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1.{American Academy of Pediatrics Subcommittee on Hyperbilirubinemia (July 2004). "Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation". Pediatrics 114 (1): 297–316.}

2 Ip S, Glicken S, Kulig J, Obrien R, Sege R, Lau J. Management of Neonatal Hyperbilirubinemia. Rockville, MD: .(Effect of Bilirubin on the Central Nervous System US Department of Health and Human

Services, Agency for Healthcare Research and Quality; 2003. AHRQ Publication 03-E011 ) • 3.Hovi L, Siimes M. Exchange transfusion with fresh heparinized blood is a safe procedure: Experiences from 1069 newborns. Acta Paediatr Scand.1985;74 :360– 365) • 4.Jackson JC Adverse events associated with exchange transfusion in healthy and ill newborns. Pediatrics.1997;99(5) • •
4.Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 2004;114(1):297-316.)

5. ( Subcommittee on hyperbilirubinemia management of

hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. Pediatrics 114, 297-316 (2004).

• • 6.National guidelines that provide a system-based framework for the prevention and management of hyperbilirubinemia in newborn infants of 35 or more weeks of gestation. ) 7.(Bhutani VK, Johnson LH, Maisels MJ et al.: Kernicterus: epidemiological strategies for its prevention through systems-based approaches. J. Perinatol. 24, 650-662 (2004)

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• • 8.Johnson L, Bhutani VK, Karp K, Sivieri EM, Shapiro SM: Clinical report from the pilot USA Kernicterus Registry (1992 to 2004). J. Perinatol. 29(Suppl. 1), S25-S45 (2009). ) 7.Engle WA, Tomashek KM; Committee on Fetus and Newborn: 'Latepreterm' infants: a population at risk. Pediatrics 120, 1390-1401 (2007). 8.(Kaplan M, Renbaum P, Levy-Lahad EM et al.: Gilbert syndrome and glucose-6-phosphate dehydrogenase deficiency: a dose-dependent genetic interaction crucial to neonatal hyperbilirubinemia. Proc. Natl Acad. Sci. USA 94, 12128-12132 (1997).

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8. Kaplan M, Beutler E, Vreman HJ et al.: Neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient heterozygotes. Pediatrics 104, 68-74 (1999). • 9. Kaplan M, Muraca M, Hammerman C et al.: Imbalance between production and conjugation of bilirubin: a fundamental concept in the mechanism of neonatal jaundice. Pediatrics 11(4), E47 (2002). • 10. Kaplan M, Hammerman C: The need for neonatal glucose-6phosphate dehydrogenase screening: a global perspective. J. Perinatol. 29(Suppl. 1), S46-S52 (2009). • 10. Johnson L, Bhutani VK, Karp K, Sivieri EM, Shapiro SM: Clinical report from the pilot USA Kernicterus Registry (1992 to 2004). J. Perinatol. 29(Suppl. 1), S25-S45 (2009). 11. Wennberg RP, Ahlfors CE, Bhutani VK, Johnson LH, Shapiro SM: Toward understanding kernicterus: a challenge to improve the management of jaundiced newborns. Pediatrics 117, 474-485 (2006) 12. Maisels MJ, Bhutani VK, Bogen D, Newman TB, Stark AR, Watchko J: Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. A commentary. Pediatrics (2004

14. .Newman TB, Liljestrand P, Escobar GJ: Infants with bilirubin levels of 30 mg/dl or more in a large managed care organization. Pediatrics 111(6 Part 1), 1303-1311 (2003). Harris MC, Bernbaum JC, Polin JR, Zimmerman R, Polin RA: Developmental follow-up of breastfed term and near-term infants with marked hyperbilirubinemia. Pediatrics 107, 1075-1080 (2001). Hankø E, Lindemann R, Hansen TW: Spectrum of outcome in infants with extreme neonatal jaundice. Acta Paediatr. 90(7), 782-785 (2001). 16. Bhutani VK, Johnson L: A proposal to prevent severe neonatal hyperbilirubinemia and kernicterus. J. Perinatol. 29(Suppl. 1), S61-S67 (2009). 17. .Ip S, Chung M, Kulig J. et al. An evidence-based review of important issues concerning neonatal hyperbilirubinemia. Pediatrics.2004;113 (6).) (American Academy and of Pediatrics, A Steering taxonomy Committee of on Quality

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45. (Hansen TW. Kernicterus: an international perspective. Semin Neonatol. 2002 Apr;7(2):103-9.) 46. Unconjugated bilirubin exposure impairs hippocampal long-term synaptic plasticity. ) Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. 47. (The PLoS Medicine Editors Are we publishing “the right stuff”? PLoS Med. 2006;3:e512. doi: 10.1371/journal.pmed.0030512.) 48. Gordon AL, English M, Dzombo JT, Karisa M, Newton CR. Neurological and developmental outcome of neonatal jaundice and sepsis in rural Kenya. Trop Med Int Health. 2005;10:798–817. 49. Vinod K. Bhutani ,Screening for HyperbilirubinemiaPediatr Health. 2009;3(4):369-379) • Severe Neonatal

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51. Lucy M.Osborn,Carl Lenarsky,Raymond C.Oakes,and Michael I.Reiff Phototherapy in Full-Term Infants With Hemolytic Disease Secondary to ABO IncompatibilityPediatrics 74:371-374,september 1984.)

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60. .( Newman TB, Liljestrand P, Jeremy RJ, Ferriero DM, Wu YW, Hudes ES, Escobar GJ; Jaundice and Infant Feeding Study Team.Outcomes among newborns with total serum bilirubin levels of 25 mg per deciliter or more. N Engl J Med. 2006 May 4;354(18):1889-900.)

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81. .( Vohr BR, Lester B, Rapisardi G, O'Dea C, Brown L, Peucker M, Cashore W, Oh W.Abnormal brain-stem function (brain-stem auditory evoked response) correlates with acoustic cry features in term infants with hyperbilirubinemia. J Pediatr. 1989 Aug;115(2):303-8. (SourceNeonatal Follow-up Clinic, Women and Infants' Hospital, Providence, RI 02905.) 82. HUANG, MAY-JEN; KUA, KA-EM; TENG, HSIU-CHEN; TANG, KUNGSHENG; WENG, HUI-WEN; HUANG, CHING-SHAN Risk Factors for Severe Hyperbilirubinemia in Neonates PEDIATRICS Vol. 21 No. 1 January 1958, pp. 27-39 83. .( Martin K. Gorten M.D.1, Sheila Shear 1, Marilee Hodsdon 1, , Samuel P. Bessman M.D.1 COMPLICATIONS OF HYPERBILIRUBINEMIA IN THE NEWBOR—POSSIBLE RELATION TO THE METABOLISM OF AMMONIA 1 Department of Pediatrics, University of Maryland Medical School 84. ( Factors influencing the incidenc eof neonatal jaundice, The British Medical Journal.1978) 85. Albert Einstein College of Medicine, Bronx, New York; Effect of Neonatal Jaundice and Phototherapy on the Frequency of First-Year Outpatient Visits. [My paper] Danielle Usatin, Petra Liljestrand, Michael W Kuzniewicz, Gabriel J Escobar, Thomas B Newman 86. Michael Kuzniewicz, Thomas B Newman Interaction of hemolysis and hyperbilirubinemia on neurodevelopmental outcomes in the collaborative perinatal project. Pediatrics. 2009 Mar ;123 (3):1045-50 87. Petra Liljestrand, Rita J Jeremy, Yvonne W Wu, Donna M Ferriero, Gabriel J Escobar, Thomas B Newman Use of the motor performance

checklist to study motor outcomes in 5-year-olds. J Paediatr Child Health. 2007 Sep 3;: 88. Fang-Yu Chang, Cheng-Che Lee, Chiung-Chun Huang, Kuei-Sen Hsu ,Unconjugated bilirubin exposure impairs hippocampal long-term synaptic plasticity.Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan. ) 89. .( B O Olusanya, A O Somefun Ann ,Sensorineural hearing loss in infants with neonatal jaundice in Lagos: a community-based study. Ann Trop Paediatr. 2009 Jun ;29 (2):119-28 ) 90. Ruth Heimler, Ponthenkandath Sasidharan , Neurodevelopmental and audiological outcome of healthy term newborns with moderately severe non-haemolytic hyperbilirubinemia. J Paediatr Child Health. 2010 Jul 7;: 91. Weir, C. and Millar, W. S. (1997), The Effects of Neonatal Jaundice and Respiratory Complications on Learning and Habituation in 5- to 11-month-old Infants. Journal of Child Psychology and Psychiatry, 38: 199–206. doi: 10.1111/j.1469-7610.1997.tb01854.x) 92. Clarós P, Turcanu D, Caballero M, Costa C, Clavería MA, Clarós A Jr, Clarós A[Sensorineural hearing loss due to neonatal hyperbilirubinemia]. [Article in Spanish] 94. .( Newman TB, Maisels MJ.Does hyperbilirubinemia damage the brain of healthy full-term infants? Clin Perinatol. 1990 Jun;17(2):33158.Department of Pediatrics, University of California, San Francisco)

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Iraq. [Journal Article, Research Support, Non-U.S. Gov't]Neonatology 2011; 100(1):57-63. 99. .( Michael Kaplana, b, Ruben Bromikera, b, Cathy Hammermana, bSevere Neonatal Hyperbilirubinemia and Kernicterus: Are These Still Problems in the Third Millennium? Neonatology 2011;100:354-362 ) 100. McNamee MB, Cardwell CR, Patterson CC (july 2011 )Neonatal jaundice is associated with a small increase in the risk of childhood type 1 diabetes: a meta-analysis of observational studies. [JOURNAL ARTICLE]Acta Diabetol 2011 Oct 9.) 101. .( Arun Babu T, Bhat B V, Joseph NM. Association between Peak Serum Bilirubin and Neurodevelopmental Outcomes in Term Babies with Hyperbilirubinemia. Indian J Pediatr. 2011 Jun 25.) 102. .( Usatin D, Liljestrand P, Kuzniewicz MW, Escobar GJ, Newman TB.Effect of neonatal jaundice and phototherapy on the frequency of first-year outpatient visits. Pediatrics. 2010 apr;125(4):729-34. Epub 2010 Mar 15.)

103. Maimburg RD, Vaeth M, Schendel DE, Bech BH, Olsen J, Thorsen P.Neonatal jaundice: a risk factor for infantile autism? Paediatr Perinat Epidemiol. 2008 Nov;22(6):562-8.)

104. Maimburg RD, Bech BH, Vaeth M, Møller-Madsen B, Olsen J.Neonatal jaundice, autism, and other disorders of psychological development. Pediatrics. 2010 Nov;126(5):872-8. Epub 2010 Oct 11.) 105. Oh W, Tyson JE, Fanaroff AA, Vohr BR, Perritt R, Stoll BJ, Ehrenkranz RA, Carlo WA, Shankaran S, Poole K, Wright LL ,Association between peak serum bilirubin and neurodevelopmental outcomes in extremely low birth weight infants. Pediatrics. 2003 Oct;112(4):773-9.) 106. .( Oh W, Stevenson DK, Tyson JE, Morris BH, Ahlfors CE, Bender GJ, Wong RJ, Perritt R, Vohr BR, Van Meurs KP, Vreman HJ, Das A, Phelps DL, O'Shea TM, Higgins RD; NICHD Neonatal Research Network Bethesda MDInfluence of clinical status on the association between plasma total and unbound bilirubin and death or adverse neurodevelopmental outcomes in extremely low birth weight infants. Acta Paediatr. 2010 May;99(5):673-8. Epub 2010 Jan 25.)

107. .( Wolf MJ, Wolf B, Beunen G, Casaer P.Neurodevelopmental outcome at 1 year in Zimbabwean neonates with extreme hyperbilirubinaemia. Eur J Pediatr. 1999 Feb;158(2):111-4.)

108. Heimler R, Sasidharan P.Neurodevelopmental and audiological outcome of healthy term newborns with moderately severe nonhaemolytic hyperbilirubinemia. J Paediatr Child Health. 2010 Oct;46(10):588-91. 109. Mukhopadhyay K, Chowdhary G, Singh P, Kumar P, Narang A.Neurodevelopmental outcome of acute bilirubin encephalopathy. J Trop Pediatr. 2010 Oct;56(5):333-6. Epub 2010 Feb 1.) 110. .( Aspberg S, Dahlquist G, Kahan T, Källén B.Is neonatal phototherapy associated with an increased risk for hospitalized childhood bronchial asthma? Pediatr Allergy Immunol. 2007 Jun;18(4):313-9. Epub 2007 Mar 7.)

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112. Brand PL, van de Bor M, Fetter WP, Kollée LA, de Leeuw R, de Nef JJ.Hyperbilirubinemia in full-term neonates: sequelae for long-term development better than expected. Ad-hoc Commission Hyperbilirubinemia and Phototherapy of the Section Neonatology of the Netherlands Society for Pediatrics]. Ned Tijdschr Geneeskd. 1997 Jan 18;141(3):144-7. [Article in Dutch]

113. Seidman DS, Paz I, Stevenson DK, Laor A, Danon YL, Gale R.Neonatal hyperbilirubinemia and physical and cognitive performance at 17 years of age. Pediatrics. 1991 Oct;88(4):828-33. 114. Seidman DS, Paz I, Stevenson DK, Laor A, Danon YL, Gale R.Effect of phototherapy for neonatal jaundice on cognitive performance.J Perinatol. 1994 Jan-Feb;14(1):23-8.) 115. (Ozmert E, Erdem G, Topçu M, Yurdakök M, Tekinalp G, Genç D, Renda Y.Long-term follow-up of indirect hyperbilirubinemia in full-term Turkish infants. Acta Paediatr. 1996 Dec;85(12):1440-4.) 116. .( Kuzniewicz M, Newman TB.Interaction of hemolysis and hyperbilirubinemia on neurodevelopmental outcomes in the collaborative perinatal project. Pediatrics. 1993 Jan;91(1):164; author reply 165-6.

117. van de Bor M, Ens-Dokkum M, Schreuder AM, Veen S, Brand R, Verloove-Vanhorick SP.Hyperbilirubinemia in low birth weight infants and outcome at 5 years of age. Pediatrics. 1992 Mar;89(3):359-64.) 118. Newman TB, Klebanoff MA.Neonatal hyperbilirubinemia and longterm outcome: another look at the Collaborative Perinatal Project. Pediatrics. 1993 Nov;92(5):651-7.) 119. Croen LA, Yoshida CK, Odouli R, Newman TBNeonatal hyperbilirubinemia and risk of autism spectrum disorders. Pediatrics. 2005 Feb;115(2):e135-8.) 120. Scheidt PC, Bryla DA, Nelson KB, Hirtz DG, Hoffman HJPhototherapy for neonatal hyperbilirubinemia: six-year follow-up of the National Institute of Child Health and Human Development clinical trial. Pediatrics. 1990 Apr;85(4):455-63. 121. .( Scheidt PC, Graubard BI, Nelson KB, Hirtz DG, Hoffman HJ, Gartner LM, Bryla DA.Intelligence at six years in relation to neonatal bilirubin levels: follow-up of the National Institute of Child Health and Human Development Clinical Trial of Phototherapy. Pediatrics. 1991 Jun;87(6):797-805.) 122. (Hosono S, Ohno T, Kimoto H, Nagoshi R, Shimizu M, Nozawa M, Harada KFollow-up study of auditory brainstem responses in infants with high unbound bilirubin levels treated with albumin infusion therapy. Pediatr Int. 2002 Oct;44(5):488-92.) 123. Shapiro SM.Bilirubin toxicity in the developing nervous system. Pediatr Neurol. 2003 Nov;29(5):410-21. 124. Funato M, Teraoka S, Tamai H, Shimida S.Follow-up study of auditory brainstem responses in hyperbilirubinemic newborns treated with exchange transfusion. Acta Paediatr Jpn. 1996 Feb;38(1):17-21.) 125. Chen WX, Wong VC, Wong KY.Neurodevelopmental outcome of severe neonatal hemolytic hyperbilirubinemia.J Child Neurol. 2006 Jun;21(6):474-9.)

126. Govaert P, Lequin M, Swarte R, Robben S, De Coo R, WeisglasKuperus N, De Rijke Y, Sinaasappel M, Barkovich J.Changes in globus pallidus with (pre)term kernicterus. Pediatrics. 2003 Dec;112(6 Pt 1):1256-63.)

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• Deepeshwara Nepal; Dinesh Banstola; Ajaya Kumar Khakal; Udbhabhat Mishra; Chandeshawar MahesethClinico-Laboratory Profile and Immediate Outcomes of Hyperbilirubinemic Babies Admitted in Kanti Children Hospital

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