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Teratogenic potency of drugs and other disadvantages Drug dosage and the ability to cross the placenta The stadium of pregnancy General condition of the mother. .

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Directly 2. Indirectly .Elimination : Renal blood flow and GFR increase “Steady state” only slight declines but the dosage does not need increase Drug could damage the fetus : 1.

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basic .Placental determinants Drug determinants Area exchange Molecular weight < 600 Thickness of membranes Lipid soluble Enzyme systems Non-charged.

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Death => abortion Malformation / anomalies Retardation Changing in behavior .