The TWiV posse considers viral insulin-like peptides encoded in fish genomes, and insect antiviral immunity by production of viral DNA from defective genomes of RNA viruses. Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Kathy Spindler, and Brianne Barker Become a patron of TWiV! Links for this episode ASM Microbe 2018 Insulin-like peptides in Iridovirus genomes (PNAS) Dicer-2 dependent generation of cvDNA from defective genomes (Cell Host Micr) Carla Saleh on insect antiviral immunity (TWiV 301) RNAseIII ancient antiviral RNA platform (TWiV 450) cvDNA precursor to EVEs (TWiV 482) Image credit: Paul Young Letters read on TWiV 485 Weekly Science Picks Kathy - Vegas casinos lost money on physicists Brianne - Astronaut twin's DNA is not 7% different! Dickson - Parasitic Diseases lecture videos Alan - In Season blog by Donna Long Vincent - Buckyball viruses Listener Picks Paul - Wine labels (front, back) Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv