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Influence of asthma definition on the asthma-obesity relationship


Andrea Antunes Cetlin1, Manoel Romeu Gutierrez2, Helosa Bettiol2, Marco Antnio Barbieri2

Laksmita Tetanel Harun Iskandar

Background
Overweight and obesity are major causes of

morbidity and mortality. The prevalence of asthma has experienced an increase, with rates that are greater today than they were 30 years ago. Different causes for this increase have been postulated. Epidemiological studies have suggested an association between obesity and asthma in adults and children

Methods
O This is a cross-sectional analysis of a

Brazilian population sample. We interviewed 2063 men and women aged 23 to 25 years randomly selected from a cohort of 6827 O singleton babies born during the years of 1978 and 1979 O in the city of Ribeiro Preto, a regional center in the Northeastern region of So Paulo State, SoutheasternBrazi

The ECRHS questionnaire translated into

Portuguese and adapted to the Brazilian lexicon was employed to evaluate respiratory symptoms and a previous physician diagnosis of asthma. Four questions of the ECRHS questionnaire were selected: a question about wheezing, about chest tightness, about night-time and daytime breathlessness at rest. The presence of any of these symptoms within the last 12 month in association with bronchial hyperresponsiveness (BHR) was defined as BHR-confirmed asthma

We also asked about physical activity

status, smoking status and educational level of the subjects. Physical activity status was defined as active if the subject regularly practiced physical activity, including activity at work and inactive when the reply was negative. determined by asking about the numbers of years of schooling and divided into three groups: 8 years or less, 9 to 11 years or 12 years or more. interview chart

Anthropometric evaluation
For the analysis of BMI (body mass index =

weight/height2), the subjects were divided into three groups: normal (BMI 24.9 kg/m2 ), overweight (BMI between 25.0 and 29.9 kg/m2) and obese (BMI 30 kg/ m2 )
Waist circumference was abnormal when

94 centimeters for men and 80 centimeters for women and normal when below these values

Bronchial responsiveness
The bronchial responsiveness to methacholine was

measured using the 2 minute tidal breathing method. Increasing concentrations of methacholine (0.06, 0.125, 0.25, 0.5, 1, 2, 4, 8, and 16 mg/mL) The provocative concentration causing a 20% fall in FEV1 (PC20 ) was calculated with Koko software. We considered PC20 4 mg/mL to indicate BHR The contraindications of the methacholine challenge test were all conditions that might compromise the quality of the test or that might subject the patient to increased risk or discomfort, including FEV1 < 60% of the predicted value, pregnancy, nursing mothers and inability to perform acceptable quality spirometry

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