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Presented By: Omar Ramirez

What is Osteosarcoma?   The most common primary malignant neoplasm of bone that occurs in children and young adults Accounts for 60% of malignant bone lesions in the first two decades of life .

Occurrence is slightly higher in AfricanAmericans than in Whites and higher in males than in females.Statistics     On average. The highest occurrence in adolescence is 15 to 19 years old. . The overall survival rate for patients diagnosed between 1974 and 1994 is 63%. 400 cases are diagnosed per year.

are also risk factors that may be involved in genetic predisposition. such as Paget disease.Causes The exact cause of Osteosarcoma is unknown.  Abnormal development in bone tissue. . This most commonly occurs during the adolescent growth spurt in the metaphyseal area nearby the growth plate of long bones. risk factors include:  Rapid Bone Growth appears to predispose persons to this disease.  Exposure to radiation is an environmental factor that causes a secondary form of Osteosarcoma. however.

Symptoms   Pain and swelling of the affected area are the most common clinical findings On rare occasions. . fever and night sweats may occur.

A procedure performed for the specific purpose of removal Allograft replacement .the process of transplanting tissues and organs .Treatment    Preoperative and/or postoperative chemotherapy Resection .

Medications   Antineoplastic agents -. Antiemetic agents – Reduce the effects associated with chemotherapy . thereby inhibiting tumor growth and promoting tumor cell death.These agents disrupt DNA replication or cell division.

Note dramatic tumor extension into adjacent soft tissue regions.Diagnostic Imaging  MRI appearance (T1weighted image) of Osteosarcoma of the proximal humerus. .

.Diagnostic Imaging Radiographic appearance (plain x-ray) of proximal humeral Osteosarcoma.

Prognosis   The prognosis for patients diagnosed with Osteosarcoma depends primarily on whether metastases are detectable at diagnosis. For patients with initially localized disease. with long-term survival rates of less than 25%. Patients who present with metastases have a very poor prognosis. the prognosis depends mainly on 2 variables: resectability and response to chemotherapy. Those who have completely resectable disease and those whose tumors have an excellent histologic response to neoadjuvant chemotherapy have the best chance for cure. .

and longterm side effects will continue to be a goal of clinical trials for Osteosarcoma. . is curing patients with unresectable metastatic disease.Future Directions  Improving the survival rate and functional outcome and minimizing the short. however. The major challenge. .Works Cited    Pediatric Radiology: The Requisites American Cancer Society (www.cancer.