyxhloroquine (Plaquenil)!!! Anti-inflammatory: Sulfasalazine (Azulfidine) Tetracycline antibiotic: Minocycline (Minocin) Biologic response modifiers: Etanercept (Enbrel) Infliximab (Remicade) Adalimumab (Humira) Rituximab (Rituxan) Abatacept (Orencia) Gold salts: Aurothioglucose (Solganal) Penicillamine (Cupimine. toxicity (severe pruritis. Enbrel: monitor subcutaneous site for redness following injection. fetal death/congenital abnormalities. eye pain. No breasfeeding. blurred vision. Fosamax: take in the morning b/f eating. moderate to severe Piaget’s dis of bone & hypercalcemia caused by hyperthyroidism & cancer. hepatitis. DO NOT take w erythromycin (toxicity) Provide symptomatic relief of inflam & pain. Depen) Cytotoxic : Azathioprine (Imuran) Cyclosporine (Neoral) malignancy. Report bruising/pruritis/stomatitis.↑risk of infection (esp TB). hepatic dysfn. Provide rapid/symptomatic relief of inflam & pain. KT. NOT for preg. Penicillamine SE/AE: bone marrow suppr. HG. SE/AE: N. leukopenia. SE: see antinlammation drugs. severe skin reactions.Ibandronate sodium (Boniva) Risedronate (Actonel) Calci- Calcitonin Calcitonin salmon (Fortical. HF. NOT for allergy to fish protein. musculoskeletal pain. RA – chronic dis w autoimmune/inflammatory components. risk for hyperparathyroidism. GID. abd pain. DO NOT drink grapefruit. No cure! DMARDs slow joint degeneration & progression of RA.

Disrupt topoisomerase (enzyme that nicks and straighten DNA helix allowing it to be copied) needed for DNA cell . extravasation can cause severe tissue damage. alopecia. lung. Cells require metabolites to begin/continue the reaction. dysrhythmias. Chemo “counterfeit” metabolites. cardiomyopathy. lung. bone. Cisplatin: KT. SE/AE: bone marrow suppr. Interfere w formation of tubules so cells cannot separate during division. bone. SE: bone marrow suppr. 5-fu Cladribine Decitabine Gemcitabine Fludatabine Methotrexate (Rheumatrex) -mycin -bicin -nib Antitumor antibiotics -taxel -ine Antimitotics -mustine -platin -mide Alkylating agents -tecan Topoisomerase inhibitors Bleomycin Plicamycin Adriamycin Mitomycin Doxorubicin Doxorubicin Epirubicin Valrubicin Idarubicin Valrubicin Dasatinib Erlotinib Imatinib Mitoxantrone Docetaxel Paclitaxel (breast) Vinblastine Vincristine Vinorelbine Etoposide Estramustine Carmustine Lomustine Carboplatin Oxaliplatin (colon) Ifosfamide (sarcoma) Cyclophosphamide Temozolomide Melphalan Altretamine Busulfan Irinotecan (lung) Topotecan (colon) Metastasis sites: LUNG CA: brain. Methotrexate: mucositis (in entire GI tract)/hyperurecemia. hearing loss. BREAST: brain. They disrupt cell growth. AE: stomatitis (sores in mouth) indicates toxicity>call Dr! Kill cancer cells by stopping the synthesis of RNA/DNA/proteins. liver. anemia. ↓hearing. If emesis: gloves + wash sheets twice in warm water. PN (weakness/paresthesia). liver. HB. thrombocytopenia (BL precautiouns). alopecia. Avoid crowds during nadir (7-14 days after chemo immune system down). Carmustine: pulmonary fibrosis. neutropenia. fool cancer cells. flu-like symptoms. CHANGES IN COGNITIVE FN. alopecia. Methotrexate (Rheumatrex) Tx of severe psoriasis/RA/cancer (treats cancer by slowing the growth of cancer cells. bone. wear gloves and mask while working in the dirt (fungus infection).alopecia (not all chemos). liver. alopecia. N/V. Paclitaxel: anaphylaxis (HPT/dyspnea/rash). two DNA strands bind tightly together preventing proper synthesis. LT/KT. N/V. Wash fresh fruit/veggies. Chemo schedule based upon timing to max cancer cell death & min normal cell damage. fluid shifts & capillary leak. MI. HF. SE/AE: bone marrow suppr. DO NOT change cat litter. SE: in neuro endings of kidney. Doxorubicin: acute cardio toxicity. PROSTATE: pelvis. may have delayed onset. RA by↓the activity of the immune system). psoriasis by slowing the growth of skin cells to stop scales from forming.5 call. Brush teeth after each meal w soft brush.Naproxen (Naprosyn) Celecoxib (Celebrex) Antineoplastic Cancer Drugs -abine Antimetabolites Xeloda. MOA varies by agent. N/V. Cross link DNA. Flush twice first three days. Check T twice a day >100. bone marrow suppr. lung Chemo: use plastic utensils to prevent metallic taste. Cyclophosphamide: acute hemorrhagic cystitis. Condoms. BC. reproductive toxicity (congenital abnorm). PN. extravasation of vesicants cause severe tissue damage. COLON: liver.

endometrial CA. Modify pt’s biologic responses to tumor cells. enhance attack on CA cells by macrophages. Little SE: some AR. hyperkalemia!!! Fainting/falling. Block one or more steps in a pathway – signal for turning on cell division does not reach the nucleus. AE: N. Cytokines: small protein hormones made by WBC’s make immune system work better. SE: rash. Interlukines/interferones. target & block growth factor receptors (EGFR & VEGFR). OH. flu-like symptoms. DIZ. AE: Falling/fainting. hyperuremia (gout).↑risk of BL. Slow down/turn off sodium pumps in the nephron tube in dif place. alopecia. light headedness. Flutamide) Anti-estrogen block estrogen from enhancing cell growth (Faslodex. muscle weakness. MOA unknown Immunotherapy Targeted therapies -mab Monoclonal antibodies Erbitux Avastin Rituximab Imatinib Trastuzumab Anti-androgen block testosterone from enhancing growth – does not kill CA cell. Diuretics Thiazide #1 Cardiovascular Drugs Hydrochlorothiazide (HCTZ. syncope. No alcohol/sun!!! – PS!!! lasix+ digoxin=digoxin toxicity lasix+ NSAIDs=↓diuretic effect lasix+ beta blockers=difficulty manage BS lasix+ steroids=hypokalemia lasix+ aminoglycosides=risk of hearing loss Inhibit sodium & water resorption. SE: DIZ. Aromatase inhibitors block production of estrogen specific hormones (Femara. SE/AE: bone marrow suppr. hypomagnesimia. CHF. RF. Gentle & sustained diuresis. SE: acne. hypercalcemia. AE: Hypokalemia. SE: dehydration. HPT. NKC & tumor-infiltrating lymphocytes. halts growth (Casodex. N/V. met alkalosis. ↑ Na+/ K+/H2O excretion via urine. Arimidex). 2. calcium loss. HG. hyponatremia. vaginal discharge/bleeding. edema. 6: charge up immune system. Combine effect of gene &immunotherapy. Produce aggressive & short lived diuresis. Eat K+ foods! thiazide+ digoxin=toxicity + hypokalemia! thiazide+ NSAIDs=↓effect thiazide+ beta blockers=difficulty manage BS thiazide+ steroids=hypokalemia For HTN. Hormone manipulation Arsenic Asparaginase Hydroxyurea Pegaspargase Dacarbazine Procarbazine Casodex Flutamide Faslodex Tamoxifen (SE:clots) Femara Arimidex division & synthesis. HPT. hypokalemia. PE. effective in pts w KD. 1st line for HTN! SE: dehydration. hyponatremia. HG.Misc. inflam. dehydration. Not appropriate for edema caused by inflam/hypoproteinuria. dysrhythmias. hot flashes (anti-estrogen). OH. hypercalcemia. Work only if the CA overexpresses (aggressive CA) actual target substances. fever. Target only cells w receptors. Diuretics do not ↑GFR. renal insufficiency. ototoxicity. N/V. ↓K+ excretion. Microzide) Metolazone (Zaroxolyn) Hydrochlorothiazide (Hydrodiuril) Methychothiazide (Enduron) Furosemide (Lasix) Torsemide (Demadex) Bumetanide (Bumex) Ethacrynic acid (Edecrin) -semide Loop (most powerful diuretics) -actone Aldosterone blockers Spironolactone . IL-1. Eliminate excess water and salt via urine. Tamoxifen) Tamoxifen SE: menstrual irregularities.

GIU. PS. HB. pulm edema. AE: DN!!! difficulty breathing. slow HR and V force of contractions like beta -lol -olol Atenolol (Tenormin) Esmolol Metoprolol (Lopressor. HF!! angina. angina. SE: OH. DROW. HTN. AE: HB. Prevent RF in hypovolemic shock & severe HPT. Promotes renal excretion of sodium. N/V/D.(Aldactone) Eplerenone (Inspra) Potassium . ↓HR & force of contractions. Older: confusion. call Dr if big change in HR. HG. NSAIDs↓diuretic effect. AE: fainting/falling. Diuretic>monitor elec bal (met acidosis)! Carbonic anhydrase is a protein in the body. Too rapid infusion of Mannitol can worsen/precipitate HF. bronchospasm. DIZ impotence. ACE I. such as Afib & Aflutter. arrhythmia.response to stimulation> ^HR. Promote sodium retention. ^conduction. dress warm in winter. SOB. Toprol) Metoprolol succinate (Toprol XL) Esmolol HCl (Brevibloc) -lol -olol Carvedilol (Coreg). For HTN. OH. kidneys Cardiovascular Drugs Propranolol (Inderal) Nadolol (Corgard) Labetalol (Normodyne) Pindolol (generic) Sotalol (Betapace) Timolol (generic) gynecomastia. bronchodilation) Selective Beta Blockers (Class II Beta adrenergic blockers) (Beta 1 – cardiac tissue. ↓CO. gynomastia. COPD. For GLAUCOMA. HF. HA. HA. hypercalcemia. ↑ sodium & water excretion w/o ↑K+ excretion. impotence. insomnia. impotence. Block the effect of epinephrine and norepinephrine throughout the body (beta 1 & 2). SE: N/V. SE: OH. For HTN. Labetalol (Normodyne. Aflutter. arrhythmia. for short term to↓aquous humor in the eye prior to surgery. DIZ. angina. hyponatremia. anorexia. trandate) . BS change. Relax blood vessels like alpha blockers. menstrual irregularities. DO NOT take K+ supplements/salt substitutes/ACE I (hyperkalemia). DO NOT stop taking suddenly (rebound myocardium excitation). NOT for asthma. dysrhythmias. HPT. For SVT. HYPERKALEMIA. DROW. Stop infusion. DIZ. HB. ↓ICP & IOP by ↑serum osmolality & drawing fluid back into vascular/extravascular space. epileptic seizures. arrhythmia. DO NOT stop taking suddenly. SE: impotence. avoid monosodium glutamate (keep↓sodium diet) Aldosterone blockers+ other K+ sparring. RF. bicarbonate. WL. hyponatremia. Masks sign of low sugar. DM BC. impotence. DN. Stay out of direct sun. potassium. Take w food(↑absorption). MI. Tx of mountain sickness (altitude: resp alkalosis). SE/AE: HF. chest pain. Works only on CVS (beta 1 only).sparing Triamterene (Dyrenium) Spirolactone (Aldactone) Amiloride (Midamor) Osmotic Diuretics Mannitol (Osmitrol) zolamide Carbonic anhydrase inhibitors Acetazolamide (Diamox) Brinzolamide Dorzolamide Methazolamide -olol -lol -lol -olol Beta Blockers (Sympatholytics) Non-selective Beta (Class II Beta adrenergic blockers) (Beta 2 – vascular &bronchial smooth muscle. chest pain. HF. If dyspnea (HF) > call Dr. fatigue. Combine the effects of alpha & beta blockers. Esmolol: short ½ life 9 min. dysrhythmias. take apical pulse b/f each dose. Tx of supraventricular TC. Beta1 SE/AE: BC. Afib. HB (AV block)!!! dyspnea. part of Tx of CHF. call Dr. dilate blood vessels and narrow airway passages! Beta2 SE/AE: HG (glucogenesis inhibited). angina. ^contractility) Beta-Alpha Blockers (Alpha – vessels of skin. wheezing. angiotensin II receptor blockers= HYPERKALEMIA Aldosterone blockers+NSAIDs=↓diuretic effect Inhibits Na+/K+ pump. fatigue. HB. MI. Correct arrhythmias. DIZ. OH. HF. ↓CO. For HTN. response to stimulation> vasodilation of peripheral arterioles. arrhythmia. AE: BC. paresthisias. fluid & elect imb. DM.↓BP via vasodilation. Atenolol(Tenormin): report Lightheadedness >HPT.↓IOP. muscles. Avoid K+ containing salt substitutes. confusion. NOT for BC. SOB.

Tridil for acute HF. PS. AE: chest pain. Minoxidil: Steven-Johnson’s syndrome!!! For angina. HA. DIZ. Discontinue gradually. weigh. DO NOT stop taking suddenly. PO: large first pass (loss) effect. For HTN. flushing. GIU. For angina. SE: OH>syncope. Must use infusion pump if IV. flushing. wheezing. HG. also dilates coronary vessels. WG. Phentolamine: for control BP & sweating caused by pheochromocytoma (epinephrine secreting tumor that can arise from the adrenal medulla). NOT for ICP. must use infusion pump. keep infusion protected from light (foil wrap). HF. long term therapy>fluid & water retention. Hydralazine: very potent arterial dilator. SOB. No alcohol (HPT crisis). Extreme vasoconstriction can provoke myocardial ischemia & angina. Peripheral vasoconstrictor at unnaturally high doses. PO: large first pass (loss) effect. hypernatremia. NOT for PALS. HA. DRY COUGH. Dilate peripheral arteries (veins) leading to low BP. pulseless VT. DIZ. vasodilation and narrowing airways!! SE: DIZ. ↓venous return (preload). mental status changes. impotence. Requires arterial line monitoring if IV. fatigue. Dilates blood vessels – primarily VENOUS. fatigue. NOT for HB. taste disturbances (dysguesia). OH. BC. TOLERANCE/DEPENDENCE> remove patch each evening: med free time of 12-14 hours b/f applying a new patch. Relaxes vascular smooth muscle causing dilation of coronary arteries &↓SVR.response to stimulation: vasoconstriction of peripheral arterioles) blockers. check for edema. DN. swelling in the feet or ankles. report persistant HR↑of more than 20 bpm. Block production of angiotensin II (causes vasoconstriction. AE: severe HPT. SE: HPT. Do not take with Viagra (Sildenafil). SE: HPT. vasodilatory shock. Vasodilation. HPT. SE: OH. Cardiovascular Drugs -pril ACEI Angiotensin Converting Enzyme Lisinopril (Prinivil. No alcohol (HPT crisis). pulmonary edema. Metabolized to thiocyanate (cyanide toxicity: HA& DROW >cardiac arrest). water/salt retention)>↓PVR. anemia. Do breaks. OH. SE: reflex TC. Imdur: if reflex TC adm Metoprolol. Older: more sensitive to the effects. BC. For HTN crisis. preop control of BP. ↑coronary BF by vasodilation. NOT for ICP. HA. DM. Labetalol: for acute stroke & hypertensive emergencies. lightheadedness. Peripheral blockers of Alpha receptors in veins & arteries> vasodilation. Do breaks. cyanide poisoning (HA& DROW >cardiac arrest). OH. anemia. Vasodialators Vasodialators Cardiovascular Drugs Hydralazine (Apresoline) Minoxidil Antianginals Short Acting Nitrates Nitroglycerin (Nitrostat) Nicardipine (Cardene) Enalaprilat (Vasotec IV) Sodium Nitroprusside (Nitropress) Antianginals Long Acting Nitrates Intravenous nitroglycerin (Tridil) Isosorbide mononitrate (Imdur) Isosorbide dinitrate (Isordil) Labetalol (Normodyne) Phentolamine (Regitine) Alpha-Adrenergic Blockers Vasoconstrictor Vasopressin Meds for hypertensive crisis. SE: profound HPT>ischemia/infarction. HPT. BC. DIZ. impact CO by ↑ or v afterload. TOLERANCE /DEPENDENCE. Zestril) Ramipril (Altace) Enalapril (Vasotec) IV . Imdur: DO NOT adm if systolic BP<90. DM people. reflex TC. HPT. NOT for responsive pts w angina. emergency Tx of HF.& intestines. reflex TC. directly stimulates smooth muscle. Vasoactive drugs: by causing peripheral vasodilation or constriction. Naturally occurring antidiuretic hormone. HF from acute MI. AE: neutropenia. lightheadedness. For VF. acute aortic dissection. DO NOT take w Viagra (Sildenafil).

worsening HF. arrhythmia. 2 line. symptomatic PVCs. stroke prevention DM NP. seizures w extreme toxicity. resp arrest) Mexiletine Tocainide Class IC: Encainide Flecainide Propafenone . vasodilation and v water/salt retention. SE: confusion. NOT for preg (renal stenosis): fetal injury (2-3 trimester). For HTN. fatigue. HPT. Class IA/IC: A&V arrhythmias. HPT. AVOID Verapamil/Diltazem in Afib of Wolff-Parkinson-White syndr. Slow conduction of heart. MEMBRANE STABILIZER! Class IA: for recurrent VT/VF. st 1 dose of Enalapril (Vasotec) risk of OH. CON>↑ dietary fiber. Numbing constricts the blood vessels> pale look. SE: DIZ. Suppresses V dysrhythmias. May depress myocardiac contractility. D. KF. disorientation. BC /TC. Verapamil/Diltazem for supraventricular TC caused by AV nodal reentry!!! Arterial vasodilators. STOP Procainamide if widening of QRS of more than 50%/if dysrhythmia is suppressed/HPT develops. DROW. -mide Sodium Channel Blockers Class IA: Quinidine Procainamide (Pronestyl) Disopyramide Class IB: Lidocaine (CNS effects. ↑in QRS duration and lengthening of QT interval. hyperkalemia. AE: dysrhythmias. hyperkalemia>avoid salt substitutes! Angioedema. Control both V & supraV dysrhythmias at the AV node.Inhibitors -sartan ARB Angiotensin II Receptor Blockers -pine -dipine CCB Calcium Channel Blockers (Class IV drugs) Benazepril (Lotensin) Perindopril (Aceon) Trandolapril (Mavik) Captopril (Capoten) oral rapid onset 1 hr Moexipril (Univasc) Quinapril (Accupril) Losartan (Cozaar) Valsartan (Diovan) Irbesartan (Avapro) Olmesartan (Benicar) Candesartan (Atacand) Telmisartan (Micardis) Eprosartan (Teveten) Amiodipine (Norvasc) Felodipine Nimodipine Nifedipine (Procardia) oral Nisoldipine Diltazem (Cardizem) Verapamil (Calan) Nicardipine (Cardene) IV proteinuria. Verapamil (Calan): if severe HPT Calcium chloride! If giving IV push adm slowly over 2-3 min. Class IC: the most potent Na+ channel blockers & have little effect on repolarization. HF. John’s wort v effect. #1 for stable VT w EF>40%. NO alcohol. Excessive doses> myocardial & circulatory depression. prolonging action potential. coronary spasm (angina). Nifedipine (Procardia)SE: reflex TC. Class IB: for V ectopy (VF/VT). ↑effects of diuretics & K+ sparing. toxicity. cause cardiac arrest!! St. DO NOT eat grapefruit (toxicity!) DO NOT stop suddenly. HA. Cautious in KD. SE: HA. N. peripheral edema>wear stockings. Stabilizes cell membrane &↓rate of impulse conduction. angioedema. flushing. Report irregular rhythm. resp arrest. AE: seizure. wheezing. Toxicity: DROW. ↑effects of diuretics & K+ sparing For HTN. HR< 60 beats/min or >100.↓the influx of calcium in the arterial resistance vessels. HPT. Block calcium from entering the muscle cells of heart & arteries causing v contraction & dilated arteries. blocks both the fast sodium channels & phase 3 repolarization. edema. AE: dyspepsia. LT. HF. Have only moderate effect on Na+ channels & accelerate phase 3 repolarization to shorten nd the action potential duration. SOB. Block angiotensin II receptors and its effect (vasoconstriction & sodium water retention) in type 1 receptors.↑PR & QRS intervals. twitching.

NOT for HR<60 bpm/ hypokalemia. Act within CNS to v sympathetic outflow> v stimulation of Alpha/Beta receptors of heart/peripheral. Lung damage can persist for months after med stop (long ½ life). causes arterial & venous dilation). Very narrow therapeutic range (0. Normal levels help prevent some abnor heart rhythms. Report s&s of GI BL. confusion. GIU. BPH (relaxes smooth muscle of the prostatic capsule & bladder st neck). For asystole.↑CO. ↑afterload. restlessness. For hypomagnesemia. VT/VF (Torsades de pointes) Normal levels help prevent some abnormal heart rhythms. ↓BP: For HTN (primary). caution w RF. blindness. dry mouth. angina >ischemia. For HTN (primary. Vasoconstriction/↑HR/↑rate AV node/ bronchodilation. SE: HPT. HPT.5-2 ng/mL). severe CA pain. SE/AE: DROW. facial flushing. SED. hyperkalemia. abd pain N/V. cardiotoxicity>BC. ↑HR. HB. Never give potassium IV push! DO NOT take potassium on empty stomach. dyspnea}. irritation @site. tremor. abd discomf.↑force of myocardial contraction. For HF and Afib. NOT for BC. GIU. Withhold cardiac glycosides prior to cardioversion> can↑V irritability &↑risk for V fib after the synchronized countershock of cardioversion. w cardioversion of PSTV & A TC. Incompatible w sodium bicarbonate. Simulate effects of SNS. migraine. VT/VF. AV block. Watch for dry mouth. dysrhythmias>V ectopy. Take at bedtime/w food. Digitek) Drugs to ↑ CO Cardiac Glycosides Adrenergic agonists Sympathomimetic agents Vasopressors Cardiac drugs Epinephrine (Adrealine) . ↑myocardial contraction. st Cardiac Glycosides Digoxin (Lanoxin.AE: HTN >hypertensive crisis. SE: N/V/D. SE: slows absorption of local anesthetics/fix superficial BL/ ↓nasal congestion/ Tx of AV block & cardiac arrest. 1st line for narrow complex SVT. AE: report hypermagnesemia. dysrhythmias. Depresses AV & SA node activity. AE: HF. ↑automaticity. terminates reentry dysrhythmias. ↓HR. SE: 1 dose OH. yellow/green halos vision. PN. ↑myocardial O2 consumption. rebound HTN (discontinue gradually). SE: transient {chest pain. Inotropic agents – improve CO by improving the force of myocardial contraction. hypothyroidism. flushing. worsened arrhythmias. IV potassium causes pain. ↑coronary &cerebral BF. gas. Slows repolarization & prolongs the duration of action potential. Digibind is used for digoxin toxicity. leading to slowed conduction & prolonged refractoriness. AE: toxicity: anorexia. SE: fatigue. Block potassium channels. ARDS. SE: corneal deposits. LT>monitor liver enzymes. weakness/fatigue . Clonidine (Catapres): helps to abstinence from opioids. Check pulse & rhythm b/f adm. BC. circulatory shock. If toxicity hold drug & draw blood level for digoxin. ↑BP. photophobia. PEA. somnolence (sleepy). ↑SVR. SE: HA. sinus BC.↓DTR.Potassium Channel Blockers (class III drugs) Amiodarone (long half-life) Replacement therapy Magnesium sulfate Potassium Adenosine (short halflife<5 sec) -azosin Alpha adrenergic blockers (sympatholytics) Alpha 2 agonists Centrally Acting Doxazosin (Cardura) Prazosin (Minipress) Terazosin Clonidine (Catapres) Guanfacine HCl(Tenex) Methyldopa (Aldomet) 1 line drug! For uncontrolled A&V arrhythmias. blurred vision. pulm toxicity/fibrosis w extended use.

GI obstruction. DO AntiCholinergic drugs -fenacin Antimuscarinic (anticholinergics. Normal: glucose 90-130 mg/dl b/f meals. diaphoresis. Used as vasopressor to ↑BP in shock states (sepsis. ACH SE:↓reaction. NOT for glaucoma. For urinary incontinence. HPT. Similar to epinephrine but lacks B2 effects of epinephrine. for overactive bladder. AR> anaphylaxis. hair loss. HA.↑CO. 2-10 mcg/kg/min-↑CO. SE: Nose bleeds common.HF esp in HPT patients.↑myocardial contractility/vasoconstriction. septic shock). DO NOT give via peripheral line: tissue necrosis if extravasation>infiltrate w phentolamine 5-10 mg in 10-15 ml NS. cerebral arteries. swallow whole. moves potassium into cells along with glucose. It works by slowing the production of certain natural substances that can cause pimples to form. mesenteric. may cause dysrhythmias. For pulmonary congestion. BPH. Goal to keep HbA1c <7% (glycosylated Hg) Promotes cellular uptake of glucose. weakness. peeling of the skin from the palms/soles. Precautions: V dysrhythmias. ↑myocardial O2 consumption at high doses>angina. UR. DO NOT exersice in hot weather> ↓sweating>heat stroke. ↑myocardial O2 needs. ↑HR. older: risk of HPG if beta blockers or Coumadin!!! Sweating – early sign of HPG. palpitations. lispro/aspart: Humalog/Novolog/Apidra . Renal blood vessel dilation/↑HR/↑rate AV node/ vasoconstriction. tissue necrosis if extravasation.CON LD. shakiness. To treat severe recalcitrant nodular acne. v CO w no signs of shock. DO NOT crush tab. Dose dependent: 1-2 mcg/kg/min-vasodilation of renal.Norepinephrine (Levophed) Dobutamine (Dobutrex) Milrinone lactate (Primacor) IV 50 mg/ml NS Dopamine (Intropin) IV 400 mg in 250 ml NS For HPT (unstable/symptomatic) that does not respond to epinephrine/dopamine. antispasmodic) Darifenacin (Enablex) Solifenacin Dermatologic drugs -tretin tretinoin Retinoid.TERATOGENIC. HA. < 180 md/dl after meals. For shock/HF. myocardial ischemia at high doses. arrhythmias. For severe HF/cardiogenic shock. myocardiardial contractility & HR AE: extreme TACH>severe dysrhythmias esp if hypovolemic> optimize volume status first. ↑CO/↑HR/↑rate AV node/ possible peripheral & coronary vasodilation. For hemodynamically significant HPT: sys 70100 w signs of shock. mild to moderate peripheral vasoconstriction. Strict BP monitoring via arterial line.↓PCWP/SVR. inflam of the eyes. UC. Incompatible w sodium bicarbonate. For acne. Incompatible w sodium bicarbonate. >10 mcg/kg/min-profound↑in peripheral vasoconstriction. converts glucose to glycogen. tremors. dermatologic agent Form of vit A Acitretin Alitretinoin Isotretinoin (Accutane) Insulin products (sub Q) AntiDiabetic drugs Insulin Rapid–Ins. Dose dependent positive inotrope & vasodilator w min chronotropic response. SE/AE: TC. Oral. skin rash. can cause miscarriage> NOT for preg! HPG: TC. symptomatic BC if atropine is ineffective & in the absence of pacer.

NOT for HF. WL. SE: fluid retention. Prandin: 30 min b/f meal.↓ glucagon. older w KD low dose. alpha Glucosidase Inhibitor -gliptin -tide DPP-4 inhibitor Incretin mimetics GLP – 1 Glucagonlikepeptide1 Amylin mimetics Synthetic analogue Acarbose (Precose) Mignitol (Glyset) Sitagliptin (Januvia) Exenatide (Byetta) 2x a day Sub Q 1hr b/f am/pm meals Pramlintide (Symlin) Sub Q b/f meals -tide Hyperglycemic agent Glucagon Boosts production of insulin RAPIDLY. HPG. ↑incretins. AE: severe HPG. NOT for renal dysfn. photosensitivity. monitor s&s infection Mimics the effects of GLP 1>↑ insulin secretion/ suppress glucagon production/↓GI motility. does not promote insulin release from the pancreas> do not cause HPG. blurred vision. SE: infection.SE: GAS. take in the a. Glyburide (DiaBeta. use of IV dye: withhold before & after 48 hrs. D. HA. SE/AE: N. Type II.↓insulin demand. ↓glycogen synthesis enhances synthesis of glucose. risk for anemia (v iron absorption) LT (if long term). Type II w/o HF. ↓postprandial plasma glucose rise. WL. Poiglitazone (Actos) Glucophage (Metformin) Boosts production of insulin. pancreatitis (report abd pain). NFC. . edema. no meals no drug. For HF patients. Long acting. C>10 years. C>10 years old. peak 6-12 hrs. WG. Works 3 ways. AE: LD/KD. Glipizide (Glucotrol). Reduces insulin resistance. WL. Long – insulin glardine: Lantus/Levemir (onset 1 hr and lasts 24 hrs w/o peaking) Oral antidiabetic -ride -zide Sulfonylureas AntiDiabetic drugs Glimeperide (Amaryl). Carry glucose tablets always.m. dur 4 hrs) Short– Regular: Humulin R/Novolin R clear (onset 30-60 mins. Works w insulin only! Type II. Enzyme inhibitor/inhibits carb breakdown. ↑LDL. discard open vials after 28 days. Type II. Works w insulin only! Type II. Repaglinide (Prandin) Rosiglitazone (Avandia). colonic ulceration or cirrhosis. dur 1824 hrs) NOT mix insulin glardine (Lantus) w any other insulin in the same syringe. deficient in DM. Longest Acting. flu like (URI) back pain. WG. AE:LD/KD. SE: N/V/D. SE/AE: HPG (too much insulin). Glipizide: NO alcohol> disulfiram -like reaction (N/V/flushing/palpitations) -nide glitazone Meglitinides Thiazolidinedione (TZD) Biguanide AGI. Glynase) Chlorpropamide (Diabinese) Nateglinide (Starlix). Insulin Independent!!! Type I + II. older: worse SE/AE Mimics actions of Amylin (↓postprandial glucose by inhibiting glucagon secretion) peptide hormone in pancreas. Rosiglitazone v effectiveness of oral contraceptives. caution in older. AE: HF.↓ blood glucose levels by ↑breakdown of glycogen into glucose. For emergency of HPG reactions/Insulin overdose. short acting. reaction @inj site.↑insulin release. WG. peak 2-4 hrs. NOT for >85 years. AE: lactic acidosis – do not use if abuse alcohol (prone to lactic acidosis). Type II. anemia.(onset 15 mins. infl bowel dis. AE: HPG. less SE: N/V/anorexia. Take oral meds 1hr b/f inj (symlin delays meds absorption). dur 5-7 hrs) Intermediate – NPH: Humulin N/Novolin N cloudy (onset 1-2 hrs. peak 1 hr. DIZ. SE: HPG. LT. lipohypertrophy (rotate inj site) 10 u of Humulin R w 40 u of NPH: 1) 40 u air (NPH) 2) 10 u of air (Humulin) 3) withdraw 10 u Humulin 4) withdraw 40 u NPH.

N/V/D. AE: Intest obstr ↓secretion of intestinal fluids and slow bacterial activity. bowel obstr. AE: dehydration. NOT for appendicitis. impotence.hypertonic. cramps. elect imb (hypernatremia. stool color change. cramps. SE: CON. Lactulose: promotes excretion of ammonia ↑ in LF (cirrhosis). thrombocytopenia>call dr if BL. elect imb (hypernatremia. dysrhythmias. AE: HA. AE: HPT&falls in older. Drugs for CON Bulk forming laxatives Osmotic laxatives Gastrointestinal Drugs Methylcellulose (Citrucel) Psyllium (Metamucil) Lactulose. bloating. HPT&falls in older. elec imb (hypernatremia. gas. bowel obstr. flushing. GAS. Magnesium Hydroxide AE: UTI. Lactose. lethargy. neutropenia>report green sputum). stool color change. Slows perilstasis. DO NOT take w milk>GI irritation. SE: abd distention. NOT for PUD. AE: Toxic megacolon(fever/abd pain/rapid HR/dehydrat/shock) Have dual effect. AE: v libido. bowel obstr. LD/KD. Coat surface of stool to retain water. dehydration. dyspepsia. Magnesium Hydroxide (milk of magnesia).surgery due to aspirin content. Safe in pt using antidepressants. hypokalemia) causing dysrhythmias. bowel obstruction. pulm arterial HTN (PAH). altitude sickness. N/V/D. recent stroke/MI. elec imb (hypernatremia. SE: abd distention.SE: abd distention. AE: dehydration. NFC:Rye syndrom For pain in PUD use acetaminophen (Tylenol) ↓acid production by blocking H2 on parietal cell in stomach. bloating. NOT for HTN if sodium containing laxative. GAS. pre-/post. confusion. gas. SE: CON. making expulsion easier. hypokalemia) causing dysrhythmias. ↑GI perilstalsis. MiraLax) sodium phosphate (Fleet edema) Castor oil Lubricants Stool softeners Docusate (Colace) Stimulants Bisacodyl (Dulcolax) AntiDiarrheal Drugs Antimotility drugs Gastrointestinal Drugs Loperamide (Imodium) max dose 16 mg Diphenoxylate with atropine (Lomotil) Calcium polycarbophil (FiberCon) Adsorbent/Absorbent Antisecretory Pepto – Bismol Drugs GERD & PUD -tidine Histamine H2 Blockers Gastrointestinal Drugs Ranitidine (Zantac) Cimentidine (Tagamet) Nizatidine (Axid) . ↑ water absorption (dry stool). agranulocytosis. blurred vision. Add fatty substance (↑absorption of oil) to allow stool move easily. gas. Lomotil has ACH SE. AE: HPT&falls in older. bloating. ↓PH in stomach>↑risk of infection. Also absorbs the substance that induces D in GI. cramps. retinal dis. Fleet enema. Contains aspirin> BL & bruising. N/V/D. stool color change. SE: CON.Erectile dysfunction drugs -afil PDE Phosphodiesterase inhibitor Sildenafil Tadalafil Vardenafil Tx of erectile dysfn. structurally similar to Meperedine. GAS. bloating. bloating. Polyethylene glycol (GoLYTELY. cramps. hypokalemia) causing dysrhythmias. watery content. N/V/D. HPT. HPT. ACH SE. depression. HPT&falls in older. hypokalemia) causing dysrhythmias. GAS. Retention of fluid in bowel. bloating. Short term. SE: abd distention. bloating. bone marrow suppr (anemia. NOT for nitroglycerin/CV risk factors. Can take every day! Soften fecal mass &↑bulk (like diet fiber) Metamucil: peak action 24-72 hrs. binds w water and provides ↑ bulk & moisture for stool to easily pass. dehydration. photophobia. For D ↓intestinal transit time > less frequent bowel movement.

-mine -zine -mine -dine Anticholinergics Antihistanimes H1 blockers! Dopamine Antagonists (or promotility drugs used for GERD) 5HT3 receptor antagonists -setron Ondansetron (Zofran) Panolosetron Dolasetron AntiCoagulants Antiplatelets Hematologic Drugs Aspirin Clopidagrel (Plavix) Ticlodipine Eptifibatide . ACH SE. Block action of histamine at H1 site.-prazole PPI Proton Pump Inhibitors Antacids Lansoprazole (Prevacid). SED. tardive dyskinesia. ACH SE. balance disturbance. SE: CON. Long term use ↑of infection (older). Bonamine. NO smoking w PUD meds!! Less effective. UR. for preg to induce labor by causing cervical ripening. fluid retention (if w sodium). NOT for glaucoma. BPH. BPH. Neutralize stomach acid. SE/AE: EPS!!! HPT. N/V/D. HA. neutropenia. NOT for preg. Work well in arterial circulation where other anticoagulants are not effective. Dramamine) Metochlopramide (Reglan) ACH SE (CON). SE: CON. CON. Block dopamine from binding leading to ↑GI motility. OH. NFC & older: EPS. SE/AE: D. DO NOT take w NSAIDs/alcohol (BL). Omeprazole (Prilosec)+Phenytoin= ↑EE Phenytoin. Cytoprotectives Bismuth Subsalicycate (Pepto Bismol) Sucralfate (Carafate) Clarithromycin Metronidazole Tetracycline Amoxicillin Antibiotics for H pillory infection For pt taking long term NSAIDs to prevent ulcers. vertigo. thick coating. AE: anemia due to B12 & iron malabsorbtion. For N/V. NOT for glaucoma. stool impaction (infants). DN. claudication. Work at initial step in coagulation by block platelets from clumping to form clots. tardive dyskinesia Phenergan Older: acute confusion. Al salts) D(Mg salts). Reglan: NOT if intest obstr. CON.SE: BL. gas. NOT for glaucoma. Inhibit H pylori bacteria penetrating the lining. SE rare: CON (Ca. bruising. ↓acid production by blocking proton pump located in parietal cells in stomach. For chemotherapy N best works as combination of antiemetic drugs. pylori infection. SED. TIA. risk for falls! Causes depression of XTZ in medulla. prevent AMI/stroke. DN. SED. RD. AE: NMS. ↓acid secretion/↑secretion of bicarbonate & protective mucus. Cimentidine w Warfarin monitor PT. DN. dyspepsia. Prochlorperazine SE: tardive dyskinesia. HTN. Meals 6 x/ day. grayish tongue. Milk of Magnesia Calcium Carbonate (TUMS) Prostaglandin E analog Misoprostol (Cytotec) Cimentidine (Tagamet) incompatible w Cefazolin. tinnitus> hearing loss or salicylate poisoning (aspirin). UR. Sucralfate (Carafate): if combined w phenytoin (Dilantin) to control seizures allow 2hrs bw meds! Eradication of H. AE: hemorrhagic stroke. For angina. Block serotonin receptor in intestinal tract & brain. post stent thrombosis. Avoid taking antacid w Mg>diarrhea Coating the mucosal lining. ACH SE. ACH SE. AntiEmetic drugs -azine Phenothiazines Gastrointestinal drugs Promethazine (Phenergan) Prochlorperazine (Comprazine) Scopolamine (L-hyoscine) Meclizines (Antivert. dysmenorrheal/spotting. Omeprazole (Prilosec) Esomeprazole (Nexium) Magnesium/Aluminium Hydroxide/Simethicone (Maalox. Bismuth: black stools. CON. BPH. Ranitidine (Zantac) impairs absorp of Vit B12 >do not take together. DN. rash. abd pain. D. UR. itching.

ischemic stroke. PE. Warfarin NOT for preg X. severe HTN. thrombocytosis. Monitor for coffee-ground emesis/black tarry stools.↑risk MI/stroke/cardiac arrest (w↑in Hg>12). meat. massive PE. soybeans). SE/AE: HTN (if elevation in hematocrit too rapidly > HTN & seizures). SE/AE: bone pain. recent (7 days) surgery/trauma. Warfarin antidote: vit K (phytonadione).5-2 x the control Enoxaparin (Lovenox) Fondaparinux (Arixtra) -ase Thrombolytics (clot busters) Alteplase (Activase) Eminase Retaplase (Retavase) Streptokinase (Streptase) Tenecteplase (TNKase) Tissue plasminogen activator (t-PA) Stop 1 week b/f surgery /dental. Peds: Reye’s syndrome! Brain fn damage/LD.000). For immunodeficiency. CLL. Leukopoetic growth factors Granulocyte macrophage colony stimulating factor Thrombopoetic growth factors Figrastim (Neupogen) Pegfilgrastim (Neulasta) Sargamostim (Leukine) Oprelvekin (Interleukin-11) Supplements Iron supplements Immune System Drugs Immune globulin Ig G (Gamma globulin G) Deep IM/IV . cabbage. blurring of vision. SE: BL. To↓thrombocytopenia & the need for platelet transfusions in pt receiving chemotherapy. Clots are dissolved by conversion of plasminogen to plasmin (destroy clotting factors) AE: serious risk of BL (brain. Heparin antidote: protamine sulfate. AE: 1-10 % report s&s of fluid retention (swelling in legs. HPT. Procrit) Sub Q/ IV Darbepoetin alfa (Aranesp) Methoxy polyethylene glycol (MGEG) (long acting) For anemia related to CRF. Absorption is best when taken on empty stomach. dysrhythmias. AE: HA. NOT for hemophilia. Monitor thrombocyte count (>50. discard open vial after use. No effect on formed clot! Inhibit certain clotting factors/prevent formation of fibrin. prevent stroke in pt w Afib. Take w food to v SE. Prevent & treat DVT.Tx of failed bone marrow transplant. No additional iron Vits required. Bone marrow transplantation. SE/AE: D. puncture site). and be consistent w diet of dark green vegies. NOT for active BL. Eat ↑ fiber foods to prevent CON SE of iron. DO NOT shake med. Vit C↑ absorption. Be consistent w vit K intake. dyspnea on exertion). Warfarin: full therapeutic effect 3-5 days. MMR/chicken pox exposure. Stimulates bone marrow to produce neutrophils. rash. Adm Protamine sulfate slowly IV.) ↓the risk of infection in pt w neutropenia (from cancer).↑production of platelets. DVT. Blood tests to monitor response. DO NOT take w milk> v absorption. thrombocytopenia (HIT): Warfarin-induced skin necrosis. preg. yokes & poultry (Iron). For acute MI. SE/AE: fluid retention (peripheral edema. same amount of green leafy veg (dark green leafy vegetables. cauliflower. no faster than 50 mg in 10 minutes. Aminocaproic acid (Amicar) reverses trombolytic effects. Stop Heparin if thrombocytopenia (platelets<100. NOT if sensitive to E-coli protein. NOT for HTN pt. AE: hemorrhage. leukocytosis. leukocytosis. malaise. AR. Monitor for changes in LOC (cranial BL). after chemotherapy. Takes 2-4 weeks to start working.-aparine -parin Anticoagulants Warfarin(Coumadin)preg X PT 18-24 sec INR 2-3 x the control Heparin: PTT (60-80 sec) aPPT 1. Stimulants Erythropoetic growth factors Hematologic drugs Epoetin alfa (Epogen. bone pain.000) to see effectiveness. weakness. prosthetic heart valve/post cardiac procedures. Antidote: protamine sulfate. Hep A & B exposure. Acts on bone marrow to produce WBC. Stimulates bone marrow to produce RBC. NOT if allergic to yeast. AR>anaphylaxis. To hasten bone marrow fn after bone marrow transplant.

healing impaired . DN). buffalo hump. Glucocorticoids (cortisol) control carb/fat/protein metabolism & are anti-inflam by preventing mediator production. Inflam – nonspecific. Teach selfinjection. SE: flu like symptoms. Celecoxib (Celebrex) the only drug does not kill COX 1. COX 1 binding drugs v clotting for a week> GI BL. COX 2: inflammatory cells at site. CML. hypernatremia (neural issues). DO NOT shake vial. NSAIDs Nonselective COX inhib: Oral: Aspirin. KT. v fn. hair loss. Ibuprofen (Advil. MG). fluid retention. Herbs: DO NOT take aspirin with Coumadin/Willow bark. swelling. wasted muscle and mass (osteoporosis).SCF: granulocyte stimulating colony factor. moon face. Report s/s rejection. Mineralocorticoids SE: HTN. acne (bold with pimples). Asmanex) Oral (mineralocorticoids): Prednisone Prednisolone Parenteral (mineralocort): -sone -solone -cort-predPred- 2. Glucocorticoids SE: CUSHING’S syndrome 6B3W2S2MHA: HTN. Most powerful drug. prevent organ rejection in transplants (lifelong therapy). HTN (v renal BF) AE: KD. Aldeslukin (Interleukin 2) Sub Q/IM -limus Immunostimulants G. Pulmicort) Fluticosone (Flonase. SLE. NOT for 1st 3 months preg (pre-close ductus arteriosus). Cytotoxics SE: bone marrow suppr. WG. Motrin) Naproxen (Aleve. AR /anaphylaxis are rare: watch for facial edema! Preg C. sleeping problem due to “nervous feeling”. Provides passive immunity (temporary) & antibodies. Local s&s: redness. BL/bruises. anemia. Flovent) Memetasone furoate (Nasonex. Systemic s&s: fever. malignant melanoma. Enhance host immune responses & ↓ proliferation of cancer cells.Immunostimulants Interferon Alfa. alopecia. cardiotoxicity. Act on helper T lymphocytes to suppress production of immune response resulting in suppr of the proliferation of B cells and cytotoxic T cells. Neoral) Glucocorticoids: Prednisone Cytotoxics: Azathioprine (Imuran) Tacrolimus (Prograf) Methotrexate (Rheumatrex) pruritis. AIDS related Kaposi’s Sarcoma. pain). can be allergy/injury. pus. monitor for↓ cell proliferation (effectiveness). Anaprox. Ketorolac (Toradol) check for bruising! Pimecrolimus Sirolimus Inflammation drugs Antinflammatory -fenac -profen 1. mix cyclosporine w milk/OJ (NO grapefruit while on therapy). HPT. Naprosyn) Oxaprozin (Daypro) Indomethacin (Indameth) Nabumetone (Relafen) Oral/Parenteral: Ketorolac (Toradol) COX 2 inhibitors: Celecoxib (Celebrex) for RA Nasal spray: Budesonide (Rhinocort. Steroids ↓inflam to prevent damage. G. Cyclosporine SE: LT/KT. HG (DM). ↓inflam by counteracting the cyclooxygenase(COX) enzymes & preventing prostaglandins production (PG2. hypokalemia(cardiac issues. bone marrow suppr. pain. swelling. warm. For hairy cell leukemia. store in refrigerator. does not always mean infection is present. Gengraf. erythema. pain. Report if bone pain. For autoimmune disorders (RA. exacerbation of asthma & AR. Take after meal w full glass water/milk. adenopathy (swelling of the lymph nodes) local reaction. Mineralocorticoids (aldosterone) control electrolyte & water levels by promoting sodium retention in kidney. mood swings (anxiety. stretch marks. SE: GI ulcers/pain. weak immune system. bloated (swell from sodium and water retention). Stimulates production of platelets in clients receiving chemotherapy. SE: N/V. Initial cyclosporine over 2-6 hours. COX 1: GI tract normal cells.SCF Platelets production stimulant Immunosuppressants Filgrastim (Neupogen) Sub Q Oprelvekin (Interleukin 11) Calcineurin inhibitors: Cyclosporine (Sandimmune.

Inhibits absorption of diet cholesterol. HTN. BL w Coumadin (↑effect). ↓liver fn. Expect therapy to be lifelong. Hep/LD!!! Zetia+Fibrates=gallstones Zetia+Resins= ↓EE Zetia+Statins= ↑ EE & LT No cure! AD – v neurotransmitter levels/activity (acetylcholine: memory. myopathy. gout. Gemfibrozil (Lopid): periodic liver fn tests. LD: liver tests /6 months. SE: myopathy. muscle aches. SE: sleepiness. Ezetrol) Cholesterol Absorption inhibitors Drugs for Alzheimer’s Disease -mine Cholinesterase/Acetyl cholinesterase Mental Drugs Donepezil (Aricept) Rivastigmine (Exelon) . Keep neurotransmitter levels higher. To↓inflam by stopping histamine effect. NOT for PUD. AE: angioedema. UR. Thiazides. Risk: age. genetics. DO NOT stop suddenly! Take w food. No grapefruit juice! Liver tests /6 months. attention. gallstones. Takes 4-6 weeks to work. Avoid crowds. NOT for BPH. K)(give vits 1 hr bf/4hrs after). cataract. infections. Pneumonia #1 reason they die. abd pain. SE: HA. Colesevelam (Welchol): oral tab-do not need to be mixed in water. dry mouth. inhibit breakdown of AntiLipidemic drugs -statin Statins. ACH SE. PN. glaucoma. LT. binds w cholesterol in the intestine to prevent reabsorption. ARF. dilated blood vessels. BL (w Coumadin). For mild to moderate AD. gas.-mine -iramine -zine -dine -tadine 3. SE: GID. DO NOT take when having acute asthma attack – make too drowsy to work on breathing. LDis. If jaundice call Dr. LT. E. AE: rhabdomyolysis. AE: seizures (rare). TC. Lipitor: monitor Cr level rise in response to enzyme released w muscle injury. neck/face flushing. CSR. AE: LD. AE: BL. HTN. HG. ↑fluid intake/fiber. circulation). ↑Cr levels in pt w KD. adrenal insufficiency. OH. AR (hives & anaphylaxis) Zileuton (Zyflo) is leukotriene modifier NOT BLOCKER! Lower LDL. Only donepezil for advanced AD. Bile acid sequestrants Cholestyramine (Questran) Colesevelam (Welchol) Colestipol (Colestid) NiaFibr- Niacin (Vitamin B3). GID. Leukotriene modifiers (inhibitors) Dexamethasone (Decadron) Hydrocortisone (Solucortef) Methylprednisolone (SoluMedrol) 1st gen (more sedating): Diphenhydramine (Benadryl) 2nd gen (less sedating): Loratadine (Claritin) Fexofenadine (Allegra) Desloratadine (Clarinex) Cetirizine (Zyrtec) Zafirlukast (Accolate) Motelukast (Singular) Zileuton (Zyflo) (immunosuppr effects)AE: vision loss. Lower LDL. SE: GID. NOT for breastfeeding. Take w meal (↑absorp). D. AE: myopathy>rhabdomyolysis. ↑IOP. LT/LD. Stop b/f surgery/dental Lower triglycerides. Prednisone causes demineralization of bones> osteoporosis & stress fractures. Nicotinic acid agents Fibrates. ↓inflam by preventing Leukotriene from binding to its receptors. blurred vision. ↑warfarin and statins effects. Take at bedtime (body makes cholesterol at night). hyperuricemia (itching). irreversible. Preg X . GIU. Antihistamines -luk-leu- 4. Tetracyclines (take 1 hr b/f/4 hr after) Lower triglycerides. Peds: risk intestinal obstr. GID. Gemfibrozil (Lopid) Ezetimibe (Zetia. active BL. Inhibits absorption of fat soluble drugs and vits (A. CON>older: stool softener). HMG –CoA reductase inhibitors Atorvastatin (Lipitor) Rosuvastatin (Crestor) Simvastatin (Zocor) Lovastatin (Mevacor) ColeChole- Resins. SE: gas. back and joint pain. CON. Avoid Digoxin. Fibric acid Niacin (Niacor) Fenofibrate (Tricor). block eosinophil infiltration.

DUMBELLS AE: arrhythmias. SE/AE: HA. N/V/D/CON. DIZ. Rivastigmine (Exelon) CAUTIOUSLY w asthma. NOT for seizure dis/BPH/DM/LD. dry mouth. CNS stimulants. older (hyponatremia). toxicity. Antidepressant Mental drugs -pram -mine -tine -line SSRI Selective Serotonin Reuptake Inhibitors Paroxetine (Paxil) Sertraline (Zoloft) Citalopram (Celexa) Escitalopram (Lexapro) Fluoxetine (Prozac) Fluvoxamine (Luvox) triptyline pramine -pine TCA Tricyclic Antidepressants Amitriptyline (Elavil) sun! Imipramine (Tofranil) Nortriptyline (Pamelor) Cyclobenzaprine (Flexaril) – muscle relaxant Isocarboxazid (Marplan) Phenelzine (Nardil) Selegiline (Eldepryl. Serotonin syndrome: Cognitive effects: mental confusion. HTN crisis. ACH SE. AE: HA. dysuria. tinnitus. SE/AE: OH.↓ excitement. report rash>AR For depression. AE: N. stroke. COPD (bronchoconstriction). N. N/D. SE: GIU. . coma. Fluoxetine (Prozac) suppr platelets aggregation when used w NSAIDs & anticoagulants >↑risk for BL. Block MAO-A in the brain. Autonomic effects: shivering. local rash. Serotonin: sex/appetite/aggression Norepinephrine: concentration/interest/motivation Both: depressive mood/anxiety/irritability/thought process. HA. bulimia nervosa. TC. Antidepressant. GI BL. opioids. glaucoma.John’sWort. Elavil: photophobia>wear sun glasses For atypical DN. NMDA blocker prevent overstimulation of receptors in brain. sleepiness. fibromyalgia. fever. DO NOT use w vasopressors (caffeine) >HTN. HA. confusion. illicit drugs. insomnia. tremor. DIZ. somnolence/ insomnia. bad taste. seizures. restlessness. cerebrovascular events. hyperreflexia. Long acting. sweating. withdrawal syndrome. NOT for MAOI users. Donepezil (Aricept) report dyspnea!!! Glutamate is released when brain cells are damaged by AD & cause further brain cell damage. SE: SLUDGE. ↓rate of psychosis & agitation in AD. sweating. OCD. rash. mydriasis (dilation of pupils). fatigue. Drug interaction w St. For DN/aid to quit smoking/prevention of SAD. dry mouth. Avoid aged&fermented foods.↑norepinephrine /dopamine/ serotonin. Inhibit dopamine reuptake. NOT for long-term. Prozac: if fever>stop&call Dr (serotonin syndrome) Inhibit the uptake pumps for norepinephrine & serotonin>more serotonin around. DO NOT take w SSRIs/HF/ renal insufficiency. agitation. AE: hallucinations. HTN. DO NOT take w coumadin/aspirin/antihistamines /alcohol. hallucinations. generalized anxiety dis. hypomania. antidepressants MAOI/TCA. ACH SE. Short acting. bruxism. HA. SED. stress urinary incontinence. SE: less ACH SE & impotence than TCAs. cognitive decline. bipolar. ↑HR. movement difficulties. seizures. DM NP pain. SE: HTN!!! SE: impotence. Somatic effects: myoclonus/clonus (muscle twitching). Helps w agitation. stomach pain. Prior to start Amitriptyline (Elavil) ECG ordered for older cardiovascular SE. Emsam Tranylcypromine (Parnate) Nefazodone (Serzone) Trazadone (Desyrel) sleepy Duloxetine (Cymbalta) Venafaxine (Effexor) -line -mine -zine MAOI Monoamine Oxidase Inhibitors -done -xine -tine SARI Serotonin Antagonist & Reuptake Inhibitors SNRI Serotonin Norepinephrine Reuptake Inhibitors Atypical Bupropion (Zyban. CON. insomnia.Inhibitors Galantamine (Razadyne) -tine NMDA Blocker (glutamate blocker) (anti-influenza agent) Memantine (Namenda) Risperidone (Risperidal) Olzapine (Zyprexa) Haldol acetylcholine &↑concentration in the brain. SE: OH. Management of neuropsychiatric s&s. GI BL.

Carbamazepine SE/AE: nystagmus. Lithobid) For bipolar dis. ECG changes. staggering gait. Anticolvulsants (Antiepileptic drugs) Valproic acid (Depakene) Valproate (Depacon) Divalproex (Depakote) Lamotrigine (Lamictal) Carbamazepine (Tegretol) Gabapentin (Neurontin) Oxcarbazepine (Trileptal) Topiramate (Topamax) Tiagabine (Gabitril) -lam -pam Atypical Antipsychotics Benzodiazepines -pine -mil CCB Calcium Channel Blockers Alprazolam (Xanax) Chlordiazepoxide (Librium) Clonazepam (Klonopin) Clorazepate (Tranxene) Diazepam (Valium) Halazepam (Paxipam) Lorazepam (Ativan) Oxazepam (Serax) Verapamil (Calan) Nifedipine (Adalat. blurred vision. Carbamazepine (Tegretol) cause agranulocytosis & lethal in overdose. Signs of lithium toxicity: slurred speech (early). teratogenic >NOT for preg. ataxia. weakness. vertigo. Chlordiazepoxide (Librium) to prevent delirium tremens in acute alcohol withdrawal. range: -0. Modulate mood by inhibiting calcium channels in the postsynaptic neuron. skin dis (dermatitis. schizophrenia.↓BP. Signs of lithium intoxication: fever. CBC. trauma & street drugs. cardiac changes. Takes 2-3 months to work. rash. Avoid aerobic activity in hot weather (cause water/sodium depletion). SE & toxicity: WG. GI. DROW.Antidepressants NDRI (Norepinephrine Dopamine Reuptake Inhibitors) Wellbutrin) restlessness. cognitive effects w long term use. HA. rarely N. polyuria. hand tremor. HA. thyroid dysfn (goiter & hypothyroidism). renal.6 to 1. anemia. Use in 1st trimester intrauterine growth retardation. blood dyscrasias (leukopenia. mental dullness. seizures.AE: tremors.↓sodium> ↓lithium excretion> toxicity. DIZ. fatigue. alcoholism. suppr appetite>WL. rashes. lethargy. SE: see cardiac drugs. confusion. anterograde amnesia. action similar to Lithium. thrombocytopenia). LD). ataxia. N/V. For mixed mania/rapid cycling bipolar dis. irregular pulse. muscle twitching. insomnia. DO NOT drink grapefruit juice.↓UO. fasting BS. bulimia. death. ECG. coma. HA. DROW. DO NOT take w MAOIs (toxicity)/seizure dis. irritability/hostility.4mEq/L. tinnitus. Can use in pts w HTN/supraventricular arrhythmias/preg. Enhance the effects of the inhibitory neurotransmitter GABA & desensitizing the kindling effect of stress. Promotes secretion of ADH> retain water> HF. N/V. Valproic acid (Depakene): thrombocyte count/amylase levels/L fn tests (thrombocytopenia. feeling of detachment. STEVEN-JOHNSON syndrome). Narrow therap. thyroid. NO Coumadin. Check b/f: renal. HPT>coma/death. pancreatitis. vertigo. aches. rebound insomnia/anxiety. DN. hyperactive DTR. SED. Divalproex (Depakote) can be lethal in overdose. seizures. altered level of consciousness. Procardia) Nimodipine (Nimotop) Amlopidine (Norvasc) SE: dose related/short term/harmless. Antianxiety & Mental drugs . tolerance/dependency. anorexia. Mood Stabilizers (AKA euthymics) Antimania Mental drugs Lithium (Eskalith. double vision.

premenstrual dysphoric dis. DO NOT take Paroxetine (Paxil) & MAOI/TCAs> Serotonin synd: Cognitive effects: mental confusion. offers SED w few cholinergic effects. DIZ. HA. glaucoma. DROW. rarely N. Somatic effects: myoclonus/clonus (muscle twitching). N/D. withdrawal syndrome. tremor. Chlordiazepoxide (Librium) prevents delirium tremens in acute alcohol withdrawal. can be used to suppress alcohol withdrawal.Sedative/Anxiolytic -lam -pam Benzodiazepines Alprazolam (Xanax) Chlordiazepoxide (Librium) Clonazepam (Klonopin) Clorazepate (Tranxene) Diazepam (Valium) Halazepam (Paxipam) Lorazepam (Ativan) Oxazepam (Serax) Midazolam For short term use (2-6 weeks). PTSD. Midazolam (Versed)/ Diazepam (Valium) AE: RD> adm antidote Flumazenil (Romazicon). hypomania. Vistaril) Paroxetine (Paxil) Sertraline (Zoloft) Fluoxetine (Prozac) Ventafaxine (Effexor) Trazodone (Desyrel) Nonbenzodiazepine Antihistamines (also used for sleep) Nonbenzodiazepine Antidepressants (SSRI) -barbital Nonbenzodiazepine Barbiturates Nonbenzodiazepine Beta Blocker Nonbenzodiazepine Secobarbital Pentobarbital Propranolol Clonadine (Catapres) -lol -olol . Autonomic effects: shivering. Significant sedating effects. SED & hypnotic. anticonvulsant. N. anxiety. confusion. MG. bruxism. take in a. & effect should be gone by morning. Generally well tolerated. feeling of detachment. antidepressants. SE: CNS depression (somnolence. DIZ. Addictive> withdrawal symptoms. coma. NOT for ataxia. much greater safety profile in overdose compared to trycyclic antidepressants. WG. for sleep dis/insomnia. rebound insomnia/anxiety. anxiety (tremor. For generalized anxiety dis. anterograde amnesia. skeletal muscle relaxant. Rarely used. Paroxetine (Paxil) can cause insomnia. panic dis. Anesthetic. alcohol use. opioids. short term alcohol detoxification. sleep apnea. Because they are in the same class as alcohol. ataxia. Bind more selectively to neuronal receptors involved in inducing sleep (benzodiazepine-1 receptors on BZ/GABA receptor complex) Antianxiety. SED. AR. sweating. Block peripheral/central noradrenergic (norepinephrine) activity. anesthesia for short procedures w min pain. For off-label Tx of anxiety. irritability/hostility. anticonvulsant. Desyrel – preffered antidepressant for insomnia.John’sWort. SE: OH. anterograde amnesia. OCD. LD. Use in 1st trimester intrauterine growth retardation. lethargy) tolerance/ dependence. AE: RD. For off-label Tx of anxiety. HA.m w food. temp Tx insomnia. palpitations. sweating). bulimia. cognitive effects w long term use. NOT usually as effective as BZs but DO NOT cause physical dependence/abuse. fever. CNS stimulants. When used as hypnotics. DIZ. TC. hyperreflexia. TC. DN. Block peripheral/central -lam -pam Nonbenzodiazepine Sedative-hypnotics agents Sedative-hypnotics (benzodiazepine derivatives) Zolpidem (Ambien) Zaleplon (Sonata) Eszopiclone (Lunesta) Estazolam (ProSom) Flurozepam (Dalmane) Temazepam (Restoril) Triazolam (Halcion) Quazepam (Doral) Diphenhydramine (Benadryl) Hydroxyzine (Atarax. SE: somnolence.SE: dose related/short term/harmless. preg. Risk for falls!! Sometimes used as sedative-hypnotic agents for SED effects. For epilepsy. Drug interaction w St. ataxia. HA. illicit drugs. they induce sleep rapidly. sex dysfn. severe DN. older> hyponatremia. seasonal affective dis. agitation. tolerance/dependency. HTN. hallucinations. Avoid alcohol.

act at the injury site. Suppress inflammatory induced pain. Chronic pain: daily for 6 months. irritation GI (PUD/GERD)> give w meals /after meal. BUT: WG. metabolic abnormalities. Disadvantages: does not have anti-inflam or antiplatelet qualities. NMS. ACH SE. Do not change perception of pain. HA. less SE encourage med compliance. agitation. Report: agranulocytosis. disorganized speech. attentional deficit. DIZ. Safe to use when client is taking anticoagulants. Less expensive. OH. hypercholesteremia.aspirin only (tinnitus. <24hrs. bizarre behavior. bruise. alogia (lack of content in speech). avolition/apathy. Avoid alcohol. Inhibits prostaglandin synthesis.symptoms of schizophrenia. Clozapine (Clozaril) watch for WBC count (agranulocytosis). asociality. Advantages over Aspirin: not associated with GIU. opisthotonos (arching back like in tetanus). Change the perception of pain. EPS (pseudoparkinsonism. tinnitus or GI BL. Analgesic and antipyretic effects. New nonscheduled sleep aid. SE: N/V. TC. 1st line!! Diminishes + &. sweating. not associated with Reye's Syndrome. loss of BS control in DM. AE: permanent LD/KD. For panic dis. PTSD. hopelessness. For mild to moderate@bone/cancer/soft tissue trauma. Watch for neck spasms. NOT for last 3 months preg (pre-close ductus Pain Drugs Non-Opioid Analgesics Acetaminophen Acetaminophen (Tylenol) -fenac -profen NSAIDs Nonsteroidal Anti – inflammatory Drugs 1st gen NSAIDs (COX 1&2 inhibitors): Aspirin Ibuprofen (Motrin. Zydis) Quetiapine (Seroquel) Ziprasidone (Geodon) noradrenergic (norepinephrine) activity. BUT do not treat negative s. suicidality.symptoms: affective flattening. salicylism . . sweating). Safe for children. social anxiety dis.Alpha 2 Blocker Atypical Anxiolytic/ Nonbarbiturate Anxiolytic Buspirone (Buspar) Ramelteon (Rozerem) Antipsychotics Mental drugs Typical/Traditional or Conventional Antipsychotics Phenothiazines: Chlorpromazine (Thorazine Thiothixene (Navane) Butyrophenone: Haloperidol (Haldol) -done -pine Atypical: 5-HT2A antagonists Serotonin/Dopamine Antagonists Risperidone (Risperdal Consta. ACH SE. BL. hallucinations. specific melatonin agonist. anemia. M-Tabs) Clozapine (Clozaril) Paliperidone (Invega) Olazapine (Zyprexa. thought dis. does not exhibit muscle relaxant/anticonvulsant activity.SE: DIZ. AE: induction of asthma. v suicidal behavior. antipyretic. v clotting. avoid grapefruit/erythromycin/ketoconazole(↑effects) For schizophrenia + symptoms: delusions. Mood symptoms: dysphoria. tardive dyskinesia). OCD. oculogyric crisis (rotating of eyeballs). resp alkalosis). improves s&s of DN & anxiety. N. IV. adm with a full glass of water. Advil) Naproxen (Naprosyn) Indomethacin (Indocin) Ketorolac (Toradol) Diclofenac (Voltaren) . akathisia (unable to sit still). palpitations. inappropriate affect. may cause mild EPS (tremor). For mild pain. bone marrow depr. Take w food (v N). moderate: combined w opioids. renal dysfn (↓u/o. HA. Thorazine: if extreme restlessness & involuntary mov-ts>tx w Amantadine (Symmetrel) antiparkinsonian drug to treat EPS. anxiety (tremor. thrombocytopenia. Inhibit prostaglandins synthesis preventing pain sensation. Abd pain may indicate overdose. fluid retention>WG/HTN/HF. lower seizure threshold. anhedonia (lack of pleasure). Interaction w CNS depressants: sedative-hypnotic properties. Antidote: acetylcysteine (Mucomyst). Monitor renal and hepatic fn.

Stop 2448 hr b/f surgery. Antagonistic – block mu receptors ↓ effects of euphoria. Codeine: cough suppr. In high does. Do nothing at the site of damage! Act on mu receptors to produce analgesia. Methadone (Dolophine): for opioid withdrawal. Demerol: use >48 hrs results in accumulation of normeperidine>seizures. and kidney. Short Acting: Tramadol (Ultram) Codeine (Paveral) Morphine (Roxanol) Hydromorphone (Dilaudid) Meperedine (Demerol) Oxycodone w acetaminophen (Endocet. who have demonstrated opioid tolerance. Have no effect in the absence of opioids. OH!! Miosis. confusion. Ketorolac (Toradol) is effective post op pain med. I&O. auscultate lung sounds and encourage TCDB. confusion. feeling lightheaded. SED & ↓ GI. respiratory depression. Percodan) Oxymorphone (Opana. smaller pupils. Call provider if RR<12/BPM. SED. DROW. around the clock opioid adm for an extended period of time. urticaria. less analgesic effect. sedation. SED and ↓GI motility. cannot be managed by other means such as NSAIDs. altering perception of pain & ↓ anxiety. MI. Hypersensitivity (allergies) – skin rash. Not for preg. Low potential for abuse (little euphoria). Reyes syndrome. angioedema. ↓of bowel motility. Addiction/dependence/tolerance. restlessness and mental confusion can occur. cancer). & ↓ GI motility. opioid combination products or immediate-release opioids. For moderate to severe. concurrent use w morphine sulfate ↑analgesia w no risks of opioid SE. anxiety. liver. SE/AE: Abstinence syndrome (cramping. Adjunct drug for surgery/labor (epidural). coma. Numorphan) 2. Long Acting: Morphine (MS Contin) Oxycodone (OxyContin) Hydrocodone (Lortab. For moderate to severe pain (postop. Opioids: NO breasfeeding!! Avoid meperidine (Demerol). slow heartbeat. emesis. euphoria and SED. cold/clammy skin.-codone -phine -tanyl morphon e Opioid Agonists Hydrophillic Lipophillic Opioids (Opioid Agonists) Nepafenac Fenoprofen Ketoprofen Bromfenac 2nd gen NSAIDs (selective COX 2 inhibitors) Meloxicam (Mobic) Celecoxib (Celebrex) for RA 1. physical dependence. DIZ. Available as transdermal patch! None of the other opioids is available in this form. Compete w opioids for opioid receptors. Inhibition of COX 2: v inflam/fever/pain. MOA: bind to opioid receptor sites in brain. Celecoxib: NOT for allergy to sulfonamides. SE: UR. Should only be used in clients who already receiving opioid therapy. fainting. anxiousness). opioid agonists. HTN. vomiting. Does not occur w other opioids. hypoactive bowel sounds. Assess for bladder distension. Adm IV opioids slowly over 45 min. less RD. SED. Vicodin) Hydrocodone w/ tylenol (Vicodin) Always long acting! Fentanyl Transdermal (Duragesic) Methadone Opioid Agonist Antagonists Butorphanol (Stadol) Nalbuphine (Nabain) Buprenorphine Hydrochloride (Buprenex) Opioid Antagonists Naloxone (Narcan) arteriosus). RD. Act on kappa receptors to produce analgesia. AE: RD!!! biliary colic. migraine (intranasal spray). Antidote: Narcan. motility. Salicylate specific allergies: tinnitus. Agonistic – Act on Kappa receptors producing analgesia. analgesia. . moderate to severe chronic pain that: required continuous. CON. cough suppr. dyspnea. Aspirin NFC : Reye syndrome. For opioid overdose/reversal of RD. For persistent. Opioid agonist –antagonists differ from pure opioid agonists that they may cause abstinence syndrome in pt physically dependent to opioids. GIU (reduced). KT.↑ICP. Inhibition of COX1: v platelet aggregation/KD. Do not take with Warfarin/Glucocosteroid. SED. HA. Withdrawal. RD. Dilaudid SE: shallow breathing.

NOT for visceral/bone/muscle pain. lie down in a dark quiet room at the onset. weakness. SE: adrenal insufficiency. The nerve cells send fewer pain signals to the brain. migraines. SE: Flu-like symptoms. CA pain. osteoporosis. physical dependence. low back pain). Relief should occur in 30-50 min of oral dosing. Tegretol) Clonazepam (Klonopin. worsen UR/glaucoma. thrombocytopenia> monitor platelets. Gabapentin/ carbamazepine SE/AE: bone marrow suppr. CA pain /chronic (arthritis. Report jaundice/N/V/blue purple skin color. ergotism (muscle pain. muscle aches. fibromyalgia. SE: DROW. IOP. avoid foods containing tyramine. For CA induced bone pain. Valproic acid (Depakote): LT>monitor ASTL/ALT liver fn. Used in conjunction w antibiotics for cystitis. SED. migraine. Take 1-2 wks to work. NOT for preg. ↑urination SE: turns urine into orange/red color. Most effective if taken at the onset of symptoms. clumsiness. Amitriptyline (Elavil) SE: ACH SE. Chronic pain patients are depressed. fetal abortion. DIZ. Used for neuropathic pain (sharp/burning) and cancer-related conditions. Adjuvant Clutcocorticoids Adjuvant Biphosphates To ↓ ICP & relive spinal cord compression. DM neuropathy. WG NOT for LD. burning. Peds: cause aggressive behavior (paradox). glucose intolerance. hypokalemia.↑risk for falls. Enhance the effects of opioids. a 2 dose can be taken after 2 hrs. HTN. Hand tremors (call Dr) sign of allergy! Older: heart problems. For neuropathic pain. HA.Azo Dye Phenazopyridine hydrochloride (Pyridium) Adjuvant Drugs Pain Drugs Anticolvulsants (not for acute!) Adjuvant drugs Gabapentin (Neurontin) 1st choice. 1 tablet should be taken immediately after the onset of aura/HA. GIU> take w food. parethesias in fingers & toes. N/V/D. Rivotril) Decadron Deltasone Didronel Aredia -line -tine -xine Antidepressants Adjuvant drugs SE/AE: TC/tachypnea. DM. abstinence syndrome (cramping. If migraine: identify & avoid triggers. SE: tightness in the chest (expected). Used in combination with but not a substitute for opioids. NOT Migraine -ergotErgotamines (anti-migraine) Pain Drugs Ergotamine Dehydroxyergotamine Cafergot -triptan NSAIDS Triptans Advil. ataxia (can’t walk the drunk test). For chronic. venous irritation @ inj site. PUD. Prevent inflam/dilation of the intracranial blood vessels> relieving migraine pain. SE/AE: N/V. Change the way sodium & calcium travel across the surface of sensory nerve cells in the brain. DM NEUROPATHIC PAIN. cold/pale extremeties). DO NOT wear contact lenses. ASA Sumatripan (Imitrex) Relpax . Treats pain. pulmonary edema. If st nd the response to 1 dose is not effective. Local analgesic effect on urinary tract. fibromyalgia. blurred vision. confusion. G6PD deficiency. For acute attack/prevention. See antinflammatory drugs For migraines. OH. Helps to ↓the dosage of opioids by 50% without altering effect. but 4 wks to work Pregabalin (Lyrica) 1 wk to work Carbamazepine (Tegretol) Dilantin Amitriptyline (Elavil) Nortriptyline Sertraline Gabapentin (Neurontin) Pregabalin (Lyrica) Lamotrigine (Lamictal) Valproic acid (Depakote) Carbamazepine (Carbamax. trigeminal. vomiting).

NMS. postural instability and gait. DROW. ACH SE. Lowprotein diet for breakfast and lunch or take levodopa 30 min b/f meals. Prevent COMT from metabolizing levodopa. dyskinesias. psychosis. For initial motor symptoms to delay motor complications + complimentary therapy w “on/off” fluctuations and dyskinesias from levodopa in late PD. DO NOT stop suddenly (NMS). N. COMT is enzymes that degrade dopamine. Hx of ischemic heart dis> it is vasoconstrictor. CON. Psychosis (hallucinations.↓if tobacco use! No cure. See antiemetic drugs Parkinson’s Disease Drugs -dopa Dopaminergics # 1 choice Caridopa/Levodopa (Sinemet. Sinemet CR) -ole Dopamine Agonist #2 Pramipexole (Mirapex) Ropinirole (Requip) Apomorphine (Apokin) Piribedil (Trivastan) Bromocriptine (Parlodel) Benzotropine (Cogentin) Benadryl. SE: DROW. Any AE from Sinemet are due to potentiating the effects of levodopa. environment. palpitations. Inhibit monoamine oxidase B that breaks down dopamine in brain. norepinephrine. Do drug holiday (dyskinesia). stiff joint. irregular heartbeat. abnor movements and psychiatric disturbances may occur sooner and may be more intense than when levodopa is employed alone. OH. Work both on CNS and peripheral. Block cholinergic nerve impulses that help control muscles. fluctuations in response: “on/off” state. Benzotropine (Congentin) SE:N/V. “punding” OCD. Motor related. Levodopa – precursor can enter the BBB (5-10% cross) and convert to dopamine > work on the brain. TC. same time each day. insomnia. tremors at rest. Sinemet: Carbidopa has no AE of its own. hallucinations. OH. Allow more levodopa to reach brain. Med holiday: ↑client’s immobility>↑risk for pressure ulcers. MI. aspiration pneumonia> potential for impaired skin integrity during holiday. 90-95 % metabolized in peripheral. bradykinesia. Artane Entacapone (Comtan) -pine -pone Anticholinergics COMT Inhibitors -line MAO-B Inhibitors Rasagiline (Azilect) Pargyline (Eutonyl) 2 Neurodegenerative disorder after AD. SE/AE: muscle aches. OH!!! AE: impulse control disorders (compulsive gambling. ↑dopamine activity in the brain. tremors. DYSKINESIA. When levodopa is combined with carbidopa. shopping). activation of malignant melanoma. DVT. head bobbing. genetics. NMS. DN w suicide. eating. nightmares). epinephrine. tremors. Death of dopamine-containing cells in the substantia nigra (midbrain). Mirapex SE: sleep attacks & daytime sleepiness. sex. SED & DROW. SE/AE: N/V. N. tics. water retention. discolored sweat & urine. rigidity.↓dopamine (motivation drive hormone) levels in CNS. Avoid↑protein meals (amino acids interfere w levodopa absorption). Risk: age. Less effective. RHABDOMYOLISIS. neutropenia. More effective. For later onset.Antiemetics Butalbital combinations Opiates Compazine Reglan Medications that combine the sedative butalbital with ASA or acetaminophen Codeine for angina pectoris. delay the need for nd . LT. To improve motor symptoms.

discourages penetration by sperm. hormonal deficiencies. Carbamazepine (Tegretol) causes an accelerated inactivation of oral contraceptives due to action on hepatic med-metabolizing enzymes. Monitor closely for breathing. depression of DTR. HA. bloating) may↑risk of breast CA. edema. N. Teaching: breast exam. circulatory collapse. For postpartum women that lactate. DIZ. vaginal candidiasis. ↑u/o. Prevent implantation of fertilized egg. Act by providing negative feedback to pituitary (shuts down secretion of LH & FSH).Antiviral Selegline (Deprenyl) Lazabemide (Pakio. to ↓ incidence of dysmenorrheal. ONLY antibiotics that impact effectiveness RIFAMPIN & GRISEOFLUVIN. postmenopausal osteoporosis. Small doses prevent conceptions by blocking ovulation – progesterone effect. Magnesium toxicity results in CNS depression (↓LOC) Drugs for Infertility Reproductive System Drugs Clomiphene (Clomid. Monitor for thrombophlebitis. Produce thick/viscous mucus at entrance to uterus.only contraceptives Hormonal contraceptives Ethinyl estradiol w norethindrone (Ortho-Novum 1/35) Emergency contraceptives Emergency contraceptives Plan B (levonorgestrel in 2 doses. breast CA/tenderness. The discoloration is caused by swelling of the medium veins in the skin. Drugs for Preterm Labor Tocolytics Reproductive System Drugs Magnesium sulfate Nifedipine (Adalat. lethargy. Oral contraceptives Reproductive System Drugs Estrogens & progestins r For contraception. Thicken cervical mucus to slow sperm passage/alter endometrial lining to prevent implantation/inhibit ovulation. N. Most r combinations of estrogens & progestins. WG. thus preventing ovulation. acne. ACH SE. DVT. Prostaglandins. restlessness. N/V. SOB (chest pain. Progestin. Magnesium displaces calcium. for improvement in menstrual-cycle regularity. photosensitivity. dysmenorrheal. CHD. MOA: inhibit release of FSH & LH. SE: WG. blurred vision. HA. thromboembolic disorders. calf pain)> thromboembolism!!avoid caffeine > may↑CNS stimulation. report calf pain. May be adm within 72 hrs after unprotected sex. SE: BP. AE: HB. skin rash. NOT for: pregnancy. N/V/D. no smoking. . HTN. Can mimic symptoms of pregnancy (breast tenderness. Stimulate release of LH. Less effective than levodopa + more AE. Procardia) Terbutaline sulfate (Brethine) Slow uterine contractions to delay labor. discoloration of skin. 12 hrs apart) Preven (comb of ethinyl estradiol & levonorgestrel) Mifepristone (Mifeprex. abd cramps. effective in advanced stage too. fatigue. livedo reticularis (mottled reticulated vascular pattern that appears like a lace-like purplish discoloration of the lower extremities. which makes them more visible). #1 choice for female infertility. Tempium) Amantadine (Simmetrel) levodopa in early stage. AE: HTN. CVA. weakness. For clients w premature labor. cycle control – estrogen effect. SE: exaggerated SE see above. SE: confusion. mid-cycle breakthrough BL. RU-486) Misoprostol (Cytotec) To abort implanted embryo. thromboembolic events more common in smokers. As contraceptive. respiratory paralysis. Vit C can↓ breakthrough bleeds.

dysmenorrheal. Inhibit effects of estrogen on uterus. coma.↑in LH level sufficient to induce ovulation in 90% of treated women. vaginal candidiasis. postpartum fever. thromboembolism. Common reason for hysterectomy. breast CA/tenderness. unexpected utherine BL. NOT for previous uterine surgery. Often an imb bw estrogen & progesterone. hot flashes. Danazole (Danocrine): HTN. related to water intoxication from drug’s antidiuretic hormone effects). spontaneous abortion. maternal dyspnea. Syntocinon) Methylergonovine (Methergine) Ergot alkaloids Prostaglandins Ergonovine maleate (Ergotrate) Miseprostol (Cytotec) results in maturation of↑# of ovarian follicles. DN. pituitary tumor. vaginal dryness. HTN. Prevents LT consequences of estrogen loss. CVA!!! DO NOT smoke (trombophlebitis)!! For premenstrual syndrome if 1 line is ineffective.↑risk for thromboembolic dis>MI. PS.LT use has serious AE. AE: N/V. migraine HA. BP. contraception). Oxytocics . N/V. v physical effects associated. neonatal jaundice. # 1 choice to induce labor/fetal stress test. chills. secondary amenorrhea. maternal/fetal dysrhythmias. mother uterine rupture. AE: breakthrough BL. suppl estrogen & progestin might be prescribed. cephalopelvic disproportion. for promotion of breast milk ejection. uterine cramping. Methylergonovine (Methergine) AE: HTN crisis. Prevents osteoporotic st Drugs for Dysfunctional Uterine bleeding Reproductive System Drugs -trel Progestins Ovulation suppressant Medroxyprogesterone (Provera) Desogestrel Etonogestrel Levonorgestrel Norethindrone (Micronor) Megestrol acetate (Megace Leuprolide (Lupron) Hormone Replacement Therapy HTR Reproductive System Drugs Conjugated estrogens .Serophene) Choriogonadotropin (Ovidrel) Drugs for Labor Oxytocics Uterine stimulants Reproductive System Drugs Oxytocin (Pitocin. Suckling stimulates release of oxytocin. SE: TC. preg> can cause premature labor. stimulate uterine contractions to induce labor. Restores normal hormonal balance. uterine lacerations/perforation due to intense contractions. seizures. Replacement of female sex hormones. To induce labor by ↑frequency & force of uterine contractions. ↑risk of CAD. jaundice. Monitor frequency/duration of contractions. N/V. AE: after the use for 36 months osteoporosis. SE: v libido. HA. 1st line for premenstrual syndrome is Zoloft & Prozac (phsycologycal effects of it). pruritis. Teratogenic! Estrogen-progestin combinations used during/after menopause. uterine cramping AE: N/V/D. AE: fetal dysrhythmias/intracranial hemorrhage. hypertensive crisis may occur if combined w local/regional anesthesia. Estrogen causes proliferation of endometrium. ovarian cyst/ovarian enlargement. Discontinue if fetal distress. # 1 choice to treat uterine abnormalities (dysfn uterine BL. unengaged fetal head. To treat unpleasant symptoms of menopause. anxiety. Hemorrhaging that occurs on noncyclic basis or in abnormal amounts. HPT/HTN. HTN is potential AE of androgen Tx of enmetriousis.natural hormone secreted by posterior pituitary. Risk for imbalanced fluid volume (excess. progesterone limits & stabilizes endometrial growth. edema (WG). PE. NOT for uncontrolled thyroid/adrenal dysfn.

mental depression. ↑ appetite. lots of fluids. ↓viscosity of mucus. DIZ. capillaries & nerves during AR. nervousness. No alcohol – SED. non-productive hacky cough. DROW. ↑water content of mucus. oropharyngeal candidiasis (rinse mouth after). For allergic rhinitis. For productive COPD. DIZ. For CF. AE: irritate airways. No alcohol – SED. oral form generalized vasoconstriction & TC. 1st gen SE: SED. PUD. osteoporosis. ↓immune fn. fatigue. osteoporosis. -nide -solone -predPred- Steroids Glucocorticoids -mine -dine -zine -tadine Antihistamines H 1 blocker 1st gen (more sedating): Diphenhydramine (Benadryl) 2nd gen (less sedating): Loratadine (Claritin) Fexofenadine (Allegra) Expectorants Guaifenesin (Musinex) Acetylcyteine (Mucomyst) Mycolytics . -rine -line Decongestants (Upper) vasoconstrictors For sinusitis relieving nasal stuffiness. dyspnea. WBC count!!! Nasal SE: cataract/glaucoma. pneumonia. AE: acute toxicity. fluid retention. 1st line asthma prophylaxis therapy!! Acute attacks of severe COPD. non-productive hacky cough. AE: ACH SE. N/V. RD. Benadryl overdose can produce TC. NFC<5 years -sone. TC. Nasal drops for allergic rhinitis should be adm in position: lateral w head in low position for best effect. For dry. GIU.work by constricting blood vessels. DROW. nasal is better than oral because of systemic effect related to oral. palpitations. HTN. When used over 5 days> rebound nasal congestion. NOT for adren suppr. NOT for BPH and glaucoma. DO NOT use longer 3-5 days. Humidifier. SED. dysphonia (use spacer). No alcohol-SED. SE: GIU. SED. breast tenderness. leading to bronchospasm/aspiration. anxiety (systemic effects). growth suppr. acne. TC. ACH SE. AE: HPT/HTN. WG. CF. Flovent) Beclomethasone (QVAR) Oral (acute attack): Prednisone. edema. Block H 1 receptor on the surface of basophils and mast cells. N. HPT. For dry. CON. antedote for acetaminophen overdose. PUD. HA. Fever if w MAOI. NOT for preg/breastfeeding. GIU. NFC<4 years Lyses protein bonds in mucus. NOT productive cough!! SE: DROW. Suppress inflam by v histamine release/vascular permeability (edema)/eosinophil infiltration. SE: N/V. bronchitis. Prednisone: ↓body responses to vaccines ↑risk of infection from live vaccines> wait until completed med. nd 2 gen SE: HA. acute pancreatitis. Sympathomimetics . N/V. CA. blocking of histamine release in the small blood vessels. fatigue. Tx<5 years! AE: N. abd cramps & bloating. ↑risk: cardiac problems. Oral SE: HG. for short term relief in bronchitis. seizures. hallucinations.(Premarin) Conjugated estrogens w medroxyprogesterone (Prempro) Respiratory Drugs Antitussives (URI) Opioids Antitussives (URI) Non opioids Codeine Hydrocodone Dextrometrophan (DM/DMX) Benzonatate (Tessalon) Dephenhydramine (Benadryl) Nasal: Phenylephrine (Neo-Synephrine) Oxymetasoline(Afrin) Oral: Pseudoephredrine (Sudafed) Nasal (prophylaxis): budesonide (Rhinocort. stroke. expensive. DIZ. coma. ↓libido. Pulmicort) Fluticasone (Flonase. Extra calcium and vit D required. WG. to↓inflam/insomnia/anaphylaxis/ motion sickness. cardiac disorders. Peds – paradox reaction. No alcohol-SED. NOT productive cough!! SE: DROW. Prednisolone bone loss. fluid retention. HA. NOT for chronic bronchitis/COPD could worsen hypoxia due to RD & R distress caused by ↑viscosity of secretions. AR>rash. DO NOT smoke (trombophlebitis)!! Estrogens ↓warfarin EE. DIZ. AE: HTN. DROW.

No anti inflam action. For all seizures except absence. NOT for PUD. skin rash. Prophylaxis. report ↑need for bronchodilator.-terol SABA bronchodialators Beta 2 agonists Albuterol (Proventil) Levalbuterol (Xopenex) -terol LABA bronchodialators Beta agonists Formoterol ( Foradil) Salmeterol (Serevent) -tropium Anticholinergic Bronchodialators (Inhaled) Ipratropium (Atrovent) Tiotropium (Spirivia) -phylline Xanthine Bronchodialators (methylxanthines) Theophylline Amynophylline -luk-leu- Leukotriene modifiers (inhibitors) Zafirlukast (Accolate) Motelukast (Singular) Zileuton (Zyflo) Cromolyn Sodium (Intal. Wait at least 5 min bw different drugs. HA. endocrine effects. hypokalemia. Zileuton (Zyflo)& Zafirlukast (Accolate )SE: LD Mediator release inhibitor. cough. dysrhythmias. Theophylline toxicity>20 mcg/ml: TC. SE: dry mouth. nervousness. seizures. 1st line for COPD. For Asthma prophylaxis. NasalCrom) Omalizumab (Xolair) Epinephrine (Adrenaline) Mast Cell Stabilizers Anti-inflammatories Monoclonal antibody For Asthma. KD. Give 15 min prior to exercise! Safest of all asthma meds. allergy mediated asthma. palpitations. Stimulate B receptors in lungs & relax smooth muscle. heart defects). HA. SE: URI. For C>6 years. 2nd line drug. CA 1 For severe Asthma attack. cardiac dis (TC). skeletal muscle tremor. irritability. taste perversion. ↑BS AE: hypersensitivity. Seizures Drugs Phenobarbital (Luminal) Phenytoin (Dilantin) . nervousness. seizures. confusion. GI BL. HA. Antagonism of Ig E. Long acting. Block bronchoconstriction and eosinophil infiltration mucus production and airway edema. Always give bronchodilator 1st. NOT for peanut allergy (inhaled aerosol contains soya lecithin) SE: local ACH SE. nervousness. Acute Attack. bronchospasm(paradox). AE: angina. anxiety. Can v bronchoconstriction. MI. bad taste in mouth. hyperactivity. Cause cAMP build up (smooth muscle relaxant. LD. may aggravate DM. partial seizures. cardiac arrhythmias. dry mouth.↓mucus secretion. Few AE because syst absorption is poor: ACH SE For Asthma. ↓mediator release from mast cells) CNS stimulant. insomnia. coma. Take once in p. insomnia.Toxicity: nystagmus. Relax smooth muscle. used to relax bronchial smooth muscle & dilate airway.↑phenytoin levels w alcohol. anaphylaxis. HPT. For Asthma. epitaxis. AE: TC & HTN For Tonic-clonic seizures. SE: CNS effects. pinpoint pupils. Short acting Rapid onset. muscle cramps. nasal dryness. RD. arrhythmias. Blocks constriction of airway smooth muscle & blocks production of mucus. sinusitis. TC. slower onset of action. Prophylaxis. NO bronchodilation. HTN. malignancy.N. Prophylaxis. Less potent than Beta agonists.m. seizures. viral infection. ataxia. prophylaxis. anaphylaxis. death. ↑BP&HR. restlessness. HPT. SE: tremors. ↓effect of oral contraceptives/Warfarin (Coumadin)/ glucocorticoids. If use> 2x week call Dr b/c asthma is not under control. angina. insomnia. hoarsness. For Asthma & COPD. diazepam. HA. AE: GI ulcers. SE: N. CNS SE: adultsDROW. children-irritability. gingival hyperplasia> let the dentist know about this med. LT. anxiety. pharyngitis. HPT). tremors. teratogenic effects (cleft palate. CNS stimulant. cardiovascular (dysrhythmias. heart attack.

For Tonic-clonic seizures. carbamazepine & phenobarbital. anxiety). heart arrhythmias. partial seizures. For partial seizures. pancreatitis. phone calling. fatigue. myxedemia.Carbamazepine (Tegretol) Ethosuximide (Zarontin) Valproic acid (Depakote) Gabapentin (Neurontin) Diazepam (Valium) Insomnia Benzodiazepine agonists (#1)or nonBenzo Sleep Drugs Zolpidem (Ambien) Eszopiclone (Lunesta) Zaleplon (Sonata) Trazodone (Desyrel) cimetidine & valproic acid. HPG. DO NOT stop suddenly (withdrawal. SE: sleepiness. absence seizures. Additive CNS depression with barbiturates & alcohol.↓phenytoin levels w chronic alcohol use. Older: falls & urinary incontinence. fatigue. UR. DIZ. SE: CNS effects For static epilepticus—medical emergency. dependence. hypo-osmolarity that puts CHF clients at risk for fluid overload. neuropathic pain. anemia. galactorrhea) NOT for preg. infertility. GIU. DIZ. Phenytoin & phenobarbital↓effects of carbamazepine. glaucoma. Keep a seizure frequency chart to determine the effectiveness. edema face/hands. Short acting /short term use (7-10 days). anterograde amnesia.e For absence seizures only. tonic-clonic seizures. blurred vision. HA. eating. teratogenesis. irritability. SE: CNS effects. SE:N/V. bipolar dis. DIZ. ↓libido. -pam -lam Benzodiazepine (sedative hypnotics) Temazepam (Restoril) Clonazepam (Klonopin) Lorazepam (Ativan) Alprazolam (Xanax) Chlordiazepoxide (Librium) Diphenhydramine (Benadryl) Hydroxyzine (Atarax. dry skin. NOT for elder: risk for SE (daytime sleepiness. DIZ) and drug interaction. If↓ libido> report ↓T3/T4. SLEEP-RELATED BEHAVIOR. SE: RD. CON. hyponatremia. SE: day time sleepiness. Addictive. SE: next day DROW. slow speech/ memory/DTR. WG. DO NOT eat high fat foods (↓absorption). Act on neurotransmitter gamma-aminobutyric acid (GABA-A) receptor sites in the brain to induce sleep. For partial seizures. It ↓the time to fall asleep & the time spent asleep. Can help mild insomnia w/o daytime sleepiness. SE: RD (IV). ↑TSH. anterograde amnesia. bipolar dis. Grapefruit inhibits drug metabolism. teratogenic Sedative hypnotics # 1 choice. ↑levels of phenytoin & phenobarbital. CNS effects. Vistaril) Trazodone (Desyrel) Tylenol PM Melatonin Ramelteon (Rozerem) -mine -zine Antihistamines Sedating Antidepressants Pain Relievers Supplement Hypothyrodism Thyroid problems drugs . indigestion. DO NOT use CNS depressants>additive effects. daytime sleepiness. Improve both sleep maintenance & daytime alertness. S&S: BC. blood dyscrasias (leukopenia. SLEEP-RELATED BEHAVIOR (sleep driving. cognitive impairment. Zolpidem (Ambien) for older : confusion!!! For anxiety/seizure dis/insomnia/muscle spasm/alcohol withdrawal/panic dis/anesthesia. insomnia. unrestful sleep. skin disorders.↓effects of oral contraceptives & Warfarin. LT. arthralgias. indigestion. Congenital causes cretinism. dry mouth. fatigue. migraine HA prevention. NOT for angina. thrombocytopenia). Slow metabolism. SE: N/V. daytime sleepiness. Used as mild sleep inducers. goiter. Temazepam (Restoril): schedule IV drug low potential for abuse. hyperkalemia. leading to↑serum drug levels. AE: hormonal effects (amenorrhea. sleepwalking) NO alcohol (CNS depressants). thrombocytopenia. trigeminal & glossopharyngeal neuralgias. Used for secondary insomnia caused be DN. migraine HA.

HA. AE: angina. AE: bone marrow suppr (low RBC/WBC/platelets. Calcium decreased peristalsis>constipation. Prevalence proportion can be calculated given how many people were affected at a given time and the total population. Hyperthyrodism Thyroid problems drugs ↑T3/T4. AGRANULOCYTOSIS (WBC die). N. s&s: palpitation (TACH). infection. Radioactive Iodine Radioactive Iodine hypothyroidism (intolerance to cold. BC. SOB. bruising). WL. 300 people living w asthma in a town of 4000. cauliflower. pepperoni. limit creams/thickened soups and premade salads. HB. Incidence proportion. Brown rice has least sodium. soy sauce. Individuals exposed to pertussis should be treated prophylactically with erythromycin for 7 days. DN). HF. red wine. D. same brand. hyprenatremia. Well-seasoned/hot (T) food can worsen nausea. Tx is effective if TSH =0. BC. DM. Etiology: high dose amidarone. NOT for preg. Do not eat 1-2 hrs b/f radiation Tx. Avoid crowds. cabbage. COPD. Block Beta Blockers Propranolol (Inderal) sympathetic nerve system effect “fight or flight”. Dose: start low go slow. DN). soups. SE: (Nonselective) impotence. SE/AE: radiation sickness. Yogurt provides 9 essential amino acids. WG. DO NOT substitute. avocado. hypokalemia. don’t share utensils. BC.HYPERTONIC solution. flush twice. wheezing. Same time. some beers. no kissing/sex for 5 days. Due to Propylthiiouracil (PTU) overmedication signs of hypothyroidism (intolerance to cold. salami.↑RR. DTap 5 doses starting at 2 months. thyroidectomy Surgical intervention D5LR – Dextrose 5% in lactated Ringer’s . HG. lifelong therapy. Take it after breastfeeding. 1 artichoke – 135 mg of calcium. D5W – Dextrose 5% in water – ISOTONIC solution. insomnia. If thyroid CA. NOT for asthma. “Thyroid crisis” untreated thyroitoxicosis.↑appetite/BM/DTR. HTN. figs. SE: rash. muscle weakness. LR – Lactated Ringer’s – ISOTONIC solution to expand blood volume>prevent shock Tyramine-rich foods: aged cheese. HB! dyspnea. bronchospasm. bananas. Takes weeks to work. During lactation your caloric intake by 300-400 cal /day. ↑risk of BL w Coumadin. Swimming is not weight bearing exercise. anemia. To↓TC & tremors in pt w hyperthyroidism. LT. protein dieteary supplements. dysrhythmias.↓TSH. soybeans) 1 cup of low-fat yogurt 314 mg of calcium. DIZ.5 to 2. chest pain. fatigue. insomnia. Chicken liver source of folate. Diet high in fiber improves cholesterol levels. warm skin. bone marrow depression. TH Replacement Therapy Levothyroxin (Synthroid) . no crowds. seizures. incomplete protein. Mashed potatoes are good choice. Green leafy veg Vit K (dark green leafy vegetables. Pinto beans – plant protein. edema. AE: BC. attack rate. meatcomplete (animal) protein. Calcium suppl interfere with absorption!!! If dry/itchy skin dosage need to be↑. heat intolerance. Caffeine can aggravate diarrhea.Only Hep B vaccine is given at birth. moist skin. smoked fish. WG. Faster metabolism. heart attack. HG. nervousness. 3500 calories a week (500 cal a day) = 1 lb weight gain. For those not candidates Anti-thyroid drugs Methimazole (Tapazole) for radiation/prior to surgery & radiation. inhance effect of coumadin. Chemotherapy reciepients: discard leftover food after 3 days. muscle/joint aches. Baked Potatoes have the highest glycemic index 85. anxiety.Work like pt own TH. Cirrhosis & ascites: limit your sodium intake to 1-2 g/day to decrease fluid retention. monitor jaundice. goiter. ½ cup of spinach 122 mg of calcium. EXOPHTALMOS!! Systolic BP of 170 is indicative of thyroid storm> report Inhibit thyroid hormone synthesis. DO NOT stop taking suddenly. SE: TC. Vit D helps increase absorption of calcium. cheddar cheese 1 oz 214 mg of calcium. Sole use of bathroom. EE:↓HR (opposite of hyperthyroidism). DM 1: limit sautéed/breaded/fried foods. edema. Investigating health hazards of local community is a component of the public health core fn of assessment.

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