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Stem Cell Treatments What is available today?

Agenda
What is a stem cell? Types of stem cells How does the body naturally heal? What is Stem cell Therapy? Risks and secondary effects Myths of stem cells Current therapies

A cell is the basic functional structure of the human body


Tissue is formed by more cells Organs are formed by more tissues

Sistems are formed by more organs


A body is formed by many systems.

Mature Cells
A mature cell has specific functions depending on
the organ where it belongs.

A mature cell has a limited number of replications.

What is a Stem Cell?


A special type of cell, referred to as a master cell.
Is capable of reproducing itself many times: Produce a cell that has identical properties as the original. Is capable of differentiation into another kind of cell. (transformation
to another type of tissue).

Homing capability.

How does the body naturally heal?


When in balance, there is a life cycle.
Stem cell is born, travels to the tissue to be worked on, differentiates into that type of tissue (becomes tissue cell), when a cell of that tissue dies and is discarded, the new cell replaces it. We have continuous production of stem cells.

Out of balance, accelerated damaged cells.


Could be many reasons. Body does not release enough stem cells to repair damage. Chronic disease.

Types of stem cells by source


Embryonic They are located inside the blastocyte or embryos up to 8 weeks of fertilization. Adult stem cells. They are located all over a formed body with higher concentration on:
Cord blood and placenta Fat Bone Marrow

Types of stem cells by potential


Totipotent Could grow and form a complete new organism Pluripotent Could form any other kind of cell Multipotent Could diferentiate only on a cell of its line. Unipotent Only can form one type of cell

Why embryonic stem cells are controversial?


Pros:
They are Highly prolific- Very easy to duplicate They are Pluripotent - Can be differentiated into all kind of tissue
Has to come from a blastocyte - Embryo They are Pluripotent- could differentiate into unwanted kind of tissue on unwanted locations. They are Highly prolific- risk of growing theratomas Gene information is also transferred to recipient. Legal issues

Cons:

Culture and differentiation from embryonic stem cell

Adult stem cells


Pros:


Cons:

They are Highly prolific- but not unlimited They are Pluripotent or multipotent Primitive undifferentiated cells Easier access

Limited on proliferation Limited in quantity on some areas

Bone Marrow Stem Cell

What is Stem Cell Therapy?


Stem cell therapy = use of stem cells to treat medical conditions.

Difference between Infusion and Transplant Infusion: adding to your body. Reinforces your current tissues and systems (immunologic, neurologic and metabolic) Transplant: replacing an organ. Usually involves an organ transportation and storage, and an aggressive patient preparation.

Types of Transplant
Autologous- own tissue. Same donor and recipient. Homologous / Allogenic- Tissues from the same species Heterologous Tissue from other species

Risks and secondary effects of Stem cell therapy infusion


Autologous
Risk: Infection Secondary effects: head ache, bruise skin.

Allogenic
Genetic Disease transmission Low viability if not stored/processed properly Tissue rejection Secondary Effects: same as above and variable with the complications.

CAUTION: the more different the tissue is, the more aggressive the risks are. (example: animal stem cells)

Myths of stem cells


In the near future Stem cells will cure all and everyone! Stem cells cause theratomas. Stem cells from your own body cannot treat your own illness. All Stem cells are illegal. Stem cells therapies are super expensive, 50K+. Stem cells from Shark cartilage are much better. Stem cells from Placenta or Fat have 10x the number of cells compared to bone marrow or umbilical cord.

Conditions with the best results:


IMMUNOLOGICAL DISEASES
Rheumatoid Arthritis Fibromyalgia Sjgren Syndrome Systemic Lupus Psoriatic Arthritis Asthma

METABOLIC DISEASES
Diabetes Mellitus Cardiac Insufficiency Renal Insufficiency Hepatic Insufficiency

NEURODEGENERATIVE DISEASES
Multiple Sclerosis Parkinson's disease Alzheimer's disease

Conditions with the best results:


OPHTHALMIC DISEASES Maculopathy Diabetic Retinopathy Optic Nerve Atrophy Central Retinal Vascular Occlusion Other: Pediatric: Muscular dystrophia Immunologic Neurologic (Autism, Cerebral Palsy)

Healthy Aging (Anti-aging) Esthetics: Face lift, Hair growth

Trends
Bone Marrow Stem Cell Therapy
Been here for a few years and continues to grow.

Cord Blood Stem Cell Therapy


Still Being studied. Not so regulated Consequences because of being allogenic.

Fat tissue Stem Cell Therapy


Growing interest (easy to provide in a Drs office) Specially for Esthetics

Embryonic Stem Cell Therapy


Is going to take even longer to be useful.

The Procedure
Case Study: Consultation, Blood work, Specialist assessment (if needed). Patient Preparation Procedure:
Aspiration of Bone marrow with local anesthesia Cell preparation, Dilution, Cell concentration Infusion by IV and/or Catheter Direct injection to organs, Lumbar, joints, retro bulbar, thyroid, subcutaneous, injuries, etc.

Recovery/Observation after procedure


Usually, 3 day and 2 nights trip, but could be done in 1 day.

Patient steps for treatment


1. Study patients condition (Questionnaire, X-Ray, MRI, blood work, reports) 2. Medical team determines best therapy for specific case 3. Coordination and Scheduling (date of procedure, transportation, accommodation, meals, etc.) 4. Patient travel and logistics support. 5. PROCEDURE 6. Follow up (1 day, 7, 30, 60 and 90 days)

ProgenCell performs safe Stem cell therapies with NO complications up to date!


In other words, ProgenCell provides outpatient treatment to improve patients health conditions by autoinfusion of stem cells obtained from bone marrow.

Powerful, Practical and Cost Effective!

ProgenCell Results
More than 600 treatments No complications - very safe All cases have had improvement 50% excellent results, only one case with bad results because of other factors. Factors influencing the outcome Bone marrow condition Chronic Disease stage (advanced/early stage) Multiple conditions present Harmful habits

Medical Commitee
Our medical staff are pioneers in stem cell therapies, with more than 10 years of experience.

The Scientific and Ethic committees are formed by doctors with different specialties:
President of the Scientific Committee: Dr. Luis Romero President of the Committee of Scientists: Dr. Jorge Luis Gavio Internal Medicine: Dr. Miguel Angel Matildes Orthopedics: Dr. Joaqun Garcia Zeevaert Ophthalmology: Dra. Norma Nio Sulkowska Cardiology: Dr. Hctor Soto Espinoza Neurology: Dr Hugo Navarrete

Facilities
ProgenCell is located just one block inside Mexico, at the USMEXICO border.

Conclusions
Stem cell therapy is: Effective for selected cases. Is not for everyone and cant cure all. A new perspective in medicine. Treatment with scientific base Possible hope for current incurable diseases Definitely a promising future!

Learn more about stem cell therapies by contacting us!