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Respiratory System
Respiration
Ventilation: Movement of air into and out of lungs External respiration: Gas exchange between air in lungs and blood Transport of oxygen and carbon dioxide in the blood Internal respiration: Gas exchange between the blood and tissues
Lower tract
Larynx, trachea, bronchi, lungs
Pharynx
Common opening for digestive and respiratory systems Three regions
Nasopharynx Oropharynx Laryngopharynx
Larynx
Functions
Maintain an open passageway for air movement Epiglottis and vestibular folds prevent swallowed material from moving into larynx Vocal folds are primary source of sound production
Vocal Folds
Trachea
Windpipe Divides to form
Primary bronchi Carina: Cough reflex
Tracheobronchial Tree
Conducting zone
Trachea to terminal bronchioles which is ciliated for removal of debris Passageway for air movement Cartilage holds tube system open and smooth muscle controls tube diameter
Respiratory zone
Respiratory bronchioles to alveoli Site for gas exchange
Tracheobronchial Tree
Fig. 4. Effects of methacholine on depth of airway surface liquid. a: control tissue not exposed to methacholine. b: 2-min methacholine exposure. Putative sol and mucous gel are clearly visible. c: 30-min exposure. Tissues were radiant etched for 20 s to 1 min. Scale bar 5 20 m. From Am. J. Physiol. 274 (Lung Cell. Mol. Physiol. 18): L388 L395, 1998.
Lungs
Divisions
Lobes, bronchopulmonary segments, lobules
Thoracic Volume
Pleura
Ventilation
Movement of air into and out of lungs Air moves from area of higher pressure to area of lower pressure Pressure is inversely related to volume
Pleural pressure
Negative pressure can cause alveoli to expand Pneumothorax is an opening between pleural cavity and air that causes a loss of pleural pressure
Compliance
Measure of the ease with which lungs and thorax expand
The greater the compliance, the easier it is for a change in pressure to cause expansion A lower-than-normal compliance means the lungs and thorax are harder to expand
Conditions that decrease compliance
Pulmonary fibrosis Pulmonary edema Respiratory distress syndrome
Pulmonary Volumes
Tidal volume
Volume of air inspired or expired during a normal inspiration or expiration
Residual volume
Volume of air remaining in respiratory passages and lungs after the most forceful expiration
Pulmonary Capacities
Inspiratory capacity
Tidal volume plus inspiratory reserve volume
Vital capacity
Sum of inspiratory reserve volume, tidal volume, and expiratory reserve volume
Carbon dioxide
Moves from tissues into tissue capillaries Moves from pulmonary capillaries into the alveoli
Bohr effect:
Temperature effects:
Cl
Movement
Ventilation-perfusion coupling:
Rhythmic Ventilation
Starting inspiration
Medullary respiratory center neurons are continuously active Center receives stimulation from receptors and simulation from parts of brain concerned with voluntary respiratory movements and emotion Combined input from all sources causes action potentials to stimulate respiratory muscles
Increasing inspiration
More and more neurons are activated
Stopping inspiration
Neurons stimulating also responsible for stopping inspiration and receive input from pontine group and stretch receptors in lungs. Inhibitory neurons activated and relaxation of respiratory muscles results in expiration.
Modification of Ventilation
Cerebral and limbic system
Respiration can be voluntarily controlled and modified by emotions
Chemical control
Carbon dioxide is major regulator
Increase or decrease in pH can stimulate chemo- sensitive area, causing a greater rate and depth of respiration
Oxygen levels in blood affect respiration when a 50% or greater decrease from normal levels exists
Modifying Respiration
Herring-Breuer Reflex
Limits the degree of inspiration and prevents overinflation of the lungs
Infants
Reflex plays a role in regulating basic rhythm of breathing and preventing overinflation of lungs
Adults
Reflex important only when tidal volume large as in exercise
Ventilation in Exercise
Ventilation increases abruptly
At onset of exercise Movement of limbs has strong influence Learned component
Effects of Aging
Vital capacity and maximum minute ventilation decrease Residual volume and dead space increase Ability to remove mucus from respiratory passageways decreases Gas exchange across respiratory membrane is reduced
19
Unit Five
III. Organs of the Respiratory System (p.740; Fig. 19.1; Table 19.1)
A. The organs of the respiratory tract can be divided into two groups: the upper respiratory tract (nose, nasal cavity, sinuses, and pharynx), and the lower respiratory tract (larynx, trachea, bronchial tree, and lungs). B. Nose (p. 740) C. Nasal Cavity (p. 740; Figs. 19.2, 19.3) D. Sinuses (p. 741; Fig. 19.4)
III. Organs of the Respiratory System (p.740; Fig. 19.1; Table 19.1)
E. F. G. H. I. Pharynx (p. 741) Larynx (p. 742; Figs. 19.5-19.7) Trachea (p. 744; Figs. 19.8-19.11) Bronchial Tree (p. 746, Figs. 19.12-19.18) Lungs (p. 750; Fig. 19.19)
The End.