Petanda Tumor Blok 25 Mei 2012

Sanarko Lukman Halim

Bagian Patologi Klinik Fakultas Kedokteran UKRIDA

2 Alfa Feto Protein (AFP) 4.1 Human Chorionic Gonadotrophin (HCG) 4. 10/11/2013 CA-125: . 3. 2.3 Cancer Antigen-125 ( CA125) 4.5 Carcino Embryonic Antigen (CEA) 5.4 CA 19-9 4.Sasaran Belajar : mahasiswa/I memahami tentang 1. α-Feto Protein 7. HCG: . Definisi PT (petanda tumor) Manfaat pemeriksaan PT Kriteria PT PT ginekologi 4. 4.pada Mola Hidatidosa 6.pada Endometriosis 2 .

Definisi Petanda Tumor (PT) Petanda Tumor adalah idikator biokimiawi yang diproduksi selektif oleh jaringan neoplasma. masuk dalam darah dan terdeteksi dalam darah atau cairan tubuh lain. Manfaat pemeriksaan PT :    Deteksi adanya tumor Monitor perkembangan penyakit Monitor keberhasilan pengobatan Tidak dapat untuk diagnosis primer tumor 10/11/2013 3 .

Enzymes.  Hormone. Kriteria petanda tumor Ideal : • • • Spesifik Sensitif Esei harus murah dan mudah pelaksanaannya 10/11/2013 4 . Cytoplasmic proteins.Petanda Tumor (PT) Jenis jenis Petanda Tumor    Cell surface antigens.

antidepressants & antiepileptics. pelvic TB associated with amenorrhoea.HCG: pada Choriocarcinoma False positive test for serum and urinary HCG can occur When a patient is taking drugs like phenothiazines. 5 10/11/2013 .  In proteinuria / menopause.

4mg/ml at 34 weeks of gestation. resembles albumin. Physiologically AFP is produced by The yolk sac of human foetus more than 4 weeks old and Later by liver & GI tract.e.  10/11/2013 6 . AFP exists in a number of isoforms which can be separated by their differential binding to lectins. AFP attains peak values i.Alfa Feto Protein /α-Feto Protein (AFP) A major foetal serum protein.

•High levels of CA-125 is detected also in advanced cases of Adenocarcinoma of CX.2% of healthy blood donors and 1% of normal healthy women and 5% Benign gynaecological disorder like endometriosis & PID. •16% of woman in 1st trimester of pregnancy •25% of non gynaecological conditions like cancers of GI tract and breast cancer. endometrium & fallopian tube. • 10/11/2013 7 .CA-125 It can also be positive in 0.

disease was still detected in 44% during second look surgery.  10/11/2013 8 . Persistently high levels of CA125 after treatment with cycles of chemotherapy indicates presence of resistant clones of tumour tissue. The predictive value of a -ve test is only 56% and dose not exclude the presence of tumour because when the level of ca125 was <35u/ml.CA-125: pada kanker Ovarium The predictive value of a +ve test is 100% and indicates presence of tumour tissue because when the level of ca125 was >35u/ml. disease was always detected during second look surgery.

5. In normal person with out endometriosis level is : .   If the ratio during menstrual phase to follicular phase is more then 1.13 to 95 u/ml (non-menstrual phase)  CA-125: pada Endometriosis The specificity in endometriosis is about 80% The sensitivity is around 66%. then it is a better sensitive marker.In minimal to mild endometriosis serum CA125 level is normal but in moderate to severe endometriosis the level rises. 10/11/2013 9 .14 to 31 u/ml (non-menstrual phase) In moderate to severe endometriosis level is: .8 to 22 u/ml (non-menstrual phase) In minimal to mild endometriosis level is: .

dan tidak mudah ditemukan dimana mana.Kesimpulan Banyak jenis petanda tumor ditemukan yang terkait dengan keganasan ginekologik. Agar dapat digunakan dengan praktis persolan petanda tumor harus diselesaikan 10/11/2013 10 . Namun kebanyakan spesifitas rendah sekali. Cara pemeriksaan deteksi dan estimasi sulit.

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