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Michael L. Villavert BSN 33rd Batch
Objectives • • • • To know and describe what stem cells are. To know what stem cell technology is. To know the different types of stem cells. • To know the recent advances involving stem cells. To know how stem cells originated and how it was discovered. .
geneticists. and clinicians and offers hope of effective treatment for a variety of malignant and non-malignant diseases • a field of medical research studying human and animal stem cells .Stem Cell Technology • a rapidly developing field that combines the efforts of cell biologists.
• If allowed to reach their full potential. . they could be used to treat and cure various diseases and conditions.What are stem cells??? • Stem cells are cells without specific structure that may give rise to other kinds of cells.
– granulocytes – megakaryocytes. Ernest Armstrong McCulloch and Dr. These Canadian physician scientists were studying mouse hematopoiesis (blood formation) and identified cells that when transplanted into irradiated mice would give rise to individual cellular colonies on the host spleen. these colonies underwent self-renewal and were differentiating into three different cell lines: – erythrocytes (red blood cells). Microscopically. James Edgar Till during the early 1960s (1).History The origination of stem cell research must mention the studies of Dr. .
over 50 years earlier. a hypothesis proposed by a Russian scientist.History • These results supported the Unitarian Theory of Hematopoiesis. Maximov. . and were heralded as the discovery of stem cells. Alexander A.
Types of Stem Cells • Totipotent – "total power" stem cells that can differentiate into any cell types. .
Types of Stem Cells • Pluripotent – stem cells that can form any cell type (e. embryonic stem cells) EXCEPT extraembryonic cells (i. those outside the embryo).e.g. .
g. . hematopoietic stem cell).Types of Stem Cells • Multipotent – have the power to differentiate into cells in the same family of cells (e.
.Types of Stem Cells • Oligopotent – stem cells may only differentiate into a subset of cells in a particular family (e. lymphoid or myeloid stem cells).g.
Types of Stem Cells • Unipotent – cells perform selfrenewal and are committed to a single cell type (e. . hepatocytes).g.
. and there is still much work to be done so that they may reach their full potential.How exactly do Stem Cells Treat Diseases? • Stem cells could be used to treat diseases because of their ability to become different types of cells. • The extent of stem cells' abilities to treat and cure diseases has not yet been fully discovered.
Stem Cell Advances • • • • • • ALS (Lou Gehrig’s Disease) Alzheimer’s Disease Blindness Blood Disorders Blood Supply Brain Tumors .
Stem Cell Advances • • • • • • • Cancer Cartilage Damage Diabetes Hearing Loss Heart Disease & Damage Infertility Lung Damage .
Stem Cell Advances • • • • • • • Multiple Sclerosis Muscular Dystrophy Organ Replacement Parkinson’s Disease Platelet Transfusions Spinal Cord Injury Tissue Damage .
Issues • Stem cell as cancer cells • Tissue rejection • Use of adult stem cells from other part of the body • Human stem cells from embryos .