Sistem Penghantaran Obat Mutakhir (Advanced Drug Delivery
Dr. Ahmad Kharis Nugroho, Apt. Dr.rer.nat. Ronny Martien C.M. Ratna Rini N., M.Pharm., Apt.
Drug delivery (system)?
Vehicle? Dosage form?
safely.Ultimate goal of drug delivery ?
To deliver the active pharmacological ingredients to the site of action. efficiently and effectively
Spatial placement site specific targeting delivery Temporal delivery rate / time efficiency
. 2.2 aspects of controlled release
Delivery design consideration
Disease/abnormalities determination Type and goal of therapy Criteria for ideal system Route of administration physiological condition Natural barrier anticipation Possibility of modification or combination of delivery
Points to concern
Challenges (read: barriers) of delivery Ideal system Technology development Critical factors
Type of drug delivery
Conventional drug delivery
Advanced drug delivery
General purposes of study
To gain better understanding of advanced drug delivery To distinguish the delivery systems based on the unique mechanisms To identify the critical factors on the delivery system studied
Students can explain the role of drug delivery system in encouraging patientoriented therapy Students are capable to distinguish the advanced drug delivery systems based on the mechanism of delivery and release Students are able to identify the critical factors of the delivery systems learnt
Conscience to develop
The objectiveness in accessing information Critical and logical thinking The importance of communication and team work/collaboration spirit Self confidence to decide the right things Imagination leading to creativity
Willingly to contribute to the transfer of correct information about drug delivery system Highly motivated to design the drug delivery system which fully concerns on patient’s overall condition
Week I-II Agenda Nanotechnology delivery PIC Dr.
Nanotech on cancer chemotherapy strategies Transdermal delivery
. Ronny Martien Dr. Ronny Martien Dr. Akhmad Kharis.
.Pharm.Pharm. M. M. Apt PIC to guide
Oral Modified Delivery
Week Agenda Mid exam VIII-X Pulmonary and nasal delivery Iin.
and Dr.Schedule description
Dr. M. Akhmad Kharis. is not available to give lectures on weekdays due to must-to-do agendas on Gadjah Mada University (there will be notification) Learning with Iin. Akhmad Kharis. Apt.Pharm will start after mid exam for 6 weeks
. Apt. Ronny Martien will teach on weekdays schedule for all classes Saturday classes are only carried out if Dr.
Distribution of assessment
I:K:R =50% : 25% : 25% Description of I mark:
exam : max 30 Assignment & presentation : max 20 (10 for presentation. 10 for discussion)
Learning together guided by bu iin
drug delivery (3) Nasal delivery (1) Sustained delivery & Pulsatile delivery (2) Oral macromolecular delivery (3)
.Activity class discussion
A class is divided into 9 groups@2 assignments Iin.
drug delivery (3) 2 meetings
and physiology of lung. lung natural defense and physical factors affecting drug disposition Design of pulmonary delivery system Exuberra® review
delivery (1) 1 meeting
of nose and reason behind delivery Design of nasal delivery system Review on pulmonary and nasal delivery
delivery & pulsatile delivery (2) 1
Oral macromolecular delivery (3) 2 meetings (+review and reflection) Strategy to overcome enzymatic barriers Role of penetration enhancers Strategy to overcome efflux pump
Aspects to discuss
Concept of delivery
of either the anatomy and physiology of the site of action or the physiological barriers The purpose of the delivery system
The unique mechanism of the system What critical factors to concern and why?
Use slides of Power Point (use 3 slides/page no more than 8 pages) No plagiarism!!! If you refer to any articles or figures. always refer on a right manner (with acknowledgement) and the statement of “only for learning purposes” Handout should be copied and distributed at least one day before class If the handout needs to be revised. revision will be done after class
See the SPO folder on Filey!